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  1. Book ; Thesis: Der Selective Estrogen Receptor Modulator (SERM) Raloxifen verbessert die diaphysäre Frakturheilung in der Maus

    Khadem, Shahram

    2014  

    Author's details vorgelegt von Shahram Khadem
    Language German
    Size 71 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hamburg, Univ., Diss., 2014
    Note Enth. Sonderabdr., Text engl.
    HBZ-ID HT018613945
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 E 606 order for loan Magazin

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  2. Article: Safety profile of a multimodal fail-safe model to minimize postoperative complications in oncologic colorectal resections-a cohort study.

    Khadem, Shahram / Herzberg, Jonas / Honarpisheh, Human / Jenner, Robert Maximilian / Guraya, Salman Yousuf / Strate, Tim

    Perioperative medicine (London, England)

    2023  Volume 12, Issue 1, Page(s) 5

    Abstract: Background: Despite innovations in surgical techniques, major complications following colorectal surgery still lead to a significant morbidity and mortality. There is no standard protocol for perioperative management of patients with colorectal cancer. ... ...

    Abstract Background: Despite innovations in surgical techniques, major complications following colorectal surgery still lead to a significant morbidity and mortality. There is no standard protocol for perioperative management of patients with colorectal cancer. This study evaluates the effectiveness of a multimodal fail-safe model in minimizing severe surgical complications following colorectal resections.
    Methods: We compared major complications in patients with colorectal cancers who underwent surgical resections with anastomosis during 2013-2014 (control group) with patients treated during 2015-2019 (fail-safe group). The fail-safe group had preoperative bowel preparation and a perioperative single dose of antibiotics, on-table bowel irrigation and early sigmoidoscopic assessment of anastomosis in rectal resections. A standard surgical technique for tension-free anastomosis was adapted in the fail-safe approach. The chi-square test measured relationships between categorical variables, t-test estimated the probability of differences, and the multivariate regression analysis determined the linear correlation among independent and dependent variables.
    Results: A total of 924 patients underwent colorectal operations during the study period; however, 696 patients had surgical resections with primary anastomoses. There were 427 (61.4%) laparoscopic and 230 (33.0%) open operations, while 39 (5.6%) laparoscopic procedures were converted. Overall, the rate of major complications (Dindo-Clavien grade IIIb-V) significantly reduced from 22.6% for the control group to 9.8% for the fail-safe group (p < 0.0001). Major complications mainly occurred due to non-surgical reasons such as pneumonia, heart failure, or renal dysfunction. The rates of anastomotic leakage (AL) were 11.8% (22/186) and 3.7% (n = 19/510) for the control and fail-safe groups, respectively (p < 0.0001).
    Conclusion: We report an effective multimodal fail-safe protocol for colorectal cancer during the pre-, peri-, and postoperative period. The fail-safe model showed less postoperative complications even for low rectal anastomosis. This approach can be adapted as a structured protocol during the perioperative care of patients for colorectal surgery.
    Trial registration: This study was registered in the German Clinical Trial Register (Study ID: DRKS00023804 ).
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2683800-X
    ISSN 2047-0525
    ISSN 2047-0525
    DOI 10.1186/s13741-023-00291-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Der Selektive Estrogen Receptor Modulator (SERM) Raloxifen verbessert die diaphysäre Frakturheilung in der Maus

    Khadem, Shahram

    2014  

    Author's details vorgelegt von Shahram Khadem
    Language German ; English
    Size 71 Bl., Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., FB Medizin, Diss.--Hamburg, 2014
    Note Enth. 1 Zeitschriftenart. ; Text in dt. u. engl. Sprache
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article: Intraoperative Colonic Irrigation for Low Rectal Resections With Primary Anastomosis: A Fail-Safe Surgical Model.

    Herzberg, Jonas / Khadem, Shahram / Guraya, Salman Yousuf / Strate, Tim / Honarpisheh, Human

    Frontiers in surgery

    2022  Volume 9, Page(s) 821827

    Abstract: Aim: Regardless the technological developments in surgery, the anastomotic leakage (AL) rate of low rectal anastomosis remains high. Though various perioperative protocols have been tested to reduce the risk for AL, there is no standard peri-operative ... ...

    Abstract Aim: Regardless the technological developments in surgery, the anastomotic leakage (AL) rate of low rectal anastomosis remains high. Though various perioperative protocols have been tested to reduce the risk for AL, there is no standard peri-operative management approach in rectal surgery. We aim to assess the short-term outcome of a multidisciplinary approach to reduce the rates of ALs using a fail-safe-model using preoperative and intraoperative colonic irrigation in low rectal resections with primary anastomosis.
    Methods: Between January 2015 and December 2020, 92 patients received low rectal resections for rectal cancer with primary anastomosis and diverting ileostomy. All these patients received pre-operative mechanical bowel preparation (MBP) without antibiotics as well as intraoperative colonic irrigation. The intraoperative colonic irrigation was performed
    Results: In the study period, 1.987 colorectal surgical procedures were performed. This study reports AL in 3 (3.3%) of 92 recruited patients. Other postoperative complications (Dindo-Clavien I-IV) were reported in 25 patients (27.2%), which occurred mainly due to non-surgical reasons such as renal dysfunction and sepsis. According to the fail-safe model, AL was treated by endoscopic or re-do surgery. The median postoperative length of hospitalization was 8 days (4-45) days.
    Conclusion: This study validates the effectiveness of a multi-disciplinary fail-safe model with a pre-operative MBP and an intraoperative colonic irrigation in reducing AL rates. Intraoperative colonic irrigation is a feasible approach that lowers the AL rates by reducing fecal load and by decontamination of the colon and anastomotic region. Our study does not recommend a pre-operative administration of oral antibiotics for colorectal decontamination.
    Language English
    Publishing date 2022-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.821827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Quality of Life in Patients With Rectal Resections and End-to-End Primary Anastomosis Using a Standardized Perioperative Pathway.

    Herzberg, Jonas / Khadem, Shahram / Begemann, Valentin / Strate, Tim / Honarpisheh, Human / Guraya, Salman Yousuf

    Frontiers in surgery

    2022  Volume 8, Page(s) 789251

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2022-01-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2021.789251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clinical presentation and operative repair of Morgagni hernia.

    Aghajanzadeh, Manouchehr / Khadem, Shahram / Khajeh Jahromi, Sina / Gorabi, Hamed Esmaili / Ebrahimi, Hannan / Maafi, Alireza Amir

    Interactive cardiovascular and thoracic surgery

    2012  Volume 15, Issue 4, Page(s) 608–611

    Abstract: Objectives: Morgagni hernia (MH) is an uncommon type of diaphragmatic hernia. This study aimed to summarize clinically relevant data with respect to MHs in adults.: Methods: We performed a retrospective chart review of patients who underwent surgical ...

    Abstract Objectives: Morgagni hernia (MH) is an uncommon type of diaphragmatic hernia. This study aimed to summarize clinically relevant data with respect to MHs in adults.
    Methods: We performed a retrospective chart review of patients who underwent surgical repair of foramen due to MH at our hospitals between 1996 and 2010. Data were collected on patient demographics, presenting symptoms, modes of diagnosis, surgical procedures, surgery outcomes, recurrence of hernia and follow-up of the patients.
    Results: We included 36 patients with the mean age of 50.2 years. Of these 66.7% (n = 24) were female. Thirty-one patients had MH on the right side and 1 patient had bilateral MH. Most of the patients experienced abdominal symptoms. 72.2% of patients underwent laparotomy (n = 26, 72.2%), (n = 6, 16.7%) thoracotomy (n = 6, 16.7%), and a thoraco-abdominal approach (n = 4, 11.1%). Resection of the hernia sac and insertion of a mesh were not done in any patients. No recurrence occurred.
    Conclusions: We conclude that preoperative diagnosis and early diagnosis of MH by using laparotomy and thoracotomy is useful for safe and effective repair. Also we suggest that resection of the hernia sac and insertion of a mesh are not necessary.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Early Diagnosis ; Female ; Hernia, Diaphragmatic/complications ; Hernia, Diaphragmatic/diagnosis ; Hernia, Diaphragmatic/surgery ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Recurrence ; Retrospective Studies ; Thoracotomy/adverse effects ; Time Factors ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2012-07-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivs203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5730: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The SERM raloxifene improves diaphyseal fracture healing in mice.

    Spiro, Alexander S / Khadem, Shahram / Jeschke, Anke / Marshall, Robert Percy / Pogoda, Pia / Ignatius, Anita / Amling, Michael / Beil, Frank Timo

    Journal of bone and mineral metabolism

    2013  Volume 31, Issue 6, Page(s) 629–636

    Abstract: Although several studies reported that raloxifene treatment improves postmenopausal osteoporotic bone structure and reduces fracture risk, only a few animal and no human studies have examined its effects on the fracture healing process. Thus the aim of ... ...

    Abstract Although several studies reported that raloxifene treatment improves postmenopausal osteoporotic bone structure and reduces fracture risk, only a few animal and no human studies have examined its effects on the fracture healing process. Thus the aim of the present study was to determine, whether systemic application of the selective estrogen receptor modulator raloxifene promotes fracture healing compared to untreated control-, estrogen-deficient-, as well as estrogen-treated mice using a standardized femoral osteotomy model (n = 60 mice). Ten days after surgery, contact radiography and undecalcified histomorphometric analysis revealed that raloxifene administration significantly improved the early stage of fracture healing compared to all other groups. At day 20, raloxifene and estrogen treatment led to a significant increase in callus mineralization and trabecular thickness compared to control mice. μCT analyses revealed no evidence of complete bony bridging of the fracture site in any control-, nor estrogen-deficient mouse after 20 days, while all femoral fractures in the raloxifene and estrogen group already healed adequately at this time. These data indicate that raloxifene treatment significantly improves all phases of fracture healing at least in mice. Therefore, raloxifene could be a possible pharmaceutical to enhance fracture healing in women, without the known side effects of estrogen.
    MeSH term(s) Animals ; Diaphyses/drug effects ; Estrogens/pharmacology ; Female ; Femoral Fractures/drug therapy ; Femoral Fractures/etiology ; Femur/drug effects ; Fracture Healing/drug effects ; Fractures, Bone/drug therapy ; Fractures, Bone/etiology ; Humans ; Mice ; Mice, Inbred C57BL ; Osteoporosis, Postmenopausal/complications ; Raloxifene Hydrochloride/pharmacology ; Selective Estrogen Receptor Modulators/pharmacology
    Chemical Substances Estrogens ; Selective Estrogen Receptor Modulators ; Raloxifene Hydrochloride (4F86W47BR6)
    Language English
    Publishing date 2013-04-02
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1295123-7
    ISSN 1435-5604 ; 0914-8779
    ISSN (online) 1435-5604
    ISSN 0914-8779
    DOI 10.1007/s00774-013-0461-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4894: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: BMP-7-induced ectopic bone formation and fracture healing is impaired by systemic NSAID application in C57BL/6-mice.

    Spiro, Alexander S / Beil, F Timo / Baranowsky, Anke / Barvencik, Florian / Schilling, Arndt F / Nguyen, Khoa / Khadem, Shahram / Seitz, Sebastian / Rueger, Johannes M / Schinke, Thorsten / Amling, Michael

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    2010  Volume 28, Issue 6, Page(s) 785–791

    Abstract: Nonsteroidal antiinflammatory drugs (NSAIDs) are known to potentially impair the fracture healing process. The aim of the present study was to determine if the impairment of bone healing by systemic NSAID application is, at least in part, due to an ... ...

    Abstract Nonsteroidal antiinflammatory drugs (NSAIDs) are known to potentially impair the fracture healing process. The aim of the present study was to determine if the impairment of bone healing by systemic NSAID application is, at least in part, due to an interaction of NSAIDs with the bone anabolic BMP-7 pathway. Therefore, we first analyzed fracture healing in control and diclofenac-treated mice, where we not only found a significant impairment of fracture healing due to diclofenac treatment as assessed by biomechanical testing and microCT imaging, but also found high coexpression of bone morphogenetic protein-7 (BMP-7) and cyclooxygenase-2 (COX-2) within the fracture callus of both groups. To experimentally address the possible interaction between BMP-7 and COX-2, we then induced ectopic bone formation in control (n = 10) and diclofenac-treated mice (n = 10) by application of BMP-7 (recombinant human OP-1, rhOP-1) into the hamstring muscles. After 20 days of treatment, each ectopic bone nodule was analyzed by contact-radiography, microCT, histology, and histomorphometry. Diclofenac application decreased the trabecular number and bone mass in the ectopic bone nodules significantly due to reduced osteoblast number and activity. These data demonstrate that the bone anabolic effect of BMP-7 and fracture healing is impaired by diclofenac application, and suggest that the potential negative impact of NSAIDs on fracture healing is, at least in part, due to interference with BMP-7 signaling.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/toxicity ; Bone Morphogenetic Protein 7/pharmacology ; Cyclooxygenase 2/physiology ; Diclofenac/toxicity ; Female ; Fracture Healing/drug effects ; Humans ; Mice ; Mice, Inbred C57BL ; Osteogenesis/drug effects ; Recombinant Proteins/pharmacology
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Bone Morphogenetic Protein 7 ; Recombinant Proteins ; Diclofenac (144O8QL0L1) ; Ptgs2 protein, mouse (EC 1.14.99.-) ; Cyclooxygenase 2 (EC 1.14.99.1)
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605542-4
    ISSN 1554-527X ; 0736-0266
    ISSN (online) 1554-527X
    ISSN 0736-0266
    DOI 10.1002/jor.21044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1879: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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