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Article ; Online: The Effect of Ginger (

Asghari-Jafarabadi, Mohammad / Khalili, Leila

2022 Volume 28, Issue 35, Page(s) 2920–2943

Abstract: Background: Beneficial effects of ginger consumption on metabolic biomarkers has been reported previously. The current research aimed to investigate the effects of ginger supplementation on lipid profile and body weight using a meta-analysis of ... ...

Abstract	Background: Beneficial effects of ginger consumption on metabolic biomarkers has been reported previously. The current research aimed to investigate the effects of ginger supplementation on lipid profile and body weight using a meta-analysis of randomized, controlled trials. Methods: Online databases PubMed, Embase, Web of Science, and Science Direct were searched until December 2021 to identify eligible articles. Twenty-six trials were included. Results: The results showed that ginger consumption could significantly improve lipid profile including total triglyceride (-12.54 (-20.01 to -5.08)), cholesterol (-6.53 (-10.76 to -2.31)), LDL (-5.14 (-8.79 to -1.50)), and HDL (1.13 (0.35 to 1.91)). Moreover, ginger supplementation could significantly decrease body mass index (BMI) (-0.49 (-0.79 to -0.18)). However, the small number of sample studies that investigated reductions in body weight (-0.52 (-1.48 to 0.43)) were not statistically significant. Sub-group analysis of treatment dose and duration showed that in most of the analyzed lipid profiles, both ≤1500 and >1500 mg/d for both of ≤8 and >8 weeks could be effective; however, in the case of weight control dose of >1500 mg/d for more than 8 weeks was more effective. Besides, the results of multivariate meta-analysis revealed the effect of the intervention on all lipid profiles simultaneously. Conclusion: The present meta-analysis and review revealed that ginger supplementation can improve lipid profile and body weight if used at the appropriate dose and duration. More studies are needed to fully evaluate the effect of ginger supplements' different doses and duration on lipid profile and BMI.
MeSH term(s)	Humans ; Zingiber officinale ; Body Weight ; Lipids ; Triglycerides ; Body Mass Index ; Dietary Supplements
Chemical Substances	Lipids ; Triglycerides
Language	English
Publishing date	2022-09-24
Publishing country	United Arab Emirates
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612828666220926093847
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Article ; Online: The Effects of Curcumin Supplementation on Metabolic Biomarkers and Body Mass Index in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Khalili, Leila / Nammi, Srinivas

Current pharmaceutical design

2022 Volume 28, Issue 23, Page(s) 1911–1925

Abstract: Background and aims: Curcumin is one of the most commonly used indigenous molecules endowed with various shielding functionalities that protect the liver. In the present research, we aimed to investigate the effects of curcumin on metabolic factors and ... ...

Abstract	Background and aims: Curcumin is one of the most commonly used indigenous molecules endowed with various shielding functionalities that protect the liver. In the present research, we aimed to investigate the effects of curcumin on metabolic factors and body mass index (BMI) in patients with non-alcoholic fatty liver disease (NAFLD) using a meta-analysis of randomized, controlled trials. Methods: Online databases PubMed, Embase, Web of Science, and Science Direct were searched until April 2021 to identify eligible articles. Fourteen trials were included. Results: The results showed that curcumin consumption can significantly reduce AST (-0.35, (-0.57 to -0.14)), total cholesterol (-0.81, (-1.34 to -0.27)), TG (-0.49, (-0.71 to -0.27)), and FBS (-0.28, (-0.46 to -0.09)) in patients with NAFLD. However, the improvements in ALT (-0.29, (-0.58 to 0.00)), LDL (-0.48, (-0.97 to 0.01)), HDL (0.03, (-0.38 to 0.44)), and BMI (-0.13, (-0.29 to 0.02)) were not statistically significant. Furthermore, the findings revealed that the optimal dose and duration of curcumin consumption for patients with NAFLD is <500 mg/d for less than 10 weeks. Conclusion: The present study suggests that consuming curcumin can improve liver enzymes, lipid profile, FBS, and BMI in patients with NAFLD. Moreover, curcumin supplementation may provide beneficial effects on metabolic biomarkers and body weight if used at the appropriate dose and duration. Further RCTs are required to confirm our findings.
MeSH term(s)	Biomarkers ; Body Mass Index ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Dietary Supplements ; Humans ; Non-alcoholic Fatty Liver Disease/drug therapy ; Randomized Controlled Trials as Topic
Chemical Substances	Biomarkers ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2022-03-28
Publishing country	United Arab Emirates
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612828666220328111141
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Article ; Online: Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies.

Khalili, Leila / Centner, Ann Marie / Salazar, Gloria

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Atherosclerosis is a major cause of death and disability. The beneficial effects of phytochemicals and probiotics on atherosclerosis have gained significant interest since these functional foods can improve inflammation, oxidative stress, and microbiome ... ...

Abstract	Atherosclerosis is a major cause of death and disability. The beneficial effects of phytochemicals and probiotics on atherosclerosis have gained significant interest since these functional foods can improve inflammation, oxidative stress, and microbiome dysbiosis. The direct effect of the microbiome in atherosclerosis, however, needs further elucidation. The objective of this work was to investigate the effects of polyphenols, alkaloids, and probiotics on atherosclerosis using a meta-analysis of studies with mouse models of atherosclerosis. Identification of eligible studies was conducted through searches on PubMed, Embase, Web of Science, and Science Direct until November 2022. The results showed that phytochemicals reduced atherosclerosis, which was significant in male mice, but not in females. Probiotics, on the other hand, showed significant reductions in plaque in both sexes. Berries and phytochemicals modulated gut microbial composition by reducing the Firmicutes/Bacteroidetes (F/B) ratio and by upregulating health-promoting bacteria, including
MeSH term(s)	Female ; Male ; Animals ; Mice ; Gastrointestinal Microbiome ; Fruit ; Atherosclerosis/microbiology ; Probiotics ; Cardiovascular Diseases ; Plaque, Atherosclerotic ; Phytochemicals/pharmacology ; Verrucomicrobia ; Dysbiosis/microbiology
Chemical Substances	Phytochemicals
Language	English
Publishing date	2023-02-04
Publishing country	Switzerland
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043084
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Article ; Online: Lupus clinical trials and the promise of future therapies.

Khalili, Leila / Tang, Wei / Askanase, Anca D

Rheumatology and immunology research

2023 Volume 4, Issue 3, Page(s) 109–114

Language	English
Publishing date	2023-09-27
Publishing country	Germany
Document type	Editorial
ISSN	2719-4523
ISSN (online)	2719-4523
DOI	10.2478/rir-2023-0018
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Article ; Online: State-of-the-art advancement of surface functionalized layered double hydroxides for cell-specific targeting of therapeutics.

Khalili, Leila / Dehghan, Gholamreza / Fazli, Arezou / Khataee, Alireza

Advances in colloid and interface science

2023 Volume 314, Page(s) 102869

Abstract: Over the years, layered double hydroxides (LDHs) hold a specific position in biomedicine due to their tunable chemical composition and appropriate structural properties. However, LDHs lack adequate sensitivity for active targeting because of less active ... ...

Abstract	Over the years, layered double hydroxides (LDHs) hold a specific position in biomedicine due to their tunable chemical composition and appropriate structural properties. However, LDHs lack adequate sensitivity for active targeting because of less active surface area and low mechanical strength in physiological conditions. The exploitation of eco-friendly materials, such as chitosan (CS), for surface engineering of LDHs, whose payloads are transferred only under certain conditions, can help develop stimuli-responsive materials owing to high biosafety and unique mechanical strength. We aim to render a well-oriented scenario toward the latest achievements of a bottom-up technology relying on the surface functionalization of LDHs to fabricate functional formulations with promoted bio-functionality and high encapsulation efficiency for various bioactives. Many efforts have been devoted to critical aspects of LDHs, including systemic biosafety and the suitability for developing multicomponent systems via integration with therapeutic modalities, which are thoroughly discussed herein. In addition, a comprehensive discussion was provided for the recent progress in the emergence of CS-coated LDHs. Finally, the challenges and future perspectives in the fabrication of efficient CS-LDHs in biomedicine are considered, with a special focus on cancer treatment.
MeSH term(s)	Hydroxides/chemistry ; Chitosan/chemistry
Chemical Substances	Hydroxides ; Chitosan (9012-76-4)
Language	English
Publishing date	2023-03-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	210507-x
ISSN	1873-3727 ; 0001-8686
ISSN (online)	1873-3727
ISSN	0001-8686
DOI	10.1016/j.cis.2023.102869
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Article: Smart active-targeting of lipid-polymer hybrid nanoparticles for therapeutic applications: Recent advances and challenges

Khalili, Leila / Dehghan, Gholamreza / Sheibani, Nader / Khataee, Alireza

International journal of biological macromolecules. 2022 July 31, v. 213

2022

Abstract: The advances in producing multifunctional lipid-polymer hybrid nanoparticles (LPHNs) by combining the biomimetic behavior of liposomes and architectural advantages of polymers have provided great opportunities for selective and efficient therapeutics ... ...

Abstract	The advances in producing multifunctional lipid-polymer hybrid nanoparticles (LPHNs) by combining the biomimetic behavior of liposomes and architectural advantages of polymers have provided great opportunities for selective and efficient therapeutics delivery. The constructed LPHNs exhibit different therapeutic efficacies for special uses based on characteristics of different excipients. However, the high mechanical/structural stability of hybrid nano-systems could be viewed as both a negative property and a positive feature, where the concomitant release of drug molecules in a controllable manner is required. In addition, difficulties in scaling up the LPHNs production, due to involvement of several criteria, limit their application for biomedical fields, especially in monitoring, bioimaging, and drug delivery. To address these challenges bio-modifications have exhibited enormous potential to prepare reproducible LPHNs for site-specific therapeutics delivery, diagnostic and preventative applications. The ever-growing surface bio-functionality has provided continuous vitality to this biotechnology and has also posed desirable biosafety to nanoparticles (NPs). As a proof-of-concept, this manuscript provides a crucial review of coated lipid and polymer NPs displaying excellent surface functionality and architectural advantages. We also provide a description of structural classifications and production methodologies, as well as the biomedical possibilities and translational obstacles in the development of surface modified nanocarrier technology.
Keywords	bioimaging ; biomimetics ; biosafety ; drugs ; lipids ; nanocarriers ; polymers
Language	English
Dates of publication	2022-0731
Size	p. 166-194.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.05.156
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Article ; Online: The Evolving Role of Telemedicine in the Care of Patients With Connective Tissue Diseases.

Barasch, Julia G / Tang, Wei / Khalili, Leila / Askanase, Anca

Arthritis care & research

2023 Volume 76, Issue 1, Page(s) 19–21

MeSH term(s)	Humans ; Telemedicine ; Connective Tissue Diseases/diagnosis ; Connective Tissue Diseases/therapy ; Patients
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Editorial
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.25259
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Zs.A 2446: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Smart active-targeting of lipid-polymer hybrid nanoparticles for therapeutic applications: Recent advances and challenges.

Khalili, Leila / Dehghan, Gholamreza / Sheibani, Nader / Khataee, Alireza

International journal of biological macromolecules

2022 Volume 213, Page(s) 166–194

Abstract	The advances in producing multifunctional lipid-polymer hybrid nanoparticles (LPHNs) by combining the biomimetic behavior of liposomes and architectural advantages of polymers have provided great opportunities for selective and efficient therapeutics delivery. The constructed LPHNs exhibit different therapeutic efficacies for special uses based on characteristics of different excipients. However, the high mechanical/structural stability of hybrid nano-systems could be viewed as both a negative property and a positive feature, where the concomitant release of drug molecules in a controllable manner is required. In addition, difficulties in scaling up the LPHNs production, due to involvement of several criteria, limit their application for biomedical fields, especially in monitoring, bioimaging, and drug delivery. To address these challenges bio-modifications have exhibited enormous potential to prepare reproducible LPHNs for site-specific therapeutics delivery, diagnostic and preventative applications. The ever-growing surface bio-functionality has provided continuous vitality to this biotechnology and has also posed desirable biosafety to nanoparticles (NPs). As a proof-of-concept, this manuscript provides a crucial review of coated lipid and polymer NPs displaying excellent surface functionality and architectural advantages. We also provide a description of structural classifications and production methodologies, as well as the biomedical possibilities and translational obstacles in the development of surface modified nanocarrier technology.
MeSH term(s)	Drug Delivery Systems ; Lipids/chemistry ; Liposomes ; Nanoparticles/chemistry ; Polymers/chemistry
Chemical Substances	Lipids ; Liposomes ; Polymers
Language	English
Publishing date	2022-05-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.05.156
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Article: Effect of

Khalili, Leila / Valdes-Ramos, Roxana / Harbige, Laurence S

Metabolites

2021 Volume 11, Issue 11

Abstract: Beneficial effects ... ...

Abstract	Beneficial effects of
Language	English
Publishing date	2021-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11110742
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Article: Combination of surgery and laser for the treatment of extensive VIN3 and vulval condyloma: A case report.

Farzaneh, Farah / Khalili, Leila / Rakhshani, Nasser / Beyraghdar, Faramarz / Hosseini, Afsaneh

Annals of medicine and surgery (2012)

2022 Volume 78, Page(s) 103763

Abstract: Introduction and importance: Vulval intraepithelial neoplastic lesions (VINs) are rare lesions that appear with limited signs of pre-malignancy restricted to the vulvar epithelium. One of the principal causes of VINs is the human papillomavirus (HPV) ... ...

Abstract	Introduction and importance: Vulval intraepithelial neoplastic lesions (VINs) are rare lesions that appear with limited signs of pre-malignancy restricted to the vulvar epithelium. One of the principal causes of VINs is the human papillomavirus (HPV) infection, especially in people with weakened immune systems and young women. Case presentation: A 35-year-old woman presented with VIN3 who had severe immunosuppression and was under corticosteroid treatment. Her lesions were treated with a laser and surgical excision. Clinical discussion: Pathological findings indicated full thickness dysplasia and HPV infection. Follow-up after 5 years showed complete recovery and no recurrence, with a restoration of the vulva esthetics. Conclusion: Due to the increasing prevalence of VIN malignancy in young women and the importance of maintaining normal anatomy and function of the genitalia, a combination of surgery and laser can be used instead of extensive surgery only.
Language	English
Publishing date	2022-05-18
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2022.103763
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