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Article ; Online: ECM-based bioadhesive hydrogel for sutureless repair of deep anterior corneal defects.

Borouman, Safieh / Sigaroodi, Faraz / Ahmadi Tafti, Seyed Mohsen / Khoshmaram, Keyvan / Soleimani, Masoud / Khani, Mohammad-Mehdi

Biomaterials science

2024 Volume 12, Issue 9, Page(s) 2356–2368

Abstract: Corneal transplantation is the gold standard treatment for corneal-related blindness; however, this strategy faces challenges such as limited donor cornea, graft rejection, suture-related complications, and the need for specialized equipment and advanced ...

Abstract	Corneal transplantation is the gold standard treatment for corneal-related blindness; however, this strategy faces challenges such as limited donor cornea, graft rejection, suture-related complications, and the need for specialized equipment and advanced surgical skills. Development of tissue adhesives for corneal regeneration is of great clinical value. However, currently available corneal tissue sealants pose challenges, such as lack of safety, biocompatibility, and desired mechanical properties. To meet these requirements simultaneously, a bovine stromal corneal extracellular matrix (dCor) was used to design a bioadhesive photocurable hydrogel based on gelatin methacrylate (GelMA) and polyethylene glycol diacrylate (PEGDA) hydrogels (dCor/Gel-PEG). Integration of dCor into the dual networks of GelMA and PEGDA (Gel-PEG) led to a bioadhesive hydrogel for curing corneal defects, which could be crosslinked by Irgacure 2959 within 5 min ultraviolet irradiation. The viability of corneal stromal stem cells (CSSCs) was improved on the dCor/Gel-PEG hydrogel in comparison to the Gel-PEG hydrogel. The gene expression profile supported the keratocyte differentiation of CSSCs seeded on dCor/Gel-PEG
MeSH term(s)	Animals ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Hydrogels/administration & dosage ; Cattle ; Polyethylene Glycols/chemistry ; Gelatin/chemistry ; Extracellular Matrix/chemistry ; Tissue Adhesives/chemistry ; Tissue Adhesives/pharmacology ; Tissue Adhesives/administration & dosage ; Methacrylates/chemistry ; Cornea ; Stem Cells/cytology ; Stem Cells/drug effects
Chemical Substances	Hydrogels ; Polyethylene Glycols (3WJQ0SDW1A) ; Gelatin (9000-70-8) ; Tissue Adhesives ; Methacrylates ; poly(ethylene glycol)diacrylate ; gelatin methacryloyl
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d4bm00129j
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Article ; Online: Correction: ECM-based bioadhesive hydrogel for sutureless repair of deep anterior corneal defects.

Boroumand, Safieh / Sigaroodi, Faraz / Ahmadi Tafti, Seyed Mohsen / Khoshmaram, Keyvan / Soleimani, Masoud / Khani, Mohammad-Mehdi

Biomaterials science

2024 Volume 12, Issue 9, Page(s) 2444

Abstract: Correction for 'ECM-based bioadhesive hydrogel for sutureless repair of deep anterior corneal defects' by Safieh ... ...

Abstract	Correction for 'ECM-based bioadhesive hydrogel for sutureless repair of deep anterior corneal defects' by Safieh Boroumand
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Published Erratum
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d4bm90027h
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Article ; Online: Altered mechanical properties of actin fibers due to breast cancer invasion: parameter identification based on micropipette aspiration and multiscale tensegrity modeling.

Tabatabaei, Mohammad / Tafazzoli-Shadpour, Mohammad / Khani, Mohammad Mehdi

Medical & biological engineering & computing

2021 Volume 59, Issue 3, Page(s) 547–560

Abstract: The biophysical properties of cells change with cancer invasion to fulfill their metastatic behavior. Cell softening induced by cancer is highly associated with alterations in cytoskeleton fibers. Changes in the mechanical properties of cytoskeletal ... ...

Abstract	The biophysical properties of cells change with cancer invasion to fulfill their metastatic behavior. Cell softening induced by cancer is highly associated with alterations in cytoskeleton fibers. Changes in the mechanical properties of cytoskeletal fibers have not been quantified due to technical limitations. In this study, we used the micropipette aspiration technique to calculate and compare the viscoelastic properties of non-invasive and invasive breast cancer cells. We evaluated the mechanical properties of actin fibers and microtubules of two cancerous cell lines by using multiscale tensegrity modeling and an optimization method. Cancer invasion caused altered viscoelastic behavior of cells and the results of modeling showed changes in mechanical properties of major cytoskeleton fibers. The stiffness and viscosity constant of actin fibers in non-invasive cells were 1.28 and 2.27 times higher than those of the invasive cells, respectively. However, changes in mechanical properties of microtubules were minor. Immunofluorescent staining of fibers and their quantified distributions confirmed altered actin distribution among two cell lines, in contrast to microtubule distribution. This study highlights the function of cytoskeletal fibers in cancer progression, which could be of interest in designing therapeutic strategies to target cancer progress. Firstly, the viscoelastic behavior of non-invasive and invasive cells is examined with micropipette aspiration tests. A tensegrity model of cells is developed to mimic the viscoelastic behavior of cells, and tensegrity element stiffness is evaluated in an optimization procedure based on micropipette aspiration tests. Finally, by using immunofluorescent staining and confocal imaging, mechanical properties of actin filaments and microtubules of cancer cells are investigated during the course of metastasis.
MeSH term(s)	Actin Cytoskeleton ; Actins ; Cytoskeleton ; Microtubules ; Neoplasms ; Viscosity
Chemical Substances	Actins
Language	English
Publishing date	2021-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	282327-5
ISSN	1741-0444 ; 0025-696X ; 0140-0118
ISSN (online)	1741-0444
ISSN	0025-696X ; 0140-0118
DOI	10.1007/s11517-021-02318-w
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Zs.A 294: Show issues

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Article: Effects of Different Perfusing Routes through The Portal Vein, Hepatic Vein, and Biliary Duct on Whole Rat Liver Decellularization.

Jambar Nooshin, Bahram / Tayebi, Tahereh / Babajani, Amirhesam / Khani, Mohammad Mehdi / Niknejad, Hassan

Cell journal

2023 Volume 25, Issue 1, Page(s) 35–44

Abstract: Objective: Organ transplantation is the last therapeutic choice for end-stage liver failure, which is limited by the lack of sufficient donors. Decellularized liver can be used as a suitable matrix for liver tissue engineering with clinical application ... ...

Abstract	Objective: Organ transplantation is the last therapeutic choice for end-stage liver failure, which is limited by the lack of sufficient donors. Decellularized liver can be used as a suitable matrix for liver tissue engineering with clinical application potential. Optimizing the decellularization procedure would obtain a biological matrix with completely removed cellular components and preserved 3-dimensional structure. This study aimed to evaluate the decellularization efficacy through three anatomical routes. Materials and methods: In this experimental study, rat liver decellularization was performed through biliary duct (BD), portal vein (PV), and hepatic vein (HV); using chemical detergents and enzymes. The decellularization efficacy was evaluated by measurement of DNA content, extracellular matrix (ECM) total proteins, and glycosaminoglycans (GAGs). ECM preservation was examined by histological and immunohistochemical (IHC) staining and scanning electron microscopy (SEM). Scaffold biocompatibility was tested by the MTT assay for HepG2 and HUVEC cell lines. Results: Decellularization through HV and PV resulted in a transparent scaffold by complete cell removal, while the BD route produced an opaque scaffold with incomplete decellularization. H and E staining confirmed these results. Maximum DNA loss was obtained using 1% and 0.5% sodium dodecyl sulfate (SDS) in the PV and HV groups and the DNA content decreased faster in the HV group. At the final stages, the proteins excreted in the HV and PV groups were significantly less than the BD group. The GAGs level was diminished after decellularization, especially in the PV and HV groups. In the HV and PV groups the collagen amount was significantly more than the BD group. The IHC and SEM images showed that the ECM structure was preserved and cellular components were entirely removed. MTT assay showed the biocompatibility of the decellularized scaffold. Conclusion: The results revealed that the HV is a more suitable route for liver decellularization than the PV and BD.
Language	English
Publishing date	2023-01-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2647430-X
ISSN	2228-5814 ; 2228-5806
ISSN (online)	2228-5814
ISSN	2228-5806
DOI	10.22074/cellj.2022.557600.1081
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Article ; Online: Aspirin effect on bone remodeling and skeletal regeneration: Review article.

Fattahi, Roya / Mohebichamkhorami, Fariba / Khani, Mohammad Mehdi / Soleimani, Masoud / Hosseinzadeh, Simzar

Tissue & cell

2022 Volume 76, Page(s) 101753

Abstract: Bone tissues are one of the most complex tissues in the body that regenerate and repair themselves spontaneously under the right physiological conditions. Within the limitations of treating bone defects, mimicking tissue engineering through the ... ...

Abstract	Bone tissues are one of the most complex tissues in the body that regenerate and repair themselves spontaneously under the right physiological conditions. Within the limitations of treating bone defects, mimicking tissue engineering through the recruitment of scaffolds, cell sources and growth factors, is strongly recommended. Aspirin is one of the non-steroidal anti-inflammatory drugs (NSAIDs) and has been used in clinical studies for many years due to its anti-coagulant effect. On the other hand, aspirin and other NSAIDs activate cytokines and some mediators in osteoclasts, osteoblasts and their progenitor cells in a defect area, thereby promoting bone regeneration. It also stimulates angiogenesis by increasing migration of endothelial cells and the newly developed vessels are of emergency in bone fracture repair. This review covers the role of aspirin in bone tissue engineering and also, highlights its chemical reactions, mechanisms, dosages, anti-microbial and angiogenesis activities.
MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal ; Aspirin/pharmacology ; Bone Remodeling ; Endothelial Cells ; Osteogenesis ; Tissue Engineering ; Tissue Scaffolds
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2022-02-07
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2022.101753
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Zs.A 1016: Show issues

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Article ; Online: Correlation of the cell mechanical behavior and quantified cytoskeletal parameters in normal and cancerous breast cell lines.

Tabatabaei, Mohammad / Tafazzoli-Shadpour, Mohammad / Khani, Mohammad Mehdi

Biorheology

2019 Volume 56, Issue 4, Page(s) 207–219

Abstract: Background: Cancerous transformation of cells affects their mechanical behavior and cytoskeleton structure.: Objective: The objective of this research is to investigate a correlation between mechanical properties and cytoskeletal structure features ... ...

Abstract	Background: Cancerous transformation of cells affects their mechanical behavior and cytoskeleton structure. Objective: The objective of this research is to investigate a correlation between mechanical properties and cytoskeletal structure features in cancer cell formation. Methods: Micropipette aspiration was used to compare mechanical properties of normal (MCF10A) and cancerous (T47D) epithelial breast cell lines. Immunofluorescence and confocal microscopy were employed for staining and imaging F-actin and microtubules, and quantifying their fluorescent intensity, anisotropy and fiber distribution. Results: Results indicated higher F-actin intensity (43%) and anisotropy (50%) in normal cells compared to cancer cells, although there was no difference in the microtubules intensity between cell lines. Furthermore, reductions of cortex thickness and actin layer index (60%) were observed in suspended cancer cells compared to normal cells. Changes in cell physical properties induced by cancer were attributed to microtubules. The arranged fibrous structure of microtubules in normal cells was replaced by a disorganized structure in cancer cells. Cancerous cells were about four times softer with higher creep compliance compared to normal cells. Conclusions: Results of this study confirmed that alterations in cell mechanical properties induced by cancer are highly correlated with changes in F-actin and microtubule content and arrangement. It is suggested that such changes can enhance our knowledge of cancer initiation and progression.
MeSH term(s)	Actins/chemistry ; Actins/metabolism ; Biomechanical Phenomena ; Breast Neoplasms/chemistry ; Breast Neoplasms/metabolism ; Cell Line ; Cell Line, Tumor ; Cytoskeleton/chemistry ; Cytoskeleton/metabolism ; Female ; Humans ; Microtubules/chemistry ; Microtubules/metabolism
Chemical Substances	Actins
Language	English
Publishing date	2019-09-27
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	82015-5
ISSN	1878-5034 ; 0006-355X
ISSN (online)	1878-5034
ISSN	0006-355X
DOI	10.3233/BIR-190214
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Zs.A 394: Show issues

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Article ; Online: The cooperative effects of micro-grooved topography and TGF-β1 on the vascular smooth muscle cell contractile protein expression of the mesenchymal stem cells.

Abolhasani, Sakhavat / Rajabibazl, Masoumeh / Khani, Mohammad-Mehdi / Parandakh, Azim / Hoseinpoor, Reyhaneh

Differentiation; research in biological diversity

2020 Volume 115, Page(s) 22–29

Abstract: Cell morphological changes induced by micro-grooved topography have been shown to be an important regulator of smooth muscle (SM) differentiation of mesenchymal stem cells (MSCs). In addition to the micro-grooved topography, transforming growth factor- ... ...

Abstract	Cell morphological changes induced by micro-grooved topography have been shown to be an important regulator of smooth muscle (SM) differentiation of mesenchymal stem cells (MSCs). In addition to the micro-grooved topography, transforming growth factor-β
MeSH term(s)	Actins/genetics ; Calcium-Binding Proteins/genetics ; Cell Differentiation/genetics ; Gelsolin/genetics ; Gene Expression Regulation, Developmental/genetics ; Humans ; Mesenchymal Stem Cells/cytology ; Microfilament Proteins/genetics ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/metabolism ; Transforming Growth Factor beta1/genetics ; Calponins
Chemical Substances	Actins ; Calcium-Binding Proteins ; Gelsolin ; Microfilament Proteins ; TGFB1 protein, human ; Transforming Growth Factor beta1
Language	English
Publishing date	2020-07-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184540-8
ISSN	1432-0436 ; 0301-4681
ISSN (online)	1432-0436
ISSN	0301-4681
DOI	10.1016/j.diff.2020.06.003
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Zs.A 1170: Show issues

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Article ; Online: Stepwise morphological changes and cytoskeletal reorganization of human mesenchymal stem cells treated by short-time cyclic uniaxial stretch.

Parandakh, Azim / Tafazzoli-Shadpour, Mohammad / Khani, Mohammad-Mehdi

In vitro cellular & developmental biology. Animal

2017 Volume 53, Issue 6, Page(s) 547–553

Abstract: This study aimed to investigate stepwise remodeling of human mesenchymal stem cells (hMSCs) in response to cyclic stretch through rearrangement and alignment of cells and cytoskeleton regulation toward smooth muscle cell (SMC) fate in different time ... ...

Abstract	This study aimed to investigate stepwise remodeling of human mesenchymal stem cells (hMSCs) in response to cyclic stretch through rearrangement and alignment of cells and cytoskeleton regulation toward smooth muscle cell (SMC) fate in different time spans. Image analysis techniques were utilized to calculate morphological parameters. Cytoskeletal reorganization was observed by investigating F-actin filaments using immunofluorescence staining, and expression level of contractile SMC markers was followed by a quantitative polymerase chain reaction method. Applying cyclic uniaxial stretch on cultured hMSCs, utilizing a costume-made device, led to alteration in fractal dimension (FD) and cytoskeleton structure toward continuous alignment and elongation of cells by elevation of strain duration. Actin filaments became more aligned perpendicular to the axis of mechanical stretch by increasing uniaxial loading duration. At first, FD met a significant decrease in 4 h loading duration then increased significantly by further loading up to 16 h, followed by another decrease up to 1 d of uniaxial stretching. HMSCs subjected to 24 h cyclic uniaxial stretching significantly expressed early and intermediate contractile SM markers. It was hypothesized that the increase in FD after 4 h while cells continuously became more aligned and elongated was due to initiation of change in phenotype that influenced arrangement of cells. At this point, change in cell phenotype started leading to change in morphology while mechanical loading still caused cell alignment and rearrangement. Results can be helpful when optimized engineered cells are needed based on mechanical condition for functional engineered tissue and cell therapy.
Language	English
Publishing date	2017-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1077810-x
ISSN	1543-706X ; 0883-8364 ; 1071-2690
ISSN (online)	1543-706X
ISSN	0883-8364 ; 1071-2690
DOI	10.1007/s11626-017-0131-8
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Zs.A 851: Show issues

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Article ; Online: Nanoscale vibration could promote tenogenic differentiation of umbilical cord mesenchymal stem cells.

Karimi, Elahe / Vahedi, Negin / Sarbandi, Reza Ramezani / Parandakh, Azim / Ganjoury, Camellia / Sigaroodi, Faraz / Najmoddin, Najmeh / Tabatabaei, Mohammad / Tafazzoli-Shadpour, Mohammad / Ardeshirylajimi, Abdolreza / Khani, Mohammad-Mehdi

In vitro cellular & developmental biology. Animal

2023 Volume 59, Issue 6, Page(s) 401–409

Abstract: Regulation of mesenchymal stem cell (MSC) fate for targeted cell therapy applications has been a subject of interest, particularly for tissues such as tendons that possess a marginal regenerative capacity. Control of MSCs' fate into the tendon-specific ... ...

Abstract	Regulation of mesenchymal stem cell (MSC) fate for targeted cell therapy applications has been a subject of interest, particularly for tissues such as tendons that possess a marginal regenerative capacity. Control of MSCs' fate into the tendon-specific lineage has mainly been achieved by implementation of chemical growth factors. Mechanical stimuli or 3-dimensional (D) scaffolds have been used as an additional tool for the differentiation of MSCs into tenocytes, but oftentimes, they require a sophisticated bioreactor or a complex scaffold fabrication technique which reduces the feasibility of the proposed method to be used in practice. Here, we used nanovibration to induce the differentiation of MSCs toward the tenogenic fate solely by the use of nanovibration and without the need for growth factors or complex scaffolds. MSCs were cultured on 2D cell culture dishes that were connected to piezo ceramic arrays to apply nanovibration (30-80 nm and 1 kHz frequency) over 7 and 14 d. We observed that nanovibration resulted in significant overexpression of tendon-related markers in both gene expression and protein expression levels, while there was no significant differentiation into adipose and cartilage lineages. These findings could be of assistance in the mechanoregulation of MSCs for stem cell engineering and regenerative medicine applications.
MeSH term(s)	Animals ; Tissue Engineering/methods ; Vibration ; Cell Differentiation ; Mesenchymal Stem Cells ; Umbilical Cord
Language	English
Publishing date	2023-07-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1077810-x
ISSN	1543-706X ; 0883-8364 ; 1071-2690
ISSN (online)	1543-706X
ISSN	0883-8364 ; 1071-2690
DOI	10.1007/s11626-023-00780-4
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Zs.A 851: Show issues

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Article ; Online: A Bilayered, Electrospun Poly(Glycerol-Sebacate)/Polyurethane-Polyurethane Scaffold for Engineering of Endothelial Basement Membrane.

Rekabgardan, Mahmood / Rahmani, Mahya / Soleimani, Masoud / HosSein Zadeh, Simzar / Roozafzoon, Reza / Parandakh, Azim / Khani, Mohammad-Mehdi

ASAIO journal (American Society for Artificial Internal Organs : 1992)

2021 Volume 68, Issue 1, Page(s) 123–132

Abstract: In the cardiovascular system, heart valves and vessels are subjected to continuous cyclic mechanical loadings due to the pulsatile nature of blood flow. Hence, in leveraging tissue engineering (TE) strategies to regenerate such a system, the candidate ... ...

Abstract	In the cardiovascular system, heart valves and vessels are subjected to continuous cyclic mechanical loadings due to the pulsatile nature of blood flow. Hence, in leveraging tissue engineering (TE) strategies to regenerate such a system, the candidate scaffold should not only be biocompatible with the desired biodegradation rate, but it should also be mechanically competent to provide a supportive structure for facilitating stem cells retention, growth, and differentiation. To this end, herein, we introduced a novel scaffold composed of poly(glycerol-sebacate) (PGS) and polyurethane (PU), which comprises of two layers: an electrospun pure PU layer beneath another electrospun PGS/PU layer with a different ratio of PGS to PU (3:2, 1:1, 2:3 Wt:Wt). The electrospun PGS/PU-PU scaffold was mechanically competent and showed intended hydrophilicity and a good biodegradation rate. Moreover, the PGS/PU-PU scaffold indicated cell viability and proliferation within ten days of in vitro cell culture and upon 7 day vascular endothelial growth factor (VEGF) stimulation, supported endothelial differentiation of mesenchymal stem cells by significant overexpression of platelet-endothelial cell adhesion molecule-1, von Willebrand factor, and VEGF receptor 2. The results of this study could be implemented in cardiovascular TE strategies when regeneration of blood vessel or heart valve is desired.
MeSH term(s)	Basement Membrane ; Cell Proliferation ; Decanoates ; Glycerol/analogs & derivatives ; Polymers ; Polyurethanes ; Tissue Engineering ; Tissue Scaffolds ; Vascular Endothelial Growth Factor A
Chemical Substances	Decanoates ; Polymers ; Polyurethanes ; Vascular Endothelial Growth Factor A ; poly(glycerol-sebacate) ; Glycerol (PDC6A3C0OX)
Language	English
Publishing date	2021-06-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	759982-1
ISSN	1538-943X ; 0162-1432 ; 1058-2916
ISSN (online)	1538-943X
ISSN	0162-1432 ; 1058-2916
DOI	10.1097/MAT.0000000000001423
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