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  1. Article ; Online: Role of exercise therapy and cardiac rehabilitation in heart failure.

    Patel, Lajjaben / Dhruve, Ritika / Keshvani, Neil / Pandey, Ambarish

    Progress in cardiovascular diseases

    2024  Volume 82, Page(s) 26–33

    Abstract: Heart failure (HF) is a common cause of hospitalization and death, and the hallmark symptoms of HF, including dyspnea, fatigue, and exercise intolerance, contribute to poor patient quality of life (QoL). Cardiac rehabilitation (CR) is a comprehensive ... ...

    Abstract Heart failure (HF) is a common cause of hospitalization and death, and the hallmark symptoms of HF, including dyspnea, fatigue, and exercise intolerance, contribute to poor patient quality of life (QoL). Cardiac rehabilitation (CR) is a comprehensive disease management program incorporating exercise training, cardiovascular risk factor management, and psychosocial support. CR has been demonstrated to effectively improve patient functional status and QoL among patients with HF. However, CR participation among patients with HF is poor. This review details the mechanisms of dyspnea and exercise intolerance among patients with HF, the physiologic and clinical improvements observed with CR, and the key components of a CR program for patients with HF. Furthermore, unmet needs and future strategies to improve patient participation and engagement in CR for HF are reviewed.
    MeSH term(s) Humans ; Cardiac Rehabilitation ; Quality of Life ; Heart Failure/diagnosis ; Heart Failure/therapy ; Exercise Therapy/adverse effects ; Dyspnea
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209312-1
    ISSN 1873-1740 ; 1532-8643 ; 0033-0620
    ISSN (online) 1873-1740 ; 1532-8643
    ISSN 0033-0620
    DOI 10.1016/j.pcad.2024.01.002
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  2. Article ; Online: Skeletal Muscle Mitochondrial Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction.

    Pandey, Ambarish / Keshvani, Neil / Alonso, Windy

    JAMA cardiology

    2023  Volume 8, Issue 6, Page(s) 584–585

    MeSH term(s) Humans ; Stroke Volume ; Heart Failure ; Muscle, Skeletal ; Mitochondria
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.0963
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  3. Article ; Online: Prevalence and Incidence of Pre-HF Among Hispanics/Latinos.

    Pandey, Ambarish / Keshvani, Neil / Piña, Ileana L

    JACC. Heart failure

    2023  Volume 11, Issue 8 Pt 1, Page(s) 958–960

    MeSH term(s) Humans ; United States/epidemiology ; Prevalence ; Incidence ; Heart Failure ; Risk Factors ; Hispanic or Latino
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.05.021
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  4. Article ; Online: From prediction to prevention: The role of heart failure risk models: Heart to Heart: The Promise and Pitfalls of Heart Failure Risk Prediction Models.

    Segar, Matthew W / Keshvani, Neil / Pandey, Ambarish

    European journal of heart failure

    2023  Volume 25, Issue 10, Page(s) 1739–1741

    MeSH term(s) Humans ; Heart Failure/epidemiology ; Heart Failure/prevention & control ; Heart ; Risk Factors ; Risk Assessment
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3034
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  5. Article ; Online: Are post-influenza vaccine reactions truly 'adverse'?

    Patel, Lajjaben / Keshvani, Neil / Pandey, Ambarish

    European journal of heart failure

    2023  Volume 25, Issue 2, Page(s) 311–312

    MeSH term(s) Humans ; Influenza Vaccines ; Heart Failure ; Influenza, Human/prevention & control
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2023-01-22
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2765
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  6. Article ; Online: Beyond Physical Impairment: The Role of Social Frailty in Heart Failure.

    Keshvani, Neil / Pandey, Ambarish

    Journal of the American Heart Association

    2021  Volume 10, Issue 17, Page(s) e022187

    MeSH term(s) Aged ; Frail Elderly ; Frailty/diagnosis ; Frailty/epidemiology ; Heart Failure/epidemiology ; Humans
    Language English
    Publishing date 2021-09-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.022187
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  7. Article ; Online: Association of Beta-Blocker Use With Exercise Capacity in Participants With Heart Failure With Preserved Ejection Fraction: A Post Hoc Analysis of the RELAX Trial.

    Patel, Lajjaben / Segar, Matthew W / Keshvani, Neil / Subramanian, Vinayak / Pandey, Ambarish / Chandra, Alvin

    The American journal of cardiology

    2024  Volume 216, Page(s) 48–53

    Abstract: Patients with heart failure with preserved ejection fraction (HFpEF) often receive β-blocker (BB) therapy for management of co-morbidities. However, the association of BB therapy with exercise capacity and health-related quality of life (HRQL) in HFpEF ... ...

    Abstract Patients with heart failure with preserved ejection fraction (HFpEF) often receive β-blocker (BB) therapy for management of co-morbidities. However, the association of BB therapy with exercise capacity and health-related quality of life (HRQL) in HFpEF is not well-studied. In this post hoc analysis of the Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in HFpEF (RELAX) trial, which included patients with chronic stable HFpEF with peak exercise capacity assessment at baseline and at 12 and 24 weeks of follow-up, we evaluated the association of BB use with the measures of exercise capacity (peak exercise oxygen uptake), anaerobic threshold, and HRQL (Minnesota living with heart failure questionnaire). Separate linear mixed-effect models were constructed for each outcome with adjustment for treatment arm, demographics, medical history, left ventricular ejection fraction, and duration of heart failure. Of the 216 study participants (median age 69 years, 48.2% women), 76% reported BB use at baseline. Participants with (vs without) BB therapy were older (70 vs 63.5 years, p = 0.001) and had a higher prevalence of ischemic heart disease (44% vs 23%, p = 0.01). In the adjusted linear mixed model, BB use over time was not associated with peak exercise oxygen uptake (β 95% confidence interval [CI] 0.2 (-0.31 to 0.7), p = 0.5) and 6-minute walk distance (β 95% CI 14.69 [-14.25 to 43.63], p = 0.3). However, BB use was associated with a higher anaerobic threshold (β 95% CI 0.32 (0.02 to 0.62), p = 0.036) and better HRQL (lower quality of life as assessed by Minnesota living with heart failure questionnaire score) (β 95% CI -6.68 [-10.96 to -2.4], p = 0.002). Future trials are needed to better evaluate the effects of BB on exercise capacity in patients with chronic stable HFpEF.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Adrenergic beta-Antagonists/therapeutic use ; Adrenergic beta-Antagonists/pharmacology ; Exercise Tolerance/physiology ; Heart Failure ; Oxygen ; Quality of Life ; Stroke Volume/physiology ; Ventricular Function, Left
    Chemical Substances Adrenergic beta-Antagonists ; Oxygen (S88TT14065)
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2024.01.023
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  8. Article ; Online: Should Polypills Be Used for Heart Failure With Reduced Ejection Fraction?

    Pandey, Ambarish / Keshvani, Neil / Wang, Thomas J

    Circulation

    2022  Volume 146, Issue 4, Page(s) 276–278

    MeSH term(s) Heart Failure/diagnosis ; Heart Failure/drug therapy ; Humans ; Stroke Volume ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.059661
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  9. Article ; Online: Emphasising classification in emphysematous pyelonephritis.

    Hinkamp, Colin Andrew / Keshvani, Neil

    Lancet (London, England)

    2020  Volume 395, Issue 10230, Page(s) 1145

    MeSH term(s) Emphysema/diagnosis ; Emphysema/etiology ; Emphysema/therapy ; Female ; Humans ; Middle Aged ; Pyelonephritis/diagnosis ; Pyelonephritis/etiology ; Pyelonephritis/therapy ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-04-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30475-X
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  10. Article ; Online: Reply: The Urgent Need for More Cardiac Rehabilitation in the Aim to "Preserve" Patients With Heart Failure.

    Keshvani, Neil / Pandey, Ambarish / Fonarow, Gregg C

    JACC. Heart failure

    2021  Volume 9, Issue 8, Page(s) 611

    MeSH term(s) Cardiac Rehabilitation ; Exercise Therapy ; Exercise Tolerance ; Heart Failure ; Humans
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2021.06.003
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