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  1. Book: The DNA Way

    Khan, Kashif

    Unlock the Secrets of Your Genes to Reverse Disease, Slow Ageing and Achieve Optimal Wellness

    2023  

    Size 256 p.
    Publisher Hay House UK Ltd
    Document type Book
    Note PDA Manuell_21
    Format 229 x 151 x 23
    ISBN 9781788178969 ; 1788178963
    Database PDA

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  2. Article ; Online: Impact of rapid on-site evaluation in expediting the fast investigative lung cancer pathway.

    Fowell, Andrew / Khan, Kashif

    Cytopathology : official journal of the British Society for Clinical Cytology

    2023  Volume 35, Issue 2, Page(s) 250–255

    Abstract: Objective: EBUS-TBNA is a method of acquiring tissue samples from intrathoracic lymph nodes and central intrathoracic tumours in patients suspected of having lung cancer. Rapid on-site evaluation (ROSE) denotes assessing tissue samples during EBUS (or ... ...

    Abstract Objective: EBUS-TBNA is a method of acquiring tissue samples from intrathoracic lymph nodes and central intrathoracic tumours in patients suspected of having lung cancer. Rapid on-site evaluation (ROSE) denotes assessing tissue samples during EBUS (or bronchoscopy), providing instant feedback on sample adequacy and provisional cytomorphological diagnosis. Sector multidisciplinary team (MDT) discussion can then make informed treatment decisions, with confirmatory immunohistochemistry being finalised before provision of final treatment. Currently, impact of ROSE on length of time patients spend on the lung cancer diagnostic pathway remains unclear.
    Methods: We retrospectively evaluated the impact of ROSE on the length of time between patients' EBUS/bronchoscopy procedures and discussion at sector MDT, referred to as time to treatment decision (TTD), at our institution. Additionally, we assessed impact of ROSE on number of passes (number of times nodes/masses were sampled) per procedure.
    Results: The mean TTD was 77.9% shorter (p = 0.001) with ROSE present than when absent. Patients who received ROSE spend 34.3% less time (p = 0.028) on lung cancer diagnostic pathway overall. There was a significant reduction in number of passes in non-malignant nodes with ROSE present (2.23) than when absent (3.14) (p < 0.001). With ROSE present there was a significantly greater number of passes at malignant sites (5.07) than non-malignant sites (2.23) (p < 0.001).
    Conclusions: These findings support conclusions made in our institution's previous study, that utilisation of ROSE reduces TTD. ROSE also allows safe advancement through nodes with low suspicion of malignant involvement, focusing time on sampling nodes/masses of greater suspicion.
    MeSH term(s) Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Rapid On-site Evaluation ; Retrospective Studies ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods ; Lung/pathology ; Bronchoscopy/methods ; Lymph Nodes/pathology
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034190-0
    ISSN 1365-2303 ; 0956-5507 ; 1350-4037
    ISSN (online) 1365-2303
    ISSN 0956-5507 ; 1350-4037
    DOI 10.1111/cyt.13345
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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Electrochemical detection and removal of brilliant blue dye

    Khan, Kashif Ali / Shah, Afzal / Nisar, Jan

    RSC advances

    2024  Volume 14, Issue 4, Page(s) 2504–2517

    Abstract: Herein, we report a sensitive electrochemical platform prepared by modifying the electrode surface with copper-doped zinc oxide nanoparticles; these nanoparticles were ... ...

    Abstract Herein, we report a sensitive electrochemical platform prepared by modifying the electrode surface with copper-doped zinc oxide nanoparticles; these nanoparticles were prepared
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra07519b
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  4. Article: Knowledge, attitudes and perceptions regarding human papillomavirus among university students in Hail, Saudi Arabia.

    Alshammari, Farhan / Khan, Kashif Ullah

    PeerJ

    2022  Volume 10, Page(s) e13140

    Abstract: Background: Human papillomavirus (HPV) is a well-known cause of cervical cancer. The prevalence of HPV, insufficient preventive services, inadequate treatment access, socioeconomic conditions, certain cultural causes and values and opinions regarding ... ...

    Abstract Background: Human papillomavirus (HPV) is a well-known cause of cervical cancer. The prevalence of HPV, insufficient preventive services, inadequate treatment access, socioeconomic conditions, certain cultural causes and values and opinions regarding cervical cancer have been established as factors contributing to the occurrence of cervical cancer in various parts of the world.
    Objective: To determine university students' knowledge, attitudes and perceptions regarding HPV and its vaccine.
    Material and methods: The present cross-sectional study included students enrolled at the University of Hail, Saudi Arabia. Data were collected from January to May 2020 using a previously validated 26-item questionnaire.
    Results: A total of 386 participants responded to the survey; the response rate was 80%. The majority of the respondents (63%) were male and 332 (86%) respondents were single among the overall study population. Most respondents were aged 21-25 years (75.6%), followed by 26-30 years (12.7%). In total, 130 (33.7%) respondents reported that they had heard of HPV before, while 174 (45.1%) reported that HPV infections are rare in Saudi Arabia. Furthermore, 102 (26.4%) respondents thought that HPV causes genital warts, while almost 29.5% believed that HPV infection is a sexually transmitted disease. Nearly 76.2% of the respondents did not believe that HPV infection can occur without symptoms. Moreover, 53.4% of the respondents stated that they did not know the health problems associated with HPV infection, while 148 (38.8%) stated that cervical cancer is a health problem associated with HPV infection. When asked about their understanding of the HPV vaccine, nearly 267 (62.2%) respondents believed that there is no vaccine for HPV, while 239 (61.9%) believed that the vaccine does not minimise the risk of cervical cancer. In addition, the respondents reported that they would be far more likely to get an HPV vaccine if recommended by their doctors [relative importance index (RII) = 0.745], followed by their friends (RII = 0.675).
    Conclusion: The present findings provide a clear understanding of university students' knowledge, perceptions and attitudes regarding HPV; this information can be used to raise awareness by developing an effective educational strategy. However, further research with a larger sample size is recommended; such efforts would also aid in the development of educational services for various age ranges.
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.13140
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  5. Article: Cross-reactivity and inclusivity analysis of CRISPR-based diagnostic assays of coronavirus SARS-CoV-2.

    Khan, Kashif Aziz / Duceppe, Marc-Olivier

    PeerJ

    2021  Volume 9, Page(s) e12050

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; initially named as 2019-nCoV) is the cause of the novel coronavirus disease 2019 (COVID-19) pandemic. Its diagnosis relies on the molecular detection of the viral RNA by polymerase chain ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; initially named as 2019-nCoV) is the cause of the novel coronavirus disease 2019 (COVID-19) pandemic. Its diagnosis relies on the molecular detection of the viral RNA by polymerase chain reaction (PCR) while newer rapid CRISPR-based diagnostic tools are being developed. As molecular diagnostic assays rely on the detection of unique sequences of viral nucleic acid, the target regions must be common to all coronavirus SARS-CoV-2 circulating strains, yet unique to SARS-CoV-2 with no cross-reactivity with the genome of the host and other normal or pathogenic organisms potentially present in the patient samples. This stage 1 protocol proposes
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.12050
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  6. Article: Anti-inflammatory, analgesic, and antipyretic potential of

    Sherif, Asmaa E / Sajid-Ur-Rehman, Muhammad / Asif, Muhammad / Qadeer, Iram / Khan, Kashif Ur Rehman

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1326968

    Abstract: The objective of the current study was to evaluate the anti-inflammatory, analgesic, and antipyretic potential ... ...

    Abstract The objective of the current study was to evaluate the anti-inflammatory, analgesic, and antipyretic potential of
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1326968
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  7. Article: Presence of mismatches between diagnostic PCR assays and coronavirus SARS-CoV-2 genome.

    Khan, Kashif Aziz / Cheung, Peter

    Royal Society open science

    2020  Volume 7, Issue 6, Page(s) 200636

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; initially named as 2019-nCoV) is responsible for the recent COVID-19 pandemic and polymerase chain reaction (PCR) is the current standard method for its diagnosis from patient samples. This ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; initially named as 2019-nCoV) is responsible for the recent COVID-19 pandemic and polymerase chain reaction (PCR) is the current standard method for its diagnosis from patient samples. This study conducted a reassessment of published diagnostic PCR assays, including those recommended by the World Health Organization (WHO), through the evaluation of mismatches with publicly available viral sequences. An exhaustive evaluation of the sequence variability within the primer/probe target regions of the viral genome was performed using more than 17 000 viral sequences from around the world. The analysis showed the presence of mutations/mismatches in primer/probe binding regions of 7 assays out of 27 assays studied. A comprehensive bioinformatics approach for
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.200636
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  8. Article ; Online: Evaluation of the Sequence Variability within the PCR Primer/Probe Target Regions of the SARS-CoV-2 Genome.

    Khan, Kashif Aziz / Cheung, Peter

    Bio-protocol

    2020  Volume 10, Issue 24, Page(s) e3871

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; initially named 2019-nCoV) is responsible for the recent coronavirus disease (COVID-19) pandemic, and polymerase chain reaction (PCR) is the current standard method for diagnosis from patient ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; initially named 2019-nCoV) is responsible for the recent coronavirus disease (COVID-19) pandemic, and polymerase chain reaction (PCR) is the current standard method for diagnosis from patient samples. As PCR assays are prone to sequence mismatches due to mutations in the viral genome, it is important to verify the genomic variability at primer/probe binding regions periodically. This step-by-step protocol describes a bioinformatics approach for an extensive evaluation of the sequence variability within the primer/probe target regions of the SARS-CoV-2 genome. The protocol can be applied to any molecular diagnostic assay of choice using freely available software programs and the ready-to-use multiple sequence alignment (MSA) file provided. Graphic abstract
    Language English
    Publishing date 2020-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.3871
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  9. Article ; Online: A lightweight noise-tolerant encryption scheme for secure communication: An unmanned aerial vehicle application.

    Shafique, Arslan / Mehmood, Abid / Elhadef, Mourad / Khan, Kashif Hesham

    PloS one

    2022  Volume 17, Issue 9, Page(s) e0273661

    Abstract: In the modern era, researchers have focused a great deal of effort on multimedia security and fast processing to address computational processing time difficulties. Due to limited battery capacity and storage, Unmanned Aerial Vehicles (UAVs) must use ... ...

    Abstract In the modern era, researchers have focused a great deal of effort on multimedia security and fast processing to address computational processing time difficulties. Due to limited battery capacity and storage, Unmanned Aerial Vehicles (UAVs) must use energy-efficient processing. In order to overcome the vulnerability of time inefficiency and provide an appropriate degree of security for digital images, this paper proposes a new encryption system based on the bit-plane extraction method, chaos theory, and Discrete Wavelet Transform (DWT). Using confusion and diffusion processes, chaos theory is used to modify image pixels. In contrast, bit-plane extraction and DWT are employed to reduce the processing time required for encryption. Multiple cyberattack analysis, including noise and cropping attacks, are performed by adding random noise to the ciphertext image in order to determine the proposed encryption scheme's resistance to such attacks. In addition, a variety of statistical security analyses, including entropy, contrast, energy, correlation, peak signal-to-noise ratio (PSNR), and mean square error (MSE), are performed to evaluate the security of the proposed encryption system. Moreover, a comparison is made between the statistical security analysis of the proposed encryption scheme and the existing work to demonstrate that the suggested encryption scheme is better to the existing ones.
    MeSH term(s) Computer Security ; Efficiency ; Image Processing, Computer-Assisted ; Multimedia/standards ; Nonlinear Dynamics ; Time Factors ; Unmanned Aerial Devices/standards
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0273661
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  10. Article: Genome Editing and Cardiac Regeneration.

    Bassawon, Rayhaan / Khan, Kashif / Siddique, Ateeque / Shum-Tim, Dominique

    Advances in experimental medicine and biology

    2022  Volume 1396, Page(s) 37–52

    Abstract: Although the field of cardiac regeneration is relatively young, it is progressing rapidly with technological advancements. Genome editing tools are allowing researchers to creatively influence signaling pathways to be able to shed light on them and are ... ...

    Abstract Although the field of cardiac regeneration is relatively young, it is progressing rapidly with technological advancements. Genome editing tools are allowing researchers to creatively influence signaling pathways to be able to shed light on them and are important for addressing certain issues and limitations associated with in vitro and in vivo aspects of cardiac regeneration, such as imaging and immune rejection. In this chapter, the pathways involved in cardiac regeneration will be highlighted, and the role of gene-editing tools in endogenous and exogenous approaches to regenerate injured myocardium is discussed.
    MeSH term(s) Humans ; Gene Editing ; Heart ; Myocardium ; Research Personnel
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-19-5642-3_3
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