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  1. Article ; Online: Retraction: Influence of chemical composition on the amount of second phases precipitates and transformation temperatures of TiNiPdCu shape memory alloys prepared through novel powder metallurgy route.

    Hussain, Abid / Khan, Afzal / Khan, Muhammad Imran / Rehman, Saif Ur

    RSC advances

    2024  Volume 14, Issue 22, Page(s) 15742

    Abstract: This retracts the article DOI: 10.1039/D3RA05513B.]. ...

    Abstract [This retracts the article DOI: 10.1039/D3RA05513B.].
    Language English
    Publishing date 2024-05-15
    Publishing country England
    Document type Retraction of Publication
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra90054e
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  2. Article: Carveol mitigates the development of the morphine anti-nociceptive tolerance, physical dependence, and conditioned place preference in mice.

    Badshah, Ismail / Qazi, Neelum Gul / Anwar, Maira / Shaukat, Bushra / Khan, Muhammad Imran / Murtaza, Babar

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27809

    Abstract: Emergence of analgesic tolerance and dependence to morphine is frequently the limiting factor in the use of this agent in the management of pain. Hence, this study aimed to investigate the beneficial effects of the natural compound carveol (CV) against ... ...

    Abstract Emergence of analgesic tolerance and dependence to morphine is frequently the limiting factor in the use of this agent in the management of pain. Hence, this study aimed to investigate the beneficial effects of the natural compound carveol (CV) against morphine antinociceptive tolerance, dependence and conditioned place preference (CPP) in mice. Behavioural paradigms included hot plate and tail-flick (for tolerance), observation of withdrawal signs (for dependence) while biochemical tests involved the assays for mRNA expression, nitrite levels, antioxidants, and immunohistochemistry studies. Behavioural tests indicated that treatment with CV significantly attenuated the morphine analgesic tolerance, physical dependence and CPP in mice. It was observed during biochemical analysis that CV-treated animals exhibited reduced mRNA expression of inducible nitric oxide synthase (iNOS) and NR2B (an NMDA subtype). In addition, decreased levels of nitrite were observed in mouse hippocampus following CV treatment than morphine administration only. Further, CV enhanced the neuronal innate antioxidants including Glutathione-S-Transferase (GST), glutathione (GSH) and catalase (CAT), while curtailed lipid peroxidase (LPO) levels in mice brain tissues. Moreover, CV exerted significant anti-inflammatory effects as evidenced by reduced expression of TNF-
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27809
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  3. Article: Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs.

    Malik, Sidra / Saeed, Saira / Saleem, Ammara / Khan, Muhammad Imran / Khan, Aslam / Akhtar, Muhammad Furqan

    Frontiers in endocrinology

    2024  Volume 14, Page(s) 1294406

    Abstract: The most common cause of infertility and metabolic problems among women of reproductive age is polycystic ovary syndrome (PCOS), a multifaceted disorder. It is an endocrine disorder that occurs in approximately one in seven women. Among these PCOS ... ...

    Abstract The most common cause of infertility and metabolic problems among women of reproductive age is polycystic ovary syndrome (PCOS), a multifaceted disorder. It is an endocrine disorder that occurs in approximately one in seven women. Among these PCOS patients, two thirds will not ovulate on a regular basis and seek treatment for ovulation induction. The symptoms vary in their severity, namely ovulation disorders, excessive androgen levels, or polycystic ovarian morphology. All these symptoms require a therapeutic approach. Many drugs are used to eradicate PCOS symptoms, like metformin, clomiphene citrate, spironolactone, and pioglitazone. Long-term treatment is required to achieve the desired outcome, which is often accompanied by significant adverse reactions. Some herbs and phytochemicals are equally effective for treating PCOS and produce minimal side effects. Recently, herbal products are gaining popularity due to their wide biological activities, safety, availability, and efficacy. The present review covers aetiology, current treatment, pathophysiology, and detailed pre-clinical and clinical studies on plants and phytochemicals that are proven to be useful for the treatment of symptoms associated with PCOS.
    MeSH term(s) Polycystic Ovary Syndrome/drug therapy ; Humans ; Female ; Phytotherapy/methods ; Phytochemicals/therapeutic use ; Animals ; Plant Extracts/therapeutic use
    Chemical Substances Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1294406
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  4. Article ; Online: Updated review on analysis of long non-coding RNAs as emerging diagnostic and therapeutic targets in prostate cancers.

    Ke, Zongpan / Hu, Xuechun / Liu, Yixun / Shen, Deyun / Khan, Muhammad Imran / Xiao, Jun

    Critical reviews in oncology/hematology

    2024  Volume 196, Page(s) 104275

    Abstract: Despite advancements, prostate cancers (PCa) pose a significant global health challenge due to delayed diagnosis and therapeutic resistance. This review delves into the complex landscape of prostate cancer, with a focus on long-noncoding RNAs (lncRNAs). ... ...

    Abstract Despite advancements, prostate cancers (PCa) pose a significant global health challenge due to delayed diagnosis and therapeutic resistance. This review delves into the complex landscape of prostate cancer, with a focus on long-noncoding RNAs (lncRNAs). Also explores the influence of aberrant lncRNAs expression in progressive PCa stages, impacting traits like proliferation, invasion, metastasis and therapeutic resistance. The study elucidates how lncRNAs modulate crucial molecular effectors, including transcription factors and microRNAs, affecting signaling pathways such as androgen receptor signaling. Besides, this manuscript sheds light on novel concepts and mechanisms driving PCa progression through lncRNAs, providing a critical analysis of their impact on the disease's diverse characteristics. Besides, it discusses the potential of lncRNAs as diagnostics and therapeutic targets in PCa. Collectively, this work highlights state of art mechanistic comprehension and rigorous scientific approaches to advance our understanding of PCa and depict innovations in this evolving field of research.
    MeSH term(s) Male ; Humans ; RNA, Long Noncoding/genetics ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/therapy ; MicroRNAs ; Signal Transduction ; Gene Expression Regulation, Neoplastic
    Chemical Substances RNA, Long Noncoding ; MicroRNAs
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2024.104275
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    Zs.A 1931: Show issues Location:
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  5. Article ; Online: A comprehensive review on the applications of ferrite nanoparticles in the diagnosis and treatment of breast cancer.

    Akhtar, Muhammad Furqan / Afzaal, Aysha / Saleem, Ammara / Roheel, Amna / Khan, Muhammad Imran / Imran, Mohd

    Medical oncology (Northwood, London, England)

    2024  Volume 41, Issue 2, Page(s) 53

    Abstract: Various conventional treatments including endocrine therapy, radiotherapy, surgery, and chemotherapy have been used for several decades to treat breast cancer; however, these therapies exhibit various life-threatening and debilitating adverse effects in ... ...

    Abstract Various conventional treatments including endocrine therapy, radiotherapy, surgery, and chemotherapy have been used for several decades to treat breast cancer; however, these therapies exhibit various life-threatening and debilitating adverse effects in patients. Additionally, combination therapies are required for prompt action as well as to prevent drug resistance toward standard breast cancer medications. Ferrite nanoparticles (NPs) are increasingly gaining momentum for their application in the diagnosis and treatment of breast cancer. Spinel ferrites are particularly used against breast cancer and have shown in vitro and in vivo better efficacy as compared to conventional cancer therapies. Magnetic resonance imaging contrast agents, magnetic particle imaging tracers, cell separation, and immune assays are some aspects related to the diagnosis of breast cancer against which different ferrite NPs have been successfully evaluated. Moreover, citrate-coated nickel ferrite, Mg/Zn ferrites, poly amidoamine dendrimers, cobalt ferrites, graphene oxide cobalt ferrites, doxorubicin functionalized cobalt ferrites, chitosan-coated zinc ferrites, PEG-coated cobalt ferrite, and copper ferrite NPs have demonstrated antiproliferative action against different breast cancer cells. Oxaliplatin-loaded polydopamine/BSA-copper ferrites, functionalized cobalt and zinc ferrites of curcumin, oxaliplatin-copper ferrite NPs, tamoxifen/diosgenin encapsulated ZnO/Mn ferrites, and fabricated core-shell fibers of doxorubicin have been developed to increase the bioavailability and anti-proliferative effect and decrease the toxicity of anticancer drugs. These ferrite NPs showed an anticancer effect at different doses in the presence or absence of an external magnetic field. The present review covers the in-depth investigations of ferrite NPs for the diagnosis and management of breast cancer.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Copper ; Oxaliplatin ; Doxorubicin ; Cobalt ; Zinc
    Chemical Substances ferrite (1317-54-0) ; Copper (789U1901C5) ; Oxaliplatin (04ZR38536J) ; Doxorubicin (80168379AG) ; Cobalt (3G0H8C9362) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-023-02277-2
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    Zs.A 1899: Show issues Location:
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  6. Article ; Online: A quick prediction tool for Dengue fever: A timely response is essential!

    Qureshi, Humera / Khan, Muhammad Imran / Bae, Suk Joo / Shah, Adil

    Journal of infection and public health

    2023  Volume 16, Issue 4, Page(s) 551–553

    MeSH term(s) Humans ; Dengue/diagnosis
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2467587-8
    ISSN 1876-035X ; 1876-0341
    ISSN (online) 1876-035X
    ISSN 1876-0341
    DOI 10.1016/j.jiph.2023.02.011
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  7. Article ; Online: Expression of concern: Influence of chemical composition on the amount of second phases precipitates and transformation temperatures of TiNiPdCu shape memory alloys prepared through novel powder metallurgy route.

    Hussain, Abid / Khan, Afzal / Khan, Muhammad Imran / Rehman, Saif Ur

    RSC advances

    2023  Volume 13, Issue 51, Page(s) 35992

    Abstract: Expression of concern for 'Influence of chemical composition on the amount of second phases precipitates and transformation temperatures of TiNiPdCu shape memory alloys prepared through novel powder metallurgy route' by Abid ... ...

    Abstract Expression of concern for 'Influence of chemical composition on the amount of second phases precipitates and transformation temperatures of TiNiPdCu shape memory alloys prepared through novel powder metallurgy route' by Abid Hussain
    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Expression of Concern
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra90122j
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  8. Article: Establishment of institutional diagnostic reference level for Computed Tomography dose on 160 slicer Computed Tomography scan at Lady Reading Hospital Peshawar.

    Khan, Muhammad Imran / Khan, Muhammad Zeeshan / Afzal, Fariha / Khan, Shandana

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 73, Issue 4, Page(s) 808–811

    Abstract: Objective: To set institutional diagnostic reference level for computed tomography of multiple anatomical regions using dose length product as dosimeter parameter and to compare results with international diagnostic reference level.: Method: The ... ...

    Abstract Objective: To set institutional diagnostic reference level for computed tomography of multiple anatomical regions using dose length product as dosimeter parameter and to compare results with international diagnostic reference level.
    Method: The retrospective study was conducted at the Radiology Unit of Lady Reading Hospital, Peshawar, Pakistan, and comprised dose data of patients who underwent computed tomography from June 1 to August 31, 2018. The mean, 25th, 50th and 75th percentile of dose distribution of common computed tomography examinations was calculated and compared with other established diagnostic reference levels. Data was analysed using SPSS 20.
    Results: Of the 1001 scans, 143(14.2%) related to brain, 275(27.5%) abdomen-pelvis, 133(13.3%) kidney-ureter-bladder, 186(18.58%) thorax, 85(8.49%) triphasic, 126(12.58%) musculoskeletal, and 53(5.29%) cardiac. Institutional diagnostic reference levels for the computed tomography unit was established as 50th percentile of dose length product for different regions brain 339, abdomen-pelvis 298, thorax 165, kidney-ureter-bladder 302, triphasic 633, musculoskeletal 366 and cardiac 403. Both 50th and 75th percentile values of dose length product for each individual body region was lower than international Diagnostic reference levels.
    Conclusions: The diagnostic reference level will be used in routine computed tomography practice at the institution, and will act as the baseline for developing the national diagnostic reference levels.
    MeSH term(s) Humans ; Diagnostic Reference Levels ; Radiation Dosage ; Retrospective Studies ; Hospitals ; Tomography, X-Ray Computed/methods ; Reference Values
    Language English
    Publishing date 2023-04-13
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.6387
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    Zs.B 845: Show issues Location:
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  9. Article ; Online: Molecular mechanisms of morphine tolerance and dependence; novel insights and future perspectives.

    Badshah, Ismail / Anwar, Maira / Murtaza, Babar / Khan, Muhammad Imran

    Molecular and cellular biochemistry

    2023  

    Abstract: Drug addiction is a devastating condition that poses a serious burden on the society. The use of some drugs like morphine for their tremendous analgesic properties is also accompanied with developing tolerance, dependence and the withdrawal symptoms. ... ...

    Abstract Drug addiction is a devastating condition that poses a serious burden on the society. The use of some drugs like morphine for their tremendous analgesic properties is also accompanied with developing tolerance, dependence and the withdrawal symptoms. These symptoms are frequently severe enough to reinforce the person in recovery to start over the use of drug again and hinder the clinical use of drugs like morphine for chronic pain. Research into opioid receptors and related molecular pathways has seen resurgence in the wake of the growing opioid epidemic. The current study provides a comprehensive scientific exploration of the molecular mechanisms and underlying signalling in morphine tolerance and dependence. It also critically evaluates current therapeutic approaches, shedding light on their efficacy and limitations, and future prospects. The graphical abstract depicts an overview of the pathways involved in the emergence of morphine-related tolerance and dependence including NMDA, Nitric oxide, and PPAR, as well as behavioural sensitization along with present and future innovative treatment strategies including stem cell therapy that have been discussed in the current manuscript.
    Language English
    Publishing date 2023-07-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-023-04810-3
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    Zs.A 892: Show issues Location:
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  10. Article ; Online: Influence of chemical composition on the amount of second phases precipitates and transformation temperatures of TiNiPdCu shape memory alloys prepared through novel powder metallurgy route.

    Hussain, Abid / Kan, Afzal / Khan, Muhammad Imran / Rehman, Saif Ur

    publication RETRACTED

    RSC advances

    2023  Volume 13, Issue 42, Page(s) 29376–29392

    Abstract: The chemical composition of TiNiPdCu high temperature shape memory alloys (HTSMAs) affects their microstructure and martensitic transformations. In TiNiPdC HTSMAs, second phase precipitates were found. Extremely high densities of nanoscale precipitates ... ...

    Abstract The chemical composition of TiNiPdCu high temperature shape memory alloys (HTSMAs) affects their microstructure and martensitic transformations. In TiNiPdC HTSMAs, second phase precipitates were found. Extremely high densities of nanoscale precipitates of TiPdCu and Ti
    Language English
    Publishing date 2023-10-09
    Publishing country England
    Document type Journal Article ; Retracted Publication
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra05513b
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