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Article: Clinician's approach for spectrum of orbital diseases: An overview.

Khan, Lubna

Journal of family medicine and primary care

2024 Volume 13, Issue 3, Page(s) 851–858

Abstract: Purpose: To study the varied clinical presentation and outcome of management of orbital diseases and to ascertain the concordance of FNAC with histopathology.: Materials and methods: This is a prospective interventional study wherein each patient's ... ...

Abstract	Purpose: To study the varied clinical presentation and outcome of management of orbital diseases and to ascertain the concordance of FNAC with histopathology. Materials and methods: This is a prospective interventional study wherein each patient's clinical presentation was noted. Outcome of management was evaluated based on symptomatic relief, regression of signs, noting any intraoperative or postsurgical complication, recurrence, and cosmetic result in terms of surgical scar. Results: Neoplasia was commonest 33/76; (43.42%), followed by infective and inflammatory conditions 21/76; (27.63% cases), thyroid-associated orbitopathy accounting for 12/76 cases (15.78%), whereas cystic lesions and vascular malformations were 4/76 (5.26%) each. Other disorders constituted a mere 2.65%. Proptosis was the commonest mode of presentation. It was seen in seventy out of seventy-six patients (92.1%). In 86.3% of the cases, there was successful surgical outcome. Of 22 surgically managed cases, recurrence was noted in three cases (13.6%). 90% concordance was seen with histopathology in cases where FNAC was done prior to surgery for diagnosing nature of disease. Conclusions: Majority of orbital and adnexal conditions can be provisionally diagnosed based on imaging; however, an adjunct invasive investigation such as FNAC or biopsy may be required. In the present study, in seven cases (9.2%) FNAC was needed, whereas in two cases (2.63%) biopsy was needed. A definitive diagnosis was confirmed by histopathology in 22 surgically managed cases and by excision biopsy in two. 22/76 (28.94%) of the cases needed surgical treatment, and other cases required conservative or palliative approach.
Language	English
Publishing date	2024-04-04
Publishing country	India
Document type	Journal Article
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_761_23
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Article ; Online: Tubercular granuloma arising from floor of orbit : A rare occurrence.

Khan, Lubna

Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH

2023 Volume 14, Issue 28, Page(s) 150–154

Abstract: Introduction: Tuberculosis of the orbit is a unilateral entity commonly involving the bony wall, periosteum or soft tissue in left orbit. It is a rarity.: Case: A fifty seven years old female presented with a localised mass near inferior orbital ... ...

Abstract	Introduction: Tuberculosis of the orbit is a unilateral entity commonly involving the bony wall, periosteum or soft tissue in left orbit. It is a rarity. Case: A fifty seven years old female presented with a localised mass near inferior orbital margin. Owing to its small size and superficial location in orbit, there was no soft tissue displacement or motility disturbance. Observations: Dissection revealed a localised firm mass attached to periorbita covering the orbital floor. The mass was excised and on histopathological analysis it was found to be composed of multiple granulomas containing abundant Giant cells. Considering such a picture at cellular level, ELISA for tuberculosis was done. Values were suggestive of recent infection. The patient was put on antitubercular multidrug regimen for six months one week after excision of mass, with a follow up of four years, having no recurrence till date. Conclusion: Though orbital tuberculosis is much more common in childhood, it should always be considered in the differential diagnosis of orbital mass in adults also. At times, even in an otherwise healthy individual, tuberculosis might be diagnosed because of an orbital mass. Ophthalmologists should have a high index of suspicion since orbital tuberculosis has been underdiagnosed in the past.
MeSH term(s)	Adult ; Humans ; Female ; Middle Aged ; Antitubercular Agents/therapeutic use ; Diagnosis, Differential ; Granuloma/diagnosis ; Ophthalmologists
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2023-08-23
Publishing country	Nepal
Document type	Case Reports
ZDB-ID	2596436-7
ISSN	2091-0320 ; 2091-0320
ISSN (online)	2091-0320
ISSN	2091-0320
DOI	10.3126/nepjoph.v14i2.36837
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Article: Electrophysiological and Visual Parameter Changes in Retinitis Pigmentosa Patients undergoing Autologous Platelet-Rich Plasma Therapy: A Randomized Control Trial.

Khan, Perwez / Khan, Lubna / Kiran, Kumari Kanchan

Journal of current ophthalmology

2024 Volume 35, Issue 3, Page(s) 267–275

Abstract: Purpose: To assess the efficacy of autologous platelet-rich plasma (PRP) injections in suprachoroidal space and subtenon space in cases of retinitis pigmentosa, which is a genetic disease, leading to gradual loss of vision. Till date, no treatment is ... ...

Abstract	Purpose: To assess the efficacy of autologous platelet-rich plasma (PRP) injections in suprachoroidal space and subtenon space in cases of retinitis pigmentosa, which is a genetic disease, leading to gradual loss of vision. Till date, no treatment is available. Methods: Seventy-eight eyes of 39 patients of retinitis pigmentosa having visual acuity ranging from reading of Early Treatment Diabetic Retinopathy Study (ETDRS) chart from 1 m onward to patients who were not able to read the ETDRS chart but whose visual acuity ranged from finger count close to face to <1 m were included in the study. The left and right eyes of each patient were randomized as the intervention eye and control eye. 0.2 mL of autologous PRP was injected in suprachoroidal space and 0.5 mL of PRP was injected in subtenon space of the intervention eye taking aseptic precautions. Injections were repeated at 15-day intervals up to 3 injections. Results: Majority of patients were in the age group of 18-30 years (20 cases) followed by 31-45 years (13 cases) and more than 45 years (6 cases). Intervention eyes showed a statistically significant improvement in visual acuity and multifocal electroretinography (mfERG). Improvement was noted in amplitude density latency and in ring ratio of mfERG. There was a significant improvement in best-corrected visual acuity (BCVA). However, no improvement in mfERG or BCVA was observed in the control group. Conclusions: Gene therapy may be the ultimate cure for retinitis pigmentosa, but it is unaffordable for many patients due to its high cost. PRP may be recognized as a modality to improve vision and stop further deterioration, especially in cases where functional vision is preserved. Negligible treatment costs and affordability will give power to economically disadvantaged patients.
Language	English
Publishing date	2024-03-29
Publishing country	India
Document type	Journal Article
ISSN	2452-2325
ISSN	2452-2325
DOI	10.4103/joco.joco_216_22
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Article ; Online: Modified small-incision cataract surgery for combined extraction - A comparative study of two techniques.

Khan, Lubna / Verma, Sonam

Indian journal of ophthalmology

2022 Volume 70, Issue 11, Page(s) 3918–3922

Abstract: Purpose: To explore straight incision technique in terms of efficacy for intraocular pressure (IOP) lowering by small-incision cataract surgery (SICS) trab versus modified "frown" incision with triangular scleral flap technique.: Methods: This study ... ...

Abstract	Purpose: To explore straight incision technique in terms of efficacy for intraocular pressure (IOP) lowering by small-incision cataract surgery (SICS) trab versus modified "frown" incision with triangular scleral flap technique. Methods: This study was done at a tertiary health center. It included 44 eyes diagnosed with cataract and coexisting primary glaucoma that underwent SICS with trabeculectomy using modified "frown" incision with triangular scleral flap technique and straight incision in group A (n = 22) and B (n = 22), respectively. Postoperative evaluation was done at first postoperative day, then at the end of first week, third week, and 6 weeks; at the end of third month and finally at the end of sixth months. Data were entered and analyzed via Microsoft Excel sheet and SPSS software using Mann-Whitney U test for averages and Chi-square test for categorical values. Results: Mean preoperative IOP in groups A and B were 38.6 and 29.1 mm Hg respectively, by applanation tonometry. After 6-month follow-up, mean of difference in IOP (preoperative - postoperative) for group A was 20.8 ± 8.3 mm Hg and that for group B was 17.2 ± 13.5 mm Hg. Conclusion: Capacity of IOP reduction of both techniques was found to be comparable and did not show much difference up to the end of 6 months. Mastering technique of group A (modified "frown" incision with triangular scleral flap technique) requires more expertise; the simpler straight incision technique provided in group B may be effectively used by the novice and current era Ophthalmologists to combat glaucoma coexistant with cataract.
MeSH term(s)	Humans ; Visual Acuity ; Cataract Extraction/methods ; Trabeculectomy/methods ; Intraocular Pressure ; Glaucoma/surgery ; Cataract/complications ; Surgical Wound/complications ; Surgical Wound/surgery ; Treatment Outcome ; Retrospective Studies ; Follow-Up Studies
Language	English
Publishing date	2022-10-29
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_1622_22
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Article: Monotherapy with topical Natamycin to treat

Khan, Lubna / Keche, Archana Y / Kumar, Aseem

Oman journal of ophthalmology

2023 Volume 16, Issue 2, Page(s) 355–358

Abstract: Keratomycosis is common in Indian subcontinent. Diagnosis of the causal agent and successful management is a challenge for the clinician. ...

Abstract	Keratomycosis is common in Indian subcontinent. Diagnosis of the causal agent and successful management is a challenge for the clinician.
Language	English
Publishing date	2023-06-27
Publishing country	India
Document type	Case Reports
ZDB-ID	2484272-2
ISSN	0974-7842 ; 0974-620X
ISSN (online)	0974-7842
ISSN	0974-620X
DOI	10.4103/ojo.ojo_130_22
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Article: Modulation of Apoptotic and Akt/PI3K/mTOR pathways to target Glioblastoma Cells using synthetic compound PGEA-AN.

Saad, Shafea / Hanif, Farina / Simjee, Shabana Usman / Faizi, Shaheen / Khan, Lubna / Ashfaque, Ambreen

JPMA. The Journal of the Pakistan Medical Association

2024 Volume 74, Issue 1 (Supple-2), Page(s) S39–S46

Abstract: Objectives: To investigate the anticancer potential of a novel synthetic derivative of a naturally occurring diterpenoid against glioblastoma.: Methods: The in vitro study was conducted at the Ojha Campus of Dow University of Health Sciences, Karachi, ...

Abstract	Objectives: To investigate the anticancer potential of a novel synthetic derivative of a naturally occurring diterpenoid against glioblastoma. Methods: The in vitro study was conducted at the Ojha Campus of Dow University of Health Sciences, Karachi, from February to December 2021, and comprised U87 cells. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to determine the growth inhibitory effect of 16(R and S) - phenylamino-cleroda3, 13(14) Zdiene- 15, 16 olide and standard drug temozolomide against glioblastoma cells, and half-maximal inhibitory concentration was calculated. Microscopy and immunocytochemistry were used to investigate apoptotic morphology and active caspase-3 and B-cell lymphoma 2 (Bcl-2) expression. Quantitative real time polymerase chain reaction was used to investigate the expression of proliferation markers. Data was analysed using SPSS 21. Results: Both the synthetic derivative and the standard drug significantly inhibited growth of U87 cells (p<0.001) with half-maximal inhibitory concentration of 19μM and 185μM, respectively. Apoptotic morphology and upregulation of active caspase-3 protein expression was observed in cells treated with half-maximal inhibitory concentration doses of both the synthetic derivative (p<0.05) and the standard drug (p<0.001), and Bcl-2 was downregulated in both the synthetic derivative (p<0.01) and the standard drug (p=0.05). However, no significant difference was observed in the expression of proliferation markers (p>0.05). Conclusions: The synthetic diterpene derivative PGEA-AN showed growth inhibitory actiity against glioblastoma.
MeSH term(s)	Humans ; Apoptosis ; Caspase 3/metabolism ; Cell Proliferation ; Diterpenes/pharmacology ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Cell Line, Tumor
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; Diterpenes ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Proto-Oncogene Proteins c-bcl-2 ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2024-02-22
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA-DUHS-S09
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Article ; Online: Recent advancements in ion-pair receptors: A critical review.

Wagay, Shafieq Ahmad / Khan, Lubna / Ali, Rashid

Chemistry, an Asian journal

2022

Abstract: Over the past two decades, non-covalent chemistry has introduced various promising artificial receptors and revolutionizes the host-guest chemistry. These versatile receptors have particularly been entertained in sensing and recognizing of diverse ... ...

Abstract	Over the past two decades, non-covalent chemistry has introduced various promising artificial receptors and revolutionizes the host-guest chemistry. These versatile receptors have particularly been entertained in sensing and recognizing of diverse neutral molecules and/or ionic entities (e.g. anions, cations and ion-pair) of particular interest. Notably, the supramolecular chemistry had given birth to a plethora of important molecules, explored in chemical, biological, environmental, & pharmacological world to resolve the critical issues related to the human health while keeping the environmental concerns in mind. Amongst the various types of supramolecular monotopic receptors (anions, cations, & neutral molecules), the heteroditopic receptors (ion-pair receptors) consisting of distinct binding sites in one system for both cation as well anion, have gained much interest from the scientific community in recent past because of their unique binding abilities. Interestingly, these promising artificial receptors have shown potential applications in sensing, recognition, transport & extraction processes besides their uses in salt/waste purification. Bearing the importance of these systems in mind, we indented to report the recent developments in ion-pair chemistry. Herein, we divided the whole document into three main sections; first one describes the introduction and history of the ion-pairs receptors. The second portion highlights, synthesis & applications of ion-pair receptors in sensing, recognition, molecular machines, photoswitching behaviour, extraction and transport properties. Whereas, the last part of this manuscript discusses the concluding remarks as well as feature prospects of ion-pair receptors. We hope that this manuscript will be very helpful to the stimulating researchers around the globe to find out the hidden opportunities in this and allied areas.
Language	English
Publishing date	2022-11-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2233006-9
ISSN	1861-471X ; 1861-4728
ISSN (online)	1861-471X
ISSN	1861-4728
DOI	10.1002/asia.202201080
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Article: The International System for Reporting Serous Fluid Cytopathology: An Institutional Experience on its Implication and Assessment of Risk of Malignancy in Effusion Cytology.

Kala, Chayanika / Kala, Sanjay / Singh, Anurag / Jauhari, R K / Bajpai, Ashutosh / Khan, Lubna

Journal of cytology

2023 Volume 40, Issue 4, Page(s) 159–164

Abstract: Background: The "international system for reporting serous fluid cytopathology"(TIS) consists of five diagnostic categories: nondiagnostic (ND), negative for malignancy (NFM), atypia of undetermined significance (AUS), suspicious for malignancy (SFM), ... ...

Abstract	Background: The "international system for reporting serous fluid cytopathology"(TIS) consists of five diagnostic categories: nondiagnostic (ND), negative for malignancy (NFM), atypia of undetermined significance (AUS), suspicious for malignancy (SFM), and malignant (MAL). The study was conducted to reclassify effusion cytology samples according to the newly proposed TIS to calculate the risk of malignancy (ROM) for each category and to conduct performance analysis. Materials and methods: The study was a retrospective observational study conducted at a tertiary care institution in North India. Clinical data of the cases from June 2013 to July 2021 were retrieved and the cases were reviewed by two cytopathologists. All cases were reclassified according to the proposed TIS system into five categories. Results: A total of 2318 patients were included in the study over a time span of 8 years, and 1614 (69.6%) cases of pleural effusion cytology, 612 (26.4%) cases of peritoneal effusion cytology, and 92 (3.9%) cases of pericardial effusion cytology were included. All effusion cytology smears were recategorized as per TIS guidelines into ND, NFM, AUS, SFM, and MAL with 4 (0.17%), 1756 (75.75%), 12 (0.51%), 57 (2.46%), and 489 (21.11%) cases, respectively, and ROM was 25%, 17.9%, 66.7%, 75.4%, and 96.5%, respectively, for the categories. Conclusion: Besides being a simple, easy, and user-friendly system, TIS has the benefit of risk stratification and ROM for each category. The TIS system proposed a tiered scheme, which places the effusion cytology into well-defined categories, and therefore has lesser chances of false-positive and false-negative cases.
Language	English
Publishing date	2023-10-16
Publishing country	India
Document type	Journal Article
ZDB-ID	645018-0
ISSN	0970-9371
ISSN	0970-9371
DOI	10.4103/joc.joc_111_22
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Article ; Online: Comparative analysis of inter-observer variability between conventional reporting system of salivary gland cytology with Milan system for reporting salivary gland cytopathology.

Khan, Lubna / Sudarsini, Saheeta / Mishra, Vandana / Dwivedi, Shobha / Kala, Chayanika

Diagnostic cytopathology

2022 Volume 50, Issue 6, Page(s) 295–299

Abstract: Background: Interpretation of salivary gland cytology often leads to inter-observer variability due to heterogenous and complex nature of these lesions. This creates a dilemma regarding their management by clinicians. Proposal of a universal system of ... ...

Abstract	Background: Interpretation of salivary gland cytology often leads to inter-observer variability due to heterogenous and complex nature of these lesions. This creates a dilemma regarding their management by clinicians. Proposal of a universal system of reporting of salivary gland lesions leading to agreement in diagnosis and better understanding among clinicians was the need of the hour. Hence Milan system for reporting salivary gland cytopathology (MSRSGC) was proposed in 2015 by the American society of cytopathology and the International Academy of Cytology. Present study was undertaken to assess inter-observer variability in reporting by conventional system and MSRSGC. Material and methods: One hundred and seventy-six cases of salivary gland lesions were subjected to fine needle aspiration cytology. Cases were interpreted by two experienced cytopathologists and were reported by both conventional system and MSRSGC. Histopathological correlation was available in 81 cases. Results: Inter-observer variability was noted in six cases reported by conventional system and in two cases by MSRSGC. Moreover three cases out six cases had different management protocols while both cases of Milan system for reporting salivary gland cytology had same management. Thirteen cases diagnosed by Milan system and 17 cases diagnosed by conventional system were discordant with histopathological diagnosis. Conclusion: Milan system for reporting salivary gland cytology has an edge over conventional system of reporting as it provides better agreement among cytopathologists and better management guidelines for clinicians with the added advantage of assessment of risk of malignancy.
MeSH term(s)	Cytodiagnosis/methods ; Humans ; Observer Variation ; Retrospective Studies ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/pathology ; Salivary Glands/pathology
Language	English
Publishing date	2022-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.24951
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Article: Medroxyprogesterone to treat corneal thinning postcurvularia keratitis.

Khan, Lubna / Batavia, Ekta

Oman journal of ophthalmology

2019 Volume 12, Issue 3, Page(s) 194–196

Abstract: Keratitis of varied etiology is not uncommon in the Indian subcontinent. This case is one such an instance of keratitis caused by dematiaceous fungus in an urban dweller not engaged in farming or any other soil/earth-related work. Although healing of the ...

Abstract	Keratitis of varied etiology is not uncommon in the Indian subcontinent. This case is one such an instance of keratitis caused by dematiaceous fungus in an urban dweller not engaged in farming or any other soil/earth-related work. Although healing of the ulcer occurred in the usual course, thinning persisted for a fortnight. This case highlights medroxyprogesterone acetate used topically to achieve collagen synthesis, thereby affect repair of the thinned cornea.
Language	English
Publishing date	2019-10-11
Publishing country	India
Document type	Case Reports
ZDB-ID	2484272-2
ISSN	0974-7842 ; 0974-620X
ISSN (online)	0974-7842
ISSN	0974-620X
DOI	10.4103/ojo.OJO_228_2018
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