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  1. Book ; Online ; E-Book: Brassica Improvement

    Wani, Shabir Hussain / Thakur, Ajay Kumar / Jeshima Khan, Yasin

    Molecular, Genetics and Genomic Perspectives

    2020  

    Abstract: Global population is mounting at an alarming stride to surpass 9.3 billion by 2050, whereas simultaneously the agricultural productivity is gravely affected by climate changes resulting in increased biotic and abiotic stresses. The genus Brassica belongs ...

    Author's details edited by Shabir Hussain Wani, Ajay Kumar Thakur, Yasin Jeshima Khan
    Abstract Global population is mounting at an alarming stride to surpass 9.3 billion by 2050, whereas simultaneously the agricultural productivity is gravely affected by climate changes resulting in increased biotic and abiotic stresses. The genus Brassica belongs to the mustard family whose members are known as cruciferous vegetables, cabbages or mustard plants. Rapeseed-mustard is world’s third most important source of edible oil after soybean and oil palm. It has worldwide acceptance owing to its rare combination of health promoting factors. It has very low levels of saturated fatty acids which make it the healthiest edible oil that is commonly available. Apart from this, it is rich in antioxidants by virtue of tocopherols and phytosterols presence in the oil. The high omega 3 content reduces the risk of atherosclerosis/heart attack. Conventional breeding methods have met with limited success in Brassica because yield and stress resilience are polygenic traits and are greatly influenced by environment. Therefore, it is imperative to accelerate the efforts to unravel the biochemical, physiological and molecular mechanisms underlying yield, quality and tolerance towards biotic and abiotic stresses in Brassica. To exploit its fullest potential, systematic efforts are needed to unlock the genetic information for new germplasms that tolerate initial and terminal state heat coupled with moisture stress. For instance, wild relatives may be exploited in developing introgressed and resynthesized lines with desirable attributes. Exploitation of heterosis is another important area which can be achieved by introducing transgenics to raise stable CMS lines. Doubled haploid breeding and marker assisted selection should be employed along with conventional breeding. Breeding programmes aim at enhancing resource use efficiency, especially nutrient and water as well as adoption to aberrant environmental changes should also be considered. Biotechnological interventions are essential for altering the biosynthetic pathways for developing high oleic and low linolenic lines. Accordingly, tools such as microspore and ovule culture, embryo rescue, isolation of trait specific genes especially for aphid, Sclerotinia and alternaria blight resistance, etc. along with identification of potential lines based on genetic diversity can assist ongoing breeding programmes. In this book, we highlight the recent molecular, genetic and genomic interventions made to achieve crop improvement in terms of yield increase, quality and stress tolerance in Brassica, with a special emphasis in Rapeseed-mustard.
    Keywords Agriculture ; Plant breeding ; Plant physiology ; Plant genetics ; Nutrition    ; Plant Breeding/Biotechnology ; Plant Physiology ; Plant Genetics and Genomics ; Nutrition ; Plantes ; Agricultura ; Genètica vegetal
    Subject code 633.85
    Language English
    Size 1 online resource (XIII, 253 p. 11 illus., 10 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-34694-3 ; 3-030-34693-5 ; 978-3-030-34694-2 ; 978-3-030-34693-5
    DOI 10.1007/978-3-030-34694-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Molecular and physiological characterization of early semi-dwarf mutants of rice and localization of SNP variants in Sd1 locus generated through gamma radiation.

    Ramchander, Selvaraj / M T, Andrew-Peter-Leon / Khan, Yasin Jeshima / Souframanien, Jegadeesan / Arumugam Pillai, Madhavan

    International journal of radiation biology

    2024  Volume 100, Issue 4, Page(s) 650–662

    Abstract: Purpose: The 'Improved White Ponni' (IWP) rice variety, which is susceptible to lodging, leading to yield losses. Our primary goal is to develop new rice lines with non-lodging traits, enhancing stem strength and resistance to adverse conditions. ... ...

    Abstract Purpose: The 'Improved White Ponni' (IWP) rice variety, which is susceptible to lodging, leading to yield losses. Our primary goal is to develop new rice lines with non-lodging traits, enhancing stem strength and resistance to adverse conditions. Additionally, we aim to improve yield-contributing agronomic traits, benefiting farmers, food security, and the environment. Our work contributes to scientific knowledge and addresses a significant issue in Southern Indian rice cultivation.
    Materials and methods: In the present study, early and semi-dwarf early mutants of IWP were developed without altering the native grain quality traits using gamma ray-mediated mutagenesis. The seeds (500) were irradiated with γ-rays after fixing the Lethal Dose 50 (LD
    Results: The response of mutants to gibberellic acid has been studied, which identified responsive mutants as well as slow-responding mutant lines including IWP-11-2, IWP-48-2, IWP-50-11, and IWP-33-2. Agar plate assay indicated low α- amylase content in IWP-50-11, IWP-33-2, IWP-43-1, IWP-47-2, and IWP-18-1. The scanning electron microscopy demonstrated that the mutants displayed an increased cellular dimension in comparison to the wild type. In dwarf mutants, null alleles were observed for the
    Conclusions: The impact of a defective gibberellic acid-mediated signaling pathway in mutants to produce a novel high-yielding and early maturing semi-dwarf rice variety.
    MeSH term(s) Oryza/genetics ; Gamma Rays ; Polymorphism, Single Nucleotide ; Phenotype ; Dwarfism ; Gibberellins ; Syndactyly
    Chemical Substances gibberellic acid (BU0A7MWB6L) ; Gibberellins
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.1080/09553002.2024.2304827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Precision Medicine and Heterogeneity of Treatment Effect in Therapies for ARDS.

    Khan, Yasin A / Fan, Eddy / Ferguson, Niall D

    Chest

    2021  Volume 160, Issue 5, Page(s) 1729–1738

    Abstract: ARDS is a clinically heterogeneous syndrome, rather than a distinct disease. This heterogeneity at least partially explains the difficulty in studying treatments for these patients and contributes to the numerous trials of therapies for the syndrome that ...

    Abstract ARDS is a clinically heterogeneous syndrome, rather than a distinct disease. This heterogeneity at least partially explains the difficulty in studying treatments for these patients and contributes to the numerous trials of therapies for the syndrome that have not shown benefit. Recent studies have identified different subphenotypes within the heterogeneous patient population. These different subphenotypes likely have variable clinical responses to specific therapies, a concept known as heterogeneity of treatment effect. Recognizing different subphenotypes and heterogeneity of treatment effect has important implications for the clinical management of patients with ARDS. This review presents studies that have identified different subphenotypes and discusses how they can modify the effects of therapies evaluated in trials that are commonly considered to have shown no overall benefit in patients with ARDS.
    MeSH term(s) Biological Variation, Population ; Genetic Heterogeneity ; Humans ; Precision Medicine/methods ; Respiratory Distress Syndrome/genetics ; Respiratory Distress Syndrome/therapy ; Treatment Outcome
    Language English
    Publishing date 2021-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Study of Cation Distribution and Photocatalytic Activity of Nonthermal Plasma-Modified NiZnFe

    Busharat, Muhammad Aqib / Shukrullah, Shazia / Yasin Naz, Muhammad / Khan, Yasin / Ibrahim, Ahmed Ahmed / Al-Arainy, Abdulrehman Ali / Shoaib, Muhammad

    ACS omega

    2024  Volume 9, Issue 13, Page(s) 14791–14804

    Abstract: In this study, ... ...

    Abstract In this study, NiZnFe
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c06883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Insulation Performance Analysis of Field Aged and New MV XLPE Cables Using Various Diagnostic Techniques

    Al-Onazi Yousef / Wani Nissar / Al-Arainy Abdulrahman / Khan Yasin

    E3S Web of Conferences, Vol 294, p

    2021  Volume 02008

    Abstract: Cross-linked polyethylene (XLPE) cables are widely used in the distribution and transmission networks of power systems. The insulation materials of these cables are stressed by the over voltages and are also exposed to various environmental conditions. ... ...

    Abstract Cross-linked polyethylene (XLPE) cables are widely used in the distribution and transmission networks of power systems. The insulation materials of these cables are stressed by the over voltages and are also exposed to various environmental conditions. This leads the power cables to degrade during their normal life span. Therefore, it would be advantageous for the power utilities to acquire the cable’s insulation condition frequently during their operation. In this paper, experimental studies were carried out on short sections of field aged as well as un-aged medium voltage (MV) XLPE cables to investigate the insulation condition using non-destructive diagnostic techniques such as Dissipation Factor (DF), Isothermal Relaxation Current (IRC), and Partial Discharge (PD) characteristics at 60Hz. From this set of experiments, different parameters will be used to analyze the dielectric response and the insulation condition. Finally, the results show how the VLF dissipation factor works efficiently to assess cable aging.
    Keywords Environmental sciences ; GE1-350
    Subject code 621
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book: Dairy technology and engineering

    Khan, Yasin

    2013  

    Author's details Yasin Khan
    Language English
    Size 233 S., Ill., graph. Darst.
    Publisher Agrotech Press
    Publishing place New Delhi
    Document type Book
    ISBN 9789383101092 ; 9383101091
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: HVD-LSTM based recognition of epileptic seizures and normal human activity.

    Khan, Pritam / Khan, Yasin / Kumar, Sudhir / Khan, Mohammad S / Gandomi, Amir H

    Computers in biology and medicine

    2021  Volume 136, Page(s) 104684

    Abstract: In this paper, we detect the occurrence of epileptic seizures in patients as well as activities namely stand, walk, and exercise in healthy persons, leveraging EEG (electroencephalogram) signals. Using Hilbert vibration decomposition (HVD) on non-linear ... ...

    Abstract In this paper, we detect the occurrence of epileptic seizures in patients as well as activities namely stand, walk, and exercise in healthy persons, leveraging EEG (electroencephalogram) signals. Using Hilbert vibration decomposition (HVD) on non-linear and non-stationary EEG signal, we obtain multiple monocomponents varying in terms of amplitude and frequency. After decomposition, we extract features from the monocomponent matrix of the EEG signals. The instantaneous amplitude of the HVD monocomponents varies because of the motion artifacts present in EEG signals. Hence, the acquired statistical features from the instantaneous amplitude help in identifying the epileptic seizures and the normal human activities. The features selected by correlation-based Q-score are classified using an LSTM (Long Short Term Memory) based deep learning model in which the feature-based weight update maximizes the classification accuracy. For epilepsy diagnosis using the Bonn dataset and activity recognition leveraging our Sensor Networks Research Lab (SNRL) data, we achieve testing classification accuracies of 96.00% and 83.30% respectively through our proposed method.
    MeSH term(s) Epilepsy/diagnosis ; Human Activities ; Humans ; Seizures ; Vibration ; Walking
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2021.104684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: [No title information]

    Barrett, Kali / Khan, Yasin A / Mac, Stephen / Ximenes, Raphael / Naimark, David M J / Sander, Beate

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 46, Page(s) E1474–E1481

    Title translation Estimation de l’épuisement des ressources hospitalières attribuable à la COVID-19 en Ontario, au Canada.
    Keywords covid19
    Language French
    Publishing date 2020-11-16
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.200715-f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Estimation of COVID-19-induced depletion of hospital resources in Ontario, Canada.

    Barrett, Kali / Khan, Yasin A / Mac, Stephen / Ximenes, Raphael / Naimark, David M J / Sander, Beate

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 24, Page(s) E640–E646

    Abstract: Background: The global spread of coronavirus disease 2019 (COVID-19) continues in several jurisdictions, causing substantial strain to health care systems. The purpose of our study was to predict the effect of the COVID-19 pandemic on patient outcomes ... ...

    Abstract Background: The global spread of coronavirus disease 2019 (COVID-19) continues in several jurisdictions, causing substantial strain to health care systems. The purpose of our study was to predict the effect of the COVID-19 pandemic on patient outcomes and use of hospital resources in Ontario, Canada.
    Methods: We developed an individual-level simulation to model the flow of patients with COVID-19 through the hospital system in Ontario. We simulated different combined scenarios of epidemic trajectory and hospital health care capacity. Our outcomes included the number of patients who needed admission to the ward or to the intensive care unit (ICU) with or without the need for mechanical ventilation, number of days to resource depletion, number of patients awaiting resources and number of deaths.
    Results: We found that with effective early public health measures, hospital system resources would not be depleted. For scenarios with late or ineffective implementation of physical distancing, hospital resources would be depleted within 14-26 days, and in the worst case scenario, 13 321 patients would die while waiting for needed resources. Resource depletion would be avoided or delayed with aggressive measures to increase ICU, ventilator and acute care hospital capacities.
    Interpretation: We found that without aggressive physical distancing measures, the Ontario hospital system would have been inadequately equipped to manage the expected number of patients with COVID-19 despite a rapid increase in capacity. This lack of hospital resources would have led to an increase in mortality. By slowing the spread of the disease using public health measures and by increasing hospital capacity, Ontario may have avoided catastrophic stresses to its hospitals.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Communicable Disease Control ; Computer Simulation ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/prevention & control ; Health Resources ; Health Services Needs and Demand ; Hospital Bed Capacity ; Hospitals ; Humans ; Intensive Care Units ; Ontario/epidemiology ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Surge Capacity ; Ventilators, Mechanical
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.200715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Relationship Between Metabolic Syndrome and Mortality Among Patients With Acute Respiratory Distress Syndrome in Acute Respiratory Distress Syndrome Network and Prevention and Early Treatment of Acute Lung Injury Network Trials.

    Tea, Kevin / Zu, Yuanhao / Chung, Cheng Han / Pagliaro, Jaclyn / Espinoza-Barrera, Diana / Mehta, Prakriti / Grewal, Himmat / Douglas, Ivor S / Khan, Yasin A / Shaffer, Jeffrey G / Denson, Joshua L

    Critical care medicine

    2023  Volume 52, Issue 3, Page(s) 407–419

    Abstract: Objectives: Metabolic syndrome is known to predict outcomes in COVID-19 acute respiratory distress syndrome (ARDS) but has never been studied in non-COVID-19 ARDS. We therefore aimed to determine the association of metabolic syndrome with mortality ... ...

    Abstract Objectives: Metabolic syndrome is known to predict outcomes in COVID-19 acute respiratory distress syndrome (ARDS) but has never been studied in non-COVID-19 ARDS. We therefore aimed to determine the association of metabolic syndrome with mortality among ARDS trial subjects.
    Design: Retrospective cohort study of ARDS trials' data.
    Setting: An ancillary analysis was conducted using data from seven ARDS Network and Prevention and Early Treatment of Acute Lung Injury Network randomized trials within the Biologic Specimen and Data Repository Information Coordinating Center database.
    Patients: Hospitalized patients with ARDS and metabolic syndrome (defined by obesity, diabetes, and hypertension) were compared with similar patients without metabolic syndrome (those with less than three criteria).
    Interventions: None.
    Measurements and main results: The primary outcome was 28-day mortality. Among 4288 ARDS trial participants, 454 (10.6%) with metabolic syndrome were compared with 3834 controls (89.4%). In adjusted analyses, the metabolic syndrome group was associated with lower 28-day and 90-day mortality when compared with control (adjusted odds ratio [aOR], 0.70 [95% CI, 0.55-0.89] and 0.75 [95% CI, 0.60-0.95], respectively). With each additional metabolic criterion from 0 to 3, adjusted 28-day mortality was reduced by 18%, 22%, and 40%, respectively. In subgroup analyses stratifying by ARDS etiology, mortality was lower for metabolic syndrome vs. control in ARDS caused by sepsis or pneumonia (at 28 d, aOR 0.64 [95% CI, 0.48-0.84] and 90 d, aOR 0.69 [95% CI, 0.53-0.89]), but not in ARDS from noninfectious causes (at 28 d, aOR 1.18 [95% CI, 0.70-1.99] and 90 d, aOR 1.26 [95% CI, 0.77-2.06]). Interaction p = 0.04 and p = 0.02 for 28- and 90-day comparisons, respectively.
    Conclusions: Metabolic syndrome in ARDS was associated with a lower risk of mortality in non-COVID-19 ARDS. The relationship between metabolic inflammation and ARDS may provide a novel biological pathway to be explored in precision medicine-based trials.
    MeSH term(s) Humans ; Metabolic Syndrome/complications ; Retrospective Studies ; Respiratory Distress Syndrome ; Acute Lung Injury ; Pneumonia
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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