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  1. AU="Khadadah, Sulaiman"
  2. AU="Renard, Patricia"
  3. AU=Jewell Nicholas P
  4. AU="Huikun Hong"
  5. AU="Bodo, Juraj"
  6. AU="Starr, Lindsey A"
  7. AU="Hao Yu"
  8. AU="Weinberger, D R"
  9. AU=Reiter Russel J
  10. AU="Rutkove, Seward B."
  11. AU="Vallorani, Luciana"
  12. AU="Hashimoto, Norikazu"
  13. AU="Lassaigne, C"
  14. AU="Ozturk, Serefnur"
  15. AU="Ruiz, Asier"
  16. AU="Abd-Alrazaq, Alaa"
  17. AU=Sardana Girish
  18. AU="Rutkowski, Robert" AU="Rutkowski, Robert"
  19. AU="Satti, Muniza Manshad"
  20. AU="Maalampi, J."
  21. AU=Forrest Christopher B
  22. AU="Steger, Klaus"
  23. AU=Tremaine W J
  24. AU="Pitha, Paula M"
  25. AU="Carmen Ruiz de Almodóvar"
  26. AU="Qiu, Xudong"
  27. AU="Groh, M"
  28. AU="Defres, S"
  29. AU="Khurana, Navneet"
  30. AU="Yanshan Yang"
  31. AU=Brouillet Emmanuel AU=Brouillet Emmanuel
  32. AU="Rajput, Sandeep"
  33. AU="Mansfield, Shawn D"
  34. AU="Isolan, Cecilia"
  35. AU="Li, Yiran"
  36. AU="Kang, Weechang"
  37. AU="Landoni, Elisa"
  38. AU=McCubbin Keith I AU=McCubbin Keith I
  39. AU="Jessica Bijsterbosch"
  40. AU="Dela Cruz, Charles S."
  41. AU="Yoo, Jennifer"
  42. AU="Berger, Miriam B"
  43. AU="Carlson, Jeffrey R"

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  1. Artikel ; Online: Scoring heart rate increases as a surrogate arousal marker on portable monitor studies for obstructive sleep apnea: Impact on diagnostic accuracy and clinical decision-making.

    Lachapelle, Philippe / Khadadah, Sulaiman / Taseen, Ryeyan / Pamidi, Sushmita / Kimoff, R John

    Journal of sleep research

    2022  Band 31, Heft 5, Seite(n) e13594

    Abstract: Cortical arousal-related hypopneas are not scored on type 3 home devices, which therefore limits their diagnostic accuracy for obstructive sleep apnea. The objective of this study was to evaluate whether scoring heart rate accelerations as surrogate ... ...

    Abstract Cortical arousal-related hypopneas are not scored on type 3 home devices, which therefore limits their diagnostic accuracy for obstructive sleep apnea. The objective of this study was to evaluate whether scoring heart rate accelerations as surrogate markers of arousal improves type 3 portable monitor diagnostic agreement compared with polysomnography and improves therapeutic decision-making. We prospectively recruited patients evaluated for obstructive sleep apnea to undergo in-laboratory simultaneous full polysomnography + type 3 portable monitoring. Hypopnea events were scored on portable monitor studies with and without autonomic scoring, which was defined as an associated increase in pulse oximetry-derived heart rate ≥6 beats per min (autonomic hypopnea). Portable monitor diagnostic agreement compared with polysomnography with and without autonomic hypopnea scoring was assessed. We also evaluated whether reporting autonomic hypopnea scoring improves portable monitor clinical treatment decision agreement after four physicians reviewed clinical data and sleep study results (polysomnography, portable monitor with autonomic hypopnea, portable monitor without autonomic hypopnea). Eighty-two participants completed simultaneous polysomnography and in-laboratory portable monitor studies. Scoring autonomic hypopnea resulted in a decreased mean difference between in-laboratory portable monitor respiratory event index and polysomnography apnea-hypopnea index in Bland-Altman analysis (mean difference 14.6 per hr without versus 6.1 per hr with autonomic hypopnea scoring [p ˂ 0.01]), and increased intraclass correlation from 0.769 to 0.844. Inclusion of autonomic hypopnea scoring resulted in better accuracy between portable monitor and polysomnography expert's treatment decisions, and ultimately resulted in 24% fewer additional polysomnographies requested. The addition of pulse oximetry heart rate increases for autonomic hypopnea scoring during portable monitor resulted in better diagnostic agreement, improved clinical decision-making and reduced additional polysomnography testing.
    Mesh-Begriff(e) Arousal/physiology ; Biomarkers ; Clinical Decision-Making ; Heart Rate ; Humans ; Sleep Apnea, Obstructive/diagnosis
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2022-04-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1122722-9
    ISSN 1365-2869 ; 0962-1105
    ISSN (online) 1365-2869
    ISSN 0962-1105
    DOI 10.1111/jsr.13594
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3464: Hefte anzeigen Standort:
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    Zs.MO 343: Hefte anzeigen

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  2. Artikel ; Online: Long term effects of continuous positive airway pressure treatment of obstructive sleep apnea-hypopnea syndrome in multiple sclerosis patients.

    Mazerolle, Mylene / Kimoff, R John / Khadadah, Sulaiman / Duquette, Pierre / Jobin, Vincent / Lapierre, Yves / Benedetti, Andrea / Majetic, Katarina / Robinson, Ann / Roger, Elaine / Bar-Or, Amit / Kaminska, Marta / Leonard, Gabriel / Trojan, Daria A

    Multiple sclerosis and related disorders

    2023  Band 81, Seite(n) 105144

    Abstract: Background: Obstructive sleep apnea-hypopnea (OSAH) is common in MS patients and is associated with fatigue. We recently published a randomized, controlled trial (RCT) of active vs sham continuous positive airway pressure (CPAP) treatment in MS patients ...

    Abstract Background: Obstructive sleep apnea-hypopnea (OSAH) is common in MS patients and is associated with fatigue. We recently published a randomized, controlled trial (RCT) of active vs sham continuous positive airway pressure (CPAP) treatment in MS patients with fatigue, poor sleep quality, and (OSAH) (Mult Scl J 2022;28:82-92). Our aim was to evaluate the long-term effects of CPAP treatment on fatigue (Fatigue Severity Scale, FSS, primary outcome) and other clinical outcomes in MS patients with OSAH.
    Methods: Following the RCT, participants were offered treatment with CPAP and participation in an open label study. Patients were re-evaluated with RCT outcome measures at least 6 months after completion of the RCT.
    Results: Twenty-eight of 34 (82 %) RCT-completers participated in this study a mean of 2.7 years after the RCT. Sixteen (57 %) patients were treated with CPAP (mean use 5.4 ± 1.0 h/night during the 6 months prior to follow-up visit), while the other 12 patients declined CPAP use and received no other OSAH treatments. Baseline clinical characteristics, including MS related disability and sleep outcomes, were not significantly different between CPAP-treated vs non-CPAP treated patients. Patients using CPAP at follow-up (n = 16) demonstrated significant improvements from RCT baseline in FSS (p = 0.005), Fatigue Scale for Motor and Cognitive Functions (p = 0.008, p = 0.012), Pittsburgh Sleep Quality Index (p = 0.016), Center of Epidemiological Studies-Depression Scale (p = 0.05), and Multiple Sclerosis Quality of Life-54 (MSQOL-54) physical and mental component scores (p = 0.012, p = 0.023), but no improvements in Epworth Sleepiness Scale, Pain Visual Analog Scale, or Expanded Disability Status Scale. Patients not using CPAP (n = 12) had no significant improvements in outcome measures. Using a linear mixed model, FSS (p = 0.03), morning fatigue (p = 0.048), and MSQOL-54 physical component score (p = 0.02) improved significantly in CPAP treated patients compared with non-CPAP treated patients from RCT baseline.
    Conclusion: In this post-RCT open label study, long-term CPAP use was associated with improved fatigue (FSS, our primary outcome) and physical quality of life in MS patients with OSAH.
    Mesh-Begriff(e) Humans ; Continuous Positive Airway Pressure ; Fatigue/complications ; Fatigue/prevention & control ; Multiple Sclerosis/complications ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy ; Syndrome ; Treatment Outcome ; Randomized Controlled Trials as Topic
    Sprache Englisch
    Erscheinungsdatum 2023-11-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2023.105144
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Effect of continuous positive airway pressure treatment of obstructive sleep apnea-hypopnea in multiple sclerosis: A randomized, double-blind, placebo-controlled trial (SAMS-PAP study).

    Khadadah, Sulaiman / Kimoff, R John / Duquette, Pierre / Jobin, Vincent / Lapierre, Yves / Benedetti, Andrea / Johara, Fatema T / Robinson, Ann / Roger, Elaine / Bar-Or, Amit / Leonard, Gabriel / Kaminska, Marta / Trojan, Daria A

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2021  Band 28, Heft 1, Seite(n) 82–92

    Abstract: Objective: The aim of this study was to evaluate the effect of continuous positive airway pressure (CPAP) treatment on the Fatigue Severity Scale (FSS, preplanned primary outcome), another fatigue measure, sleep quality, somnolence, pain, disability, ... ...

    Abstract Objective: The aim of this study was to evaluate the effect of continuous positive airway pressure (CPAP) treatment on the Fatigue Severity Scale (FSS, preplanned primary outcome), another fatigue measure, sleep quality, somnolence, pain, disability, and quality of life in multiple sclerosis (MS) patients with obstructive sleep apnea-hypopnea (OSAH).
    Methods: In a randomized, double-blind trial (NCT01746342), MS patients with fatigue, poor subjective sleep quality, and OSAH (apnea-hypopnea index of ⩾ 15 events per hour/sleep), but without severe OSAH (apnea-hypopnea index > 30, and 4% oxygen desaturation index > 15 events/hour or severe somnolence), were randomized to fixed CPAP or sham CPAP for 6 months. Outcome assessments were performed at 3 and 6 months.
    Results: Of 49 randomized patients, 34 completed the protocol. Among completers, FSS did not improve with CPAP compared to sham at 6 months. FSS tended to improve (
    Conclusion: In non-severe OSAH patients, CPAP did not significantly improve the primary outcome of FSS change at 6 months. In secondary analyses, we found a trend to improved FSS, and a significant reduction in somnolence with CPAP at 3 months.
    Mesh-Begriff(e) Continuous Positive Airway Pressure ; Humans ; Multiple Sclerosis/complications ; Multiple Sclerosis/therapy ; Quality of Life ; Sleep Apnea, Obstructive/therapy ; Sleep Quality ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2021-04-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585211010390
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4428: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Artikel ; Online: ATS Core Curriculum 2017: Part I. Adult Sleep Medicine.

    Jamil, Shazia M / Conwell, Walter D / T Poston, Jason / Patel, Sarah / Billings, Molly / Boland, Elaine / Gehrman, Philip / Chang, Melisa / Martin, Jennifer L / Khadadah, Sulaiman / Kaminska, Marta / Sharma, Rahul / Wolfe, Lisa / Yafawi, Jihane Zaza Dit / Hammond, Terese / De Cruz, Sharon / Balachandran, Jay / Wang, Tisha

    Annals of the American Thoracic Society

    2017  Band 14, Heft Suppl_2, Seite(n) S150–S164

    Mesh-Begriff(e) Adult ; Curriculum ; Education, Medical, Graduate/methods ; Humans ; Pulmonary Medicine ; Sleep/physiology ; Sleep Initiation and Maintenance Disorders ; Sleep Medicine Specialty/education ; Societies, Medical ; United States
    Sprache Englisch
    Erscheinungsdatum 2017-10-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201701-028CME
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5828: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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