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Book ; Online ; E-Book: Handbook of intervention and Alzheimer's disease

Raji, Cyrus A. / Leng, Yue / Ashford, John Wesson / Khalsa, Dharma Singh

(Advances in Alzheimer's disease series ; 11)

2024

Author's details	edited by Cyrus A. Raji, Yue Leng, J. Wesson Ashford and Dharma Singh Khalsa
Series title	Advances in Alzheimer's disease series ; 11
Collection
Language	English
Size	1 Online-Ressource (xiii, 752 Seiten), Illustrationen, Diagramme
Publisher	IOS Press
Publishing place	Amsterdam
Publishing country	Netherlands
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT030694943
ISBN	978-1-64368-501-4 ; 9781643685007 ; 1-64368-501-5 ; 1643685007
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Handbook of prevention and Alzheimer's disease

Raji, Cyrus A. / Leng, Yue / Ashford, John Wesson / Khalsa, Dharma Singh

(Advances in Alzheimer's disease series ; 10)

2024

Author's details	edited by Cyrus A. Raji, Yue Leng, J. Wesson Ashford and Dharma Singh Khalsa
Series title	Advances in Alzheimer's disease series ; 10
Collection
Language	English
Size	1 Online-Ressource (xiii, 658 Seiten), Illustrationen, Diagramme
Publisher	IOS Press
Publishing place	Amsterdam
Publishing country	Netherlands
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT030694964
ISBN	978-1-64368-493-2 ; 9781643684925 ; 1-64368-493-0 ; 1643684922
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Spiritual Fitness: A New Dimension in Alzheimer's Disease Prevention.

Khalsa, Dharma Singh / Newberg, Andrew B

Journal of Alzheimer's disease : JAD

2021 Volume 80, Issue 2, Page(s) 505–519

Abstract: Background: Religious and spiritual interventions may have an effect on Alzheimer's disease prevention. Kirtan Kriya meditation has been shown to mitigate the deleterious effects of chronic stress on cognition, reverse memory loss, and create ... ...

Abstract	Background: Religious and spiritual interventions may have an effect on Alzheimer's disease prevention. Kirtan Kriya meditation has been shown to mitigate the deleterious effects of chronic stress on cognition, reverse memory loss, and create psychological and spiritual wellbeing, which may reduce multiple drivers of Alzheimer's disease risk. Objective: To detail a new concept in medicine called Spiritual Fitness, a merging of stress reduction, basic wellbeing, and psycho/spiritual wellbeing to prevent Alzheimer's disease. Methods: The literature on the topics mentioned above is described, including an in-depth discussion on why and how each are critical to advancing the future of Alzheimer's disease prevention. The many negative effects of chronic stress, and the benefits of Kirtan Kriya, are reviewed. The four pillars of basic wellbeing, six practical aspects of psychological wellbeing, and the four new non-sectarian features of spiritual fitness are then disclosed. Moreover, instructions on practicing Kirtan Kriya are offered in the Supplementary Material. Conclusion: Religious and spiritual practices, including Kirtan Kriya, are crucial components in the development of enhanced cognition and well-being, which may help prevent and, in some cases, reverse cognitive decline. The key point of this review is that making a commitment to live a brain longevity lifestyle including spiritual fitness is a critically important way for aging Alzheimer's disease free. We hope that this article will inspire scientists, clinicians, and patients to embrace this new concept of spiritual fitness and make it a part of every multidomain program for the prevention of cognitive disability.
MeSH term(s)	Alzheimer Disease/prevention & control ; Alzheimer Disease/psychology ; Humans ; Life Style ; Love ; Meditation ; Spirituality
Language	English
Publishing date	2021-02-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-201433
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Stress, Meditation, and Alzheimer's Disease Prevention: Where The Evidence Stands.

Khalsa, Dharma Singh

Journal of Alzheimer's disease : JAD

2015 Volume 48, Issue 1, Page(s) 1–12

Abstract: Although meditation is believed to be over five thousand years old, scientific research on it is in its infancy. Mitigating the extensive negative biochemical effects of stress is a superficially discussed target of Alzheimer's disease (AD) prevention, ... ...

Abstract	Although meditation is believed to be over five thousand years old, scientific research on it is in its infancy. Mitigating the extensive negative biochemical effects of stress is a superficially discussed target of Alzheimer's disease (AD) prevention, yet may be critically important. This paper reviews lifestyle and stress as possible factors contributing to AD and meditation's effects on cognition and well-being for reduction of neurodegeneration and prevention of AD. This review highlights Kirtan Kriya (KK), an easy, cost effective meditation technique requiring only 12 minutes a day, which has been successfully employed to improve memory in studies of people with subjective cognitive decline, mild cognitive impairment, and highly stressed caregivers, all of whom are at increased risk for subsequent development of AD. KK has also been shown to improve sleep, decrease depression, reduce anxiety, down regulate inflammatory genes, upregulate immune system genes, improve insulin and glucose regulatory genes, and increase telomerase by 43%; the largest ever recorded. KK also improves psycho-spiritual well-being or spiritual fitness, important for maintenance of cognitive function and prevention of AD. KK is easy to learn and practice by aging individuals. It is the premise of this review that meditation in general, and KK specifically, along with other modalities such as dietary modification, physical exercise, mental stimulation, and socialization, may be beneficial as part of an AD prevention program.
MeSH term(s)	Alzheimer Disease/complications ; Alzheimer Disease/prevention & control ; Alzheimer Disease/psychology ; Cognition Disorders/etiology ; Humans ; Life Style ; Meditation/methods ; Stress, Psychological
Language	English
Publishing date	2015-10-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-142766
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Four Pillars of Alzheimer's Prevention.

Khalsa, Dharma Singh / Perry, George

Cerebrum : the Dana forum on brain science

2017 Volume 2017

Abstract: Much is yet to be discovered about the precise biological changes that cause Alzheimer's, disease, why it progresses more quickly in some than in others, and how the disease can be prevented, slowed, or stopped. And while researchers continue to search ... ...

Abstract	Much is yet to be discovered about the precise biological changes that cause Alzheimer's, disease, why it progresses more quickly in some than in others, and how the disease can be prevented, slowed, or stopped. And while researchers continue to search for the magic pill that can prevent or halt the spread of amyloid in the brain, our authors believe that changing or modifying one's lifestyle and attitude can make a difference in both prevention and treatment
Language	English
Publishing date	2017-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2251230-5
ISSN	1524-6205
ISSN	1524-6205
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Incorporating a Usual Care Comparator into a Study of Meditation and Music Listening for Older Adults with Subjective Cognitive Decline: A Randomized Feasibility Trial.

Innes, Kim E / Montgomery, Caitlin / Selfe, Terry Kit / Wen, Sijin / Khalsa, Dharma Singh / Flick, Madison

Journal of Alzheimer's disease reports

2021 Volume 5, Issue 1, Page(s) 187–206

Abstract: Background: Recent studies suggest meditation and music listening (ML) may improve cognitive and psychosocial outcomes in adults with subjective cognitive decline (SCD). However, lack of a usual care group has limited conclusions.: Objective: To ... ...

Abstract	Background: Recent studies suggest meditation and music listening (ML) may improve cognitive and psychosocial outcomes in adults with subjective cognitive decline (SCD). However, lack of a usual care group has limited conclusions. Objective: To assess the: 1) feasibility of incorporating an enhanced usual care (EUC) comparator in a trial of Kirtan Kriya meditation (KK) and ML for adults experiencing SCD; and 2) preliminary effects of active treatment (KK/ML) versus an EUC program. Methods: Forty participants with SCD were randomized 1:1:2 to a 12-week KK, ML, or EUC program. KK and ML participants were asked to practice 12 minutes/day; EUC participants were given a comprehensive educational packet regarding healthy aging and strategies for improving/maintaining brain health and asked to record any activities or strategies used. Feasibility was assessed using measures of retention, adherence, treatment expectancies, and participant satisfaction, as well as information from exit questionnaires and daily practice/activity logs. Cognitive functioning, stress, mood, sleep-quality, and health-related quality of life (QOL) were measured pre- and post-intervention using well-validated instruments. Results: Thirty-two participants (80%) completed the 3-month study, with retention highest in the EUC group ( Conclusion: Findings of this pilot feasibility trial suggest incorporation of an EUC program is feasible, and that participation in a simple 12-week relaxation program may be helpful for adults with SCD versus engagement in an EUC program.
Language	English
Publishing date	2021-03-11
Publishing country	Netherlands
Document type	Journal Article
ISSN	2542-4823
ISSN (online)	2542-4823
DOI	10.3233/ADR-200249
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mindfulness effects on caregiver stress: should we expect more?

Khalsa, Dharma Singh

Journal of alternative and complementary medicine (New York, N.Y.)

2010 Volume 16, Issue 10, Page(s) 1025–1026

MeSH term(s)	Alzheimer Disease/therapy ; Caregivers/psychology ; Humans ; Meditation ; Stress, Physiological ; Stress, Psychological/therapy
Language	English
Publishing date	2010-10
Publishing country	United States
Document type	Editorial
ZDB-ID	1237383-7
ISSN	1557-7708 ; 1075-5535
ISSN (online)	1557-7708
ISSN	1075-5535
DOI	10.1089/acm.2010.0431
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4366: Show issues

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Article ; Online: Dharma Singh Khalsa, MD: The pillars of Alzheimer's prevention.

Khalsa, Dharma Singh / Gustafson, Craig

Advances in mind-body medicine

2014 Volume 28, Issue 3, Page(s) 26–32

MeSH term(s)	Alzheimer Disease/prevention & control ; Holistic Health ; Humans ; Memory Disorders/prevention & control ; Southwestern United States ; Stress, Psychological/therapy ; Yoga
Language	English
Publishing date	2014
Publishing country	United States
Document type	Interview
ZDB-ID	1425573-x
ISSN	1532-1843 ; 1470-3556 ; 0741-9783
ISSN (online)	1532-1843
ISSN	1470-3556 ; 0741-9783
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2788: Show issues

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Article ; Online: Effects of Meditation versus Music Listening on Perceived Stress, Mood, Sleep, and Quality of Life in Adults with Early Memory Loss: A Pilot Randomized Controlled Trial.

Innes, Kim E / Selfe, Terry Kit / Khalsa, Dharma Singh / Kandati, Sahiti

Journal of Alzheimer's disease : JAD

2016 Volume 52, Issue 4, Page(s) 1277–1298

Abstract: Background: Older adults with subjective cognitive decline (SCD) are at increased risk not only for Alzheimer's disease, but for poor mental health, impaired sleep, and diminished quality of life (QOL), which in turn, contribute to further cognitive ... ...

Abstract	Background: Older adults with subjective cognitive decline (SCD) are at increased risk not only for Alzheimer's disease, but for poor mental health, impaired sleep, and diminished quality of life (QOL), which in turn, contribute to further cognitive decline, highlighting the need for early intervention. Objective: In this randomized controlled trial, we assessed the effects of two 12-week relaxation programs, Kirtan Kriya Meditation (KK) and music listening (ML), on perceived stress, sleep, mood, and health-related QOL in older adults with SCD. Methods: Sixty community-dwelling older adults with SCD were randomized to a KK or ML program and asked to practice 12 minutes daily for 12 weeks, then at their discretion for the following 3 months. At baseline, 12 weeks, and 26 weeks, perceived stress, mood, psychological well-being, sleep quality, and health-related QOL were measured using well-validated instruments. Results: Fifty-three participants (88%) completed the 6-month study. Participants in both groups showed significant improvement at 12 weeks in psychological well-being and in multiple domains of mood and sleep quality (p's≤0.05). Relative to ML, those assigned to KK showed greater gains in perceived stress, mood, psychological well-being, and QOL-Mental Health (p's≤0.09). Observed gains were sustained or improved at 6 months, with both groups showing marked and significant improvement in all outcomes. Changes were unrelated to treatment expectancies. Conclusions: Findings suggest that practice of a simple meditation or ML program may improve stress, mood, well-being, sleep, and QOL in adults with SCD, with benefits sustained at 6 months and gains that were particularly pronounced in the KK group.
MeSH term(s)	Affect ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Meditation/methods ; Memory Disorders/psychology ; Memory Disorders/therapy ; Middle Aged ; Music Therapy/methods ; Pilot Projects ; Quality of Life ; Sleep ; Stress, Psychological/therapy
Language	English
Publishing date	2016-03-08
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-151106
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Article ; Online: Meditation and Music Improve Memory and Cognitive Function in Adults with Subjective Cognitive Decline: A Pilot Randomized Controlled Trial.

Innes, Kim E / Selfe, Terry Kit / Khalsa, Dharma Singh / Kandati, Sahiti

Journal of Alzheimer's disease : JAD

2016 Volume 56, Issue 3, Page(s) 899–916

Abstract: Background: While effective therapies for preventing or slowing cognitive decline in at-risk populations remain elusive, evidence suggests mind-body interventions may hold promise.: Objectives: In this study, we assessed the effects of Kirtan Kriya ... ...

Abstract	Background: While effective therapies for preventing or slowing cognitive decline in at-risk populations remain elusive, evidence suggests mind-body interventions may hold promise. Objectives: In this study, we assessed the effects of Kirtan Kriya meditation (KK) and music listening (ML) on cognitive outcomes in adults experiencing subjective cognitive decline (SCD), a strong predictor of Alzheimer's disease. Methods: Sixty participants with SCD were randomized to a KK or ML program and asked to practice 12 minutes/day for 3 months, then at their discretion for the ensuing 3 months. At baseline, 3 months, and 6 months we measured memory and cognitive functioning [Memory Functioning Questionnaire (MFQ), Trail-making Test (TMT-A/B), and Digit-Symbol Substitution Test (DSST)]. Results: The 6-month study was completed by 53 participants (88%). Participants performed an average of 93% (91% KK, 94% ML) of sessions in the first 3 months, and 71% (68% KK, 74% ML) during the 3-month, practice-optional, follow-up period. Both groups showed marked and significant improvements at 3 months in memory and cognitive performance (MFQ, DSST, TMT-A/B; p's≤0.04). At 6 months, overall gains were maintained or improved (p's≤0.006), with effect sizes ranging from medium (DSST, ML group) to large (DSST, KK group; TMT-A/B, MFQ). Changes were unrelated to treatment expectancies and did not differ by age, gender, baseline cognition scores, or other factors. Conclusions: Findings of this preliminary randomized controlled trial suggest practice of meditation or ML can significantly enhance both subjective memory function and objective cognitive performance in adults with SCD, and may offer promise for improving outcomes in this population.
MeSH term(s)	Aged ; Aged, 80 and over ; Cognition ; Cognitive Dysfunction/psychology ; Cognitive Dysfunction/therapy ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Meditation ; Memory ; Middle Aged ; Music Therapy ; Patient Compliance ; Perception ; Pilot Projects ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2016-12-19
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-160867
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