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Article ; Online: COVID-19 symptoms masking inaugural ketoacidosis of type 1 diabetes.

Potier, L / Julla, J B / Roussel, R / Boudou, P / Gauthier, D C / Ketfi, C / Gautier, J F

2020 Volume 47, Issue 1, Page(s) 101162

MeSH term(s)	Adult ; COVID-19/complications ; COVID-19/diagnosis ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetic Ketoacidosis/complications ; Diabetic Ketoacidosis/diagnosis ; Humans ; Male
Keywords	covid19
Language	English
Publishing date	2020-05-21
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2020.05.004
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Article ; Online: Impairment of central retinal artery hemodynamics in affected and fellow eyes in giant cell arteritis patients with unilateral vision loss.

Boutigny, Alexandre / Mohamedi, Nassim / Pardo, Sarah Jeanne / Bonnin, Sophie / Ketfi, Chahinez / Ghaouti, Hichem / Viana, Vincent / Frazier, Aline / Roos, Caroline / Burlacu, Ruxandra / Comarmond, Chloé / Kubis, Nathalie / Sène, Damien / Bonnin, Philippe

Autoimmunity reviews

2023 Volume 22, Issue 3, Page(s) 103272

Abstract: Objectives: Permanent visual impairment is a major complication of giant cell arteritis (GCA). We investigated the added value of color Doppler imaging (CDI) of the central retinal artery (CRA) in patients with suspected GCA for early risk evaluation ... ...

Abstract	Objectives: Permanent visual impairment is a major complication of giant cell arteritis (GCA). We investigated the added value of color Doppler imaging (CDI) of the central retinal artery (CRA) in patients with suspected GCA for early risk evaluation before temporal artery biopsy (TAB) results become available. Methods: We conducted a non-interventional observational study of 30 consecutive patients hospitalized for suspected GCA, including a comprehensive analysis of clinical, laboratory, imaging, CDI and pathology data. GCA was diagnosed or excluded (GCA+, GCA-, respectively) according to American College of Rheumatology (ACR) criteria and TAB findings. Three patients not meeting ACR criteria were excluded secondarily. The GCA- group contained ten patients, and the GCA+ group contained 17 patients, including eight with unilateral, transient or permanent clinical visual impairment (CVI). Results: Mean blood flow velocity (mBFV) in the CRA was impaired in the affected eyes of GCA + CVI+ patients (1.9 ± 0.9 cm.s Conclusion: CDI facilities the early detection of visual ischemia risk in GCA+ patients, justifying urgent high-dose corticosteroid administration to save at least the fellow eye before pathology results become available.
MeSH term(s)	Humans ; Biopsy ; Eye/pathology ; Giant Cell Arteritis/complications ; Giant Cell Arteritis/diagnosis ; Giant Cell Arteritis/pathology ; Hemodynamics ; Retinal Artery/pathology ; Retrospective Studies ; Vision Disorders
Language	English
Publishing date	2023-01-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2023.103272
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Article: COVID-19 symptoms masking inaugural ketoacidosis of type 1 diabetes

Potier, L / Julla, J B / Roussel, R / Boudou, P / Gauthier, D C / Ketfi, C / Gautier, J F

Diabetes metab

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32447100
Database	COVID19

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Article ; Online: COVID-19 symptoms masking inaugural ketoacidosis of type 1 diabetes

Potier, L. / Julla, J.B. / Roussel, R. / Boudou, P. / Gauthier, D.C. / Ketfi, C. / Gautier, J.F.

Diabetes & Metabolism ; ISSN 1262-3636

2020

Keywords	Internal Medicine ; Endocrinology, Diabetes and Metabolism ; Endocrinology ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.diabet.2020.05.004
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Article ; Online: Imbalance between procoagulant factors and natural coagulation inhibitors contributes to hypercoagulability in the critically ill COVID-19 patient: clinical implications.

Voicu, S / Delrue, M / Chousterman, B G / Stépanian, A / Bonnin, P / Malissin, I / Deye, N / Neuwirth, M / Ketfi, C / Mebazaa, A / Siguret, V / Mégarbane, B

European review for medical and pharmacological sciences

2020 Volume 24, Issue 17, Page(s) 9161–9168

Abstract: Objective: Coronavirus Disease-2019 (COVID-19) predisposes patients to thrombosis which underlying mechanisms are still incompletely understood. We sought to investigate the balance between procoagulant factors and natural coagulation inhibitors in the ... ...

Abstract	Objective: Coronavirus Disease-2019 (COVID-19) predisposes patients to thrombosis which underlying mechanisms are still incompletely understood. We sought to investigate the balance between procoagulant factors and natural coagulation inhibitors in the critically ill COVID-19 patient and to evaluate the usefulness of hemostasis parameters to identify patients at risk of venous thromboembolic event (VTE). Patients and methods: We conducted an observational study recording VTEs defined as deep vein thrombosis or pulmonary embolism using lower limb ultrasound (92% of the patients), computed tomography pulmonary angiography (6%) and both tests (2%). We developed a comprehensive analysis of hemostasis. Results: Ninety-two consecutive mechanically ventilated COVID-19 patients (age, 62 years [53-69] (median [25th-75th percentiles]); M/F sex ratio, 2.5; body-mass index, 28 kg/m2 [25-32]; past hypertension (52%) and diabetes mellitus (30%)) admitted to the Intensive Care Unit (ICU) from 03/11/2020 to 5/05/2020, were included. When tested, patients were receiving prophylactic (74%) or therapeutic (26%) anticoagulation. Forty patients (43%) were diagnosed with VTE. Patients displayed inflammatory and prothrombotic profile including markedly elevated plasma fibrinogen (7.7 g/L [6.1-8.6]), D-dimer (3,360 ng/mL [1668-7575]), factor V (166 IU/dL [136-195]) and factor VIII activities (294 IU/dL [223-362]). We evidenced significant discrepant protein C anticoagulant and chromogenic activities, combined with slightly decreased protein S activity. Plasma D-dimer >3,300 ng/mL predicted VTE presence with 78% (95%-confidence interval (95% CI), 62-89) sensitivity, 69% (95% CI, 55-81) specificity, 66% (95% CI, 51-79) positive predictive value and 80% (95% CI, 65-90) negative predictive value [area under the ROC curve, 0.779 (95%CI, 0.681-0.859), p=0.0001]. Conclusions: Mechanically ventilated COVID-19 patients present with an imbalance between markedly increased factor V/VIII activity and overwhelmed protein C/S pathway. Plasma D-dimer may be a useful biomarker at the bedside for suspicion of VTE.
MeSH term(s)	Aged ; Area Under Curve ; Betacoronavirus/isolation & purification ; Blood Coagulation Factor Inhibitors/metabolism ; Blood Coagulation Factors/metabolism ; Body Mass Index ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Critical Illness ; Factor V/analysis ; Factor VIII/analysis ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Fibrinogen/analysis ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; Protein C/analysis ; Protein S/analysis ; ROC Curve ; SARS-CoV-2 ; Venous Thromboembolism/complications ; Venous Thromboembolism/diagnosis
Chemical Substances	Blood Coagulation Factor Inhibitors ; Blood Coagulation Factors ; Fibrin Fibrinogen Degradation Products ; Protein C ; Protein S ; fibrin fragment D ; Factor V (9001-24-5) ; Factor VIII (9001-27-8) ; Fibrinogen (9001-32-5)
Keywords	covid19
Language	English
Publishing date	2020-09-23
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202009_22866
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Article: Pathophysiological Processes Underlying the High Prevalence of Deep Vein Thrombosis in Critically Ill COVID-19 Patients.

Voicu, Sebastian / Ketfi, Chahinez / Stépanian, Alain / Chousterman, Benjamin G / Mohamedi, Nassim / Siguret, Virginie / Mebazaa, Alexandre / Mégarbane, Bruno / Bonnin, Philippe

Frontiers in physiology

2021 Volume 11, Page(s) 608788

Abstract: Coronavirus disease 2019 (COVID-19) predisposes to deep vein thrombosis (DVT) and pulmonary embolism (PE) particularly in mechanically ventilated adults with severe pneumonia. The extremely high prevalence of DVT in the COVID-19 patients hospitalized in ... ...

Abstract	Coronavirus disease 2019 (COVID-19) predisposes to deep vein thrombosis (DVT) and pulmonary embolism (PE) particularly in mechanically ventilated adults with severe pneumonia. The extremely high prevalence of DVT in the COVID-19 patients hospitalized in the intensive care unit (ICU) has been established between 25 and 84% based on studies including systematic duplex ultrasound of the lower limbs when prophylactic anticoagulation was systematically administrated. DVT prevalence has been shown to be markedly higher than in mechanically ventilated influenza patients (6-8%). Unusually high inflammatory and prothrombotic phenotype represents a striking feature of COVID-19 patients, as reflected by markedly elevated reactive protein C, fibrinogen, interleukin 6, von Willebrand factor, and factor VIII. Moreover, in critically ill patients, venous stasis has been associated with the prothrombotic phenotype attributed to COVID-19, which increases the risk of thrombosis. Venous stasis results among others from immobilization under muscular paralysis, mechanical ventilation with high positive end-expiratory pressure, and pulmonary microvascular network injuries or occlusions. Venous return to the heart is subsequently decreased with increase in central and peripheral venous pressures, marked proximal and distal veins dilation, and drops in venous blood flow velocities, leading to a spontaneous contrast "sludge pattern" in veins considered as prothrombotic. Together with endothelial lesions and hypercoagulability status, venous stasis completes the Virchow triad and considerably increases the prevalence of DVT and PE in critically ill COVID-19 patients, therefore raising questions regarding the optimal doses for thromboprophylaxis during ICU stay.
Language	English
Publishing date	2021-01-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.608788
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Article ; Online: Risk of venous thromboembolism in rheumatoid arthritis.

Ketfi, Chahinez / Boutigny, Alexandre / Mohamedi, Nassim / Bouajil, Sara / Magnan, Benjamin / Amah, Guy / Dillinger, Jean-Guillaume

Joint bone spine

2020 Volume 88, Issue 3, Page(s) 105122

Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune joint disease with persistent systemic inflammation. Patients with RA suffer from joint pain and physical disability, but have their prognosis mostly driven by cardiovascular events, including venous ... ...

Abstract	Rheumatoid arthritis (RA) is a chronic autoimmune joint disease with persistent systemic inflammation. Patients with RA suffer from joint pain and physical disability, but have their prognosis mostly driven by cardiovascular events, including venous thromboembolism (VTE). The risk of VTE is more than double in patients with RA compared with the general population. The incidence rate in patients with RA is estimated around 4 cases per 1000 person-years. The etiology of thrombotic tendency in RA is linked to various mechanisms and causal factors (antiphsolpholid antibodies, hyperhomocyteinemia, inflammation…): vascular injury, hypercoagulation, and venous stasis, the three components of the Virchow's triad, are activated in patients with RA. In clinical practice, situations that put patients for VTE should be identified (e.g., surgery, first year after RA diagnosis, hospitalization for acute illness…). Patients with RA are exposed to reversible risk factors, such as major surgery (knee or hip surgery) or hospitalization with immobilization. Similarly, uncontrolled RA, which is defined by the necessity to switch a biological disease-modifying anti-rheumatic drugs (DMARD), increases the incidence of VTE in observational studies. Moreover, DMARDs may impact the risk of VTE, especially in the time window after first prescription. Several biological DMARDs like tofacitinib have been associated with an increased risk of VTE. Therefore, patients with RA may require specific measures in terms of VTE diagnosis and management. In this review, we provide current insights into the pathophysiology, epidemiology, clinical considerations, and treatment strategies of VTE highlighting gaps in evidence and perspectives in patients with RA.
MeSH term(s)	Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology ; Humans ; Incidence ; Risk Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2020-12-17
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2020.105122
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Article: Imbalance between procoagulant factors and natural coagulation inhibitors contributes to hypercoagulability in the critically ill COVID-19 patient: clinical implications

Voicu, S / Delrue, M / Chousterman, B G / Stépanian, A / Bonnin, P / Malissin, I / Deye, N / Neuwirth, M / Ketfi, C / Mebazaa, A / Siguret, V / Mégarbane, B

Eur Rev Med Pharmacol Sci

Abstract: OBJECTIVE: Coronavirus Disease-2019 (COVID-19) predisposes patients to thrombosis which underlying mechanisms are still incompletely understood. We sought to investigate the balance between procoagulant factors and natural coagulation inhibitors in the ... ...

Abstract	OBJECTIVE: Coronavirus Disease-2019 (COVID-19) predisposes patients to thrombosis which underlying mechanisms are still incompletely understood. We sought to investigate the balance between procoagulant factors and natural coagulation inhibitors in the critically ill COVID-19 patient and to evaluate the usefulness of hemostasis parameters to identify patients at risk of venous thromboembolic event (VTE). PATIENTS AND METHODS: We conducted an observational study recording VTEs defined as deep vein thrombosis or pulmonary embolism using lower limb ultrasound (92% of the patients), computed tomography pulmonary angiography (6%) and both tests (2%). We developed a comprehensive analysis of hemostasis. RESULTS: Ninety-two consecutive mechanically ventilated COVID-19 patients (age, 62 years [53-69] (median [25th-75th percentiles]); M/F sex ratio, 2.5; body-mass index, 28 kg/m2 [25-32]; past hypertension (52%) and diabetes mellitus (30%)) admitted to the Intensive Care Unit (ICU) from 03/11/2020 to 5/05/2020, were included. When tested, patients were receiving prophylactic (74%) or therapeutic (26%) anticoagulation. Forty patients (43%) were diagnosed with VTE. Patients displayed inflammatory and prothrombotic profile including markedly elevated plasma fibrinogen (7.7 g/L [6.1-8.6]), D-dimer (3,360 ng/mL [1668-7575]), factor V (166 IU/dL [136-195]) and factor VIII activities (294 IU/dL [223-362]). We evidenced significant discrepant protein C anticoagulant and chromogenic activities, combined with slightly decreased protein S activity. Plasma D-dimer >3,300 ng/mL predicted VTE presence with 78% (95%-confidence interval (95% CI), 62-89) sensitivity, 69% (95% CI, 55-81) specificity, 66% (95% CI, 51-79) positive predictive value and 80% (95% CI, 65-90) negative predictive value [area under the ROC curve, 0.779 (95%CI, 0.681-0.859), p=0.0001]. CONCLUSIONS: Mechanically ventilated COVID-19 patients present with an imbalance between markedly increased factor V/VIII activity and overwhelmed protein C/S pathway. Plasma D-dimer may be a useful biomarker at the bedside for suspicion of VTE.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #790177
Database	COVID19

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Article: Blood Flow and Shear Stress Allow Monitoring of Progression and Prognosis of Tumor Diseases.

Barral, Matthias / El-Sanharawi, Imane / Dohan, Anthony / Sebuhyan, Maxime / Guedon, Alexis / Delarue, Audrey / Boutigny, Alexandre / Mohamedi, Nassim / Magnan, Benjamin / Kemel, Salim / Ketfi, Chahinez / Kubis, Nathalie / Bisdorff-Bresson, Annouk / Pocard, Marc / Bonnin, Philippe

Frontiers in physiology

2021 Volume 12, Page(s) 693052

Abstract: In the presence of tumor angiogenesis, blood flow must increase, leading to an elevation of blood flow velocities (BFVels) and wall shear stress (WSS) in upstream native arteries. An adaptive arterial remodeling is stimulated, whose purpose lies in the ... ...

Abstract	In the presence of tumor angiogenesis, blood flow must increase, leading to an elevation of blood flow velocities (BFVels) and wall shear stress (WSS) in upstream native arteries. An adaptive arterial remodeling is stimulated, whose purpose lies in the enlargement of the arterial inner diameter, aiming for normalization of BFVels and WSS. Remodeling engages delayed processes that are efficient only several weeks/months after initiation, independent from those governing expansion of the neovascular network. Therefore, during tumor expansion, there is a time interval during which elevation of BFVels and WSS could reflect disease progression. Conversely, during the period of stability, BFVels and WSS drop back to normal values due to the achievement of remodeling processes. Ovarian peritoneal carcinomatosis (OPC), pseudomyxoma peritonei (PMP), and superficial arteriovenous malformations (AVMs) are diseases characterized by the development of abnormal vascular networks developed on native ones. In OPC and PMP, preoperative blood flow in the superior mesenteric artery (SMA) correlated with the per-operative peritoneal carcinomatosis index (OPC:
Language	English
Publishing date	2021-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.693052
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