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Article ; Online: Immunohistochemical expression of vimentin, E-cadherin, and CD45 in natural cases of canine cutaneous round tumors.

Oda, S S / Tawfik, M F / Othman, S I / Rudayni, H A / Allam, A A / Khafaga, A F

Brazilian journal of biology = Revista brasleira de biologia

2024 Volume 84, Page(s) e278769

Abstract: Round cell tumors are common cutaneous lesions in dogs, with increased occurrence percentages among different skin tumors. This study aimed to investigate the frequency as well as gross and pathological characteristics of round cell tumors in natural ... ...

Abstract	Round cell tumors are common cutaneous lesions in dogs, with increased occurrence percentages among different skin tumors. This study aimed to investigate the frequency as well as gross and pathological characteristics of round cell tumors in natural cases of tumorous dogs in relation to breed, sex, and age. Moreover, it aimed to evaluate the immunohistochemical expression of a panel of immunohistochemical stains, including vimentin, E-cadherin, and cluster of differentiation (CD45) as an adjunct technique for the differential diagnosis of cutaneous round cell neoplasm. Data were collected from 64 dogs of both sexes (36 females and 28 males), various breeds, and different ages (8 months to 7 years). The histopathological nature of neoplastic growth was reported, and neoplasm prevalence was classified using age, sex, breed, and site on the body. We observed 48 cases of transmissible venereal tumors, 12 cutaneous histiocytomas, and 4 histiocytic sarcoma. Immunohistochemical characterization revealed an intense positive immunoreactivity for vimentin in transmissible venereal tumor cells and moderate positive immunoreactivity for E-cadherin and CD45 in cutaneous histiocytoma and histiocytic sarcoma cells. In conclusion, the canine transmissible venereal tumor was the most frequent form of round cell tumor; thus, a definitive cutaneous neoplasm diagnosis should be based on histopathological morphology and immunohistochemical findings.
MeSH term(s)	Female ; Male ; Dogs ; Animals ; Histiocytic Sarcoma/diagnosis ; Histiocytic Sarcoma/veterinary ; Vimentin ; Venereal Tumors, Veterinary/pathology ; Immunohistochemistry ; Skin Neoplasms/diagnosis ; Skin Neoplasms/veterinary ; Skin Neoplasms/pathology ; Cadherins/metabolism
Chemical Substances	Vimentin ; Cadherins
Language	English
Publishing date	2024-02-26
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2036257-2
ISSN	1678-4375 ; 1519-6984
ISSN (online)	1678-4375
ISSN	1519-6984
DOI	10.1590/1519-6984.278769
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The application of the microalgae Chlorella spp. as a supplement in broiler feed

ABDELNOUR, S.A / ABD EL-HACK, M.E / ARIF, M / KHAFAGA, A.F / TAHA, A.E

World's poultry science journal. 2019 June, v. 75, no. 2

2019

Abstract: Chlorella (vulgaris spp.; CLV) is a genus of unicellular freshwater microalgae that are fit for human consumption and are used as additives with high nutritional value in feed for agriculturally important animals. Chlorella spp. are characterised by ... ...

Abstract	Chlorella (vulgaris spp.; CLV) is a genus of unicellular freshwater microalgae that are fit for human consumption and are used as additives with high nutritional value in feed for agriculturally important animals. Chlorella spp. are characterised by their simple cultivation, high productivity and levels of protein and other nutrients. Investigations have shown that the growth performance of broilers can be positively affected by the addition of very low amounts of CLV biomass (0.5-1.0% of the diet) to feed. The effect of CLV on growth and development is considered to stem from its high protein content (60.6%) and nutritional value. Results have shown enhanced body weight gain (2.7%), better feed conversion ratio (lowered by 2.8%), meat colour and breast muscle weight (20.1%) in CLV-supplemented chicks compared to control birds (control breast weight 19.1%). Additionally, a significant decrease in drip loss (2.26%) from breast muscle was observed with CLV supplementation and levels of blood total protein, albumin, and high-density lipoprotein (HDL) cholesterol significantly increased (P<0.05), while the levels of liver enzymes indicative of oxidative damage (alanine aminotransferase, ALT) decreased by 23.2%, indicating better liver function. In terms of immunity, blood lymphocytes were increased in broilers fed a diet supplemented with liquid CLV (17.9 x 103/μl) compared with birds supplemented with dry CLV (13.5 x 103/μl). Additionally, the levels of IgA, IgG, and IgM were elevated by 29.7%, 69.1%, and 32.3%, respectively, in broilers that consumed feed containing CLV. Similarly, the intestinal diversity and abundance of Lactobacillus spp. were significantly increased (9.9 ± 1.88 and 8.99 log10 CFU/g, respectively) by dietary supplementation with liquid CLV compared to that in non-treated chicks (8.7 ± 1.22 and 8.51 log10 CFU/g, respectively). Energy digestibility was increased significantly by 1.29% in CLV-treated chicks compared to the control chicks. This review highlights the findings associated with the utilisation of CLV biomass as a feed supplement and its effect on broiler growth and health.
Keywords	Chlorella ; Lactobacillus ; additives ; alanine transaminase ; albumins ; biomass ; birds ; body weight changes ; breast muscle ; breasts ; chicks ; color ; digestible energy ; drip loss ; feed conversion ; feed supplements ; freshwater ; growth performance ; high density lipoprotein cholesterol ; humans ; immunity ; immunoglobulin A ; immunoglobulin G ; immunoglobulin M ; intestines ; liquids ; liver ; liver function ; lymphocytes ; meat ; microalgae ; nutrients ; protein content
Language	English
Dates of publication	2019-06
Size	p. 305-318.
Publishing place	Cambridge University Press on behalf of World's Poultry Science Association
Document type	Article
ZDB-ID	411210-6
ISSN	1743-4777 ; 0043-9339
ISSN (online)	1743-4777
ISSN	0043-9339
DOI	10.1017/S0043933919000047
Database	NAL-Catalogue (AGRICOLA)

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Article: Dietary Origanum vulgare essential oil attenuates cypermethrin-induced biochemical changes, oxidative stress, histopathological alterations, apoptosis and reduces DNA damage in Common carp (Cyprinus carpio)

Khafaga, A. F. / Naiel, M. A. E. / Dawood, M. A. O. / Abdel-Latif, H. M. R.

Aquatic toxicology

2020 Volume 228, Issue -, Page(s) 105624

Language	English
Document type	Article
ZDB-ID	782699-0
ISSN	0166-445x
Database	Current Contents Nutrition, Environment, Agriculture

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Article: The potential mechanistic insights and future implications for the effect of prebiotics on poultry performance, gut microbiome, and intestinal morphology

Yaqoob, M.U / El-Hack, M.E. Abd / Hassan, F / El-Saadony, M.T / Khafaga, A.F / Batiha, G.E / Yehia, N / Elnesr, S.S / Alagawany, M / El-Tarabily, K.A / Wang, M

Poultry science. 2021 July, v. 100, no. 7

2021

Abstract: Prebiotics may modify the biological processes in the chickens' gastrointestinal tract to improve poultry performance and health. Prebiotics are natural feed additives that offer many economic advantages by decreasing mortality rates, increasing growth ... ...

Abstract	Prebiotics may modify the biological processes in the chickens' gastrointestinal tract to improve poultry performance and health. Prebiotics are natural feed additives that offer many economic advantages by decreasing mortality rates, increasing growth rates, and improving birds' feed efficiency. Prebiotic action potentially affects the degradation of indigestible dietary compounds, the synthesis of nitrogen components and vitamins, and simplifies the removal of undesirable elements in the diet. Prebiotics could also induce desirable gut microbiome modifications and affect host metabolism and immune health. It is worth mentioning that gut bacteria metabolize the prebiotic compounds into organic compounds that the host can subsequently use. It is important to limit the concept of prebiotics to compounds that influence the metabolism of resident microorganisms. Any medicinal component or feed ingredient beneficial to the intestinal microecosystem can be considered a prebiotic. In this review, the impacts of prebiotics on the gut microbiome and physiological structure are discussed, emphasizing the poultry's growth performance. The current review will highlight the knowledge gaps in this area and future research directions.
Keywords	digestive tract ; feed composition ; feed conversion ; growth performance ; intestinal microorganisms ; intestines ; metabolism ; mortality ; nitrogen ; prebiotics
Language	English
Dates of publication	2021-07
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2021.101143
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The potential mechanistic insights and future implications for the effect of prebiotics on poultry performance, gut microbiome, and intestinal morphology.

Yaqoob, M U / El-Hack, M E Abd / Hassan, F / El-Saadony, M T / Khafaga, A F / Batiha, G E / Yehia, N / Elnesr, S S / Alagawany, M / El-Tarabily, K A / Wang, M

Poultry science

2021 Volume 100, Issue 7, Page(s) 101143

Abstract	Prebiotics may modify the biological processes in the chickens' gastrointestinal tract to improve poultry performance and health. Prebiotics are natural feed additives that offer many economic advantages by decreasing mortality rates, increasing growth rates, and improving birds' feed efficiency. Prebiotic action potentially affects the degradation of indigestible dietary compounds, the synthesis of nitrogen components and vitamins, and simplifies the removal of undesirable elements in the diet. Prebiotics could also induce desirable gut microbiome modifications and affect host metabolism and immune health. It is worth mentioning that gut bacteria metabolize the prebiotic compounds into organic compounds that the host can subsequently use. It is important to limit the concept of prebiotics to compounds that influence the metabolism of resident microorganisms. Any medicinal component or feed ingredient beneficial to the intestinal microecosystem can be considered a prebiotic. In this review, the impacts of prebiotics on the gut microbiome and physiological structure are discussed, emphasizing the poultry's growth performance. The current review will highlight the knowledge gaps in this area and future research directions.
MeSH term(s)	Animals ; Chickens ; Gastrointestinal Microbiome ; Gastrointestinal Tract/chemistry ; Poultry ; Prebiotics/analysis
Chemical Substances	Prebiotics
Language	English
Publishing date	2021-03-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2021.101143
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Field performance of commercial Egyptian clover (Trifolium alexandrinum L.) cultivars under high temperature condition

Zayed, E. M / Metwali, E. M. R / Khafaga, A. F / Azab, M. M

Range management & agroforestry. 2011 Dec., v. 32, no. 2

2011

Abstract: Heat stress due to high temperature is a serious threat to crop production worldwide. This investigation determined field performance of six cultivars from Egyptian clover, i.e., Helaly, Serw 1, Gemmiza 1, Giza 6, Sakha 4 and Fahl under Shandwel ... ...

Abstract	Heat stress due to high temperature is a serious threat to crop production worldwide. This investigation determined field performance of six cultivars from Egyptian clover, i.e., Helaly, Serw 1, Gemmiza 1, Giza 6, Sakha 4 and Fahl under Shandwel Agricultural Research Station Farm, Egypt at high temperature. The results showed that Giza 6 performed the best with total fresh yield (78.35 t ha⁻¹) followed by Sakha 4 (74.7 t ha⁻¹). In dry matter yield the cultivars Giza 6 (multi cut) and Helaly (multi cut) had highest values 11.28 and 11.57 t ha⁻¹, respectively and significant differences among cultivars were recorded. The values of crude protein and crude fiber and ash content per cent differed in different cuts. Fahl cultivar showed no major effect of air and soil temperature and humidity.
Keywords	Trifolium alexandrinum ; agronomic traits ; air temperature ; ash content ; crude fiber ; crude protein ; cultivars ; dry matter accumulation ; environmental factors ; forage yield ; heat ; heat stress ; heat tolerance ; relative humidity ; soil temperature ; soil water content ; Egypt
Language	English
Dates of publication	2011-12
Size	p. 87-91.
Publishing place	Range Management Society of India
Document type	Article
Note	golden set
ISSN	2249-5231
Database	NAL-Catalogue (AGRICOLA)

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Article: Phytogenic Products and Phytochemicals as a Candidate Strategy to Improve Tolerance to Coronavirus

Attia, Y. A. / Alagawany, M. M. / Farag, M. R. / Alkhatib, F. M. / Khafaga, A. F. / Abdel-Moneim, A. M. E. / Asiry, K. A. / Mesalam, N. M. / Shafi, M. E. / Al-Harthi, M. A. / Abd El-Hack, M. E.

Frontiers in Veterinary Science

Abstract: Coronaviruses are the causative agents of many infectious diseases in human and animals These included severe acute respiratory syndrome (SARS), avian infectious bronchitis (IBV) in poultry, Middle East respiratory syndrome (MERS), and coronavirus ... ...

Abstract	Coronaviruses are the causative agents of many infectious diseases in human and animals These included severe acute respiratory syndrome (SARS), avian infectious bronchitis (IBV) in poultry, Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19) in humans These results had considerable death burdens and negative influences on social–economic life Since the appearance of the outbreak of the COVID-19 pandemic, continuous investigations have been carried out by researchers to find active compounds, mainly from plants, as natural sources, that could inhibit or stop the proliferation of the causative agent of COVID-19 (SARS-CoV-2) The most common symptoms caused by infections with COVID-19 can include cough, fever, and sore throat Nevertheless, there is a shortage of active antiviral compounds for treating different strains of coronavirus Herbal medicine is a class of medication that originates from nature and is aimed at decreasing the use of preservatives, excipients, or other additives and, consequently, lesser side effects The rapid spread of COVID-19 infection besides the lack of knowledge about any treatments and the growing concern of the public from the virus directed us toward writing this review article in an aim to provide alternatives to the allopathic medicine use There is a wealth of chemical diversity in the naturally existing compounds, including their antiviral activities, which may encourage their utilization as therapeutics against viral infections, including coronaviruses The majority of publications on the herbal remedies of coronavirus, MERS, or SARS focused primarily on the use of polar compounds These substances displayed encouraging inhibitory influences on coronavirus in humans These include psoralidin, scutellarein, silvestrol, tryptanthrin, caffeic acid, quercetin, myricetin, saikosaponin B2, griffithsin (lectins), and isobavachalcone Some other agents like lycorine may be useful, if the antiviral activity is obtained by concentrations below the toxic plasma levels According to the available literatures, the most promising inhibitors of coronaviruses are polyphenolic compounds, which are small molecules with conjugated fused ring structures © Copyright © 2020 Attia, Alagawany, Farag, Alkhatib, Khafaga, Abdel-Moneim, Asiry, Mesalam, Shafi, Al-Harthi and Abd El-Hack
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #914470
Database	COVID19

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Article: Field performance of commercial Egyptian clover (Trifolium alexandrinum L.) cultivars under high temperature condition

Zayed, E.M. / Metwali, E.M.R. / Khafaga, A.F. / Azab, M.M.

Range Management and Agroforestry (India)

(Dec 2011) , Issue (2)

Abstract	Heat stress due to high temperature is a serious threat to crop production worldwide. This investigation determined field performance of six cultivars from Egyptian clover, i.e., Helaly, Serw 1, Gemmiza 1, Giza 6, Sakha 4 and Fahl under Shandwel Agricultural Research Station Farm, Egypt at high temperature. The results showed that Giza 6 performed the best with total fresh yield (78.35 t ha-1) followed by Sakha 4 (74.7 t ha-1). In dry matter yield the cultivars Giza 6 (multi cut) and Helaly (multi cut) had highest values 11.28 and 11.57 t ha-1, respectively and significant differences among cultivars were recorded. The values of crude protein and crude fiber and ash content per cent differed in different cuts. Fahl cultivar showed no major effect of air and soil temperature and humidity.
Keywords	TRIFOLIUM ALEXANDRINUM ; STRESS ; FORAGE ; HEAT TOLERANCE ; SOIL TEMPERATURE ; TRIFOLIUM ALEXANDRINUM ; STRESS ; FOURRAGE ; TOLERANCE A LA CHALEUR ; TEMPERATURE DU SOL ; TRIFOLIUM ALEXANDRINUM ; ESTRES ; FORRAJES ; TOLERANCIA AL CALOR ; TEMPERATURA DEL SUELO ; http://www.fao.org/aos/agrovoc#c_7911 ; http://www.fao.org/aos/agrovoc#c_7452 ; http://www.fao.org/aos/agrovoc#c_36108 ; http://www.fao.org/aos/agrovoc#c_11486 ; http://www.fao.org/aos/agrovoc#c_7197
Language	English
Document type	Article
ISSN	0971-2070
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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