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  1. AU="Khan, Asad Majeed"
  2. AU=Ismail Mohd Iswadi
  3. AU="Jewel Park"
  4. AU="Hunter-Smith, David J"
  5. AU="Requião-Moura, Lúcio Roberto"
  6. AU=DesRochers Teresa M.
  7. AU="Kruschwitz, Sabine"
  8. AU=Sriwijiatalai Won
  9. AU="Bozzaro, Claudia"
  10. AU="Beckendorf, C"
  11. AU="Birge, N W"
  12. AU="Hoang, Oi Pui"
  13. AU="Saradha Baskaran"
  14. AU="Culotta, Lorenza"
  15. AU=Cleaver Ondine
  16. AU="Jordan A. Kreidberg"
  17. AU="Al-Marshoud, Majida"
  18. AU="David S Hui"
  19. AU="Manjappa, Shivaprasad"
  20. AU="Balkan, S"
  21. AU="Chen, Emma"
  22. AU="Delean, Ada"
  23. AU="Gurao, Ankita"
  24. AU="Lang, Zhen"
  25. AU="Mahnaz Mohammadpour"
  26. AU="Britta Grillitsch"
  27. AU=Hoeffner Ellen G
  28. AU="Al Harbi, Shmeylan"
  29. AU=Polevoda Bogdan
  30. AU="Raffaele Galiero"
  31. AU=Hruskova Z
  32. AU="Ayers, J"
  33. AU="Cohen, A D"
  34. AU="Brunetti, Gian Luca"
  35. AU=Andrade Daniel
  36. AU=Hay William W Jr

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  1. Artikel ; Online: Advanced polymers and recent advancements on gastroretentive drug delivery system; a comprehensive review.

    Waqar, Muhammad Ahsan / Mubarak, Naeem / Khan, Asad Majeed / Khan, Rabeel / Shaheen, Farwa / Shabbir, Afshan

    Journal of drug targeting

    2024  , Seite(n) 1–17

    Abstract: Oral route of drug administration is typically the initial option for drug administration because it is both practical and affordable. However, major drawback of this route includes the release of drug at a specified place thus reduces the ... ...

    Abstract Oral route of drug administration is typically the initial option for drug administration because it is both practical and affordable. However, major drawback of this route includes the release of drug at a specified place thus reduces the bioavailability. This could be overcome by utilising the gastroretentive drug delivery system (GRRDS). Prolonged stomach retention improves bioavailability and increases solubility for medicines that are unable to dissolve in high pH environments. Many recent advancements in the floating, bio adhesive, magnetic, expandable, raft forming and ion exchange systems have been made that had led towards advanced form of drug delivery. From the past few years, floating drug delivery system has been most commonly utilised for the delivery of drug in a delayed manner. Various polymers have been utilised for manufacturing of these systems, including alginates, chitosan, pectin, carrageenan's, xanthan gum, hydroxypropyl cellulose, carbomer, polyethylene oxide and sodium carboxy methyl cellulose. Chitosan, pectin and xanthan gum have been found to be most commonly used polymers in the manufacturing of drug inclusion complex for gastroretentive drug delivery. This study aimed to define various types and advanced polymers as well as also highlights recent advances and future perspectives of gastroretentive drug delivery system.
    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2024.2347366
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet.

    Khan, Asad Majeed / Hanif, Muhammad / Bukhari, Nadeem Irfan / Shamim, Rahat / Rasool, Fatima / Rasul, Sumaira / Shafique, Sana

    Drug design, development and therapy

    2020  Band 14, Seite(n) 2435–2448

    Abstract: Background: Severe bleeding and perforation of the colon and rectum are complications of ulcerative colitis which can be treated by a targeted drug delivery system.: Purpose: Development of colon-targeted delivery usually involves a complex ... ...

    Abstract Background: Severe bleeding and perforation of the colon and rectum are complications of ulcerative colitis which can be treated by a targeted drug delivery system.
    Purpose: Development of colon-targeted delivery usually involves a complex formulation process and coating steps of pH-sensitive methacrylic acid based Eudragit
    Materials and methods: Mesalamine formulations were compressed using wet granulation technique with varying compositions of dicalcium phosphate (DCP) and Eudragit-S100. The developed formulations were characterized for physicochemical and drug release profiles. Infrared studies were carried out to ensure that there was no interaction between active ingredients and excipients. Artificial neural network (ANN) was used for the optimization of final DCP-Eudragit-S100 complex and the experimental data were employed to train a multi-layer perception (MLP) using quick propagation (QP) training algorithm until a satisfactory root mean square error (RMSE) was reached. The ANN-aided optimized formulation was compared with commercially available Masacol
    Results: Compressed tablets met the desirability criteria in terms of thickness, hardness, weight variation, friability, and content uniformity, ie, 5.34 mm, 7.7 kg/cm
    Conclusion: DCP-Eudragit-S100 blend was found explicative for mesalamine release without coating in gastric and colonic regions. This combination may provide a better control of ulcerative colitis.
    Mesh-Begriff(e) Calcium Phosphates/chemical synthesis ; Calcium Phosphates/chemistry ; Drug Compounding ; Hydrogen-Ion Concentration ; Neural Networks, Computer ; Polymethacrylic Acids/chemical synthesis ; Polymethacrylic Acids/chemistry ; Tablets/chemical synthesis ; Tablets/chemistry
    Chemische Substanzen Calcium Phosphates ; Polymethacrylic Acids ; Tablets ; methylmethacrylate-methacrylic acid copolymer (25086-15-1) ; calcium phosphate, dibasic, dihydrate (O7TSZ97GEP)
    Sprache Englisch
    Erscheinungsdatum 2020-06-22
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S244016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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