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Article ; Online: A de novo TINF2, R282C Mutation in a Case of Dyskeratosis Congenital Founded by Next-Generation Sequencing.

Khakzad, Motahareh / Shahbazi, Zahra / Naderi, Majid / Karimipoor, Morteza

2023 Volume 27, Issue 2 & 3, Page(s) 146–151

Abstract: Background: Dyskeratosis congenita (DC), an inherited and rare disease prevalent in males, is clinically manifested by reticulate hyperpigmentation, nail dystrophy, and leukoplakia. DC is associated with the increased risk of malignancy and other ... ...

Abstract	Background: Dyskeratosis congenita (DC), an inherited and rare disease prevalent in males, is clinically manifested by reticulate hyperpigmentation, nail dystrophy, and leukoplakia. DC is associated with the increased risk of malignancy and other potentially lethal complications such as bone marrow failure, as well as lung and liver diseases. Mutations in 19 genes were found to be correlated with DC. Herein, we report a 12-year-old boy carrying a de novo mutation in TINF2 gene. Methods: Whole exome sequencing (WES) was performed on DNA sample of the proband, and the variant was investigated in the family by Sanger sequencing. Population and bioinformatics analysis were performed. Results: The NM_ 001099274.3(TINF2): c.844C>T (p.Arg282Cys) mutation was found by WES. Conclusion: There was no history of the disease in the family, and the variant was classified as a de novo mutation.
MeSH term(s)	Male ; Humans ; Child ; Mutation/genetics ; Family ; Dyskeratosis Congenita/genetics ; High-Throughput Nucleotide Sequencing ; Telomere-Binding Proteins/genetics
Chemical Substances	TINF2 protein, human ; Telomere-Binding Proteins
Language	English
Publishing date	2023-03-01
Publishing country	Iran
Document type	Case Reports ; Journal Article
ZDB-ID	2489282-8
ISSN	2008-823X ; 1028-852X
ISSN (online)	2008-823X
ISSN	1028-852X
DOI	10.61186/ibj.3783
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparison of the effects of itraconazole and prednisolone on

Manafi Varkiani, Mahsa / Mirsadraee, Majid / Anhaee Nasseri, Zahra / Khakzad, Mohammadreza / Ghaffari, Shadi / Rabbani Nia, Tayebeh

Current medical mycology

2024 Volume 9, Issue 2, Page(s) 1–9

Abstract: Background and purpose: Considering the possible role of fungal sensitization in the treatment of resistant asthma, which may lead to the remodeling of bronchial structure, we theorized that itraconazole could result in better control of asthma. In this ...

Abstract	Background and purpose: Considering the possible role of fungal sensitization in the treatment of resistant asthma, which may lead to the remodeling of bronchial structure, we theorized that itraconazole could result in better control of asthma. In this regard, this study aimed to compare the effects of itraconazole and prednisolone (routinely prescribed) on clinical, structural, and biomarker findings of the remodeling of asthma. Materials and methods: This double-blind controlled randomized clinical trial was performed on 70 adult patients suffering from severe persistent asthma. The intervention group received 200 mg of itraconazole per day, and the control group received 10 mg of prednisolone per day, for 32 weeks, in addition to the classic treatment of asthma. The subjects were randomly divided into two groups, and assigned by sealed envelope. Blinding was performed by repacking the drug in a similar container. Primary outcomes were asthma control test score, fibroblast growth factor 2, and wall area percentage on RB1 bronchus measured by computed tomography. The outcomes were compared in subjects classified as allergic, eosinophilic, T2 low asthma, and four types of inflammatory cell classification in sputum. Results: Seventy subjects finished the 32-week trial (35 subjects in each group). Baseline data did not show significant differences between groups. A comparison of asthma variants showed significantly more severe cough and dyspnea in the allergic variant and higher spirometry results in T2-low asthma. Sputum cytology revealed a mixed pattern as the most frequent type (47%). After the trial, two groups improved in many parameters; however, FGF-2 improved more significantly by itraconazole (4.66±16.92 decreased to 1.14±2.98), and FEV1/FVC was significantly higher in the itraconazole group, compared to the control group. These results did not change in terms of asthma variants and sputum classification. Conclusion: Itraconazole was superior to prednisolone in the treatment of many clinical and spirometry aspects in severe persistent asthma.
Language	English
Publishing date	2024-02-05
Publishing country	Iran
Document type	Journal Article
ZDB-ID	3015705-5
ISSN	2423-3420 ; 2423-3439
ISSN (online)	2423-3420
ISSN	2423-3439
DOI	10.22034/CMM.2023.345036.1401
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Zur epitherapeutischen Nutzung von zwei Butyrophenon-Derivaten (unterschiedlicher neuroleptischer Potenz) bei hirnorganischen Psychosyndromen in der Gerontopsychiatrie

Khakzad, Madjid

1983

Size	III, 209 S.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Düsseldorf, Univ., Diss., 1983
HBZ-ID	HT003104619
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Unilateral Buccinator Flap for Lengthening of Short Palate.

Hassani, Mohammad-Esmaiil / Latifi, Noor-Ahmad / Karimi, Hamid / Khakzad, Mohammad

The Journal of craniofacial surgery

2018 Volume 29, Issue 6, Page(s) 1619–1624

Abstract: Background: Velopharyngeal insufficiency is one of the most frequent complications after cleft palate repair.: Purpose: To evaluate the results and complications of unilateral Buccinator flap (BMF) in velopharyngeal insufficiency.: Materials and ... ...

Abstract	Background: Velopharyngeal insufficiency is one of the most frequent complications after cleft palate repair. Purpose: To evaluate the results and complications of unilateral Buccinator flap (BMF) in velopharyngeal insufficiency. Materials and methods: During 4 years the authors performed unilateral BMF in all short palates. Age, sex, demographic data, length of palate, cause of short palate, nasopharyngoscopy and videofluroscopy results, hyper nasality, nasal escape, nasal emission, nasal fluid leak, speech evaluation and results, outcome and complications of the treatment were surveyed before surgery and in 1, 3, 6 months after treatment. Results: The authors had 43 patients, 29 below 8 years old and 14 adults. Velopharyngeal gap was between 10 and 27 mm, mean 21 mm. Buccinator flap were measuring 15 to 19 mm in width and 32 to 56 mm in length. The operation time was 80 to 100 minutes, mean 86 minutes.Nasal emission, nasal escape, and nasal leak were treated in all patients.Hyper nasality was completely improved in all of the patients below 8 years old (29 patients) and in 10 patients of the adults (totally 39 patients, 90.6%). And it was improved significantly in other 4 patients (9.4%). The speech evaluation reported between 70% and 86% improvements.The lengthening of the palate was between 12 and 19 mm, mean 17 mm.The satisfaction of the patients was as 0% poor, 2.3% fair, 72.1% good, and 25.6% excellent. Conclusion: Unilateral BMF is reliable, promising, and safe flap for lengthening of short palate and it can lengthen the palate up to 19 mm. The time of surgery is very short compared with other methods. It is an anatomical treatment versus pharyngeal flap which is not an anatomical one. Speech improvement will achieve in 70% to 86% patients.
MeSH term(s)	Adult ; Child ; Facial Muscles/transplantation ; Female ; Humans ; Male ; Operative Time ; Palate, Soft/surgery ; Speech ; Surgical Flaps ; Treatment Outcome ; Velopharyngeal Insufficiency/physiopathology ; Velopharyngeal Insufficiency/surgery ; Voice Quality ; Young Adult
Language	English
Publishing date	2018-09-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000004612
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article: Influence of splenectomy on immunoglobulins and complement components in major thalassemia.

Darzi, Ali Asghar / Kamali, Sakineh / Khakzad, Mohammad

Caspian journal of internal medicine

2015 Volume 6, Issue 1, Page(s) 30–33

Abstract: Background: Thalassemia is the most common anemia with hereditary base in Iran. The aim of this study was to evaluate the humoral immune system and assess the effect of splenectomy on the serum level of immunoglobulins IgG, IgM, and IgG and complement ... ...

Abstract	Background: Thalassemia is the most common anemia with hereditary base in Iran. The aim of this study was to evaluate the humoral immune system and assess the effect of splenectomy on the serum level of immunoglobulins IgG, IgM, and IgG and complement components in patients with major thalassemia. Methods: This quasi-experimental study (before-after) was performed on 40 patients with major thalassemia that referred to the treatment centers of Babol for splenectomy from March 2011 to March 2013. Results: The mean age of patients under study was 25.38±6.89 years. The results of this study showed that the rate of IgA and IgM had a significant decrease after splenectomy. However, the increase of serum level in IgG in this study was not significant. The serum levels of C3 and CH50 were evaluated in all patients that its reduction was statistically significant, but the decrease of serum levels in C4 was not significant. Conclusion: The spleen plays a role in releasing immunoglobulins and starter proteins of complement activation pathways and splenectomy causes reduction in the serum levels of immunoglobulins and complement components.
Language	English
Publishing date	2015-07-22
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2971933-1
ISSN	2008-6172 ; 2008-6164
ISSN (online)	2008-6172
ISSN	2008-6164
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19.

Azizi Jalilian, Farid / Keshavarz, Gheisar / Khazaei, Salman / Nezamdoost, Manije / Hashemi, Seyed Hamid / Mamani, Mojgan / Ansari, Nastaran / Amini, Razieh / Khalkhali, Aref / Keshavarz, Arghavan / Ayubi, Erfan / Fazeli, Maryam / Heidari Moghadam, Rashid / Alizadeh, Saeid / Pourhossein, Behzad / Teimouri, Ali / Keramat, Fariba / Karampour, Sajad / Khakzad, Mohammadreza

Frontiers in immunology

2022 Volume 13, Page(s) 919402

Abstract: The present study aimed to evaluate the effects of Nutrition Bio-shield Superfood (NBS) powder on the immune system function and clinical manifestations in patients with COVID-19. We compare the effects of NBS powder on the immune system function and ... ...

Abstract	The present study aimed to evaluate the effects of Nutrition Bio-shield Superfood (NBS) powder on the immune system function and clinical manifestations in patients with COVID-19. We compare the effects of NBS powder on the immune system function and clinical manifestations among two different groups: 1) intervention group receiving standard treatment scheduled according to treatment guidelines plus NBS powder, and 2) control group receiving only the same standard treatment. The serum levels of IL-2, IL-6, IL-17, IFNγ, and TNFα were determined after four weeks of treatment by specific ELISA kits according to the manufacturer's instructions. Finally, the level of immune system stimulation and inflammatory markers were compared at baseline and after intervention in both groups. Data were analyzed using SPSS (version 22). A p-value of ≤ 0.05 was set as significant. A total of 47 patients with COVID-19 (24 patients in the intervention group and 23 patients in the control group) were included in this study. Results showed that the differences in the mean decrease of IL-2, IL-6, and TNF-α in the intervention group in comparison to the control group were 0.93, 10.28, and 8.11 pg/ml, respectively (P<0.001). On the other hand, there was no difference in IL-17, IFNγ, monocytes, eosinophil, and other inflammatory indices between the intervention and control groups. Although NBS powder was able to significantly decrease the levels of some proinflammatory cytokines in patients with COVID-19, however, it is noteworthy that the course of the disease was to large part unaffected by NBS power and there was a reduction independent of treatment. The present study indicates that NBS powder could provide a beneficial anti-inflammatory effect in patients with COVID-19. Hence, NBS in treating patients with COVID-19 shows promise as an adjuvant to the current standard antiviral treatment of such patients. Clinical trial registration: https://www.irct.ir, identifier IRCT20200426047206N1.
MeSH term(s)	COVID-19/drug therapy ; Humans ; Interleukin-17 ; Interleukin-2 ; Interleukin-6 ; Monocytes ; Powders ; Tumor Necrosis Factor-alpha
Chemical Substances	Interleukin-17 ; Interleukin-2 ; Interleukin-6 ; Powders ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2022-08-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.919402
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Value of the polymerase chain reaction method for detecting tuberculosis in the bronchial tissue involved by anthracosis.

Mirsadraee, Majid / Shafahie, Ahmad / Reza Khakzad, Mohammad / Sankian, Mojtaba

Journal of bronchology & interventional pulmonology

2014 Volume 21, Issue 2, Page(s) 131–134

Abstract: Background: Anthracofibrosis is the black discoloration of the bronchial mucosa with deformity and obstruction. Association of this disease with tuberculosis (TB) was approved. The objective of this study was to find the additional benefit of assessment ...

Abstract	Background: Anthracofibrosis is the black discoloration of the bronchial mucosa with deformity and obstruction. Association of this disease with tuberculosis (TB) was approved. The objective of this study was to find the additional benefit of assessment of TB by the polymerase chain reaction (PCR) method. Methods: Bronchoscopy was performed on 103 subjects (54 anthracofibrosis and 49 control subjects) who required bronchoscopy for their pulmonary problems. According to bronchoscopic findings, participants were classified to anthracofibrosis and nonanthracotic groups. They were examined for TB with traditional methods such as direct smear (Ziehl-Neelsen staining), Löwenstein-Jensen culture, and histopathology and the new method "PCR" for Mycobacterium tuberculosis genome (IS6110). Results: Age, sex, smoking, and clinical findings were not significantly different in the TB and the non-TB groups. Acid-fast bacilli could be detected by a direct smear in 12 (25%) of the anthracofibrosis subjects, and adding the results of culture and histopathology traditional tests indicated TB in 27 (31%) of the cases. Mycobacterium tuberculosis was diagnosed by PCR in 18 (33%) patients, but the difference was not significant. Detection of acid-fast bacilli in control nonanthracosis subjects was significantly lower (3, 6%), but PCR (20, 40%) and accumulation of results from all traditional methods (22, 44%) showed a nonsignificant difference. Conclusions: The PCR method showed a result equal to traditional methods including accumulation of smear, culture, and histopathology.
MeSH term(s)	Aged ; Aged, 80 and over ; Anthracosis/complications ; Anthracosis/pathology ; Bronchial Diseases/complications ; Bronchial Diseases/diagnosis ; Bronchial Diseases/pathology ; Bronchoscopy/methods ; Case-Control Studies ; Female ; Fibrosis ; Humans ; Male ; Middle Aged ; Mycobacterium tuberculosis/isolation & purification ; Polymerase Chain Reaction/methods ; Predictive Value of Tests ; Prospective Studies ; Respiratory Mucosa/pathology ; Tuberculosis, Pulmonary/complications ; Tuberculosis, Pulmonary/diagnosis
Language	English
Publishing date	2014-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000063
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4027: Show issues

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Book ; Thesis: Measurement of dijet cross sections with a leading neutron in photoproduction at HERA

Khakzad, Mohsen

(DESY-Thesis ; 2000-008)

2000

Author's details	Mohsen Khakzad
Series title	DESY-Thesis ; 2000-008
Language	English
Size	XXVI, 134 Sp, graph. Darst
Publisher	DESY, Zentralbibliothek
Publishing place	Hamburg u.a.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	York Univ., Diss.--Toronto, 1999
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Thesis: Measurement of dijet cross sections with a leading neutron in photoproduction at HERA

Khakzad, Mohsen

(DESY-Thesis ; 2000-008)

2000

Author's details	Mohsen Khakzad
Series title	DESY-Thesis ; 2000-008
Language	English
Size	XXVI, 134 Sp, graph. Darst
Publisher	DESY, Zentralbibliothek
Publishing place	Hamburg u.a.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	York Univ., Diss.--Toronto, 1999
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Anti-inflammatory Potentials of Excretory/Secretory (ES) and Somatic Products of

Shirvan, Sima Parande / Borji, Hassan / Movassaghi, Ahmadreza / Khakzad, Mohammadreza / Farzin, Hamidreza / Maleki, Mohsen / Haghparast, Alireza

Iranian journal of parasitology

2017 Volume 11, Issue 4, Page(s) 515–526

Abstract: Background: Inverse relationship between helminths infection and immune-mediated diseases has inspired researchers to investigate therapeutic potential of helminths in allergic asthma. Helminth unique ability to induce immunoregulatory responses has ... ...

Abstract	Background: Inverse relationship between helminths infection and immune-mediated diseases has inspired researchers to investigate therapeutic potential of helminths in allergic asthma. Helminth unique ability to induce immunoregulatory responses has already been documented in several experimental studies. This study was designed to investigate whether excretory/secretory (ES) and somatic products of Methods: This study was carried out at the laboratories of Immunology and Parasitology of Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran during spring and summer 2015. Allergic airway inflammation was induced in mice by intraperitoneal (IP) injection with ovalbumin (OVA). The effects of ES and somatic products of Results: Treatment with ES and somatic products of Conclusion: This study provides new insights into anti-inflammatory effects of ES and somatic products of
Language	English
Publishing date	2017-01-03
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388453-8
ISSN	2008-238X ; 1735-7020
ISSN (online)	2008-238X
ISSN	1735-7020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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