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  1. Article ; Online: Management of tumor volume changes during preoperative radiotherapy for extremity soft tissue sarcoma

    De Lamarliere Marion Geneau / Lusque Amélie / Khalifa Justine Attal / Esteyrie Vincent / Chevreau Christine / Valentin Thibaud / Gangloff Dimitri / Meresse Thomas / Courtot Louis / Rochaix Philippe / Boulet Bérénice / Graulieres Eliane / Ducassou Anne

    Radiology and Oncology, Vol 57, Iss 4, Pp 507-

    a new strategy of adaptive radiotherapy

    2023  Volume 515

    Abstract: Using adaptive radiotherapy (ART), to determine objective clinical criteria that identify extremity soft tissue sarcoma (ESTS) patients requiring adaptation of their preoperative radiotherapy (RT) plan. ...

    Abstract Using adaptive radiotherapy (ART), to determine objective clinical criteria that identify extremity soft tissue sarcoma (ESTS) patients requiring adaptation of their preoperative radiotherapy (RT) plan.
    Keywords soft tissue sarcoma ; preoperative radiotherapy ; adaptive radiotherapy ; image guided radiotherapy ; volumes changes ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Management of tumor volume changes during preoperative radiotherapy for extremity soft tissue sarcoma: a new strategy of adaptive radiotherapy.

    De Lamarliere, Marion Geneau / Lusque, Amélie / Khalifa, Justine Attal / Esteyrie, Vincent / Chevreau, Christine / Valentin, Thibaud / Gangloff, Dimitri / Meresse, Thomas / Courtot, Louis / Rochaix, Philippe / Boulet, Bérénice / Graulieres, Eliane / Ducassou, Anne

    Radiology and oncology

    2023  Volume 57, Issue 4, Page(s) 507–515

    Abstract: Background: Using adaptive radiotherapy (ART), to determine objective clinical criteria that identify extremity soft tissue sarcoma (ESTS) patients requiring adaptation of their preoperative radiotherapy (RT) plan.: Patients and methods: We included ... ...

    Abstract Background: Using adaptive radiotherapy (ART), to determine objective clinical criteria that identify extremity soft tissue sarcoma (ESTS) patients requiring adaptation of their preoperative radiotherapy (RT) plan.
    Patients and methods: We included 17 patients with a lower extremity ESTS treated between 2019 and 2021 with preoperative RT, using helicoidal intensity-modulated RT (IMRT) tomotherapy, before surgical resection. We collected clinical, tumor parameters and treatment data. Repositioning was ascertained by daily Megavoltage computed tomography (MVCT) imaging. Using the PreciseART technology we retrospectively manually delineated at least one MVCT for each patient per week and recorded volume and dosimetric parameters. A greater than 5% change between target volume and planned target volume (PTV) dosimetric coverage from the initial planning CT scan to at least one MVCT was defined as clinically significant.
    Results: All 17 patients experienced significant tumor volume changes during treatment; 7 tumors grew (41%) and 10 shrank (59%). Three patients (18%), all undifferentiated pleomorphic sarcomas (UPS) with increased volume changes, experienced significant reductions in tumor dose coverage. Seven patients required a plan adaptation, as determined by practical criteria applied in our departmental practice. Among these patients, only one ultimately experienced a significant change in PTV coverage. Three patients had a PTV decrease of coverage. Among them, 2 did not receive plan adaptation according our criteria. None of the patients with decreased tumor volumes had reduced target volume coverage. Monitoring volume variations by estimating gross tumor volume (GTV) on MVCT, in addition to axial and sagittal linear tumor dimensions, appeared to be most effective for detecting reductions in PTV coverage throughout treatment.
    Conclusions: Variations in ESTS volume are evident during preoperative RT, but significant dosimetric variations are rare. Specific attention should be paid to grade 2-3 UPSs during the first 2 weeks of treatment. In the absence of dedicated software in routine clinical practice, monitoring of tumor volume changes by estimating GTV may represent a useful strategy for identifying patients whose treatment needs to be replanned.
    MeSH term(s) Humans ; Radiotherapy Dosage ; Tumor Burden ; Retrospective Studies ; Radiotherapy Planning, Computer-Assisted/methods ; Sarcoma/diagnostic imaging ; Sarcoma/radiotherapy ; Sarcoma/surgery ; Soft Tissue Neoplasms/diagnostic imaging ; Soft Tissue Neoplasms/radiotherapy ; Soft Tissue Neoplasms/surgery ; Extremities/diagnostic imaging ; Extremities/pathology
    Language English
    Publishing date 2023-11-30
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1128829-2
    ISSN 1581-3207 ; 0485-893X ; 1318-2099
    ISSN (online) 1581-3207
    ISSN 0485-893X ; 1318-2099
    DOI 10.2478/raon-2023-0056
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