Article ; Online: Perfect adaptation in biology.
2021 Volume 12, Issue 6, Page(s) 509–521
Abstract: A distinctive feature of many biological systems is their ability to adapt to persistent stimuli or disturbances that would otherwise drive them away from a desirable steady state. The resulting stasis enables organisms to function reliably while being ... ...
| Abstract | A distinctive feature of many biological systems is their ability to adapt to persistent stimuli or disturbances that would otherwise drive them away from a desirable steady state. The resulting stasis enables organisms to function reliably while being subjected to very different external environments. This perspective concerns a stringent type of biological adaptation, robust perfect adaptation (RPA), that is resilient to certain network and parameter perturbations. As in engineered control systems, RPA requires that the regulating network satisfy certain structural constraints that cannot be avoided. We elucidate these ideas using biological examples from systems and synthetic biology. We then argue that understanding the structural constraints underlying RPA allows us to look past implementation details and offers a compelling means to unravel regulatory biological complexity. |
|---|---|
| MeSH term(s) | Acclimatization ; Adaptation, Physiological ; Homeostasis ; Models, Biological ; Synthetic Biology |
| Language | English |
| Publishing date | 2021-06-17 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2854138-8 |
| ISSN | 2405-4720 ; 2405-4712 |
| ISSN (online) | 2405-4720 |
| ISSN | 2405-4712 |
| DOI | 10.1016/j.cels.2021.05.020 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.