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Article ; Online: Challenges in Diagnosis and Treatment of

Pınarlık, Fatihan / Keske, Şiran / Rozanes, İzzet / Ergönül, Önder

Infectious diseases & clinical microbiology

2023 Volume 5, Issue 1, Page(s) 49–52

Abstract: A 57-year-old female patient presented with fever, nausea, vomiting, loss of appetite, and weight loss within the last two months. Ceftriaxone and metronidazole therapy was started upon discovery of a liver abscess but provided no benefit. Following the ... ...

Abstract	A 57-year-old female patient presented with fever, nausea, vomiting, loss of appetite, and weight loss within the last two months. Ceftriaxone and metronidazole therapy was started upon discovery of a liver abscess but provided no benefit. Following the of abscess biopsy, the patient developed fever, itching, anemia, acute renal failure, hyperbilirubinemia, and eosinophilia that required intensive care unit (ICU) admission. The
Language	English
Publishing date	2023-03-11
Publishing country	Turkey
Document type	Case Reports
ISSN	2667-646X
ISSN (online)	2667-646X
DOI	10.36519/idcm.2023.197
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Article ; Online: Discrepancy between IDSA and ESGBOR in Lyme disease: Individual participant meta-analysis in Türkiye.

Yıldız, Abdullah Burak / Çetin, Ecesu / Pınarlık, Fatihan / Keske, Şiran / Can, Füsun / Ergönül, Önder

Zoonoses and public health

2024 Volume 71, Issue 4, Page(s) 337–348

Abstract: Background: The evidence on the prevalence of Lyme borreliosis (LB) is limited, but there is a suspicion of overdiagnosis of LB in recent years. We reviewed the LB diagnosis and treatment-related data in Türkiye, based on the Infectious Diseases Society ...

Abstract	Background: The evidence on the prevalence of Lyme borreliosis (LB) is limited, but there is a suspicion of overdiagnosis of LB in recent years. We reviewed the LB diagnosis and treatment-related data in Türkiye, based on the Infectious Diseases Society of America (IDSA) 2020 and European Society of Clinical Microbiology and Infectious Diseases Study Group for Lyme Borreliosis (ESGBOR) 2018 guidelines. By detecting the disagreements between these two, we outlined the areas to be improved for future guidelines. Methods: We performed a literature search according to the PRISMA guidelines in PubMed, Ovid-Medline, Web of Science, Turkish Medline, Scopus, CINAHL, ULAKBIM TR Index, Google Scholar and Cochrane Library databases. We included the published cases in a database and evaluated according to IDSA and ESGBOR guidelines. We outlined the reasons for misdiagnoses and inappropriate uses of antibiotics. Results: We included 42 relevant studies with 84 LB cases reported from Türkiye between 1990 and December 2022. Among 84 cases, the most common clinical findings were nervous system findings (n = 37, 44.0%), erythema migrans (n = 29, 34.5%) and ophthalmologic findings (n = 15, 17.9%). The IDSA 2020 and ESGBOR 2018 guidelines agreed on the diagnosis of 71 (84.5%) cases; there was an agreement that 31 cases (36.9%) were misdiagnosed and 40 cases (47.6%) were correctly diagnosed, and there was disagreement for 13 cases (15.5%). Serum immunoglobulin M (IgM), IgG measurements by ELISA and western blot were widely performed, and they were effective in definitive diagnosis merely when used according to guidelines. Inappropriate use of antibiotics was detected in 42 (50.0%) of cases which were classified in the following categories: incorrect LB diagnosis, inappropriate choice of antibiotic, inappropriate route of drug administration and prolonged antibiotic treatment. Conclusion: Overdiagnosis and non-adherence to guidelines is a common problem. The discordance between seroprevalence and clinical studies necessitates a consensus over the best clinical approach.
MeSH term(s)	Lyme Disease/diagnosis ; Lyme Disease/epidemiology ; Lyme Disease/drug therapy ; Humans ; Turkey/epidemiology ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-27
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Systematic Review ; Review
ZDB-ID	2271118-1
ISSN	1863-2378 ; 1863-1959
ISSN (online)	1863-2378
ISSN	1863-1959
DOI	10.1111/zph.13119
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Article ; Online: Alarming increase in fluoroquinolone resistance among non-typhoidal salmonella isolates.

Beşli, Yeşim / Keske, Şiran / Dikenelli, Bilge E / Palaoğlu, K Erhan / Ergönül, Önder

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2024

Language	English
Publishing date	2024-03-09
Publishing country	England
Document type	Letter
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2024.03.010
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Article ; Online: The Practice of Antimicrobial Stewardship in Thoracic Surgery and its Effectiveness.

Madran, Bahar / Keske, Şiran / Tanju, Serhan / Cesur, Ekin Ezgi / Pala, Selin / Dilege, Şükrü / Ergönül, Önder

Infectious diseases & clinical microbiology

2024 Volume 6, Issue 1, Page(s) 60–65

Abstract: This study examines the effects of the bundle of antimicrobial stewardship measures for prophylactic antibiotics among thoracic surgery patients. A local protocol, based on current guidelines starting from December 2014, was developed by the Infection ... ...

Abstract	This study examines the effects of the bundle of antimicrobial stewardship measures for prophylactic antibiotics among thoracic surgery patients. A local protocol, based on current guidelines starting from December 2014, was developed by the Infection Control and Thoracic Surgery Teams. The effects of this protocol were assessed by monitoring a total of 1380 patients before and after its implementation from January 1, 2011, to December 31, 2022.
Language	English
Publishing date	2024-03-08
Publishing country	Turkey
Document type	Journal Article
ISSN	2667-646X
ISSN (online)	2667-646X
DOI	10.36519/idcm.2024.301
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Article ; Online: Approach to Fever in the Returning Traveler.

Ergönül, Önder / Keske, Şiran

The New England journal of medicine

2017 Volume 376, Issue 18, Page(s) 1797

MeSH term(s)	Fever ; Humans ; Travel
Keywords	covid19
Language	English
Publishing date	2017--04
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc1703009
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Article ; Online: What is the 'new normal' in surgical procedures in the era of COVID-19?

Cimen, Cansu / Keske, Şiran / Ergönül, Önder

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2020 Volume 27, Issue 1, Page(s) 16–18

MeSH term(s)	COVID-19/diagnosis ; COVID-19/prevention & control ; COVID-19 Testing/methods ; Elective Surgical Procedures/methods ; Humans ; Mass Screening ; Preoperative Care/methods ; SARS-CoV-2 ; Surveys and Questionnaires
Keywords	covid19
Language	English
Publishing date	2020-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2020.09.038
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: COVID-19 associated bacterial infections in intensive care unit: a case control study.

Kaçmaz, Bahar / Keske, Şiran / Sişman, Uluman / Ateş, Sena Tuğana / Güldan, Mustafa / Beşli, Yeşim / Palaoğlu, Erhan / Çakar, Nahit / Ergönül, Önder

Scientific reports

2023 Volume 13, Issue 1, Page(s) 13345

Abstract: We described the secondary bacterial infections (SBI) among COVID-19 patients in comparison with non-COVID-19 patients. We performed a retrospective case-control study between January 01, 2020 and April 01, 2022. Including the adult patients, who stayed ≥ ...

Abstract	We described the secondary bacterial infections (SBI) among COVID-19 patients in comparison with non-COVID-19 patients. We performed a retrospective case-control study between January 01, 2020 and April 01, 2022. Including the adult patients, who stayed ≥ 72 h in intensive care unit (ICU). In total 405 patients were included, 135 had (33.3%) COVID-19, with similar age and gender. The length of stay in ICU was not different (11.4 vs 8.2, p = 0.109), however mean intubation days were higher among COVID-19 cases (6.5 vs 3.8, p = 0.005), SBI were more common among COVID-19 cases (34% vs 10.7%, p < 0.001). Among the patients with pneumonia, the rate of gram-positive bacteria was higher in COVID-19 group than the control group (39% vs 5%, p = 0.006). The predictors for SBI were having COVID-19 (OR: 2.3, Cl 1.25-4.32, p = 0.008), days of intubation (OR: 1.05, Cl 1.01-1.10, p = 0.004), and being male (OR: 2, Cl 1.12-3.58, p = 0.018). The predictors of mortality were COVID-19 (OR: 2.38, Cl 1.28-4.42, p = 0.006), days of intubation (OR: 1.06, Cl 1.03-1.09, p < 0.001), active hematologic malignancy (OR: 3.1, Cl: 1.33-7.28, p = 0.09), active solid tumors (OR: 2.44, Cl 1.21-4.91, p = 0.012), and coronary artery diseases (OR: 1.8, Cl 1.01-3.52, p = 0.045). The most common SBI in COVID-19 patients were methicillin-sensitive Staphylococcus aureus. No carbapenem-resistant Enterobacterales related infections were detected in COVID-19 patients.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Case-Control Studies ; COVID-19 ; Retrospective Studies ; Carbapenems ; Coinfection ; Intensive Care Units
Chemical Substances	Carbapenems
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-39632-2
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Article ; Online: The challenges in the monitoring of infectious diseases after the earthquake in Türkiye in 2023.

Ergönül, Önder / Keske, Şiran / Ksinzik, Apolina / Güldan, Mustafa / Özbek, Laşin / Azap, Alpay / Şimşek-Yavuz, Serap / Can, Füsun / Sakarya, Sibel

The Lancet. Infectious diseases

2023 Volume 23, Issue 11, Page(s) e482–e488

Abstract: After the devastating earthquake in Türkiye and Syria in February, 2023, the long-term failure to meet the need for shelter, unfavourable living conditions in tent settlements, poor access to clean drinking water, water suitable for personal hygiene, and ...

Abstract	After the devastating earthquake in Türkiye and Syria in February, 2023, the long-term failure to meet the need for shelter, unfavourable living conditions in tent settlements, poor access to clean drinking water, water suitable for personal hygiene, and sanitary facilities, as well as interruptions in provision of primary health-care services, have emerged as the most important risk factors contributing to the spread of infectious diseases. 3 months after the earthquake, most of these problems persist in Türkiye. Data on the control of infectious diseases are scarce according to the reports prepared by medical specialist associations based on observations of health-care providers working in the region and statements made by the local health authorities. According to these unsystematised data, and considering the conditions in the region, faecal-oral transmissible gastrointestinal infections, as well as respiratory and vector-borne infections, are the main challenges. Vaccine-preventable diseases, such as measles, varicella, meningitis, and polio can be spread in temporary shelters due to interrupted vaccine services and crowded living conditions. In addition to controlling risk factors for infectious diseases, sharing data on the status and control of infectious diseases in the region with the community, health-care providers, and relevant expert groups should be a priority to improve the understanding of the effects of interventions and prepare for possible infectious disease outbreaks.
MeSH term(s)	Humans ; Earthquakes ; Communicable Diseases/epidemiology ; Disease Outbreaks ; Health Services ; Syria
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(23)00362-6
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Article ; Online: The Effect of Vaccination with Pfizer-BioNTech or CoronaVac on Disease Prognosis Among Hospitalized COVID-19 Patients.

Güldan, Mustafa / Ateş, Sena Tuğana / Sarıoğlu, Sebile / Suyabatmaz, Sarp / İrkören, Pelin / Tekin, Süda / Kapmaz, Mahir / Keske, Şiran / Ergönül, Önder

Infectious diseases & clinical microbiology

2023 Volume 5, Issue 2, Page(s) 106–112

Abstract: Objective: The Turkish Ministry of Health offered two types of vaccines by January 13, 2021, which are CoronaVac (Sinovac Biotech, China) and Pfizer-BioNTech. We aimed to describe the impact of the CoronaVac and Pfizer-BioNTech vaccines on clinical ... ...

Abstract	Objective: The Turkish Ministry of Health offered two types of vaccines by January 13, 2021, which are CoronaVac (Sinovac Biotech, China) and Pfizer-BioNTech. We aimed to describe the impact of the CoronaVac and Pfizer-BioNTech vaccines on clinical outcomes among hospitalized patients during a six-month period. Methods: We included patients older than 18 years old and hospitalized because of COVID-19 when the vaccines were available. We conducted the study at Koç University Hospital and American Hospital between June 2021, six months after the vaccination started, and December 2021. Results: In total, 444 RT-PCR confirmed hospitalized patients were included. The mean age of the patients was 59 (standard deviation [SD]=18), and 42.8% were female. The most common comorbidity was hypertension (39%), followed by diabetes mellitus (27%), cardiovascular diseases (18.4%), chronic lung diseases (14.6%), cancer (9.2%), and chronic renal diseases (8%). In multivariate analysis, no vaccination (OR=4.7, CI=2.25-10.06; Conclusion: Among the inpatients with COVID-19, the predictors for mortality were being unvaccinated, older age, cancer, chronic kidney disease, and cardiovascular diseases. Among the vaccinated inpatients, having two doses of the Pfizer-BioNTech vaccine was the only effective protective measure against mortality, and two doses of the CoronaVac vaccine had no significant effect in preventing fatality.
Language	English
Publishing date	2023-06-23
Publishing country	Turkey
Document type	Journal Article
ISSN	2667-646X
ISSN (online)	2667-646X
DOI	10.36519/idcm.2023.226
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Article ; Online: Influenza vaccination among infection control teams: A EUCIC survey prior to COVID-19 pandemic.

Keske, Şiran / Mutters, Nico T / Tsioutis, Constantinos / Ergönül, Önder

Vaccine

2020 Volume 38, Issue 52, Page(s) 8357–8361

Abstract: We aimed to describe the influenza vaccination rate and its determinants among infection control team (ICT) across different countries. Online multilingual survey consisting of 23 items, between 17 May -15 July of 2019 targeting the opinions and ... ...

Abstract	We aimed to describe the influenza vaccination rate and its determinants among infection control team (ICT) across different countries. Online multilingual survey consisting of 23 items, between 17 May -15 July of 2019 targeting the opinions and practices of ICTs regarding the 2018-2019 influenza season was employed. Participants were reached via European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and European Union Certificate for Infection Control (EUCIC) newsletters,social media, and national societies. In total, 899 participants from 56 countries responded to the survey. The overall vaccination rate was 76%, being the highest in Finland, Portugal, Norway, and Israel (100%), whereas the lowest in Italy (68%) and Turkey (39%). Influenza vaccination rate was 86% among IC physicians and 52% among IC nurses. The most significant factors affecting participants' decision were personal influenza vaccine experience (49%) and attitude of the scientific authorities (48%). In multivariate analysis, vaccination of the ICT head (OR: 16.04, 95%CI: 8.4-30.8, p < 0.001) and having free vaccine (OR: 7.56, 95%CI: 2.1-27.4, p = 0.02) were found to be the strongest predictors for influenza vaccination, whereas working in Turkey (OR: 0.41, 95%CI: 0.22-0.77, p = 0.006) and being an IC nurse (OR:0.43, 95%CI: 0.24-0.80, p = 0.007) were significantly associated with not having been vaccinated. In conclusion, COVID-19 pandemic increased the importance of protection against respiratory viruses including influenza. Vaccination strategies should have a special emphasis on IC nurses, who have a relatively lower vaccination rate, should enhance the vaccination of the ICT leaders, and put effort to provide free availability of the influenza vaccine.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19 ; Europe ; Female ; Health Personnel/statistics & numerical data ; Humans ; Infection Control ; Influenza Vaccines/therapeutic use ; Influenza, Human/prevention & control ; Male ; Middle Aged ; Nurses/statistics & numerical data ; Physicians/statistics & numerical data ; Surveys and Questionnaires ; Vaccination/statistics & numerical data ; Vaccination Refusal/psychology ; Vaccination Refusal/statistics & numerical data ; Young Adult
Chemical Substances	Influenza Vaccines
Keywords	covid19
Language	English
Publishing date	2020-11-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2020.11.003
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Zs.MO 458: Show issues

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