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  1. Article ; Online: 1,25-Dihydroxycholecalciferol down-regulates 3-mercaptopyruvate sulfur transferase and caspase-3 in rat model of non-alcoholic fatty liver disease.

    Ibrahim, Maher N / Khalifa, Abeer A / Hemead, Dalia A / Alsemeh, Amira Ebrahim / Habib, Marwa A

    Journal of molecular histology

    2023  Volume 54, Issue 2, Page(s) 119–134

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver morbidity and mortality and has multiple unclear pathogenic mechanisms. Vitamin D deficiency was associated with increased incidence and severity of NAFLD. Increased hepatic ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver morbidity and mortality and has multiple unclear pathogenic mechanisms. Vitamin D deficiency was associated with increased incidence and severity of NAFLD. Increased hepatic expression of 3-mercaptopyruvate sulfur transferase (MPST) and dysregulated hepatocyte apoptosis were involved in NAFLD pathogenesis. We aimed to explore the protective effect of 1,25-Dihydroxycholecalciferol (1,25-(OH)
    MeSH term(s) Rats ; Male ; Animals ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Calcitriol/pharmacology ; Calcitriol/metabolism ; Reactive Oxygen Species/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Caspase 3/metabolism ; Liver/metabolism ; Transferases/metabolism ; Transferases/pharmacology ; Glucose/metabolism ; Insulins/metabolism ; Insulins/pharmacology ; Sulfur/metabolism ; Sulfur/pharmacology ; Diet, High-Fat/adverse effects
    Chemical Substances Calcitriol (FXC9231JVH) ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Caspase 3 (EC 3.4.22.-) ; 3-mercaptopyruvic acid (5Z1F5OW4YB) ; Transferases (EC 2.-) ; Glucose (IY9XDZ35W2) ; Insulins ; Sulfur (70FD1KFU70)
    Language English
    Publishing date 2023-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2144021-9
    ISSN 1567-2387 ; 1567-2379
    ISSN (online) 1567-2387
    ISSN 1567-2379
    DOI 10.1007/s10735-023-10118-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 568: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Expression profile of serum LncRNAs

    Ali, Marwa A / Shaker, Olfat G / Gomaa Ali, El Shimaa / Ezzat, Eman M / Khalifa, Abeer A / Hassan, Essam A / Habib, Marwa A / Ahmed, Heba Mostafa / Dawood, Asmaa F A / Mohamed, Esam Ali

    Non-coding RNA research

    2024  Volume 9, Issue 2, Page(s) 318–329

    Abstract: Background: Ulcerative colitis (UC) has emerged as an accelerated-incidence chronic condition. UC has been identified as a precancerous lesion for colorectal cancer. Up-to-date genomic research revealed the value of many noncoding RNAs (ncRNAs) in UC ... ...

    Abstract Background: Ulcerative colitis (UC) has emerged as an accelerated-incidence chronic condition. UC has been identified as a precancerous lesion for colorectal cancer. Up-to-date genomic research revealed the value of many noncoding RNAs (ncRNAs) in UC pathogenesis, diagnosis, and prognosis.
    Aim: The present study was aimed at measuring both
    Patients and methods: Sixty-six UC patients and 80 healthy individuals participated in this study, the serum fold changes of
    Results: The current study findings include overexpressed lncRNAs
    Conclusion: MALAT-1
    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-0540
    ISSN (online) 2468-0540
    DOI 10.1016/j.ncrna.2024.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: LncRNAs

    Ali, Marwa A / Shaker, Olfat G / Khalifa, Abeer A / Ezzat, Eman M / Elghobary, Hany Ahmed / Abdel Mawla, Tamer Sayed / Elkhateeb, Ahmed Fathy / Elebiary, Ahmed Magdy Abdelrahman / Elamir, Azza Mohamed

    Non-coding RNA research

    2022  Volume 8, Issue 1, Page(s) 96–108

    Abstract: Background: Cerebrovascular stroke (CVS) is a potentially fatal disease. The most common risk factor for CVS is hypertension.: Aim: While most studies in the field have focused on the functional roles of long noncoding RNAs (lncRNAs) NEAT1, GAS5, and ...

    Abstract Background: Cerebrovascular stroke (CVS) is a potentially fatal disease. The most common risk factor for CVS is hypertension.
    Aim: While most studies in the field have focused on the functional roles of long noncoding RNAs (lncRNAs) NEAT1, GAS5, and HOTAIR in CVS, less attention has been paid to their clinical relevance to stroke incidence and prognosis. Also, a link has not yet been made between these lncRNAs and hypertension, our study aim was to investigate whether the expression of these lncRNAs differed between CVS with and without hypertension, as well as to compare each group to controls.
    Method: In total, 181 CVS patients were enrolled, including 91 chronic hypertensive patients with stroke, 90 stroke patients without hypertension, and 51 control subjects. blood samples were collected on the day of recruitment from patients with CVS and controls. Real-time qRT-PCR was used to detect the expression of target lncRNAs in serum.
    Results: When compared to controls, there was a statistically higher level of lncNEAT1 in each case group (median (IQR) = 3.68 (1.35-7.35) and 3.05 (0.95-6.45) for the hypertensive and non-hypertensive groups, respectively, with a significantly higher level in the hypertensive group (P = 0.04). When compared to controls, lncHOTAIR was significantly downregulated in all case groups (medians in hypertensive and non-hypertensive patients were 0.13, and 0.34, respectively), with a significantly lower level in the hypertensive group (P = 0.05). LncGAS5 levels in patients were significantly lower (median (IQR) = 0.16 (0.02-0.55) and 0.25 (0.03-0.99) for the hypertensive and non-hypertensive groups, respectively) compared to controls, with a significantly lower level in the hypertensive group (P = 0.02). There was a significant positive correlation between NEAT1 and GAS5, but a significant negative correlation between each with HOTAIR in both patients' groups. We also detected a significant negative correlation between each NEAT1 or GAS5 and NIHSS score while a significant positive correlation between HOTAIR and NIHSS. ROC curve analysis for
    Conclusion: Patients in each case group had statistically higher levels of NEAT1 and lower levels of HOTAIR and GAS5 compared to control levels, with higher significant NEAT1 but lower significant HOTAIR and GAS5 in the hypertensive group. Therefore, lncRNAs NEAT1, HOTAIR, and GAS5 could be used as diagnostic and prognostic biomarkers of CVS that correlate with NIHSS score and could produce a novel target for CVS therapy.
    Language English
    Publishing date 2022-11-02
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-0540
    ISSN (online) 2468-0540
    DOI 10.1016/j.ncrna.2022.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Ifng antisense RNA 1 (

    Ali, Marwa A / Hussein, Sherin Khamis / Khalifa, Abeer A / El Amin Ali, Amani M / Farhan, Marwa S / Ibrahim Amin, Amal A / Mohamed, Esam Ali

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 1007347

    Abstract: Background/aim: ...

    Abstract Background/aim:
    Language English
    Publishing date 2022-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.1007347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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