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  1. Article ; Online: Cerebral sympatholysis: experiments on in vivo cerebrovascular regulation and ex vivo cerebral vasomotor control.

    Luchkanych, Adam M S / Morse, Cameron J / Boyes, Natasha G / Khan, M Rafique / Marshall, Rory A / Morton, Jude S / Tomczak, Corey R / Olver, T Dylan

    American journal of physiology. Heart and circulatory physiology

    2024  Volume 326, Issue 5, Page(s) H1105–H1116

    Abstract: Whether cerebral sympathetic-mediated vasomotor control can be modulated by local brain activity remains unknown. This study tested the hypothesis that the application or removal of a cognitive task during a cold pressor test (CPT) would attenuate and ... ...

    Abstract Whether cerebral sympathetic-mediated vasomotor control can be modulated by local brain activity remains unknown. This study tested the hypothesis that the application or removal of a cognitive task during a cold pressor test (CPT) would attenuate and restore decreases in cerebrovascular conductance (CVC), respectively. Middle cerebral artery blood velocity (transcranial Doppler) and mean arterial pressure (finger photoplethysmography) were examined in healthy adults (
    MeSH term(s) Adult ; Male ; Female ; Humans ; Animals ; Swine ; Sympatholytics ; Blood Flow Velocity/physiology ; Adenosine Triphosphate ; Adrenergic Agents ; Adenosine/pharmacology ; Cerebrovascular Circulation/physiology ; Blood Pressure/physiology ; Cold Temperature
    Chemical Substances Sympatholytics ; Adenosine Triphosphate (8L70Q75FXE) ; Adrenergic Agents ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00714.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Elevated sympathetic-mediated vasoconstriction at rest but intact functional sympatholysis during exercise in heart failure with reduced ejection fraction.

    Boyes, Natasha G / Khan, M Rafique / Luchkanych, Adam M S / Marshall, Rory A / Bare, Idris / Haddad, Tony / Abdalla, Sherif / Al-Mouaiad Al-Azem, Ibrahim / Morse, Cameron J / Zhai, Alexander / Haddad, Haissam / Marciniuk, Darcy D / Olver, T Dylan / Tomczak, Corey R

    American journal of physiology. Heart and circulatory physiology

    2024  

    Abstract: Background: Patients with heart failure with reduced ejection fraction (HFrEF) have exaggerated sympathoexcitation and impaired peripheral vascular conductance. Evidence demonstrating consequent impaired functional sympatholysis is limited in HFrEF. ... ...

    Abstract Background: Patients with heart failure with reduced ejection fraction (HFrEF) have exaggerated sympathoexcitation and impaired peripheral vascular conductance. Evidence demonstrating consequent impaired functional sympatholysis is limited in HFrEF. This study aimed to determine the magnitude of reduced limb vascular conductance during sympathoexcitation and whether functional sympatholysis would abolish such reductions in HFrEF.
    Methods: Twenty patients with HFrEF and 22 age-matched controls performed the cold pressor test (left foot 2-min in -0.5[1] °C water) alone (CPT) and with right handgrip exercise (EX+CPT). Right forearm vascular conductance (FVC), forearm blood flow (FBF), and mean arterial pressure (MAP) were measured.
    Results: Patients with HFrEF had greater decreases in %ΔFVC and %ΔFBF during CPT (both
    Conclusions: Acute sympathoexcitation caused exaggerated peripheral vasoconstriction and reduced peripheral blood flow in patients with HFrEF. Handgrip exercise abolished sympathoexcitatory-mediated peripheral vasoconstriction and normalized peripheral blood flow in patients with HFrEF. These novel data reveal intact functional sympatholysis in the upper limb and suggest exercise-mediated, local control of blood flow is preserved when cardiac limitations that are cardinal to HFrEF are evaded with dynamic handgrip exercise.
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00130.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Muscle metaboreflex control of left ventricular systolic function in heart failure with reduced ejection fraction.

    Boyes, Natasha G / Nelson, Michael D / Palmero Canton, Alberto / Luchkanych, Adam M S / Khan, M Rafique / Bare, Idris / Haddad, Tony / Abdalla, Sherif / Marshall, Rory A / Morse, Cameron J / Zhai, Alexander / Haddad, Haissam / Marciniuk, Darcy D / Karjala, Geoffrey / Olver, T Dylan / Tomczak, Corey R

    Journal of applied physiology (Bethesda, Md. : 1985)

    2023  Volume 135, Issue 2, Page(s) 279–291

    Abstract: Heart failure with reduced ejection fraction (HFrEF) exhibits exaggerated sympathoexcitation and altered cardiac and vascular responses to muscle metaboreflex activation (MMA). However, left ventricular (LV) responses to MMA are not well studied in ... ...

    Abstract Heart failure with reduced ejection fraction (HFrEF) exhibits exaggerated sympathoexcitation and altered cardiac and vascular responses to muscle metaboreflex activation (MMA). However, left ventricular (LV) responses to MMA are not well studied in patients with HFrEF. The purpose of this study was to examine LV function during MMA using cardiac magnetic resonance imaging (MRI) in patients with HFrEF. Thirteen patients with HFrEF and 18 healthy age-matched controls underwent cardiac MRI during rest and MMA. MMA protocol included 6 min of isometric handgrip exercise followed by 6-min of brachial postexercise circulatory occlusion. LV stroke volume index (SVi), end-systolic volume index (ESVi), end-diastolic volume index (EDVi), and global longitudinal strain (GLS) were measured by two- and four-chamber cine images. Volumes were indexed to body surface area. Heart rate (via ECG) and brachial mean arterial pressure (MAP) were recorded. Cardiac output and total peripheral resistance (TPR) were calculated. SVi decreased during MMA in HFrEF (
    MeSH term(s) Humans ; Heart Failure ; Stroke Volume/physiology ; Reflex/physiology ; Hand Strength ; Arterial Pressure/physiology ; Muscle, Skeletal/physiology ; Ventricular Function, Left ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00074.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.249: Show issues Location:
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