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  1. Article ; Online: Catalase as a regulator of reactive sulfur metabolism; a new interpretation beyond hydrogen peroxide

    Kevil, Christopher G

    Redox biology

    2017  Volume 12, Page(s) 528–529

    MeSH term(s) Catalase ; Hydrogen Peroxide ; Sulfides ; Sulfur
    Chemical Substances Sulfides ; Sulfur (70FD1KFU70) ; Hydrogen Peroxide (BBX060AN9V) ; Catalase (EC 1.11.1.6)
    Language English
    Publishing date 2017-03-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ISSN 2213-2317
    ISSN (online) 2213-2317
    DOI 10.1016/j.redox.2017.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Redox Signaling and Cardiovascular Disease: New Paradigms and discoveries.

    Chen, Yabing / Kevil, Christopher G

    Redox biology

    2020  Volume 37, Page(s) 101743

    MeSH term(s) Cardiovascular Diseases ; Humans ; Oxidation-Reduction ; Reactive Oxygen Species ; Signal Transduction
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2020-09-29
    Publishing country Netherlands
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2020.101743
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  3. Article: Caveolin-1 Scaffolding Domain Peptide Regulates Colon Endothelial Cell Survival through JNK Pathway.

    Fang, Kai / Kevil, Christopher G

    International journal of inflammation

    2020  Volume 2020, Page(s) 6150942

    Abstract: It has been reported that pathological angiogenesis contributes to both experimental colitis and inflammatory bowel disease. Recently, we demonstrated that endothelial caveolin-1 plays a key role in the pathological angiogenesis of dextran sodium sulfate ...

    Abstract It has been reported that pathological angiogenesis contributes to both experimental colitis and inflammatory bowel disease. Recently, we demonstrated that endothelial caveolin-1 plays a key role in the pathological angiogenesis of dextran sodium sulfate (DSS) colitis. However, the molecular mechanism of caveolin-1 regulation of endothelial function is unknown. In this study, we examined how the antennapedia- (AP-) conjugated caveolin-1 scaffolding domain (AP-Cav) modulates vascular endothelial growth factor- (VEGF-) dependent colon endothelial cell angiogenic responses, as seen during colitis. We used mouse colon endothelial cells and found that AP-Cav significantly inhibited VEGF-mediated bromodeoxyuridine (BrdU) incorporation into colon microvascular endothelial cells. AP-Cav significantly blunted VEGF-dependent extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation at 10 minutes and 2 hours after stimulation, compared with the AP control peptide. AP-Cav + VEGF-A treatment also significantly increased c-Jun N-terminal kinase (JNK) phosphorylation at 2 hours. AP-Cav + VEGF-A treatment significantly downregulated retinoblastoma (Rb) protein levels, upregulated cleaved caspase-3 protein levels at 4 hours, and induced apoptosis. Thus, our study suggests that disruption of endothelial caveolin-1 function via the AP-Cav diverts VEGF signaling responses away from endothelial cell proliferation and toward apoptosis through the inhibition of mitogen-activated protein (MAP) kinase signaling and the induction of JNK-associated apoptosis.
    Language English
    Publishing date 2020-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573900-1
    ISSN 2042-0099 ; 2090-8040
    ISSN (online) 2042-0099
    ISSN 2090-8040
    DOI 10.1155/2020/6150942
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  4. Article ; Online: It's a "Gut Feeling": Association of Microbiota, Trimethylamine N-Oxide and Cardiovascular Outcomes.

    Kolluru, Gopi K / Kevil, Christopher G

    Journal of the American Heart Association

    2020  Volume 9, Issue 10, Page(s) e016553

    MeSH term(s) Case-Control Studies ; Gastrointestinal Microbiome ; Humans ; Methylamines ; Microbiota ; Myocardial Infarction ; Patients
    Chemical Substances Methylamines ; trimethyloxamine (FLD0K1SJ1A)
    Language English
    Publishing date 2020-05-05
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.016553
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  5. Article ; Online: Joint transformer architecture in brain 3D MRI classification: its application in Alzheimer's disease classification.

    Alp, Sait / Akan, Taymaz / Bhuiyan, Md Shenuarin / Disbrow, Elizabeth A / Conrad, Steven A / Vanchiere, John A / Kevil, Christopher G / Bhuiyan, Mohammad A N

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8996

    Abstract: Alzheimer's disease (AD), a neurodegenerative disease that mostly affects the elderly, slowly impairs memory, cognition, and daily tasks. AD has long been one of the most debilitating chronic neurological disorders, affecting mostly people over 65. In ... ...

    Abstract Alzheimer's disease (AD), a neurodegenerative disease that mostly affects the elderly, slowly impairs memory, cognition, and daily tasks. AD has long been one of the most debilitating chronic neurological disorders, affecting mostly people over 65. In this study, we investigated the use of Vision Transformer (ViT) for Magnetic Resonance Image processing in the context of AD diagnosis. ViT was utilized to extract features from MRIs, map them to a feature sequence, perform sequence modeling to maintain interdependencies, and classify features using a time series transformer. The proposed model was evaluated using ADNI T1-weighted MRIs for binary and multiclass classification. Two data collections, Complete 1Yr 1.5T and Complete 3Yr 3T, from the ADNI database were used for training and testing. A random split approach was used, allocating 60% for training and 20% for testing and validation, resulting in sample sizes of (211, 70, 70) and (1378, 458, 458), respectively. The performance of our proposed model was compared to various deep learning models, including CNN with BiL-STM and ViT with Bi-LSTM. The suggested technique diagnoses AD with high accuracy (99.048% for binary and 99.014% for multiclass classification), precision, recall, and F-score. Our proposed method offers researchers an approach to more efficient early clinical diagnosis and interventions.
    MeSH term(s) Humans ; Aged ; Alzheimer Disease/pathology ; Neurodegenerative Diseases/pathology ; Magnetic Resonance Imaging/methods ; Neuroimaging ; Brain/diagnostic imaging ; Brain/pathology
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59578-3
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  6. Article ; Online: Reactive Sulfur Species: A New Redox Player in Cardiovascular Pathophysiology.

    Kolluru, Gopi K / Shen, Xinggui / Kevil, Christopher G

    Arteriosclerosis, thrombosis, and vascular biology

    2020  Volume 40, Issue 4, Page(s) 874–884

    Abstract: Hydrogen sulfide has emerged as an important gaseous signaling molecule and a regulator of critical biological processes. However, the physiological significance of hydrogen sulfide metabolites such as persulfides, polysulfides, and other reactive sulfur ...

    Abstract Hydrogen sulfide has emerged as an important gaseous signaling molecule and a regulator of critical biological processes. However, the physiological significance of hydrogen sulfide metabolites such as persulfides, polysulfides, and other reactive sulfur species (RSS) has only recently been appreciated. Emerging evidence suggests that these RSS molecules may have similar or divergent regulatory roles compared with hydrogen sulfide in various biological activities. However, the chemical nature of persulfides and polysulfides is complex and remains poorly understood within cardiovascular and other pathophysiological conditions. Recent reports suggest that RSS can be produced endogenously, with different forms having unique chemical properties and biological implications involving diverse cellular responses such as protein biosynthesis, cell-cell barrier functions, and mitochondrial bioenergetics. Enzymes of the transsulfuration pathway, CBS (cystathionine beta-synthase) and CSE (cystathionine gamma-lyase), may also produce RSS metabolites besides hydrogen sulfide. Moreover, CARSs (cysteinyl-tRNA synthetase) are also able to generate protein persulfides via cysteine persulfide (CysSSH) incorporation into nascently formed polypeptides suggesting a new biologically relevant amino acid. This brief review discusses the biochemical nature and potential roles of RSS, associated oxidative stress redox signaling, and future research opportunities in cardiovascular disease.
    MeSH term(s) Biological Availability ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Cystathionine gamma-Lyase/genetics ; Humans ; Hydrogen Sulfide/metabolism ; Nitrogen Oxides/metabolism ; Oxidation-Reduction ; Oxidative Stress ; Polymorphism, Genetic ; Reactive Oxygen Species/metabolism ; Sulfides/metabolism ; Vascular Remodeling
    Chemical Substances Nitrogen Oxides ; Reactive Oxygen Species ; Sulfides ; persulfides ; polysulfide (9080-49-3) ; Cystathionine gamma-Lyase (EC 4.4.1.1) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2020-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.120.314084
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
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  7. Article: Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation.

    Shackelford, Rodney E / Li, Yan / Ghali, Ghali E / Kevil, Christopher G

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    Language English
    Publishing date 2021-11-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111820
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  8. Article ; Online: Sulfide regulation of cardiovascular function in health and disease.

    Kolluru, Gopi K / Shackelford, Rodney E / Shen, Xinggui / Dominic, Paari / Kevil, Christopher G

    Nature reviews. Cardiology

    2022  Volume 20, Issue 2, Page(s) 109–125

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    MeSH term(s) Humans ; Sulfides ; Hydrogen Sulfide/metabolism ; Heart ; Myocardial Infarction ; Heart Failure
    Chemical Substances Sulfides ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-022-00741-6
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    Zs.A 6019: Show issues Location:
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  9. Article ; Online: The ataxia-telangiectasia mutated gene product regulates the cellular acid-labile sulfide fraction.

    Islam, Mohammad Z / Shen, Xinggui / Pardue, Sibile / Kevil, Christopher G / Shackelford, Rodney E

    DNA repair

    2022  Volume 116, Page(s) 103344

    Abstract: The ataxia-telangiectasia mutated (ATM) protein regulates cell cycle checkpoints, the cellular redox state, and double-stranded DNA break repair. ATM loss causes the disorder ataxia-telangiectasia (A-T), distinguished by ataxia, telangiectasias, ... ...

    Abstract The ataxia-telangiectasia mutated (ATM) protein regulates cell cycle checkpoints, the cellular redox state, and double-stranded DNA break repair. ATM loss causes the disorder ataxia-telangiectasia (A-T), distinguished by ataxia, telangiectasias, dysregulated cellular redox and iron responses, and an increased cancer risk. We examined the sulfur pool in A-T cells, with and without an ATM expression vector. While free and bound sulfide levels were not changed with ATM expression, the acid-labile sulfide faction was significantly increased. ATM expression also increased cysteine desulfurase (NFS1), NFU1 iron-sulfur cluster scaffold homolog protein, and several mitochondrial complex I proteins' expression. Additionally, ATM expression suppressed cystathionine β-synthase and cystathionine γ-synthase protein expression, cystathionine γ-synthase enzymatic activity, and increased the reduced to oxidized glutathione ratio. This last observation is interesting, as dysregulated glutathione is implicated in A-T pathology. As ATM expression increases the expression of proteins central in initiating 2Fe-2S and 4Fe-4S cluster formation (NFS1 and NFU1, respectively), and the acid-labile sulfide faction is composed of sulfur incorporated into Fe-S clusters, our data indicates that ATM regulates aspects of Fe-S cluster biosynthesis, the transsulfuration pathway, and glutathione redox cycling. Thus, our data may explain some of the redox- and iron-related pathologies seen in A-T.
    MeSH term(s) Ataxia Telangiectasia/genetics ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Carbon-Sulfur Lyases/metabolism ; Glutathione/metabolism ; Humans ; Iron/metabolism ; Iron-Sulfur Proteins/genetics ; Iron-Sulfur Proteins/metabolism ; Sulfides/metabolism ; Sulfur/metabolism
    Chemical Substances Iron-Sulfur Proteins ; Sulfides ; Sulfur (70FD1KFU70) ; Iron (E1UOL152H7) ; ATM protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; Carbon-Sulfur Lyases (EC 4.4.-) ; NFS1 protein, human (EC 4.4.1.-) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2022-05-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2022.103344
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  10. Article ; Online: The pleiotropic effects of hydrogen sulfide.

    Kanagy, Nancy L / Kevil, Christopher G

    American journal of physiology. Heart and circulatory physiology

    2017  Volume 314, Issue 1, Page(s) H1–H2

    MeSH term(s) Animals ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Cardiovascular System/metabolism ; Cardiovascular System/physiopathology ; Gasotransmitters/metabolism ; Hemodynamics ; Humans ; Hydrogen Sulfide/metabolism ; Signal Transduction
    Chemical Substances Gasotransmitters ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2017-11-03
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00613.2017
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