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Conference proceedings ; Online: A survey of Mixed Rossby-gravity waves and quantification of their association with extratropical disturbances

Keshri, S. / Ettammal, S.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: In this study we have conducted a survey of Mixed Rossby-Gravity (MRG) wave events in the upper troposphere and quantified their association with intrusions of extratropical disturbances from 1979-2019. MRG events are identified by projecting equatorial ...

Abstract	>In this study we have conducted a survey of Mixed Rossby-Gravity (MRG) wave events in the upper troposphere and quantified their association with intrusions of extratropical disturbances from 1979-2019. MRG events are identified by projecting equatorial meridional winds at 200 hPa onto the meridional structure of theoretical MRG waves. 2390 MRG events are identified and majority (61%) of them occurred during May-October months, and 65% of the activity occurred over the central-east Pacific and Atlantic Ocean. Not only frequency of occurrence but also amplitude, wavenumber and trapping scale of MRG events are found to exhibit a clear seasonality. MRG events associated with intrusions of extratropical disturbances are identified when potential vorticity on 350K isentropic surface at 15° latitude exceeds 1 PVU in vicinity of MRG events. We find that 37% of MRG events are intrusion MRG events and majority (88%) of such events occurred over central-east Pacific and Atlantic Ocean. It is also noteworthy that nearly 70% of such intrusions occurred in the winter Hemisphere where the westerly wind ducts are well developed. Over central-east Pacific during Northern Hemispheric (NH) winter, it is observed that amplitude of intrusion MRG events are larger and have larger meridional extent compared to non-intrusion MRG events. They also exhibit similar spatial scale as extratropical disturbances implying that resonant interactions may be a primary mechanism for genesis of MRG events. During NH summer, on the other hand, MRG events are primarily triggered by convective processes and extratropical disturbances may be instrumental in amplifying their amplitude.
Subject code	551
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
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Conference proceedings ; Online: Major Factors governing the trends and interannual variability in the occurrences of Mixed Rossby-Gravity Wave events

Na, M. / Keshri, S. / Ettammal, S.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: Mixed Rossby-Gravity (MRG) waves are westward propagating synoptic scale equatorial disturbances, which play a crucial role in the formation of tropical cyclones and tropical depressions. They constitute a significant part of various modes of tropical ... ...

Abstract	Mixed Rossby-Gravity (MRG) waves are westward propagating synoptic scale equatorial disturbances, which play a crucial role in the formation of tropical cyclones and tropical depressions. They constitute a significant part of various modes of tropical variability, like Madden-Julian Oscillation (MJO) and Quasi-Biennial Oscillation. This study investigates the trends and Inter Annual Variability (IAV) in the occurrence of upper tropospheric MRG events using ERA-I reanalysis data for the period 1979-2018. The MRG events are identified by projecting the 200hpa meridional winds onto the theoretical spatial structure of MRG waves. A steady increasing trend is observed in the MRG events, which is contributed by the MRG events associated with intrusion of extratropical disturbances. Possible factors governing the observed trend and IAV in MRG events are El-Nino Southern Oscillation (ENSO), MJO and extratropical forcing. The MRG events over the central and eastern Pacific contribute maximum to IAV. ENSO explains about 25% of IAV and exhibits a positive correlation with non-intrusion MRG events and a negative correlation with intrusion MRG events. These observations have been investigated by exploring the properties of the westerly duct at 200hPa and Outgoing Longwave Radiation during El-Nino and La-Nina years over the central-eastern Pacific. The convectively active state of MJO over the western Pacific explains 20% of IAV. The antisymmetric heating with respect to the equator, associated with MJO, enhances non-intrusion MRG events by forbidding the intrusion of extratropical disturbances through subtropical easterlies. The increasing trend in the intrusion of extratropical disturbances explains the observed trend in MRG events.
Subject code	551
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Synthesis, physical properties, and biomedical applications of magnetic nanoparticles: a review.

Keshri, Sunita / Biswas, Sonali

Progress in biomaterials

2022 Volume 11, Issue 4, Page(s) 347–372

Abstract: Recent innovations in nanotechnology have opened the applicability of multifunctional nanoparticles (NPs) in biomedical diagnosis and treatment. The examples of NPs which have attracted considerable attention in recent years are metals (e.g., Au, Ag, Mg), ...

Abstract	Recent innovations in nanotechnology have opened the applicability of multifunctional nanoparticles (NPs) in biomedical diagnosis and treatment. The examples of NPs which have attracted considerable attention in recent years are metals (e.g., Au, Ag, Mg), alloys (e.g., Fe-Co, Fe-Pd, Fe-Pt, Co-Pt), iron oxides (e.g., Fe
Language	English
Publishing date	2022-09-26
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	2194-0509
ISSN	2194-0509
DOI	10.1007/s40204-022-00204-8
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Article ; Online: The post-translational regulation of transcription factor EB (TFEB) in health and disease.

Takla, Michael / Keshri, Swati / Rubinsztein, David C

EMBO reports

2023 Volume 24, Issue 11, Page(s) e57574

Abstract: Transcription factor EB (TFEB) is a basic helix-loop-helix leucine zipper transcription factor that acts as a master regulator of lysosomal biogenesis, lysosomal exocytosis, and macro-autophagy. TFEB contributes to a wide range of physiological functions, ...

Abstract	Transcription factor EB (TFEB) is a basic helix-loop-helix leucine zipper transcription factor that acts as a master regulator of lysosomal biogenesis, lysosomal exocytosis, and macro-autophagy. TFEB contributes to a wide range of physiological functions, including mitochondrial biogenesis and innate and adaptive immunity. As such, TFEB is an essential component of cellular adaptation to stressors, ranging from nutrient deprivation to pathogenic invasion. The activity of TFEB depends on its subcellular localisation, turnover, and DNA-binding capacity, all of which are regulated at the post-translational level. Pathological states are characterised by a specific set of stressors, which elicit post-translational modifications that promote gain or loss of TFEB function in the affected tissue. In turn, the resulting increase or decrease in survival of the tissue in which TFEB is more or less active, respectively, may either benefit or harm the organism as a whole. In this way, the post-translational modifications of TFEB account for its otherwise paradoxical protective and deleterious effects on organismal fitness in diseases ranging from neurodegeneration to cancer. In this review, we describe how the intracellular environment characteristic of different diseases alters the post-translational modification profile of TFEB, enabling cellular adaptation to a particular pathological state.
MeSH term(s)	Lysosomes/metabolism ; Protein Processing, Post-Translational ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism
Chemical Substances	Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.15252/embr.202357574
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Zs.A 5433: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Imaging for Laryngeal Malignancies: Guidelines for Clinicians.

Priya, S R / Dandekar, Mitali / Paul, Peter / Dravid, Chandra Shekhar / Anand, Abhishek / Keshri, Shekhar

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue 4, Page(s) 3386–3395

Abstract: Radiology has always been an important component in the evaluation of patients with head and neck cancers. Images that are appropriately acquired and systematically interpreted provide comprehensive information on local, regional, and distant disease ... ...

Abstract	Radiology has always been an important component in the evaluation of patients with head and neck cancers. Images that are appropriately acquired and systematically interpreted provide comprehensive information on local, regional, and distant disease extent. This impacts treatment decisions for primary or recurrent disease, and aids in prognostication and patient counselling. The recent significant advances in technology and instrumentation for treatment of head neck cancers have taken place in parallel with an increasing sophistication in radiodiagnostic systems. This is especially true for laryngeal neoplasms where there is now greater focus on functional outcomes and personalised treatment, thus expanding the scope and value of imaging. Purpose: To formulate evidence-based guidelines on imaging for cancers of the larynx, from diagnosis and staging to monitoring of disease control after completion of treatment. Methods and materials: A multidisciplinary analysis of current guidelines and published studies on the topic was performed. Results: On the basis of evidence gathered, guidelines were drawn up; optimal suggestions were included for low-resource situations. Conclusion: These guidelines are intended as an aid to all clinicians dealing with patients of laryngeal cancers. It is hoped that these will be instrumental in facilitating patient care, and in improving outcomes.
Language	English
Publishing date	2023-06-23
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-03986-w
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Article: Reversal of Acute Lead Encephalopathy in a Child.

Keshri, Swasti / Goel, Anil Kumar / Garg, Ankit Kumar

Cureus

2021 Volume 13, Issue 5, Page(s) e15155

Abstract: Lead poisoning, fairly common in the 20th century, has decreased drastically in the last decade. Severe lead poisoning in the form of encephalopathy has a fatality rate of 28% to 45% and neurological sequelae in about 82%. We present the management of a ... ...

Abstract	Lead poisoning, fairly common in the 20th century, has decreased drastically in the last decade. Severe lead poisoning in the form of encephalopathy has a fatality rate of 28% to 45% and neurological sequelae in about 82%. We present the management of a case of lead encephalopathy that recovered without any significant neurological sequelae in a resource-limited setting. A previously healthy seven-year-old boy presented with complaints of falling unconscious on the ground while playing, followed by multiple episodes of seizures, vomiting, and altered sensorium. The patient had pallor, Glasgow coma score of E2V3M3, with features of raised intracranial pressure. Lead poisoning was suspected as the patient had four months of exposure to a battery recycling factory. Management of seizures and raised intracranial pressure was done. X-ray long bones showed lead lines at the metaphysis. Blood lead levels were highly elevated (139.96 mcg/dL). Investigations revealed iron deficiency anemia, vitamin D deficiency, and renal tubular injury in the form of proteinuria. D-penicillamine with supplements was started due to unavailability of other chelating agents. Encephalopathy improved, but patient had psychiatric symptoms of hallucinations and delusions. On the 12th day, CaNa
Language	English
Publishing date	2021-05-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.15155
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Article ; Online: A Novel SCN8A mutation in a case of early-onset infantile epileptic encephalopathy: A Case Report.

Keshri, Swasti / Goel, Anil Kumar / Shah, Seema / Garg, Ankit Kumar

Acta bio-medica : Atenei Parmensis

2022 Volume 92, Issue S1, Page(s) e2021261

Abstract: SCN8A gene encodes sodium channel alpha subunit Nav1.6, and its mutation is associated with Early Infantile Epileptic Encephalopathy-13 (EIEE-13). The mean age of onset is 4-5 months. The phenotype of SCN8A mutation varies from benign epilepsy syndromes, ...

Abstract	SCN8A gene encodes sodium channel alpha subunit Nav1.6, and its mutation is associated with Early Infantile Epileptic Encephalopathy-13 (EIEE-13). The mean age of onset is 4-5 months. The phenotype of SCN8A mutation varies from benign epilepsy syndromes, movement disorder, intellectual disability to severe epileptic syndromes with different types of seizures. We hereby report a case of a one-year old female who had an onset of infantile spasms on the seventeenth day of life, which gradually progressed to focal, multifocal, GTCS, and epileptic encephalopathy by one year of age associated with global developmental delay and hypotonia. All metabolic workup, TMS, GCMS, and MRI brain were normal. EEG at 2.5 months was suggestive of epileptic discharge arising from the left frontal region, evolving into generalized discharges. Whole exome sequencing revealed a heterozygous mutation in the SCN8A gene at exon 16 (p.Val892Ala) suggestive of Early Infantile Epileptic Encephalopathy-13 (EIEE-13). This is a novel mutation in the SCN8A gene which has not been reported previously in the literature.
MeSH term(s)	Epilepsy/genetics ; Female ; Humans ; Infant ; Mutation ; NAV1.6 Voltage-Gated Sodium Channel/genetics ; NAV1.6 Voltage-Gated Sodium Channel/metabolism ; Spasms, Infantile/complications ; Spasms, Infantile/genetics
Chemical Substances	NAV1.6 Voltage-Gated Sodium Channel ; SCN8A protein, human
Language	English
Publishing date	2022-02-21
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v92iS1.11781
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Zs.B 925: Show issues

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Article: "Liver Failure in an Infant of Late-Onset Glutaric Aciduria Type II": Case Report.

Keshri, Swasti / Goel, Anil Kumar / Johns, Juliet / Shah, Seema

Indian journal of clinical biochemistry : IJCB

2021 Volume 38, Issue 4, Page(s) 545–549

Abstract: Glutaric aciduria type II, also known as Multiple acyl-CoA Dehydrogenase Deficiency, results from a defect in the mitochondrial electron transport chain resulting in an inability to break down fatty-acids and amino acids. There are three phenotypes- type ...

Abstract	Glutaric aciduria type II, also known as Multiple acyl-CoA Dehydrogenase Deficiency, results from a defect in the mitochondrial electron transport chain resulting in an inability to break down fatty-acids and amino acids. There are three phenotypes- type 1 and 2 are of neonatal onset and severe form, with and without congenital anomalies, respectively, and presents with acidosis, severe hypotonia, cardiomyopathy, hepatomegaly, and non-ketotic hypoglycemia. Type 3 or late-onset Multiple acyl-CoA Dehydrogenase Deficiency usually presents in the adolescent or adult age group with phenotype ranging from mild forms of myopathy and exercise intolerance to severe forms of acute metabolic decompensation on its chronic course. Type 3 Multiple acyl-CoA Dehydrogenase Deficiency rarely presents in infancy and in liver failure. We present a five-month-old developmentally normal female child with acute encephalopathy, hypotonia, non-ketotic hypoglycemia, metabolic acidosis, and liver failure, with a history of sibling death of suspected inborn error of metabolism. The blood acyl-carnitine levels in Tandem Mass Spectrometry and urinary organic acid analysis through Gas Chromatography-Mass Spectrometry were unremarkable. The patient initially responded to riboflavin, CoQ, and supportive management but ultimately succumbed to sepsis with shock and multi-organ dysfunction. The clinical exome sequencing reported a homozygous missense variation in exon 11 of the
Language	English
Publishing date	2021-09-27
Publishing country	India
Document type	Case Reports
ZDB-ID	1033583-3
ISSN	0974-0422 ; 0970-1915
ISSN (online)	0974-0422
ISSN	0970-1915
DOI	10.1007/s12291-021-01007-7
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Article ; Online: Thermodynamics of hydration of fullerols [C

Keshri, Sonanki / Tembe, B L

The Journal of chemical physics

2017 Volume 146, Issue 7, Page(s) 74501

Abstract: Molecular dynamics simulations of fullerene and fullerols [ ... ...

Abstract	Molecular dynamics simulations of fullerene and fullerols [C
Language	English
Publishing date	2017-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.4975230
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Article ; Online: Structural and Dynamical Properties of Alkaline Earth Metal Halides in Supercritical Water: Effect of Ion Size and Concentration.

Keshri, Sonanki / Tembe, B L

The journal of physical chemistry. B

2017 Volume 121, Issue 46, Page(s) 10543–10555

Abstract: Constant temperature-constant pressure molecular dynamics simulations have been performed for aqueous alkaline earth metal chloride [ ... ...

Abstract	Constant temperature-constant pressure molecular dynamics simulations have been performed for aqueous alkaline earth metal chloride [M
Language	English
Publishing date	2017-11-22
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.7b07690
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