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Article ; Online: Ephedra alata subsp. alenda (Ephedraceae) leaf extracts

Saber Abdelkader Saidi / Turki M. Al-Shaikh / Othman A. Alghamdi / Khaled Hamden

Heliyon, Vol 8, Iss 12, Pp e11954- (2022)

phytochemical screening, anti-diabetic, anti-obesity and anti-toxic activities on diabetic-induced liver-kidney-testes toxicities and inhibition of α-amylase and lipase enzymes

2022

Abstract: The study evaluated the phytochemical composition of Ephedra alata and its effects on α-amylase and lipase enzymes and diabetic-induced liver-kidney-testes toxicities to determine the anti-diabetic, anti-obesity, and anti-toxic potentials of the plant. ... ...

Abstract	The study evaluated the phytochemical composition of Ephedra alata and its effects on α-amylase and lipase enzymes and diabetic-induced liver-kidney-testes toxicities to determine the anti-diabetic, anti-obesity, and anti-toxic potentials of the plant. Obesity was induced by a high-fat and fructose diet (HFFD). Various compounds were identified and quantified: cafeic acid, apigenin 7-O-glucoside, apigenin, rutin, luteolin 7-O-glucoside, p-Coumaric acid and others in EA aqueous extract (EAWE). In vitro, this study showed that EAWE strongly inhibited lipase activity as compared to EA methanol (EAME) and ethyl acetate EA extracts (EAEE). In obese rats, the supplementation of EAWE inhibited significantly (P < 0.01) intestinal and pancreatic lipase activity by 35 and 36% respectively. This decrease in lipid digestive enzyme activity caused a significant (P < 0.05) reduce in the weight gain by 12.7% and significant (P < 0.05) decrease in the serum lipid rate as total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). Moreover, the supplementation of EAWE to obese rats reduced the activity of α-amylase in the small intestine and pancreas by 26 and 31% respectively (P < 0.01) and consequently decreases in serum glucose level by 20.8% (P < 0.05). In addition, administration of EAWE in type 2 diabetes protected from obesity induced liver, kidney and testes alterations. The potent protective effect EAWE may be influenced by the diversity of phenolic compounds. therefore, this study showed in the first time that EAWE are efficient for the prevention and the amelioration of obesity, hyperglycemia, and various organs toxicities.
Keywords	Ephedra alata ; Obesity ; Type 2 diabetes ; Liver ; Kidney ; Testes ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	500
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds

Amani Toumi / Faiza I.A. Abdella / Sarra Boudriga / Tahani Y. A. Alanazi / Asma K. Alshamari / Ahlam Abdulrahman Alrashdi / Amal Dbeibia / Khaled Hamden / Ismail Daoud / Michael Knorr / Jan-Lukas Kirchhoff / Carsten Strohmann

Molecules, Vol 28, Iss 21, p

Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities

2023 Volume 7443

Abstract: In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine ... ...

Abstract	In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine and diverse arylidene-imidazolidine-2,4-diones (Hydantoins). The suggested stereochemistry was ascertained by an X-ray diffraction study and NMR spectroscopy. The resulting tetracyclic heterocycles were screened for their in vitro and in vivo anti-inflammatory and analgesic activity and for their in vitro antimicrobial potency. In vitro antibacterial screening revealed that several derivatives exhibited remarkable growth inhibition against different targeted microorganisms. All tested compounds showed excellent activity against the Micrococccus luteus strain (93.75 µg/mL ≤ MIC ≤ 375 µg/mL) as compared to the reference drug tetracycline (MIC = 500 µg/mL). Compound 4e bearing a p -chlorophenyl group on the pyrrolidine ring exhibited the greatest antifungal potential toward Candida albicans and Candida krusei (MIC values of 23.43 µg/mL and 46.87 µg/mL, respectively) as compared to Amphotericin B (MIC = 31.25 and 62.50 µg/mL, respectively). The target compounds were also tested in vitro against the lipoxygenase-5 (LOX-5) enzyme. Compounds 4i and 4l showed significant inhibitory activity with IC 50 = 1.09 mg/mL and IC 50 = 1.01 mg/mL, respectively, more potent than the parent drug, diclofenac sodium (IC 50 = 1.19 mg/mL). In addition, in vivo evaluation of anti-inflammatory and analgesic activity of these spirooxindoles were assessed through carrageenan-induced paw edema and acetic acid-induced writhing assays, respectively, revealing promising results. In silico molecular docking and predictive ADMET studies for the more active spirocompounds were also carried out.
Keywords	spirooxindoles ; hydantoin ; anti-inflammatory ; analgesic ; antimicrobial ; crystal structure ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Imipenem toxicity in male reproductive organs as a result of inflammatory microenvironment and oxidative stress in germinal cells

Cherif, Boutheina / Hana Triki / Sana Sahnoun / Khaled Hamden / Afifa Sallemi / Slim Charfi / Saloua Lassoued

Toxicology. 2019 Mar. 15, v. 416

2019

Abstract: Imipenem is a beta-Lactam antibiotic characterized by a broad spectrum of activity. It is prescribed to treat severe infections. Our goal is to investigate toxicity induced in male rat reproductive systems following exposure to this drug (15, 50 or 100 ... ...

Abstract	Imipenem is a beta-Lactam antibiotic characterized by a broad spectrum of activity. It is prescribed to treat severe infections. Our goal is to investigate toxicity induced in male rat reproductive systems following exposure to this drug (15, 50 or 100 mg/kg) compared to gentamicin (50 mg/kg) treatment.Effects of imipenem on reproductive organ weights, histoarchitecture, sperm parameters, and oxidative stress parameters were evaluated. Serum testosterone levels were measured. Apoptosis and inflammatory behaviors were investigated by immunohistochemical proteins expression analysis of apoptosis regulator BAX (Bax), B-cell lymphoma 2 (Bcl-2), and interleukin-1 beta (IL-1 beta) in testis.Results showed a significant decrease in male fertility parameters including sperm count, sperm motility, reproductive organ weights and serum testosterone levels after imipenem administration as compared to the control and gentamicin treated groups. Increased sperm abnormality was significant in animals treated with high doses of imipenem. Oxidative stress analysis revealed an expressed increase in lipid peroxidation and carbonyl groups levels in testicular tissues compared to control. Similar results were observed with superoxide dismutase and catalase activities from testicular tissues. In addition, severe testicular lesions were observed in the seminiferous tubules as well as important impairments in spermatogenesis testifying an inflammatory microenvironment confirmed by the intensive expression of IL1-beta and Bax protein by germinal cells and Bcl-2 by Leydig cells.In conclusion, imipenem treatment with high doses was found to lead to oxidative stress in male reproductive organs and an inflammatory microenvironment leading to spermatogenesis dysfunction and histopathological changes in the testis.
Keywords	B-cell lymphoma ; apoptosis ; blood serum ; catalase ; drugs ; enzyme activity ; gentamicin ; histopathology ; imipenem ; immunohistochemistry ; interleukin-1beta ; lipid peroxidation ; male fertility ; males ; moieties ; oxidative stress ; rats ; seminiferous tubules ; sperm motility ; spermatogenesis ; spermatozoa ; superoxide dismutase ; testosterone ; toxicity
Language	English
Dates of publication	2019-0315
Size	p. 44-53.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	184557-3
ISSN	1879-3185 ; 0300-483X
ISSN (online)	1879-3185
ISSN	0300-483X
DOI	10.1016/j.tox.2019.02.001
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In vitro anti-diabetic, anti-obesity and antioxidant proprieties of Juniperus phoenicea L. leaves from Tunisia

Henda Keskes / Kais Mnafgui / Khaled Hamden / Mohamed Damak / Abdelfattah El Feki / Noureddine Allouche

Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S2, Pp S649-S

2014 Volume 655

Abstract: Objective: To examine chemical composition and antioxidant activity as well as the in vitro α-amylase and pancreatic lipase inhibitory activities of the essential oil and various extracts of Juniperus phoenicea (J. phoenicea). Methods: Essential oil ... ...

Abstract	Objective: To examine chemical composition and antioxidant activity as well as the in vitro α-amylase and pancreatic lipase inhibitory activities of the essential oil and various extracts of Juniperus phoenicea (J. phoenicea). Methods: Essential oil obtained by steam distillation were analyzed by gas chromatography-mass spectrometry technique. The antioxidant activity of the essential oil and various extracts of J. phoenicea were determined by DPPH and β-carotene bleaching methods. Results: Gas chromatography-mass spectrometry analysis of the J. phoenicea essential oil resulted in the identification of 37 compounds, representing 96.98% of the oil; α-Pinene (24.02%), limonene (7.94%), D-3-Carene (16.9%), Germacrene D (11.98%), Germacrene B (5.40%) and δ-cadinene (6.52%) were the major compounds. The IC50 values of essential oil, hexane and methanol extracts against α-amylase were 35.44, 30.15 and 53.76 μg/mL respectively, and those against pancreatic lipase were 66.15, 68.47 and 60.22 μg/mL respectively, suggesting powerful anti-diabetic and anti-obesity effects. Antioxidant activity (IC50=2 μg/mL) and total phenolics content (265 mg as gallic acid equivalent/g extract) of the methanol extract were found to be the highest compared to the other extracts. Conclusions: The findings showed that the extents of α-amylase and pancreatic lipase inhibitory activities of the J. phoenicea extracts as well as their antioxidant activity are in accordance with total phenolics contents. Leaves of J. phoenicea being rich in phenolics may provide a good source of natural products with interesting medicinal properties.
Keywords	Chemical composition ; α-Amylase ; Lipase ; Essential oil ; Antioxidant activity ; Arctic medicine. Tropical medicine ; RC955-962 ; Biology (General) ; QH301-705.5
Subject code	540
Language	English
Publishing date	2014-07-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protective effect of quercetin against oxidative stress caused by dimethoate in human peripheral blood lymphocytes

Lassoued Saloua / Elfekih Abdelfetteh / Abdallah Fatma / Mansour Riadh / Gargouri Bochra / Khaled Hamden

Lipids in Health and Disease, Vol 10, Iss 1, p

2011 Volume 149

Abstract: Abstract Background The aim of this study is to investigate the effect of quercetin in alleviating the cytotoxic effects of Dimethoate in human peripheral blood lymphocytes. Methods Lymphocytes were divided into too groups. The first group, lymphocytes ... ...

Abstract	Abstract Background The aim of this study is to investigate the effect of quercetin in alleviating the cytotoxic effects of Dimethoate in human peripheral blood lymphocytes. Methods Lymphocytes were divided into too groups. The first group, lymphocytes were incubated for 4 h at 37°C with different concentrations (0, 40, 60 and 100 mM) of Dimethoate. The second group was preincubated with quercetin for 30 min and followed by Dim incubation for 4 h at 37°C. Results Following in vitro incubation, Dimethoate caused a significant increase in malondialdehyde levels, a significant decrease in thiol levels, as well as a significant increase in superoxide dismutase, and catalase activities in lymphocytes at different concentrations. Quercetin pretreated lymphocytes showed a significant protection against the cytotoxic effects inducted by Dimethoate on the studied parameters. Conclusion In conclusion, antioxidant quercetin could protect against Dimethoate-induced oxidative stress by decreasing lipid peroxidation, protein oxidation and increasing superoxide dismutase and catalase activities in human lymphocytes.
Keywords	Quercetin ; Dimethoate ; malondialdehyde ; thiol ; superoxide dismutase ; catalase ; lymphocytes ; Physiology ; QP1-981 ; Science ; Q ; DOAJ:Physiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	500
Language	English
Publishing date	2011-08-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Antioxidative and ACE inhibitory activities of protein hydrolysates from zebra blenny (Salaria basilisca) in alloxan-induced diabetic rats

Ktari, Naourez / Abdelfattah El Feki / Kais Mnafgui / Khaled Hamden / Moncef Nasri / Olfa Belguith / Rim Nasri / Tahia Boudaouara

Process Biochemistry. 2014 May, v. 49

2014

Abstract: The present study investigated the antioxidant properties and angiotensin-I converting enzyme (ACE) inhibitory activities of zebra blenny protein hydrolysates (ZBPHs), obtained by treatment with three different crude enzyme extracts, in alloxan induced ... ...

Abstract	The present study investigated the antioxidant properties and angiotensin-I converting enzyme (ACE) inhibitory activities of zebra blenny protein hydrolysates (ZBPHs), obtained by treatment with three different crude enzyme extracts, in alloxan induced diabetic rats (AIDR). The thiobarbituric acid-reactive substances (TBARS) level, as an indicator of lipid peroxidation, and the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were examined. The hepatic antioxidant enzyme activities were significantly decreased and the malondialdehyde (MDA) level was increased in AIDR. Interestingly, the administration of ZBPHs to diabetic rats reduced the MDA concentration and increased the antioxidant enzyme activities. Further, ZBPHs were found to modulate ACE activity. In addition, ZBPHs were observed to protect the kidney function efficiently, which were evidenced by the significant decrease in the creatinine, uric acid and urea contents. These results suggest a strong antioxidant and antihypertensive effect of ZBPHs which can delay the occurrence of diabetic complications and be considered as functional food ingredients in nutraceuticals or pharmaceuticals.
Keywords	alloxan ; angiotensin I ; animal disease models ; antihypertensive effect ; antioxidant activity ; antioxidants ; catalase ; creatinine ; diabetic complications ; enzyme activity ; functional foods ; glutathione peroxidase ; ingredients ; lipid peroxidation ; malondialdehyde ; protein hydrolysates ; rats ; renal function ; Salaria basilisca ; superoxide dismutase ; thiobarbituric acid-reactive substances ; urea ; uric acid
Language	English
Dates of publication	2014-05
Size	p. 890-897.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	1359-5113
DOI	10.1016/j.procbio.2014.01.032
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inhibitory Activities of Zygophyllum album

Kais Mnafgui / Khaled Hamden / Hichem Ben Salah / Mouna Kchaou / Mbarek Nasri / Sadok Slama / Fatma Derbali / Noureddine Allouche / Abdelfattah Elfeki

Evidence-Based Complementary and Alternative Medicine, Vol

A Natural Weight-Lowering Plant on Key Enzymes in High-Fat Diet-Fed Rats

2012 Volume 2012

Abstract: Obesity is a serious health problem that increased risk for many complications, including diabetes and cardiovascular disease. The results showed EZA, which found rich in flavonoids and phenolic compounds, exhibited an inhibitory activity on pancreatic ... ...

Abstract	Obesity is a serious health problem that increased risk for many complications, including diabetes and cardiovascular disease. The results showed EZA, which found rich in flavonoids and phenolic compounds, exhibited an inhibitory activity on pancreatic lipase in vitro with IC50 of 91.07 μg/mL. In vivo administration of this extract to HFD-rats lowered body weight and serum leptin level; and inhibited lipase activity of obese rats by 37% leading to notable decrease of T-Ch, TGs and LDL-c levels accompanied with an increase in HDL-c concentration in serum and liver of EZA treated HFD-rats. Moreover, the findings revealed that EZA helped to protect liver tissue from the appearance of fatty cysts. Interestingly, supplementation of EZA modulated key enzyme related to hypertension such as ACE by 36% in serum of HFD animals and improve some of serum electrolytes such as Na+, K+, Cl−, Ca2+ and Mg2+. Moreover, EZA significantly protected the liver-kidney function by reverted back near to normal the values of the liver-kidney dysfunction indices AST&ALT, ALP, CPK and GGT activities, decreased T-Bili, creat, urea and uric acid rates. In conclusion, these results showed a strong antihypelipidemic effect of EZA which can delay the occurrence of dislipidemia and hypertension.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protective effect of quercetin against oxidative stress caused by dimethoate in human peripheral blood lymphocytes.

Gargouri, Bochra / Mansour, Riadh Ben / Abdallah, Fatma Ben / Elfekih, Abdelfetteh / Lassoued, Saloua / Khaled, Hamden

Lipids in health and disease

2011 Volume 10, Page(s) 149

Abstract: Background: The aim of this study is to investigate the effect of quercetin in alleviating the cytotoxic effects of Dimethoate in human peripheral blood lymphocytes.: Methods: Lymphocytes were divided into too groups. The first group, lymphocytes ... ...

Abstract	Background: The aim of this study is to investigate the effect of quercetin in alleviating the cytotoxic effects of Dimethoate in human peripheral blood lymphocytes. Methods: Lymphocytes were divided into too groups. The first group, lymphocytes were incubated for 4 h at 37°C with different concentrations (0, 40, 60 and 100 mM) of Dimethoate. The second group was preincubated with quercetin for 30 min and followed by Dim incubation for 4 h at 37°C. Results: Following in vitro incubation, Dimethoate caused a significant increase in malondialdehyde levels, a significant decrease in thiol levels, as well as a significant increase in superoxide dismutase, and catalase activities in lymphocytes at different concentrations. Quercetin pretreated lymphocytes showed a significant protection against the cytotoxic effects inducted by Dimethoate on the studied parameters. Conclusion: In conclusion, antioxidant quercetin could protect against Dimethoate-induced oxidative stress by decreasing lipid peroxidation, protein oxidation and increasing superoxide dismutase and catalase activities in human lymphocytes.
MeSH term(s)	Antioxidants/pharmacology ; Catalase/metabolism ; Dimethoate/toxicity ; Dithionitrobenzoic Acid/chemistry ; Humans ; Insecticides/toxicity ; Lymphocytes/drug effects ; Lymphocytes/enzymology ; Lymphocytes/metabolism ; Malondialdehyde/metabolism ; Osmolar Concentration ; Oxidation-Reduction ; Oxidative Stress/drug effects ; Proteins/chemistry ; Quercetin/pharmacology ; Sulfhydryl Reagents/chemistry ; Superoxide Dismutase/metabolism
Chemical Substances	Antioxidants ; Insecticides ; Proteins ; Sulfhydryl Reagents ; Malondialdehyde (4Y8F71G49Q) ; Dithionitrobenzoic Acid (9BZQ3U62JX) ; Quercetin (9IKM0I5T1E) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; Dimethoate (W6U08B045O)
Language	English
Publishing date	2011-08-23
Publishing country	England
Document type	Journal Article
ISSN	1476-511X
ISSN (online)	1476-511X
DOI	10.1186/1476-511X-10-149
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Positive effects of Green Tea on hepatic dysfunction, lipid peroxidation and antioxidant defence depletion induced by cadmium

KHALED HAMDEN / SERGE CARREA U / FATMA AYADI MARKI / HATEM MASMOUDI / ABDELFATTAH EL FEKI

Biological Research, Vol 41, Iss 3, Pp 331-

2008 Volume 339

Abstract: Cadmium (Cd) is a highly toxic environmental and industrial cumulative pollutant that affeets many organs, especially the liver. The present study was designed to evalúate the antioxidant effect of green tea on cadmium-induced hepatic dysfunction and ... ...

Abstract	Cadmium (Cd) is a highly toxic environmental and industrial cumulative pollutant that affeets many organs, especially the liver. The present study was designed to evalúate the antioxidant effect of green tea on cadmium-induced hepatic dysfunction and oxidative stress in rats. Adult male Wistar rats were administered cadmium by injection of 20 emoles /kg bw/ every 3 days for six months. This study revealed significant (p < 0.05) liver dysfunction, lipid peroxidation and a decline in antioxidant enzyme activities in the liver of cadmium-treated rats compared to control animáis. Compared to control rats, the activities of lactate dehydrogenase (LDH), gammaglutamyl transferase (GGT), acid phosphatase (PAC), phosphatase alkaline (PAL), as well as bilirubin and thiobarbituric acid-reactive substances (TBARs), were significantly (p < 0.05) increased in Cd-treated rats. Moreover, antioxidant enzyme activities, such as superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase, were significantly (p < 0.05) decreased in the liver of cadmium-treated rats. The oral administration of 5% aqueous green tea extract, along with cadmium treatment for six months, caused a significant (p < 0.05) improvement in cadmium-induced toxicity by significantly decreasing (p < 0.05) the activities of enzymatic markers of liver dysfunction (LDH, GGT, PAC, PAL activities, as well as the bilirubin rate). Indeed, green tea extract significantly increased (p < 0.05) antioxidant enzymatic activities (SOD, Catalase, GPX) in rat liver, compared to those given cadmium alone. Thus, the oral administration of green tea, along with cadmium significantly (p < 0.05) improves cadmium-induced liver dysfunction and stress oxidant in rats' liver.
Keywords	cadmium ; rat liver dysfunction ; green tea ; antioxidant enzymes ; lipid peroxidation ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2008-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats

Aloulou, Ahmed / Khaled Hamden / Dhouha Elloumi / Madiha Bou Ali / Khaoula Hargafi / Bassem Jaouadi / Fatma Ayadi / Abdelfattah Elfeki / Emna Ammar

BMC complementary and alternative medicine. 2012 Dec., v. 12, no. 1

2012

Abstract: BACKGROUND: Diabetes has become a serious health problem and a major risk factor associated with troublesome health complications, such as metabolism disorders and liver-kidney dysfunctions. The inadequacies associated with conventional medicines have ... ...

Abstract	BACKGROUND: Diabetes has become a serious health problem and a major risk factor associated with troublesome health complications, such as metabolism disorders and liver-kidney dysfunctions. The inadequacies associated with conventional medicines have led to a determined search for alternative natural therapeutic agents. The present study aimed to investigate and compare the hypoglycemic and antilipidemic effects of kombucha and black tea, two natural drinks commonly consumed around the world, in surviving diabetic rats. METHODS: Alloxan diabetic rats were orally supplied with kombucha and black tea at a dose of 5 mL/kg body weight per day for 30 days, fasted overnight, and sacrificed on the 31st day of the experiment. Their bloods were collected and submitted to various biochemical measurements, including blood glucose, cholesterol, triglcerides, urea, creatinine, transaminases, transpeptidase, lipase, and amylase activities. Their pancreases were isolated and processed to measure lipase and Î±-amylase activities and to perform histological analysis. RESULTS: The findings revealed that, compared to black tea, kombucha tea was a better inhibitor of Î±-amylase and lipase activities in the plasma and pancreas and a better suppressor of increased blood glucose levels. Interestingly, kombucha was noted to induce a marked delay in the absorption of LDL-cholesterol and triglycerides and a significant increase in HDL-cholesterol. Histological analyses also showed that it exerted an ameliorative action on the pancreases and efficiently protected the liver-kidney functions of diabetic rats, evidenced by significant decreases in aspartate transaminase, alanine transaminase, and gamma-glytamyl transpeptidase activities in the plasma, as well as in the creatinine and urea contents. CONCLUSIONS: The findings revealed that kombucha tea administration induced attractive curative effects on diabetic rats, particularly in terms of liver-kidney functions. Kombucha tea can, therefore, be considered as a potential strong candidate for future application as a functional supplement for the treatment and prevention of diabetes.
Keywords	alanine transaminase ; alloxan ; alpha-amylase ; alternative medicine ; animal disease models ; aspartate transaminase ; black tea ; blood glucose ; body weight ; carboxylic ester hydrolases ; creatinine ; diabetes ; enzyme activity ; high density lipoprotein cholesterol ; histology ; kombucha ; low density lipoprotein cholesterol ; metabolism ; pancreas ; rats ; risk factors ; triacylglycerols ; urea
Language	English
Dates of publication	2012-12
Size	p. 63.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	2050429-9
ISSN	1472-6882
ISSN	1472-6882
DOI	10.1186/1472-6882-12-63
Database	NAL-Catalogue (AGRICOLA)

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