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Article ; Online: Response to letter to the editor regarding "Characteristics and outcomes of ventricular tachycardia and premature ventricular contractions ablation in patients with prior mitral valve surgery".

Khalil, Fouad / Killu, Ammar M

Journal of cardiovascular electrophysiology

2022 Volume 33, Issue 6, Page(s) 1347–1348

MeSH term(s)	Catheter Ablation/adverse effects ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/surgery ; Ventricular Premature Complexes/diagnosis ; Ventricular Premature Complexes/surgery
Language	English
Publishing date	2022-04-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.15503
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Article: Impact of Acute Coronary Syndrome on Clinical Outcomes in Patients With Thrombotic Thrombocytopenic Purpura.

Khalil, Fouad / Ali, Mohammad / Ellithi, Moataz

Cureus

2023 Volume 15, Issue 3, Page(s) e35878

Abstract: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening clinical syndrome characterized by microangiopathy and a variable degree of end-organ ischemic damage. Cardiac involvement has been recognized as a major cause of mortality in these patients. ...

Abstract	Thrombotic thrombocytopenic purpura (TTP) is a life-threatening clinical syndrome characterized by microangiopathy and a variable degree of end-organ ischemic damage. Cardiac involvement has been recognized as a major cause of mortality in these patients. In this study, we queried the National Inpatient Sample (NIS) for all patients hospitalized with thrombotic microangiopathy from 2002 to 2017, who also received plasma exchange (PLEX) during the same admission. A total of 6,214 patients with TTP were identified. We stratified patients based on whether or not they had acute coronary syndrome (ACS) during admission. ACS was documented in 6.3% of patients. Compared with patients without ACS, those with ACS were relatively older (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.02-1.03) and had a relatively higher prevalence of heart failure (OR, 2.02; 95% CI, 1.53-2.67) and coronary artery disease (OR, 2.69; 95% CI, 2.03-3.57). Certain complications were more prevalent in the ACS group including acute cerebrovascular accident (OR, 3.33; 95% CI, 2.94-3.78), acute heart failure (OR, 1.91; 95% CI, 1.67-2.19), acute kidney injury (OR, 1.76; 95% CI, 1.59-1.95), cardiogenic shock (OR, 2.15; 95% CI, 1.72-2.69), and respiratory failure (OR, 1.48; 95% CI, 1.32-1.66). Despite wider utilization of therapeutic plasmapheresis and improved supportive management of patients with TTP, associated morbidity and mortality remain significant. We demonstrate from this large retrospective cohort that ACS is an independent predictor of higher morbidity and mortality in TTP patients.
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.35878
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Article: Intracranial Hemorrhage versus Contrast Extravasation Following Thrombolytic Therapy.

Khalil, Fouad / Ali, Mohammad / Sandhu, Divyajot

South Dakota medicine : the journal of the South Dakota State Medical Association

2023 Volume 76, Issue 2, Page(s) 60–63

Abstract: We report the case of a 51-year-old female with history of end stage renal disease on hemodialysis who presented with right hemiplegia and aphasia. On admission, head CT was negative for intracranial hemorrhage. MRI showed an area of acute infarct in the ...

Abstract	We report the case of a 51-year-old female with history of end stage renal disease on hemodialysis who presented with right hemiplegia and aphasia. On admission, head CT was negative for intracranial hemorrhage. MRI showed an area of acute infarct in the left parietal lobe. The patient received intravenous tissue plasminogen activator. Head CT 24 hours later showed areas of increased density in the left parietal and posterior temporal lobes. Contrast extravasation with superimposed intracranial hemorrhage could not be excluded. Therefore, antiplatelet therapy was held. A follow up CT scan demonstrated the same findings. Another head CT was obtained after hemodialysis showed resolution of the previously noted areas of increased density suggesting that contrast extravasation was the reason of increased density areas.
MeSH term(s)	Female ; Humans ; Middle Aged ; Tissue Plasminogen Activator ; Intracranial Hemorrhages ; Thrombolytic Therapy ; Extravasation of Diagnostic and Therapeutic Materials ; Magnetic Resonance Imaging ; Stroke/drug therapy
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article: Design of new molecules against cervical cancer using DFT, theoretical spectroscopy, 2D/3D-QSAR, molecular docking, pharmacophore and ADMET investigations.

El Rhabori, Said / El Aissouq, Abdellah / Daoui, Ossama / Elkhattabi, Souad / Chtita, Samir / Khalil, Fouad

Heliyon

2024 Volume 10, Issue 3, Page(s) e24551

Abstract: Cervical cancer is a major health problem of women. Hormone therapy, via aromatase inhibition, has been proposed as a promising way of blocking estrogen production as well as treating the progression of estrogen-dependent cancer. To overcome the ... ...

Abstract	Cervical cancer is a major health problem of women. Hormone therapy, via aromatase inhibition, has been proposed as a promising way of blocking estrogen production as well as treating the progression of estrogen-dependent cancer. To overcome the challenging complexities of costly drug design, in-silico strategy, integrating Structure-Based Drug Design (SBDD) and Ligand-Based Drug Design (LBDD), was applied to large representative databases of 39 quinazoline and thioquinazolinone compound derivatives. Quantum chemical and physicochemical descriptors have been investigated using density functional theory (DFT) and MM2 force fields, respectively, to develop 2D-QSAR models, while CoMSIA and CoMFA descriptors were used to build 3D-QSAR models. The robustness and predictive power of the reliable models were verified, via several validation methods, leading to the design of 6 new drug-candidates. Afterwards, 2 ligands were carefully selected using virtual screening methods, taking into account the applicability domain, synthetic accessibility, and Lipinski's criteria. Molecular docking and pharmacophore modelling studies were performed to examine potential interactions with aromatase (PDB ID: 3EQM). Finally, the ADMET properties were investigated in order to select potential drug-candidates against cervical cancer for experimental in vitro and in vivo testing.
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24551
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Article ; Online: Depression among Patients with an Implanted Left Ventricular Assist Device: Uncovering Pathophysiological Mechanisms and Implications for Patient Care.

Alnsasra, Hilmi / Khalil, Fouad / Kanneganti Perue, Radha / Azab, Abed N

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: Depression is a common and devastating mental illness associated with increased morbidity and mortality, partially due to elevated rates of suicidal attempts and death. Select patients with end-stage heart failure on a waiting-list for a donor heart ... ...

Abstract	Depression is a common and devastating mental illness associated with increased morbidity and mortality, partially due to elevated rates of suicidal attempts and death. Select patients with end-stage heart failure on a waiting-list for a donor heart undergo left ventricular assist device (LVAD) implantation. The LVAD provides a circulatory flow of oxygenated blood to the body, mimicking heart functionality by operating on a mechanical technique. LVAD improves functional capacity and survivability among patients with end-stage heart failure. However, accumulating data suggests that LVAD recipients suffer from an increased incidence of depression and suicide attempts. There is scarce knowledge regarding the pathological mechanism and appropriate treatment approach for depressed LVAD patients. This article summarizes the current evidence on the association between LVAD implantation and occurrence of depression, suggesting possible pathological mechanisms underlying the device-associated depression and reviewing the current treatment strategies. The summarized data underscores the need for a rigorous pre-(LVAD)-implantation psychiatric evaluation, continued post-implantation mental health assessment, and administration of antidepressant treatment as necessary.
MeSH term(s)	Humans ; Heart-Assist Devices/adverse effects ; Depression/etiology ; Heart Transplantation/adverse effects ; Heart Failure ; Treatment Outcome ; Tissue Donors ; Patient Care/adverse effects ; Retrospective Studies
Language	English
Publishing date	2023-07-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411270
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Article: Statins Therapy and Intracranial Hemorrhage.

Khalil, Fouad / Badshah, Mashood / Sathyanarayanan, Swaminathan Perinkulam / Amin, Nessim

South Dakota medicine : the journal of the South Dakota State Medical Association

2023 Volume 76, Issue 4, Page(s) 170–173

Abstract: Statins have grown to become an important class of medications in the primary and secondary prevention of cardiovascular diseases. While lowering low-density lipoprotein-C (LDL-C) levels, statins also have a role in stabilization and regression of ... ...

Abstract	Statins have grown to become an important class of medications in the primary and secondary prevention of cardiovascular diseases. While lowering low-density lipoprotein-C (LDL-C) levels, statins also have a role in stabilization and regression of atherosclerotic plaques. In the last two decades, there is a mounting body of evidence that suggests that statins and lowering serum lipid levels may be associated with an increased risk of developing intracerebral hemorrhage (ICH). This review article provides a concise summary of the most important studies performed to date and the pathophysiology behind the association between statins and ICH.
MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Cerebral Hemorrhage/chemically induced ; Cerebral Hemorrhage/drug therapy ; Secondary Prevention
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article: COVID-19 and Cardiovascular Disease: A Comprehensive Review.

Khalil, Fouad / Oleszak, Filip / Stys, Tom / Stys, Adam

South Dakota medicine : the journal of the South Dakota State Medical Association

2022 Volume 75, Issue 2, Page(s) 54–60

Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic that impacted the lives of billions of people worldwide. Angiotensin-converting enzyme 2 (ACE2) receptor act as a gate for ... ...

Abstract	Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic that impacted the lives of billions of people worldwide. Angiotensin-converting enzyme 2 (ACE2) receptor act as a gate for viral cell entry through binding to virus S-protein. Cardiovascular patients are thought to be more susceptible to severe COVID-19 infection due to overexpression of ACE2 receptors in these patients. There is a growing body of evidence suggesting worse outcomes and increased mortality among COVID-19 patients with preexisting cardiovascular diseases. SARS-CoV-2 is capable of causing a wide range of cardiovascular diseases including myocarditis, heart failure, arrhythmia, myocardial ischemia and venous thromboembolism. Drug-disease interaction in COVID-19 patients with preexisting cardiovascular conditions has become a major concern. In this review, we discuss different aspects of the relationship between COVID-19 and the cardiovascular system along with a brief pharmacological overview.
MeSH term(s)	Angiotensin-Converting Enzyme 2 ; COVID-19 ; Cardiovascular Diseases ; Humans ; Peptidyl-Dipeptidase A/metabolism ; SARS-CoV-2
Chemical Substances	Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2022-06-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article: Breakthrough Severe COVID-19 Infection After Triple Dose Pfizer Vaccination.

Khalil, Fouad / Badshah, Mashood / Perinkulam Sathyanarayanan, Swaminathan / Lamfers, Randall

South Dakota medicine : the journal of the South Dakota State Medical Association

2022 Volume 75, Issue 4, Page(s) 171–174

Abstract: The impact of COVID-19 was felt across the globe when it first emerged in December 2019. However, within a year, there was a new hope with the development and approval of mRNA vaccines. The Comirnaty and Pfizer-BioNTech BNT162b2 mRNA vaccine showed an ... ...

Abstract	The impact of COVID-19 was felt across the globe when it first emerged in December 2019. However, within a year, there was a new hope with the development and approval of mRNA vaccines. The Comirnaty and Pfizer-BioNTech BNT162b2 mRNA vaccine showed an efficacy of 95 percent in preventing COVID-19 disease. However, subsequent studies conducted on immunocompromised hosts showed the efficacy to be significantly lower than the initial reported 95 percent, making these patients prone to COVID-19 disease despite the initially recommended two doses. On Sept. 22, 2021, a third dose was approved for immunocompromised hosts. In this article, we report the case of a 67-year-old female with overlap connective tissue disease on mycophenolate mofetil who had a prolonged hospital course because of severe COVID-19 disease complicated by pulmonary embolism despite receiving three doses of the BNT162b2 mRNA vaccine.
MeSH term(s)	Aged ; BNT162 Vaccine ; COVID-19 ; COVID-19 Vaccines ; Female ; Humans ; Vaccination ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines, Synthetic ; mRNA Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article: Dapagliflozin

Arbel, Ronen / Azab, Abed N / Oberoi, Mansi / Aboalhasan, Enis / Star, Artyom / Elhaj, Khaled / Khalil, Fouad / Alnsasra, Hilmi

Frontiers in pharmacology

2024 Volume 15, Page(s) 1357673

Abstract: Background and aim: Heart failure with preserved ejection fraction (HFpEF) is associated with an increased risk of heart failure (HF) hospitalizations and cardiovascular death (CVD). Both dapagliflozin and sacubitril-valsartan have recently shown ... ...

Abstract	Background and aim: Heart failure with preserved ejection fraction (HFpEF) is associated with an increased risk of heart failure (HF) hospitalizations and cardiovascular death (CVD). Both dapagliflozin and sacubitril-valsartan have recently shown convincing reductions in the combined risk of CVD and HF hospitalizations in patients with HF and mildly reduced ejection fraction (HFmrEF) or HFpEF. We aimed to investigate the cost-per-outcome implications of dapagliflozin vs sacubitril-valsartan in the treatment of HFmrEF or HFpEF patients. Methods: We compared the annualized cost needed to treat (CNT) to prevent the composite outcome of total HF hospitalizations and CVD with dapagliflozin or sacubitril-valsartan. The CNT was estimated by multiplying the annualized number needed to treat (aNNT) by the annual cost of therapy. The aNNT was calculated based on data collected from the DELIVER trial for dapagliflozin and a pooled analysis of the PARAGLIDE-HF and PARAGON-HF trials for sacubitril-valsartan. Costs were based on 2022 US prices. Scenario analyses were performed to attenuate the differences in the studies' populations. Results: The aNNT with dapagliflozin in DELIVER was 30 (95% confidence interval [CI]: 21-62) Conclusion: Dapagliflozin provides a better monetary value than sacubitril-valsartan in preventing the composite outcome of total HF hospitalizations and CVD among patients with HFmrEF or HFpEF.
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1357673
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Article ; Online: Design of novel quinoline derivatives as antibreast cancer using 3D-QSAR, molecular docking and pharmacokinetic investigation.

El Rhabori, Said / El Aissouq, Abdellah / Chtita, Samir / Khalil, Fouad

Anti-cancer drugs

2022 Volume 33, Issue 9, Page(s) 789–802

Abstract: Breast cancer has been one of the most challenging women's cancers and leading cause of mortality for decades. There are several studies being conducted all the time to find a cure for breast cancer. Quinoline derivatives have shown their potential as ... ...

Abstract	Breast cancer has been one of the most challenging women's cancers and leading cause of mortality for decades. There are several studies being conducted all the time to find a cure for breast cancer. Quinoline derivatives have shown their potential as antitumor agents in breast cancer therapy. In this work, three-dimensional quantitative structure-activity relationships (3D-QSAR) and molecular docking with aromatase enzyme (Protein Data Bank: 3S7S) studies were performed to suggest the current scenario of quinoline derivatives as antitumor agents and to refine the path of these derivatives to discover and develop new drugs against breast cancer. For developing the 3D-QSAR model, comparative molecular similarity indices analysis (CoMSIA) and comparative molecular field analysis (CoMFA) were included. To attain the high level of predictability, the best CoMSIA model was applied. External validation utilizing a test set has been used in order to validate the predictive capabilities of the built model. According to the findings, electrostatic, hydrophobic and hydrogen bond donor, and acceptor fields had a significant impact on antibreast cancer activity. Thus, we generated a variety of novel effective aromatase inhibitors based on prior findings and we predicted their inhibitory activity using the built model. In addition, absorption, distribution, metabolism, elimination and toxicity properties were employed to explore the effectiveness of new drug candidates.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Aromatase ; Aromatase Inhibitors/pharmacology ; Breast Neoplasms/drug therapy ; Drug Design ; Female ; Humans ; Models, Molecular ; Molecular Docking Simulation ; Quantitative Structure-Activity Relationship
Chemical Substances	Antineoplastic Agents ; Aromatase Inhibitors ; Aromatase (EC 1.14.14.1)
Language	English
Publishing date	2022-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1065301-6
ISSN	1473-5741 ; 0959-4973
ISSN (online)	1473-5741
ISSN	0959-4973
DOI	10.1097/CAD.0000000000001318
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