LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Khalfallah, Ali"
  2. AU="Kopecky, O."
  3. AU="Mueller, C L"
  4. AU="Moreira, Ângela Nunes"
  5. AU="Lutscher, Daniel"
  6. AU="Ceretta Moreira, Eduardo"
  7. AU="Nalbant, Elif"

Search results

Result 1 - 10 of total 21

Search options

  1. Article: Tai Chi Care: An Exergaming Software using Microsoft Kinect V2 for Blind or Low Vision Person during Confinement

    Bouri, Marwa / Khalfallah, Ali / Bouhlel, Med Salim

    International Journal of Advanced Computer Science and Applications

    Abstract: Blind or low vision people need to practice activities for their mental and physical health to minimize the risk of suffering from articulation pain but they have problems due to difficulties and inaccessibility of displacement especially during the ... ...

    Abstract Blind or low vision people need to practice activities for their mental and physical health to minimize the risk of suffering from articulation pain but they have problems due to difficulties and inaccessibility of displacement especially during the COVID-19 pandemic where everyone in this world was asked to stay at home during confinement To solve these problems, we have developed a software tool for a care Tai Chi exergaming to encourage them to practice exercise at home using body tracking by Microsoft Kinect V2 and audio feedback This software acts as a Tai Chi treatment, teaches four poses, and has a customized audio feedback to help person to understand each pose and generates progress graphs to evaluate the success of these exercises We used the SDK libraries of the Kinect to obtain 3D joint position from sensors of the Kinect to calculate the angles and distances between joints to help the person to position in front of the Kinect, evaluate the different gestures of flexions and extensions of knees and elbows of each exercises, and body balance direction to avoid falling risk These exercises have been evaluated with persons who are blind or low vision to improve feasibility and feedback
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #800782
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Evaluation of left ventricular function by 2D Strain in acute coronary syndrome.

    Ben Slima, Hédi / Ben Gaied, Hassine Hakim / Ben Khalfallah, Ali

    La Tunisie medicale

    2019  Volume 97, Issue 7, Page(s) 898–903

    Abstract: Background: The 2D Strain is a new echo-cardiographic technique allowing the study of the myocardial deformation based on a follow-up of the acoustic markers of the LV wall. The aim of our study was to validate the contribution of this technique in the ... ...

    Abstract Background: The 2D Strain is a new echo-cardiographic technique allowing the study of the myocardial deformation based on a follow-up of the acoustic markers of the LV wall. The aim of our study was to validate the contribution of this technique in the detection of the ischemia and in the prediction of the culprit coronary axis and the number of vessels affected and also we analyzed the correlation of this parameter with the Left Ventricle Ejection Fraction (LVEF) and the Wall Motion Score Index (WMSI).
    Methods: This is a prospective study included 173 consecutive patients admitted for acute coronary syndrome (ACS) during the period between January 2015 and October 2016.  All the patients had echocardiography with analysis of function by 2DStrain and a coronary angiography .The data have been listed on an SPSS database.
    Conclusion: The 2D Longitudinal Strain represents an excellent parameter which allows a reliable detection of an alteration in the systolic function of the LV in ischemic heart disease and it's very useful to predict the culprit coronary axis and the number of vessels affected.
    MeSH term(s) Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/physiopathology ; Coronary Angiography/methods ; Echocardiography/methods ; Humans ; Prospective Studies ; Ventricular Function, Left/physiology
    Language English
    Publishing date 2019-12-22
    Publishing country Tunisia
    Document type Journal Article
    ZDB-ID 128627-4
    ISSN 0041-4131
    ISSN 0041-4131
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Association between Small Dense Low-Density Lipoproteins and High-Density Phospolipid Content in Patients with Coronary Artery Disease with or without Diabetes.

    Aoua, Hanene / Nkaies, Ymène / Ben Khalfallah, Ali / Sakly, Mohsen / Aouani, Ezzedine / Attia, Nebil

    Laboratory medicine

    2019  Volume 51, Issue 3, Page(s) 271–278

    Abstract: Objective: To evaluate the phospholipid profile in total plasma, non-high-density lipoprotein (HDL), and HDL fractions. We tried to correlate the phospholipid profile to low-density lipoprotein (LDL) size, as reflected by cholesterol content in each LDL ...

    Abstract Objective: To evaluate the phospholipid profile in total plasma, non-high-density lipoprotein (HDL), and HDL fractions. We tried to correlate the phospholipid profile to low-density lipoprotein (LDL) size, as reflected by cholesterol content in each LDL subclass.
    Methods: We measured small dense LDL-C levels after heparin-magnesium precipitation and measured high-density lipoprotein phospholipid (HDL-P) levels using a colorimetric enzymatic method.
    Results: The correlation of the phospholipid profile to small dense LDL-C (sdLDL-C) in patients with coronary problems showed a negative association between small dense low-density lipoprotein (sdLDL) and HDL-P (r = -0.73; P = .02). Moreover, a strong positive correlation was detected between TG and the ratio HDL-P/HDL-C (r = 0.83; P <.001).
    Conclusions: HDL phospholipid has an antiatherogenic effect in coronary artery disease with or without diabetes. Further, large LDL modulation seems to be associated with diabetes rather than coronaropathy.
    MeSH term(s) Adolescent ; Adult ; Aged ; Cholesterol/blood ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/metabolism ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/metabolism ; Female ; Humans ; Lipoproteins, HDL/blood ; Lipoproteins, LDL/blood ; Male ; Middle Aged ; Phospholipids/blood ; Tunisia/epidemiology ; Young Adult
    Chemical Substances Lipoproteins, HDL ; Lipoproteins, LDL ; Phospholipids ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2019-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1093/labmed/lmz067
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1013: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Diagnostic de l'asynchronisme ventriculaire par l'echocardioographie Doppler- situation actuelle et perspectives d'avenir.

    Ben Khalfallah, Ali

    La Tunisie medicale

    2007  Volume 85, Issue 1, Page(s) 84–90

    Abstract: Heart failure is among the most common chronic diseases in the modem era. It is the major cause of morbi--mortality and hospitalization in patients aged more than 60 years. Dilatation of left ventricle frequently induces intracardiac conduction delays ... ...

    Title translation Doppler echocardiographic diagnosis of ventricular asynchrony. Present situation and future perspectives.
    Abstract Heart failure is among the most common chronic diseases in the modem era. It is the major cause of morbi--mortality and hospitalization in patients aged more than 60 years. Dilatation of left ventricle frequently induces intracardiac conduction delays resulting. in asynchronous left ventricular motion. Showing as left bundle branch block in the surface EKG. Diagnosis of asynchrony based only on electrocardiogram criteria (wide QRS complex and left bundle branch block(LBBB)) proves to be non satisfactory considering the absence of parallelism between conduction unrests and cardiac dyssynchrony: 35% of LBBB are not associated with interventricular asynchrony and 20% without intraventricular asynchrony. So there is a necessity to define new criteria of asynchrony linked more directly to cardiac mechanical activity then EKG. Doppler Echocardiography brings more informative parameters concerning inter and intra ventricular asynchrony. Doppler tissue imaging can provide accurate information on electromechanical coupling and also assess interventricular and intraventricular dyssynchrony. It seems to be very promising for the prediction of the most satisfactory response to cardiac resynchronization therapy.
    MeSH term(s) Aged ; Bundle-Branch Block/diagnosis ; Bundle-Branch Block/diagnostic imaging ; Bundle-Branch Block/physiopathology ; Bundle-Branch Block/therapy ; Cardiac Pacing, Artificial ; Cardiomyopathy, Dilated/diagnostic imaging ; Cardiomyopathy, Dilated/physiopathology ; Cardiomyopathy, Dilated/therapy ; Echocardiography, Doppler/methods ; Electrocardiography ; Forecasting ; Heart Failure/diagnostic imaging ; Heart Failure/physiopathology ; Heart Failure/therapy ; Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/physiopathology ; Prognosis ; Stroke Volume ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/therapy
    Language French
    Publishing date 2007-01
    Publishing country Tunisia
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 128627-4
    ISSN 0041-4131
    ISSN 0041-4131
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Traitement à domicile des thromboses veineuses. "Le pour et le contre".

    Ben Khalfallah, Ali / Annabi, Nizar

    La Tunisie medicale

    2003  Volume 81, Issue 11, Page(s) 847–853

    Abstract: The ambulatory treatment of venous thromboses is made possible since the avenement of the low molecular weight heparins, which ensures an efficacy and a safety, comparable with the infractioned heparins, with less side effects and hemorrhagic ... ...

    Title translation Home treatment of venous thrombosis. "For and against".
    Abstract The ambulatory treatment of venous thromboses is made possible since the avenement of the low molecular weight heparins, which ensures an efficacy and a safety, comparable with the infractioned heparins, with less side effects and hemorrhagic complications. The simplicity of the therapeutic diagram with the low molecular weight heparin, the biological monitoring less astringent as well as the reduction of the cost of the treatment constitute solid arguments in favour of this therapeutic modality. The essential condition for such attitude remains the respect of the indications and of counter indications.
    MeSH term(s) Cost Control ; Fibrinolytic Agents/economics ; Fibrinolytic Agents/therapeutic use ; Health Care Costs ; Heparin, Low-Molecular-Weight/economics ; Heparin, Low-Molecular-Weight/therapeutic use ; Home Care Services/economics ; Humans ; Patient Selection ; Venous Thrombosis/drug therapy ; Venous Thrombosis/economics
    Chemical Substances Fibrinolytic Agents ; Heparin, Low-Molecular-Weight
    Language French
    Publishing date 2003-11
    Publishing country Tunisia
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 128627-4
    ISSN 0041-4131
    ISSN 0041-4131
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: -174G>C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease

    Ghazouani Lakhdar / Abboud Nesrine / Khalifa Sonia / Added Faouzi / Khalfallah Ali / Nsiri Brahim / Mediouni Mounira / Mahjoub Touhami

    Annals of Saudi Medicine, Vol 31, Iss 1, Pp 40-

    2011  Volume 44

    Abstract: Background and Objectives : A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly ...

    Abstract Background and Objectives : A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians. Patients and Methods : Study subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR-restriction fragment length polymorphism. Results : The frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity). Conclusion : The -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians.
    Keywords Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher King Faisal Specialist Hospital and Research Centre
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Evolution a long-terme de la tetralogie de Fallot operee.

    Ben Khalfallah, Ali / Annabi, N / Ousji, Monia

    La Tunisie medicale

    2004  Volume 82 Suppl 1, Page(s) 88–93

    Abstract: Tetralogy of Fallot is the most common cyanotic congenital heart disease. The surgical treatment that is palliative or complete repair has allowed to transform the preview of this heart disorder. We suggests to study the long term outcome in patients ... ...

    Title translation Long-term outcome of surgically treated teratology of Fallot.
    Abstract Tetralogy of Fallot is the most common cyanotic congenital heart disease. The surgical treatment that is palliative or complete repair has allowed to transform the preview of this heart disorder. We suggests to study the long term outcome in patients undergoing surgical repair of tetralogy of Fallot, by emphasizing the quality of their lives, the complications, as well as the mortality. Ventricular arrhythmia and sudden cardiac death after repair of tetralogy of Fallot are devastating complications in adults survivors and their prediction remains difficult.
    MeSH term(s) Adolescent ; Adult ; Arrhythmias, Cardiac/etiology ; Child ; Child, Preschool ; Death, Sudden, Cardiac ; Female ; Humans ; Infant ; Male ; Prognosis ; Quality of Life ; Retrospective Studies ; Tetralogy of Fallot/pathology ; Tetralogy of Fallot/surgery ; Treatment Outcome
    Language French
    Publishing date 2004-01
    Publishing country Tunisia
    Document type English Abstract ; Journal Article
    ZDB-ID 128627-4
    ISSN 0041-4131
    ISSN 0041-4131
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Place du Doppler tissulaire myocardique dans l'etude de la dysfonction diastolique ventriculaire gauche chez les malades hemodialyses.

    Ben Khalfallah, Ali / Sanaa, Islem / Mokrani, S / Annabi, Nizar / Ghodhbane, Lilia

    La Tunisie medicale

    2008  Volume 86, Issue 1, Page(s) 53–58

    Abstract: Background: Doppler echocardiography is currently the main tool permitting the diagnosis and the characterization of the stages of diastolic dysfunction.: Aim: The purpose of this study is to precise the contribution of Doppler tissue imaging in the ... ...

    Title translation Doppler tissue imaging contribution in the study of diastolic dysfunction in hemodialysis patients.
    Abstract Background: Doppler echocardiography is currently the main tool permitting the diagnosis and the characterization of the stages of diastolic dysfunction.
    Aim: The purpose of this study is to precise the contribution of Doppler tissue imaging in the study of diastolic function and to identify the parameters having the most discriminating power of diastolic dysfunction in hemodialysis patients.
    Methods: Conventional Doppler echocardiography study implies left ventricular diastolic function from: Doppler transmitral flow (E/A, isovolumic relaxation time (TRIV), deceleration of mitral E-wave time (TDE), duration of A wave), color M-mode flow propagation velocity (Vp); The study of pulmonary venous flow (S/D, Systolic fraction (FS) and duration of pulmonary venous A wave); The annulus Doppler Tissue Imaging (Ea/Aa, E and A waves durations, VTI of E and A); and finally combined indexes (ratio of peak E-wave velocity to Vp (E/Vp), difference in duration between pulmonary venous and mitral flow A wave (Ap-Am) and ratio of peak mitral and annulus E-wave velocities (E/Ea).
    Results: Left ventricular diastolic dysfunction is found in 88% of the 50 haemodialysis patients: abnormal relaxation pattern 56%, pseudo-normal pattern 28% and restrictive pattern 4%. The parameter Vp discriminates normal patterns. The parameters TRIV, S/D and FS characterise abnormal relaxation. Ea/Aa ratio characterises pseudo-normal pattern and E/A ratio restrictive pattern. Discriminating analysis allows a correct classification of 100% of pseudo-normal pattern patients with 3 variables: Ea/Aa, FS and Vp or E/Vp. Doppler parameters which discriminating power is significant (p < 0.0001) are, in decreasing order: E/A, Ea/Aa, TRIV, Vp, FS, S/D, E/Vp and TDE.
    Conclusion: DTI contributes mainly in the characterization of stage II diastolic dysfunction patients and allows in association with pulmonary venous flow parameters (Ap-Am) and combined indexes (E/Vp et E/Ea) an accurate appreciation of left ventricular filling pressures.
    MeSH term(s) Diastole/physiology ; Echocardiography, Doppler ; Female ; Humans ; Male ; Middle Aged ; Renal Dialysis ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology
    Language French
    Publishing date 2008-01
    Publishing country Tunisia
    Document type Journal Article
    ZDB-ID 128627-4
    ISSN 0041-4131
    ISSN 0041-4131
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: -174G>C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease.

    Ghazouani, Lakhdar / Abboud, Nesrine / Ben Hadj Khalifa, Sonia / Added, Faouzi / Ben Khalfallah, Ali / Nsiri, Brahim / Mediouni, Mounira / Mahjoub, Touhami

    Annals of Saudi medicine

    2011  Volume 31, Issue 1, Page(s) 40–44

    Abstract: Background and objectives: A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly ...

    Abstract Background and objectives: A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians.
    Patients and methods: Study subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR-restriction fragment length polymorphism.
    Results: The frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity).
    Conclusion: The -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians.
    MeSH term(s) Aged ; Alleles ; Case-Control Studies ; Coronary Artery Disease/genetics ; Female ; Genotype ; Humans ; Interleukin-6/genetics ; Logistic Models ; Male ; Middle Aged ; Mutation ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Risk Factors ; Tunisia
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2011-01-18
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 639014-6
    ISSN 0975-4466 ; 0256-4947
    ISSN (online) 0975-4466
    ISSN 0256-4947
    DOI 10.4103/0256-4947.75777
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 3022: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Functional interleukin-10 promoter variants in coronary artery disease patients in Tunisia.

    Ben-Hadj-Khalifa, Sonia / Ghazouani, Lakhdar / Abboud, Nesrine / Ben-Khalfallah, Ali / Annabi, Fatma / Addad, Faouzi / Almawi, Wassim Y / Mahjoub, Touhami

    European cytokine network

    2010  Volume 21, Issue 2, Page(s) 136–141

    Abstract: Objectives: The contribution of interleukin (IL)-10 promoter variants -1082G/A, -819C/T, and -592C/A to the risk of coronary artery disease (CAD) was investigated in 291 CAD patients and 291 age- and gender-matched control subjects.: Methods and ... ...

    Abstract Objectives: The contribution of interleukin (IL)-10 promoter variants -1082G/A, -819C/T, and -592C/A to the risk of coronary artery disease (CAD) was investigated in 291 CAD patients and 291 age- and gender-matched control subjects.
    Methods and results: IL-10 genotyping was performed using PCR-allele-specific amplification (PCR-ASA). Regression analysis was employed in assessing the contribution of the IL-10 variants to the overall CAD risk. A higher frequency of the -592A allele (p = 0.004), but not the -1082A (p = 0.828) or -819T (p = 0.952) alleles, was seen in CAD patients. A higher frequency of -592C/A (p = 0.011), and a lower frequency of -592C/C (p = 0.015) genotypes was noted in patients compared to healthy controls. Regression analysis demonstrated an association of -592C/A [OR (95% CI) = 1.82 (1.02-3.23)] and -592A/A [OR (95% CI) = 3.33 (1.27-9.09)] genotypes with 1-artery disease. Haplotype analysis revealed that none of the eight possible IL-10 haplotypes was associated with CAD or with the severity of CAD, and was confirmed by multivariate regression analysis, after adjusting for a number of confounders (smoking, systolic and diastolic blood pressure, hypertension, diabetes, glucose, cholesterol, and triglycerides).
    Conclusions: Our results suggest that the -592C/A, more so than the -1082G/A or the -819C/T IL-10 promoter variant alleles, may be considered to be a risk factor for CAD in Tunisians.
    MeSH term(s) Adult ; Aged ; Coronary Artery Disease/genetics ; Female ; Humans ; Interleukin-10/genetics ; Male ; Middle Aged ; Polymerase Chain Reaction ; Promoter Regions, Genetic ; Tunisia
    Chemical Substances Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2010-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 1118857-1
    ISSN 1952-4005 ; 1148-5493
    ISSN (online) 1952-4005
    ISSN 1148-5493
    DOI 10.1684/ecn.2010.0194
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3447: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top