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  1. Article: Trimetazidine May Potentially Confer Neuroprotective Effects against COVID-19-Induced Neurological Sequelae via Inhibition of Death-Associated Protein Kinase 1 (DAPK1) Signaling Pathways: An Evidenced-Based Hypothesis.

    Aghajani, Ali / Khakpourian, Zahra / Bakhthiarzadeh, Soodeh / Adibipour, Fatemeh / Sadr, Makan / Coleman-Fuller, Natalie / Jamaati, Hamidreza / Motaghinejad, Majid

    Tanaffos

    2024  Volume 22, Issue 2, Page(s) 182–186

    Language English
    Publishing date 2024-04-14
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2233372-1
    ISSN 1735-0344
    ISSN 1735-0344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hypothesized neuroprotective effect of minocycline against COVID-19-induced stroke and neurological dysfunction: possible role of matrix metalloprotease signaling pathway.

    Aghajani Shahrivar, Ali / Khakpourian, Zahra / Majdi, Fatemeh / Sobhani, Sarvenaz / Coleman-Fuller, Natalie / Gholami, Mina / Motaghinejad, Majid

    Biologia

    2022  Volume 77, Issue 10, Page(s) 3027–3035

    Abstract: Severe Acute Respiratory Syndrome Coronavirus-2 (COVID-19) is a respiratory disease that causes dysfunction in respiration. Since late 2019, this virus has infected and killed millions of people around the world and imposed many medical and therapeutic ... ...

    Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (COVID-19) is a respiratory disease that causes dysfunction in respiration. Since late 2019, this virus has infected and killed millions of people around the world and imposed many medical and therapeutic problems in the form of a pandemic. According to recent data, COVID-19 disease can increase the risk of stroke, which can be deadly or cause many neurological disorders after the disease. During the last two years, many efforts have been made to introduce new therapies for management of COVID-19-related complications, including stroke. To achieve this goal, several conventional drugs have been investigated for their possible therapeutic roles. Minocycline, a broad-spectrum, long-acting antibiotic with anti-inflammatory and antioxidant properties, is one such conventional drug that should be considered for treating COVID-19-related stroke, as indirect evidence indicates that it exerts neuroprotective effects, can modulate stroke occurrence, and can play an effective and strategic role in management of the molecular signals caused by stroke and its destructive consequences. The matrix metalloprotease (MMP) signaling pathway is one of the main signaling pathways involved in the occurrence and exacerbation of stroke; however, its role in COVID-19-induced stroke and the possible role of minocycline in the management of this signaling pathway in patients with COVID-19 is unclear and requires further investigation. Based on this concept, we hypothesize that minocycline might act via MMP signaling as a neuroprotective agent against COVID-19-induced neurological dysfunction, particularly stroke.
    Language English
    Publishing date 2022-08-09
    Publishing country Slovakia
    Document type Editorial
    ZDB-ID 419136-5
    ISSN 1336-9563 ; 0006-3088 ; 1335-6372 ; 1335-6380
    ISSN (online) 1336-9563
    ISSN 0006-3088 ; 1335-6372 ; 1335-6380
    DOI 10.1007/s11756-022-01162-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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