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  1. Article: The use of medicinal plants in common ophthalmic disorders: A systematic review with meta-analysis.

    Alghamdi, Ali Hendi / Ahmed, Aimun A E / Bashir, Mahadi / Abdalgadir, Haidar / Khalid, Asaad / Gul, Sheraz

    Heliyon

    2023  Volume 9, Issue 4, Page(s) e15340

    Abstract: Purpose: This study aimed to assess and compile the available research articles about medicinal plants used for ocular diseases.: Principal results: A total of 2949 articles were retrieved, 35 full-text articles were assessed for eligibility, and ... ...

    Abstract Purpose: This study aimed to assess and compile the available research articles about medicinal plants used for ocular diseases.
    Principal results: A total of 2949 articles were retrieved, 35 full-text articles were assessed for eligibility, and seven studies (4 observational and three experimental) with low to moderate quality were eligible and involved in the systematic review, with a total of 600 plants from 4 countries. Among the 600 plants, only 24 (4%) were used to assess the status. Both the fixed and random models of the studies showed that the included studies tended to predict the results for the observational studies (OR = 0.062, CI = 0.043-0.090 OR = 0.039, CI = 0.012-0.122) for different plants used for ocular diseases. High heterogeneity (estimated as I
    Conclusion: Few articles representing approximately 600 plants of low to moderate quality reported using medicinal plants for ocular diseases. The meta-analysis confirmed the systematic review findings regarding the plants' traditional use with high heterogeneity and publication bias. A considerable gap was proven in the use of medicinal plants in ocular diseases requiring intensive research.
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prospective virtual screening combined with bio-molecular simulation enabled identification of new inhibitors for the KRAS drug target.

    Ajmal, Amar / Alkhatabi, Hind A / Alreemi, Roaa M / Alamri, Mubarak A / Khalid, Asaad / Abdalla, Ashraf N / Alotaibi, Bader S / Wadood, Abdul

    BMC chemistry

    2024  Volume 18, Issue 1, Page(s) 57

    Abstract: Lung cancer is a disease with a high mortality rate and it is the number one cause of cancer death globally. Approximately 12-14% of non-small cell lung cancers are caused by mutations in ... ...

    Abstract Lung cancer is a disease with a high mortality rate and it is the number one cause of cancer death globally. Approximately 12-14% of non-small cell lung cancers are caused by mutations in KRAS
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-024-01152-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Preparation and characterization of sulphur and zinc oxide Co-doped graphitic carbon nitride for photo-assisted removal of Safranin-O dye.

    Khan, Azmat Ali / Khan, Abbas / Khan, Sumayya / Shah, Nasrullah / Khan, Ajmal / Nawaz, Faheem / Khalid, Asaad / Jan, Afnan / Al-Harrasi, Ahmed

    RSC advances

    2024  Volume 14, Issue 13, Page(s) 8871–8884

    Abstract: Recently, there has been significant interest in photocatalytic reactions involving graphitic carbon nitride (g- ... ...

    Abstract Recently, there has been significant interest in photocatalytic reactions involving graphitic carbon nitride (g-C
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra07247a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis.

    Muhammad, Gulzar / Hussain, Muhammad Ajaz / Shafiq, Zahid / Ashraf, Adnan / Shafique, Umer / Khan, Ajmal / Khalid, Asaad / Hussain, Javid / Al-Harrasi, Ahmed

    Current topics in medicinal chemistry

    2024  

    Abstract: Berbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of ... ...

    Abstract Berbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. Other pharmacological attributes ascribed to Ber included cardioprotective, anti-diabetic, anti-inflammatory, antimalarial, antioxidant, anti-hypercholesterolemic, and anti-allergic. Moreover, the synergistic effect of Ber improved the therapeutic potential of different drugs (paclitaxel (PTL), gemcitabine, dexamethasone, doxorubicin (DOX), and celecoxib) in different models. Various attempts could fabricate biologically active derivatives of Ber, such as 4-chlorobenzoyl berbamine (CBB) and O-4- ethoxyl-butyl-berbamine (EBB). The review focuses on the medicinal applications of Ber, particularly anti-cancer, cardioprotective, and anti-inflammatory, along with the mechanism of action.
    Language English
    Publishing date 2024-04-29
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/0115680266289292240420062705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Identification of new potent NLRP3 inhibitors by multi-level in-silico approaches.

    Hayat, Chandni / Subramaniyan, Vetriselvan / Alamri, Mubarak A / Wong, Ling Shing / Khalid, Asaad / Abdalla, Ashraf N / Afridi, Sahib Gul / Kumarasamy, Vinoth / Wadood, Abdul

    BMC chemistry

    2024  Volume 18, Issue 1, Page(s) 76

    Abstract: Nod-like receptor protein 3 (NLRP-3), is an intracellular sensor that is involved in inflammasome activation, and the aberrant expression of NLRP3 is responsible for diabetes mellitus, its complications, and many other inflammatory diseases. NLRP3 is ... ...

    Abstract Nod-like receptor protein 3 (NLRP-3), is an intracellular sensor that is involved in inflammasome activation, and the aberrant expression of NLRP3 is responsible for diabetes mellitus, its complications, and many other inflammatory diseases. NLRP3 is considered a promising drug target for novel drug design. Here, a pharmacophore model was generated from the most potent inhibitor, and its validation was performed by the Gunner-Henry scoring method. The validated pharmacophore was used to screen selected compounds databases. As a result, 646 compounds were mapped on the pharmacophore model. After applying Lipinski's rule of five, 391 hits were obtained. All the hits were docked into the binding pocket of target protein. Based on docking scores and interactions with binding site residues, six compounds were selected potential hits. To check the stability of these compounds, 100 ns molecular dynamic (MD) simulations were performed. The RMSD, RMSF, DCCM and hydrogen bond analysis showed that all the six compounds formed stable complex with NLRP3. The binding free energy with the MM-PBSA approach suggested that electrostatic force, and van der Waals interactions, played a significant role in the binding pattern of these compounds. Thus, the outcomes of the current study could provide insights into the identification of new potential NLRP3 inflammasome inhibitors against diabetes and its related disorders.
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-024-01178-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Innovative Encapsulation Strategies for Food, Industrial, and Pharmaceutical Applications.

    Aanniz, Tarik / El Omari, Nasreddine / Elouafy, Youssef / Benali, Taoufiq / Zengin, Gokhan / Khalid, Asaad / Abdalla, Ashraf N / Sakran, Ashraf M / Bouyahya, Abdelhakim

    Chemistry & biodiversity

    2024  , Page(s) e202400116

    Abstract: Bioactive metabolites obtained from fruits and vegetables as well as many drugs have various capacities to prevent or treat various ailments. Nevertheless, their efficiency, in vivo, encounter many challenges resulting in lower efficacy as well as ... ...

    Abstract Bioactive metabolites obtained from fruits and vegetables as well as many drugs have various capacities to prevent or treat various ailments. Nevertheless, their efficiency, in vivo, encounter many challenges resulting in lower efficacy as well as different side effects when high doses are used resulting in many challenges for their application. Indeed, demand for effective treatments with no or less unfavorable side effects is rising. Delivering active molecules to a particular site of action within the human body is an example of targeted therapy which remains a challenging field. Developments of nanotechnology and polymer science have great promise for meeting the growing demands of efficient options. Encapsulation of active ingredients in nano-delivery systems has become as a vitally tool for protecting the integrity of critical biochemicals, improving their delivery, enabling their controlled release and maintaining their biological features. Here, we examine a wide range of nano-delivery techniques, such as niosomes, polymeric/solid lipid nanoparticles, nanostructured lipid carriers, and nano-emulsions. The advantages of encapsulation in targeted, synergistic, and supportive therapies are emphasized, along with current progress in its application. Additionally, a revised collection of studies was given, focusing on improving the effectiveness of anticancer medications and addressing the problem of antimicrobial resistance. To sum up, this paper conducted a thorough analysis to determine the efficacy of encapsulation technology in the field of drug discovery and development.
    Language English
    Publishing date 2024-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202400116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The use of medicinal plants in common ophthalmic disorders: A systematic review with meta-analysis

    Alghamdi, Ali Hendi / Ahmed, Aimun A.E. / Bashir, Mahadi / Abdalgadir, Haidar / Khalid, Asaad / Gul, Sheraz

    Heliyon. 2023 Apr. 11, p.e15340-

    2023  

    Abstract: This study aimed to assess and compile the available research articles about medicinal plants used for ocular diseases. A total of 2949 articles were retrieved, 35 full-text articles were assessed for eligibility, and seven studies (4 observational and ... ...

    Abstract This study aimed to assess and compile the available research articles about medicinal plants used for ocular diseases. A total of 2949 articles were retrieved, 35 full-text articles were assessed for eligibility, and seven studies (4 observational and three experimental) with low to moderate quality were eligible and involved in the systematic review, with a total of 600 plants from 4 countries. Among the 600 plants, only 24 (4%) were used to assess the status. Both the fixed and random models of the studies showed that the included studies tended to predict the results for the observational studies (OR = 0.062, CI = 0.043-0.090 and OR = 0.039, CI = 0.012-0.122) for different plants used for ocular diseases. High heterogeneity (estimated as I² = 87.078, Tau² = 1.161 and Q-value = 23.217 with a p-value of 0.000), while for experimental studies (I² = 94.928, Tau² = 23.211 and Q-value = 39.434 with a p-value of 0.000) and publication bias were reported. Few articles representing approximately 600 plants of low to moderate quality reported using medicinal plants for ocular diseases. The meta-analysis confirmed the systematic review findings regarding the plants' traditional use with high heterogeneity and publication bias. A considerable gap was proven in the use of medicinal plants in ocular diseases requiring intensive research.
    Keywords eye diseases ; medicinal plants ; meta-analysis ; models ; observational studies ; plant diseases and disorders ; planting ; prediction ; publications ; systematic review ; Ophthalmic ; Forest plot ; Funnel plot ; Prisma chart
    Language English
    Dates of publication 2023-0411
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15340
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Trigonella foenum-graecum Methanolic Extract on Isolated Smooth Muscles and Acetylcholinesterase Enzyme: An In Vitro and Mechanistic In Silico Investigation.

    Ghayur, Muhammad Nabeel / Abdalla, Mohnad / Khalid, Asaad / Ahmad, Saeed / Gilani, Anwarul Hassan

    BioMed research international

    2022  Volume 2022, Page(s) 4849464

    Abstract: Results: When tested on the baseline of isolated tissues, Tfg.Cr was devoid of any activity (stimulant or relaxant) till 10 mg/ml. This is an interesting finding, keeping in mind that the fenugreek seeds are used to alleviate constipation and diarrhoea. ...

    Abstract Results: When tested on the baseline of isolated tissues, Tfg.Cr was devoid of any activity (stimulant or relaxant) till 10 mg/ml. This is an interesting finding, keeping in mind that the fenugreek seeds are used to alleviate constipation and diarrhoea. When Tfg.Cr was tried for any potential AChE inhibitory activity, it did show an inhibitory effect in increasing concentrations (47-380 
    Conclusion: The results show that the fenugreek extract does not possess any GI stimulant or relaxant activity even though it is used traditionally in GI motility disorders. The extract and diosgenin could inhibit the AChE enzyme pointing towards their benefit to enhance the memory.
    MeSH term(s) Acetylcholinesterase ; Diosgenin/pharmacology ; Methanol ; Molecular Docking Simulation ; Muscle, Smooth ; Plant Extracts/chemistry ; Seeds/chemistry ; Trigonella/chemistry
    Chemical Substances Plant Extracts ; Acetylcholinesterase (EC 3.1.1.7) ; Diosgenin (K49P2K8WLX) ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/4849464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Biodegradable Electrospun Scaffolds as an Emerging Tool for Skin Wound Regeneration: A Comprehensive Review.

    Sharma, Deepika / Srivastava, Shriyansh / Kumar, Sachin / Sharma, Pramod Kumar / Hassani, Rym / Dailah, Hamad Ghaleb / Khalid, Asaad / Mohan, Syam

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: Skin is designed to protect various tissues, and because it is the largest and first human bodily organ to sustain damage, it has an incredible ability to regenerate. On account of extreme injuries or extensive surface loss, the normal injury ... ...

    Abstract Skin is designed to protect various tissues, and because it is the largest and first human bodily organ to sustain damage, it has an incredible ability to regenerate. On account of extreme injuries or extensive surface loss, the normal injury recuperating interaction might be inadequate or deficient, bringing about risky and disagreeable circumstances that request the utilization of fixed adjuvants and tissue substitutes. Due to their remarkable biocompatibility, biodegradability, and bioactive abilities, such as antibacterial, immunomodulatory, cell proliferative, and wound mending properties, biodegradable polymers, both synthetic and natural, are experiencing remarkable progress. Furthermore, the ability to convert these polymers into submicrometric filaments has further enhanced their potential (e.g., by means of electrospinning) to impersonate the stringy extracellular grid and permit neo-tissue creation, which is a basic component for delivering a mending milieu. Together with natural biomaterial, synthetic polymers are used to solve stability problems and make scaffolds that can dramatically improve wound healing. Biodegradable polymers, commonly referred to as biopolymers, are increasingly used in other industrial sectors to reduce the environmental impact of material and energy usage as they are fabricated using renewable biological sources. Electrospinning is one of the best ways to fabricate nanofibers and membranes that are very thin and one of the best ways to fabricate continuous nanomaterials with a wide range of biological, chemical, and physical properties. This review paper concludes with a summary of the electrospinning (applied electric field, needle-to-collector distance, and flow rate), solution (solvent, polymer concentration, viscosity, and solution conductivity), and environmental (humidity and temperature) factors that affect the production of nanofibers and the use of bio-based natural and synthetic electrospun scaffolds in wound healing.
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Multi-Fold Computational Analysis to Discover Novel Putative Inhibitors of Isethionate Sulfite-Lyase (Isla) from

    Waqas, Muhammad / Halim, Sobia Ahsan / Ullah, Atta / Ali, Assim Alaa Mohammed / Khalid, Asaad / Abdalla, Ashraf N / Khan, Ajmal / Al-Harrasi, Ahmed

    Cancers

    2023  Volume 15, Issue 3

    Abstract: A glycal radical enzyme called isethionate sulfite-lyase (Isla) breaks the C-S bond in isethionate to produce acetaldehyde and sulfite. This enzyme was found in the Gram-negative, ... ...

    Abstract A glycal radical enzyme called isethionate sulfite-lyase (Isla) breaks the C-S bond in isethionate to produce acetaldehyde and sulfite. This enzyme was found in the Gram-negative, colonial
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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