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Article ; Online: A systematic review and physiology of pulmonary artery pulsatility index in left ventricular assist device therapy.

Yim, Ivan H W / Khan-Kheil, Ayisha M / Drury, Nigel E / Lim, Hoong Sern

Interdisciplinary cardiovascular and thoracic surgery

2023 Volume 36, Issue 5

Abstract: Objectives: Right heart failure (RHF) is a major complication following left ventricular assist device (LVAD) implantation. Pulmonary artery pulsatility index (PAPi) has been evaluated as a haemodynamic marker for RHF, but PAPi is dependent on pulmonary ...

Abstract	Objectives: Right heart failure (RHF) is a major complication following left ventricular assist device (LVAD) implantation. Pulmonary artery pulsatility index (PAPi) has been evaluated as a haemodynamic marker for RHF, but PAPi is dependent on pulmonary vascular resistance (PVR). We conducted a systematic review to assess the relationship between PAPi and RHF and death in patients undergoing LVAD implantation and examined the relationship between PAPi cut-off and PVR. Methods: We searched PubMed, EMBASE, CENTRAL and manually screened retrieved references to identify all clinical studies reporting PAPi in adult patients with a durable LVAD. Eligibility criteria were prespecified and 2 reviewers independently screened and extracted data; the Newcastle-Ottawa Scale was used to assess quality of non-randomized studies. This study was prospectively registered on PROSPERO (CRD42021259009). Results: From 283 unique records, we identified 16 studies reporting haemodynamic assessment in 20 634 adult patients with an implanted durable LVAD. Only 2 studies reported on mortality and in both, a lower PAPi was significantly associated with death. Fifteen studies reported RHF data and, in 10 studies, a lower PAPi was significantly associated with RHF. Six studies reported on PAPi cut-offs ranging from 0.88 to 3.3; and the cut-offs were directly related to PVR (r = 0.6613, P = 0.019). Conclusions: Lower PAPi was associated with RHF and death following LVAD implantation, but a single PAPi cut-off cannot be defined, as it is dependent on PVR.
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Journal Article
ISSN	2753-670X
ISSN (online)	2753-670X
DOI	10.1093/icvts/ivad068
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Echocardiographic Findings in Patients With COVID-19 Pneumonia.

Mahmoud-Elsayed, Hani M / Moody, William E / Bradlow, William M / Khan-Kheil, Ayisha M / Senior, Jonathan / Hudsmith, Lucy E / Steeds, Richard P

The Canadian journal of cardiology

2020 Volume 36, Issue 8, Page(s) 1203–1207

Abstract: The aim of this study was to characterize the echocardiographic phenotype of patients with COVID-19 pneumonia and its relation to biomarkers. Seventy-four patients (59 ± 13 years old, 78% male) admitted with COVID-19 were included after referral for ... ...

Abstract	The aim of this study was to characterize the echocardiographic phenotype of patients with COVID-19 pneumonia and its relation to biomarkers. Seventy-four patients (59 ± 13 years old, 78% male) admitted with COVID-19 were included after referral for transthoracic echocardiography as part of routine care. A level 1 British Society of Echocardiography transthoracic echocardiography was used to assess chamber size and function, valvular disease, and likelihood of pulmonary hypertension. The chief abnormalities were right ventricle (RV) dilatation (41%) and RV dysfunction (27%). RV impairment was associated with increased D-dimer and C-reactive protein levels. In contrast, left ventricular function was hyperdynamic or normal in most (89%) patients.
MeSH term(s)	Betacoronavirus/isolation & purification ; Biomarkers/analysis ; Biomarkers/blood ; C-Reactive Protein/analysis ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Echocardiography/methods ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/etiology ; Pneumonia, Viral/physiopathology ; SARS-CoV-2 ; United Kingdom/epidemiology ; Ventricular Dysfunction, Right/diagnosis ; Ventricular Dysfunction, Right/etiology
Chemical Substances	Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; C-Reactive Protein (9007-41-4)
Keywords	covid19
Language	English
Publishing date	2020-05-28
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2020.05.030
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Article ; Online: Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized With COVID-19, According to Race.

Moody, William E / Mahmoud-Elsayed, Hani M / Senior, Jonathan / Gul, Uzma / Khan-Kheil, Ayisha M / Horne, Sebastian / Banerjee, Amitava / Bradlow, William M / Huggett, Robert / Hothi, Sandeep S / Shahid, Muhammad / Steeds, Richard P

CJC open

2020 Volume 3, Issue 1, Page(s) 91–100

Abstract: Background: Epidemiologic studies suggest that Black, Asian, and minority ethnic (BAME) patients may be at risk of worse outcomes from coronavirus disease-2019 (COVID-19), but the pathophysiological drivers for this association are unknown. This study ... ...

Abstract	Background: Epidemiologic studies suggest that Black, Asian, and minority ethnic (BAME) patients may be at risk of worse outcomes from coronavirus disease-2019 (COVID-19), but the pathophysiological drivers for this association are unknown. This study sought to investigate the relationship between findings on echocardiography, mortality, and race in COVID-19 pneumonia. Methods: This was a multicentre, retrospective, observational study including 164 adults (aged 61 ± 13 years; 78% male; 36% BAME) hospitalized with COVID-19 undergoing echocardiography between March 16 and May 9, 2020 at 3 days (interquartile range 2-5) from admission. The primary outcome was all-cause mortality. Results: After a median follow-up of 31 days (interquartile range 14-42 days), 66 (40%) patients had died. The right ventricle was dilated in 62 (38%) patients, and 58 (35%) patients had right ventricular (RV) systolic dysfunction. Only 2 (1%) patients had left ventricular (LV) dilatation, and 133 (81%) had normal or hyperdynamic LV systolic function. Reduced tricuspid annulus planar systolic excursion was associated with elevated D-dimer (ρ = -0.18, Conclusions: In patients hospitalized with COVID-19 pneumonia, reduced RV systolic function is prevalent and associated with all-cause mortality. There is, however, no racial variation in the early findings on echocardiography, biomarkers, or mortality.
Keywords	covid19
Language	English
Publishing date	2020-09-20
Publishing country	United States
Document type	Journal Article
ISSN	2589-790X
ISSN (online)	2589-790X
DOI	10.1016/j.cjco.2020.09.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Persisting Adverse Ventricular Remodeling in COVID-19 Survivors: A Longitudinal Echocardiographic Study.

Moody, William E / Liu, Boyang / Mahmoud-Elsayed, Hani M / Senior, Jonathan / Lalla, Sasha S / Khan-Kheil, Ayisha M / Brown, Stewart / Saif, Abdullah / Moss, Alastair / Bradlow, William M / Khoo, Jeffrey / Ahamed, Mubarak / McAloon, Christopher / Hothi, Sandeep S / Steeds, Richard P

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2021 Volume 34, Issue 5, Page(s) 562–566

MeSH term(s)	COVID-19/diagnostic imaging ; Echocardiography ; Humans ; Survivors ; Ventricular Remodeling/physiology
Language	English
Publishing date	2021-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2021.01.020
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Zs.A 2638: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Echocardiographic Findings in Patients With COVID-19 Pneumonia

Mahmoud-Elsayed, Hani M / Moody, William E / Bradlow, William M / Khan-Kheil, Ayisha M / Senior, Jonathan / Hudsmith, Lucy E / Steeds, Richard P

Can. j. cardiol

Abstract	The aim of this study was to characterize the echocardiographic phenotype of patients with COVID-19 pneumonia and its relation to biomarkers. Seventy-four patients (59 ± 13 years old, 78% male) admitted with COVID-19 were included after referral for transthoracic echocardiography as part of routine care. A level 1 British Society of Echocardiography transthoracic echocardiography was used to assess chamber size and function, valvular disease, and likelihood of pulmonary hypertension. The chief abnormalities were right ventricle (RV) dilatation (41%) and RV dysfunction (27%). RV impairment was associated with increased D-dimer and C-reactive protein levels. In contrast, left ventricular function was hyperdynamic or normal in most (89%) patients.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #401289
Database	COVID19

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Article ; Online: Echocardiographic Findings in Covid-19 Pneumonia.

Mahmoud-Elsayed, Hani M / Moody, William E / Bradlow, William M / Khan-Kheil, Ayisha M / Hudsmith, Lucy E / Steeds, Richard Paul

2020

Abstract: The aim of this study was to characterize the echocardiographic phenotype of patients with Covid-19 pneumonia and its relation to biomarkers. Seventy-four patients (59±13 years, 78% male) admitted with Covid-19 were included after referral for ... ...

Abstract	The aim of this study was to characterize the echocardiographic phenotype of patients with Covid-19 pneumonia and its relation to biomarkers. Seventy-four patients (59±13 years, 78% male) admitted with Covid-19 were included after referral for transthoracic echocardiography (TTE) as part of routine care. A level 1 British Society of Echocardiography TTE assessed chamber size and function, valvular disease and likelihood of pulmonary hypertension. The chief abnormalities were right ventricular (RV) dilatation (41%) and RV dysfunction (27%). RV impairment was associated with increased D-dimer and CRP levels. In contrast, left ventricular (LV) function was hyper-dynamic or normal in most (89%) patients.
Keywords	QU Biochemistry ; WC Communicabable diseases ; WF Respiratory system. Respiratory medicine ; WG Cardiovascular system. Cardiology ; covid19
Publishing date	2020-05-28
Publisher	Elsevier
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Echocardiographic Findings in Patients With COVID-19 Pneumonia

Mahmoud-Elsayed, Hani M. / Moody, William E. / Bradlow, William M. / Khan-Kheil, Ayisha M. / Senior, Jonathan / Hudsmith, Lucy E. / Steeds, Richard P.

Canadian Journal of Cardiology

2020 Volume 36, Issue 8, Page(s) 1203–1207

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2020.05.030
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized with COVID-19 according to Race

Abstract: Background: Epidemiological studies suggest that black, Asian and minority ethnic (BAME) patients may be at risk of worse outcomes from Coronavirus-19 (COVID-19) but the pathophysiological drivers for this association are unknown. This study sought to ... ...

Abstract	Background: Epidemiological studies suggest that black, Asian and minority ethnic (BAME) patients may be at risk of worse outcomes from Coronavirus-19 (COVID-19) but the pathophysiological drivers for this association are unknown. This study sought to investigate the relationship between findings on echocardiography, mortality and race in COVID-19 pneumonia. Methods: This was a multicenter, retrospective, observational study including 164 adults (61±13years; 78% male; 36% BAME) hospitalized with COVID-19 undergoing echocardiography between March 16 and May 9, 2020 at 3 days (IQR 2 - 5) from admission. The primary outcome was all-cause mortality. Results: After a median follow up of 31 days (IQR 14 - 42 days), 58 (35%) patients had died. The right ventricle (RV) was dilated in 62 (38%) patients, and 58 (35%) patients had RV systolic dysfunction. Only 2 (1%) patients had left ventricular (LV) dilatation and 133 (81%) had normal or hyperdynamic LV systolic function. Reduced tricuspid annulus planar systolic excursion was associated with elevated D-dimer (ρ = -0.18, p = 0.025) and high-sensitivity cardiac Troponin (ρ = -0.30, p < 0.0001). Reduced RV systolic function (HR, 1.80; 95% CI, 1.05 - 3.09; p = 0.032) was an independent predictor of all-cause mortality after adjustment for demographic and clinical risk factors. Comparing white and BAME individuals, there were no differences in echocardiography findings, biomarkers or mortality. Conclusions: In patients hospitalized with COVID-19 pneumonia, reduced RV systolic function is prevalent and associated with all-cause mortality. There is however, no racial variation in the early findings on echocardiography, biomarkers or mortality.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #778641
Database	COVID19

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Article ; Online: Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized with COVID-19 according to Race.

2020

Abstract: Background Epidemiological studies suggest that black, Asian and minority ethnic (BAME) patients may be at risk of worse outcomes from Coronavirus-19 (COVID-19) but the pathophysiological drivers for this association are unknown. This study sought to ... ...

Abstract	Background Epidemiological studies suggest that black, Asian and minority ethnic (BAME) patients may be at risk of worse outcomes from Coronavirus-19 (COVID-19) but the pathophysiological drivers for this association are unknown. This study sought to investigate the relationship between findings on echocardiography, mortality and race in COVID-19 pneumonia. Methods This was a multicenter, retrospective, observational study including 164 adults (61±13years; 78% male; 36% BAME) hospitalized with COVID-19 undergoing echocardiography between March 16 and May 9, 2020 at 3 days (IQR 2 - 5) from admission. The primary outcome was all-cause mortality. Results After a median follow up of 31 days (IQR 14 - 42 days), 58 (35%) patients had died. The right ventricle (RV) was dilated in 62 (38%) patients, and 58 (35%) patients had RV systolic dysfunction. Only 2 (1%) patients had left ventricular (LV) dilatation and 133 (81%) had normal or hyperdynamic LV systolic function. Reduced tricuspid annulus planar systolic excursion was associated with elevated D-dimer (ρ = -0.18, p = 0.025) and high-sensitivity cardiac Troponin (ρ = -0.30, p < 0.0001). Reduced RV systolic function (HR, 1.80; 95% CI, 1.05 - 3.09; p = 0.032) was an independent predictor of all-cause mortality after adjustment for demographic and clinical risk factors. Comparing white and BAME individuals, there were no differences in echocardiography findings, biomarkers or mortality. Conclusions In patients hospitalized with COVID-19 pneumonia, reduced RV systolic function is prevalent and associated with all-cause mortality. There is however, no racial variation in the early findings on echocardiography, biomarkers or mortality.
Keywords	WG Cardiovascular system. Cardiology ; covid19
Subject code	610
Language	English
Publishing date	2020-09-20
Publisher	Elsevier
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized with COVID-19 according to Race

Moody, William E. / Mahmoud-Elsayed, Hani M. / Senior, Jonathan / Gul, Uzma / Khan-Kheil, Ayisha M. / Horne, Sebastian / Banerjee, Amitava / Bradlow, William M. / Huggett, Robert / Hothi, Sandeep S. / Shahid, Muhammad / Steeds, Richard P.

CJC Open ; ISSN 2589-790X

2020

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.cjco.2020.09.016
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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