Article ; Online: Health outcomes associated with patterns of substance use disorders among patients with type 2 diabetes and hypertension: Electronic health record findings.
2022 Volume 17, Issue 1, Page(s) 43–47
Abstract: Aims: To identify substance use disorder (SUD) patterns and their association with T2DM health outcomes among patients with type 2 diabetes and hypertension.: Methods: We used latent class analysis on electronic health records from the MetroHealth ... ...
Abstract | Aims: To identify substance use disorder (SUD) patterns and their association with T2DM health outcomes among patients with type 2 diabetes and hypertension. Methods: We used latent class analysis on electronic health records from the MetroHealth System (Cleveland, Ohio) to obtain the target SUD groups: i) only tobacco (TUD), ii) tobacco and alcohol (TAUD), and iii) tobacco, alcohol, and at least one more substance (PSUD). A matching program with Mahalanobis distance within propensity score calipers created the matched control groups: no SUD (NSUD) for TUD and TUD for the other two SUD groups. The numbers of participants for the target-control groups were 8009 (TUD), 1672 (TAUD), and 642 (PSUD). Results: TUD was significantly associated with T2DM complications. Compared to TUD, the TAUD group showed a significantly higher likelihood for all-cause mortality (adjusted odds ratio (aOR) = 1.46) but not for any of the T2DM complications. Compared to TUD, the PSUD group experienced a significantly higher risk for cerebrovascular accident (CVA) (aOR = 2.19), diabetic neuropathy (aOR = 1.76), myocardial infarction (MI) (aOR = 1.76), and all-cause mortality (aOR = 1.66). Conclusions: The findings of increased risk associated with PSUDs may provide insights for better management of patients with T2DM and hypertension co-occurrence. |
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MeSH term(s) | Humans ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/complications ; Tobacco Use Disorder/complications ; Electronic Health Records ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/complications ; Hypertension/diagnosis ; Hypertension/epidemiology ; Outcome Assessment, Health Care |
Language | English |
Publishing date | 2022-11-25 |
Publishing country | England |
Document type | Journal Article ; Research Support, N.I.H., Extramural |
ZDB-ID | 2273997-X |
ISSN | 1878-0210 ; 1751-9918 |
ISSN (online) | 1878-0210 |
ISSN | 1751-9918 |
DOI | 10.1016/j.pcd.2022.11.006 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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