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  1. Article ; Online: Anticoagulation in venous thromboembolism for the general physician.

    Stark, Katherine / Mathur, Abhinav / Khan, Mohammed M

    The journal of the Royal College of Physicians of Edinburgh

    2024  Volume 54, Issue 1, Page(s) 74–83

    Abstract: Venous thromboembolism (VTE) is frequently encountered across various specialties. The management of VTE has become more nuanced, requiring consideration of several factors when deciding on the choice and duration of anticoagulation. This evidence-based ... ...

    Abstract Venous thromboembolism (VTE) is frequently encountered across various specialties. The management of VTE has become more nuanced, requiring consideration of several factors when deciding on the choice and duration of anticoagulation. This evidence-based review article summarises the current practice and evidence behind anticoagulation in VTE, incorporating national and international guidelines. Factors influencing decision-making around the choice and duration of anticoagulation, along with special circumstances such as cancer and antiphospholipid syndrome, are discussed. The clinical utility of thrombophilia screening is also addressed.
    MeSH term(s) Humans ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control ; Anticoagulants/therapeutic use ; Health Services ; Physicians ; Risk Factors
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2866363-9
    ISSN 2042-8189 ; 0953-0932
    ISSN (online) 2042-8189
    ISSN 0953-0932
    DOI 10.1177/14782715241241834
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  2. Article ; Online: Mild FVII deficiency - Correlation between genotype and phenotype.

    Fraser, Craig / Watson, Henry G / Khan, Mohammed M

    Haemophilia : the official journal of the World Federation of Hemophilia

    2023  Volume 29, Issue 4, Page(s) 1160–1162

    MeSH term(s) Humans ; Genotype ; Phenotype ; Factor VII Deficiency/genetics ; Factor VII/genetics
    Chemical Substances Factor VII (9001-25-6)
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14817
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  3. Article: An

    Bagchi, Anandamoy / Dolker, Tundup / Talukdar, Anindita / Sowmya, Kona / Khan, Mohammed M / Raj, Urvashi

    Journal of pharmacy & bioallied sciences

    2023  Volume 15, Issue Suppl 1, Page(s) S192–S195

    Abstract: Background: Many generations of esthetic materials have been introduced in the market, the most popular being the composites. Bioactive restorative materials are a recent development in restorative dentistry. However, the main cause of secondary caries ... ...

    Abstract Background: Many generations of esthetic materials have been introduced in the market, the most popular being the composites. Bioactive restorative materials are a recent development in restorative dentistry. However, the main cause of secondary caries is the development of bacterial plaque on these restorations. Current
    Materials and methods: Only a single parameter was assessed in this study, which was the bacterial colonies on each of the material blocks that were confined in the same experimental conditions. For this assessment, three composite materials were used that were made into blocks of 10 each. "Beautifil Flow Plus X" and "ACTIVA BioACTIVE" were used as the interventional groups, while "Filtek Z250 XT" was used as the control.
    Results: When compared to other groups, ACTIVA BioACTIVE exhibited the highest quantity of dead bacteria on the material surface. There was significant variance among the three composites in the number of live and dead bacterial colonies.
    Conclusion: The highest antibacterial efficacy among the evaluated materials allows for a conclusion.
    Language English
    Publishing date 2023-07-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_451_22
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  4. Article ; Online: Outcomes in patients with nontriple antiphospholipid syndrome (APS) anticoagulated with rivaroxaban.

    Htut, Thura Win / Milne, Denis / Khan, Mohammed M / Watson, Henry G

    International journal of laboratory hematology

    2021  Volume 43, Issue 5, Page(s) e252–e253

    MeSH term(s) Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/drug therapy ; Blood Coagulation/drug effects ; Factor Xa Inhibitors/therapeutic use ; Humans ; Retrospective Studies ; Rivaroxaban/therapeutic use ; Thrombosis/blood ; Thrombosis/drug therapy ; Thrombosis/etiology ; Treatment Outcome
    Chemical Substances Factor Xa Inhibitors ; Rivaroxaban (9NDF7JZ4M3)
    Language English
    Publishing date 2021-01-20
    Publishing country England
    Document type Letter
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13464
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  5. Article ; Online: Clinical observations in patients with cerebral venous sinus thrombosis.

    Htut, Thura W / Watson, Henry G / Mackay, Graham / Khan, Mohammed M

    British journal of haematology

    2021  Volume 194, Issue 5, Page(s) 921–922

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anticoagulants/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Sinus Thrombosis, Intracranial/diagnosis ; Sinus Thrombosis, Intracranial/drug therapy ; Sinus Thrombosis, Intracranial/pathology ; Treatment Outcome ; Young Adult
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-06-16
    Publishing country England
    Document type Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17553
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  6. Article: Milling Microchannels in Monel 400 Alloy by Wire EDM: An Experimental Analysis.

    Saleh, Mustafa / Anwar, Saqib / El-Tamimi, Abdualziz / Khan Mohammed, Muneer / Ahmad, Shafiq

    Micromachines

    2020  Volume 11, Issue 5

    Abstract: This paper presents the results of an investigation on the capacity of wire electrical discharge machining (WEDM) to produce microchannels in the Nickel-based alloy, Monel 400. The main objective of the current study is to produce microchannels with ... ...

    Abstract This paper presents the results of an investigation on the capacity of wire electrical discharge machining (WEDM) to produce microchannels in the Nickel-based alloy, Monel 400. The main objective of the current study is to produce microchannels with desired/target geometry and acceptable surface quality. Square cross-sectional microchannels with dimensions of 500 × 500 µm were investigated. Experiments were conducted based on the one-factor-at-a-time approach for the key input WEDM process parameters, namely pulse-on time (TON), pulse-off time (TOFF), average gap voltage (VGAP), wire feed (WF), and dielectric flow rate (FR). Dimensional accuracy, machining speed, surface roughness, surface morphology, microhardness, and microstructure were analyzed to evaluate the microchannels. The minimum errors of 6% and 3% were observed in the width and depth of the microchannels, respectively. Furthermore, microchannels with enhanced surface integrity could be produced exhibiting smooth surface morphology and shallow recast layer (~0-2.55 µm).
    Language English
    Publishing date 2020-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi11050469
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  7. Book ; Online: Ternary oxides of $\textit{s}$- and $\textit{p}$-block metals for photocatalytic solar-to-hydrogen conversion

    Gelin, Simon / Kirchner-Hall, Nicole E. / Katzbaer, Rowan R. / Theibault, Monica J. / Xiong, Yihuang / Zhao, Wayne / Khan, Mohammed M. / Andrewlavage, Eric / Orbe, Paul / Baksa, Steven M. / Cococcioni, Matteo / Timrov, Iurii / Campbell, Quinn / Abruña, Héctor / Schaak, Raymond E. / Dabo, Ismaila

    2023  

    Abstract: Oxides containing metals or metalloids from the {\it p}-block of the periodic table ({\it e.g.}, In, Sn, Sb, Pb, Bi) are of technological interest as transparent conductors and light absorbers for solar energy conversion due to the tunability of their ... ...

    Abstract Oxides containing metals or metalloids from the {\it p}-block of the periodic table ({\it e.g.}, In, Sn, Sb, Pb, Bi) are of technological interest as transparent conductors and light absorbers for solar energy conversion due to the tunability of their electronic conductivity and optical absorption. Comparatively, these oxides have found limited applications in hydrogen photoelectrolysis primarily due to their high electronegativity, which impedes electron transfer for reducing protons into hydrogen. We have shown recently that inserting {\it s}-block cations into {\it p}-block metal oxides is effective at lowering electronegativities while affording further control of band gaps. Here, we explain the origins of this dual tunability by demonstrating the mediator role of {\it s}-block cations in modulating orbital hybridization while not contributing to frontier electronic states. From this result, we carry out a comprehensive computational study of 109 ternary oxides of {\it s}- and {\it p}-block metal elements as candidate photocatalysts for solar hydrogen generation. We downselect the most desirable materials using band gaps and band edges obtained from Hubbard-corrected density-functional theory with Hubbard parameters computed entirely from first principles, evaluate the stability of these oxides in aqueous conditions, and characterize experimentally four of the remaining materials, synthesized with high phase uniformity, to validate and further develop the computational models. We thus propose nine oxide semiconductors, including CsIn$_3$O$_5$, Sr$_2$In$_2$O$_5$, and KSbO$_2$ which, to the extent of our literature review, have not been previously considered as water-splitting photocatalysts.

    Comment: 14 pages, 5 figures, 1 supplemental material
    Keywords Condensed Matter - Materials Science
    Subject code 540
    Publishing date 2023-03-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Heparin-induced thrombocytopenia and the utility of the 4Ts score in the Intensive Care Unit.

    Khan, Mohammed M / Noble, David W / Watson, Henry G

    British journal of haematology

    2011  Volume 152, Issue 5, Page(s) 672–674

    MeSH term(s) Anticoagulants/adverse effects ; Critical Care/methods ; Heparin/adverse effects ; Humans ; Intensive Care Units ; Retrospective Studies ; Severity of Illness Index ; Thrombocytopenia/chemically induced
    Chemical Substances Anticoagulants ; Heparin (9005-49-6)
    Language English
    Publishing date 2011-03
    Publishing country England
    Document type Evaluation Studies ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/j.1365-2141.2010.08436.x
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  9. Article: Radiation enhanced B-Number

    Jiang, Fenghui / Qi, Haiying / de Ris, John L / Khan, Mohammed M

    Combustion and Flame. 2013 Aug., v. 160, no. 8

    2013  

    Abstract: Radiative heat transfer plays a crucial role in most fire hazard related combustion processes. The existing classic and modified mass transfer B-Numbers have deficiencies for some burning cases of fires because they do not involve external radiation and/ ... ...

    Abstract Radiative heat transfer plays a crucial role in most fire hazard related combustion processes. The existing classic and modified mass transfer B-Numbers have deficiencies for some burning cases of fires because they do not involve external radiation and/or assume flame transparent to thermal radiation. This study extended the concept of the mass transfer B-Number using the one-dimensional steady-state diffusion flame model. An analytical expression of the universal mass transfer B-Number BR was derived, which applies to semi-transparent flames with external radiation. Compared with the classic mass transfer B-Number, in the numerator denoting the net heat generated and held by the combustion system, BR has an additional term that represents radiative heat which is being held and transferred within the semi-transparent flame; as well as in the denominator denoting the convective heat needing for maintaining the combustion, the contribution from the radiative heat is deducted from the total heat required for vaporizing a unit mass of fuel at the fuel surface. BR increases as external radiation and/or ambient oxygen concentration raise. In order to examine its physical significance, new parameters were defined and illustrated, such as the mass transfer equivalent absorption coefficient, specific radiant heat feedback and radiation factor, that demonstrate interactions of heat and mass transfers and radiative absorption and emission within inhomogeneous flames. Effects of the external radiation and ambient oxygen concentration on these parameters were also evaluated. Increases in the radiation factor as the ambient oxygen concentration rises theoretically validated enhanced radiative heat transfer in rich oxygen combustion.
    Keywords absorption ; burning ; combustion ; fire hazard ; fires ; fuels ; heat transfer ; mass transfer ; models ; oxygen ; thermal radiation
    Language English
    Dates of publication 2013-08
    Size p. 1510-1518.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 2000795-4
    ISSN 1556-2921 ; 0010-2180
    ISSN (online) 1556-2921
    ISSN 0010-2180
    DOI 10.1016/j.combustflame.2013.02.025
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  10. Article ; Online: Sunitinib-induced severe hypothyroidism with cardiac compromise.

    Collinson, Fiona J / Vasudev, Naveen S / Berkin, Liz / Khan, Mohammed M / Selby, Peter J / Brown, Janet E

    Medical oncology (Northwood, London, England)

    2010  Volume 28 Suppl 1, Page(s) S699–701

    Abstract: Tyrosine kinase inhibitors (TKI) are an increasingly used class of anti-cancer agent. Sunitinib (sutent(®), Pfizer™, New York) is standard first-line therapy for patients with metastatic renal cancer. It is associated with a number of toxicities, ... ...

    Abstract Tyrosine kinase inhibitors (TKI) are an increasingly used class of anti-cancer agent. Sunitinib (sutent(®), Pfizer™, New York) is standard first-line therapy for patients with metastatic renal cancer. It is associated with a number of toxicities, including thyroid dysfunction. We present a case of sunitinib-induced severe hypothyroidism resulting in cardiac compromise. The case highlights the importance of interval thyroid function monitoring for patients on drugs, such as sunitinib and other TKIs.
    MeSH term(s) Heart Diseases/chemically induced ; Heart Diseases/diagnosis ; Humans ; Hypothyroidism/chemically induced ; Hypothyroidism/diagnosis ; Indoles/adverse effects ; Male ; Middle Aged ; Pyrroles/adverse effects ; Severity of Illness Index ; Sunitinib
    Chemical Substances Indoles ; Pyrroles ; Sunitinib (V99T50803M)
    Language English
    Publishing date 2010-11-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-010-9757-z
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