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Article ; Online: Association between smoking and alopecia areata: a systematic review and meta-analysis.

Khanimov, Israel

2021 Volume 61, Issue 1, Page(s) e22–e24

MeSH term(s)	Alopecia Areata/epidemiology ; Alopecia Areata/etiology ; Humans ; Smoking/adverse effects
Language	English
Publishing date	2021-09-01
Publishing country	England
Document type	Letter ; Meta-Analysis ; Systematic Review
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.15898
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Article: Lower Incidence of Hypoglycemia With Angiotensin Receptor Blocker Versus ACE Inhibitor Therapy in People With or Without Diabetes.

Khanimov, Israel / Zingerman, Boris / Rozen-Zvi, Benaya / Shimonov, Mordechai / Leibovitz, Eyal

Clinical diabetes : a publication of the American Diabetes Association

2024 Volume 42, Issue 2, Page(s) 300–307

Abstract: This article describes a study examining the association between treatment with ACE inhibitors or angiotensin receptor blockers (ARBs) and incident hypoglycemia in patients with or without diabetes who were admitted to the internal medicine departments ... ...

Abstract	This article describes a study examining the association between treatment with ACE inhibitors or angiotensin receptor blockers (ARBs) and incident hypoglycemia in patients with or without diabetes who were admitted to the internal medicine departments of a tertiary hospital in the Tel Aviv district of Israel. The authors found that treatment with ARBs, but not ACE inhibitors, compared with treatment with neither, was associated with a reduced risk of hypoglycemia regardless of diabetes status.
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025953-3
ISSN	0891-8929
ISSN	0891-8929
DOI	10.2337/cd23-0039
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Zs.A 2591: Show issues

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Article: The Effect of Percutaneous Endoscopic Gastrostomy on Prognosis of Patients at Risk of Malnutrition.

Leibovitz, Eyal / Boaz, Mona / Khanimov, Israel / Mosiev, Gary / Shimonov, Mordechai

The Israel Medical Association journal : IMAJ

2023 Volume 25, Issue 3, Page(s) 215–220

Abstract: Background: Despite its wide use, evidence is inconclusive regarding the effect of percutaneous endoscopic gastrostomy (PEG) in patients with chronic diseases and dementia among hospitalized patients with malnutrition.: Objectives: To examine the ... ...

Abstract	Background: Despite its wide use, evidence is inconclusive regarding the effect of percutaneous endoscopic gastrostomy (PEG) in patients with chronic diseases and dementia among hospitalized patients with malnutrition. Objectives: To examine the effect of PEG insertion on prognosis after the procedure. Methods: This retrospective analysis of medical records included all adult patients who underwent PEG insertion between 1 January 2009 and 31 December 2013 during their hospitalization. For each PEG patient, two controls similar in age, sex, referring department, and underlying condition were randomly selected from the entire dataset of patients admitted. The effect of PEG on mortality and repeated admissions was examined. Results: The study comprised 154 patients, 49 referred for PEG insertion and 105 controls (mean age 74.8 ± 19.8 years; 72.7% females; 78.6% admitted to internal medicine units). Compared to controls, the PEG group had a higher 2-year mortality rate (59.2% vs. 17.1%, P < 0.001) but the 2-year readmission rate did not differ significantly (44.9% vs. 56.2% respectively, P = 0.191). Regression analysis showed PEG was associated with increased risk of the composite endpoint of death or readmission (hazard ratio 1.514, 95% confidence interval 1.016-2.255, P = 0.041). No specific characteristic of admission was associated with increased likelihood of death or readmission. Among readmitted patients, reasons for admission and baseline laboratory data, including albumin and cholesterol, did not differ between the PEG patients and controls. Conclusions: In-hospital PEG insertion was associated with increased mortality at 2 years but had no effect on readmissions.
MeSH term(s)	Adult ; Female ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Male ; Gastrostomy/adverse effects ; Enteral Nutrition ; Retrospective Studies ; Prognosis ; Malnutrition/diagnosis ; Malnutrition/epidemiology
Language	English
Publishing date	2023-03-22
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article: Transient Pruritic Erythema as a Forme Fruste of Solar Urticaria.

Azrielant, Shir / Khanimov, Israel / Sprecher, Eli / Ellenbogen, Eran

The Israel Medical Association journal : IMAJ

2020 Volume 22, Issue 4, Page(s) 227–231

Abstract: Background: Solar urticaria (SU) is a rare and disabling photodermatosis. SU typically manifests as urticarial wheals and erythema appearing shortly after sun exposure. SU is often initially diagnosed clinically with subsequent confirmation through ... ...

Abstract	Background: Solar urticaria (SU) is a rare and disabling photodermatosis. SU typically manifests as urticarial wheals and erythema appearing shortly after sun exposure. SU is often initially diagnosed clinically with subsequent confirmation through photoprovocation tests. Early diagnosis is important for correct management of patients. Objectives: To present the clinical features of three cases of atypical presentation of SU and to discuss possible underlying mechanisms. Methods: We report a series of three patients who presented with transient pruritic erythema without wheals after sun exposure. All patients had photoprovocation tests conducted to confirm SU diagnosis and to determine their action spectra. Treatment outcomes were recorded. Results: All three patients developed classical manifestations of SU during photoprovocation tests within the UVA1 spectrum. Two patients required high-dose irradiation to provoke urticaria. Conclusions: Erythema without urticaria can be the primary manifestation of SU, especially in countries with sunny climates where natural skin hardening is common. Such cases require a high index of suspicion for SU and highlight the importance of photoprovocation testing to confirm the diagnosis.
MeSH term(s)	Adult ; Diagnosis, Differential ; Erythema/diagnosis ; Erythema/etiology ; Female ; Follow-Up Studies ; Humans ; Male ; Omalizumab/therapeutic use ; Photosensitivity Disorders/diagnosis ; Photosensitivity Disorders/drug therapy ; Pruritus/diagnosis ; Pruritus/drug therapy ; Pruritus/etiology ; Risk Assessment ; Sampling Studies ; Skin Tests/methods ; Sunlight/adverse effects ; Time Factors ; Treatment Outcome ; Urticaria/diagnosis ; Urticaria/drug therapy ; Urticaria/etiology
Chemical Substances	Omalizumab (2P471X1Z11)
Language	English
Publishing date	2020-04-14
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article: Changes in Serum Creatinine May Cause Hypoglycemia among Non-Critically Ill Patients Admitted to Internal Medicine Units.

Zingerman, Boris / Khanimov, Israel / Shimonov, Mordechai / Boaz, Mona / Rozen-Zvi, Benaya / Leibovitz, Eyal

Journal of clinical medicine

2022 Volume 11, Issue 22

Abstract: Background: The association between changes in serum creatinine levels and hypoglycemia during hospitalization was investigated. Methods: This was a retrospective analysis of medical charts. Patients were categorized as having significant change in ... ...

Abstract	Background: The association between changes in serum creatinine levels and hypoglycemia during hospitalization was investigated. Methods: This was a retrospective analysis of medical charts. Patients were categorized as having significant change in creatinine (SCIC) when serum creatinine levels rose or dropped ≥ 0.3 mg/dL from admission values at any time during their hospitalization. Patients were considered hypoglycemic if they had at least one documented glucose level ≤ 70 mg/dL during the hospitalization. Multiple logistic, linear and Cox regression analyses were used to ascertain the association between incident SCIC, severity and timing with incident hypoglycemia. Results: Included were 25,400 (mean age 69.9 ± 18.0, 49.3% were males). The rate of SCIC was 22.2%, and 62.2% of them were diagnosed upon admission. Patients with SCIC had a higher incidence of hypoglycemia compared to patients without (13.1% vs. 4.1%, respectively, p < 0.001). Patients with SCIC had an increased risk of hypoglycemia (OR 1.853, 95% CI 1.586−2.166, p < 0.001). The magnitude of SCIC was associated with the incidence (OR 1.316, 95% CI 1.197−1.447, p < 0.001) and the number of events (HR 0.054, 95% CI 0.021−0.087, p = 0.001). More than 60% of patients with hypoglycemia had their first event documented during days 0−6 after SCIC occurrence. Of those, the majority of events occurred on day 0−1, and the rate showed a gradual decrease throughout the first 5 days from SCIC occurrence. The results were similar for patients with and without DM. Conclusions: Changes in creatinine during hospitalization may cause hypoglycemia among patients admitted to internal medicine departments, regardless of DM status.
Language	English
Publishing date	2022-11-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11226852
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Article ; Online: Successful ligelizumab treatment of severe refractory solar urticaria.

Hershkovitz, Yoav / Khanimov, Israel / Rubin, Limor / Dranitzki, Zvika / Talmon, Aviv / Ribak, Yaarit / Shamriz, Oded / Levi, Asi / Tal, Yuval

The journal of allergy and clinical immunology. In practice

2023 Volume 11, Issue 8, Page(s) 2576–2577

MeSH term(s)	Humans ; Urticaria, Solar ; Antibodies, Monoclonal, Humanized/therapeutic use ; Urticaria/drug therapy ; Omalizumab/therapeutic use
Chemical Substances	ligelizumab (L8LE0L691T) ; Antibodies, Monoclonal, Humanized ; Omalizumab (2P471X1Z11)
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2023.01.052
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Article ; Online: Systemic Treatment With Glucocorticoids Is Associated With Incident Hypoglycemia and Mortality: A Historical Prospective Analysis.

Khanimov, Israel / Boaz, Mona / Shimonov, Mordechai / Wainstein, Julio / Leibovitz, Eyal

The American journal of medicine

2020 Volume 133, Issue 7, Page(s) 831–838.e1

Abstract: Purpose: The purpose of this study was to examine whether the increased glycemic variability associated with systemic glucocorticoid treatment is also associated with increased incidence of hypoglycemia.: Methods: All patients discharged from ... ...

Abstract	Purpose: The purpose of this study was to examine whether the increased glycemic variability associated with systemic glucocorticoid treatment is also associated with increased incidence of hypoglycemia. Methods: All patients discharged from internal medicine units between 2010 and 2013 were included in this retrospective analysis. Patients were assigned to 3 groups: Group 1: no steroids were prescribed;. Group 2: topical or inhaled steroids were prescribed with no systemic treatment; and Group 3: systemic steroids were prescribed, with or without topical or inhaled treatment. Results: A total of 45,272 patients were included in the study. Patients in Group 3 had significantly higher rates of hypoglycemia (10.9%) compared to patients in Group 2 (7.4%), and patients in Group 1 (7.3%). Patients with diabetes mellitus had higher rates of hypoglycemia compared to patients without diabetes mellitus (14.3% vs 4.9%) but exhibited similar trends in response to steroid treatment. Multivariate analysis showed that systemic steroids were associated with increased risk for hypoglycemia (odds ratio [OR] 1.513, 95% confidence interval [CI] 1.311-1.746, P <0.001). Hypoglycemia associated with systemic steroid treatment was also associated with increased risk of death (hazard ratio [HR] 2.328, 95% CI 1.931-2.807, P <0.001). Patients who were treated with systemic steroids but did not have hypoglycemia did not have higher mortality rates (HR 1.068, 95% CI 0.972-1.175, P = 0.171). Conclusion: Treatment with systemic steroids is associated with increased hypoglycemia incidence during hospitalization. Patients treated with steroids that had incident hypoglycemia had a higher 1-year mortality risk compared to patients without hypoglycemia treated with steroids.
MeSH term(s)	Aged ; Biomarkers/blood ; Blood Glucose/metabolism ; Critical Illness/therapy ; Female ; Follow-Up Studies ; Glucocorticoids/adverse effects ; Glucocorticoids/therapeutic use ; Hospitalization/trends ; Humans ; Hypoglycemia/blood ; Hypoglycemia/chemically induced ; Hypoglycemia/epidemiology ; Incidence ; Israel/epidemiology ; Male ; Prognosis ; Prospective Studies ; Survival Rate/trends
Chemical Substances	Biomarkers ; Blood Glucose ; Glucocorticoids
Language	English
Publishing date	2020-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2019.12.026
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Article ; Online: Association between estimated GFR and incident hypoglycaemia during hospitalization.

Khanimov, Israel / Zingerman, Boris / Korzetz, Asher / Boaz, Mona / Shimonov, Mordechai / Wainstein, Julio / Leibovitz, Eyal

Nephrology (Carlton, Vic.)

2021 Volume 27, Issue 2, Page(s) 162–170

Abstract: Background: Kidney function is a significant factor associated with increased incidence of hypoglycaemia, especially among patients with diabetes mellitus (DM). We here quantified the association between elevated creatinine and incident hypoglycaemia ... ...

Abstract	Background: Kidney function is a significant factor associated with increased incidence of hypoglycaemia, especially among patients with diabetes mellitus (DM). We here quantified the association between elevated creatinine and incident hypoglycaemia among patients admitted to internal medicine departments, with and without DM. Methods: This is a retrospective cohort analysis study. Included were all patients discharged from internal medicine units between 2010 and 2013. Patients were excluded if creatinine levels rose or dropped more than 0.3 mg/dL during hospitalization. The CKD-EPI equation was used to calculate glomerular filtration rate (eGFR). Logistic regression analysis (backward LR method) was used to study the association between eGFR and hypoglycaemia incidence. Results: Included were 39 316 patients (mean age 68.0 ± 18.0 years, 49.3% males, 25.9% with DM, eGFR 69.5 ± 24.9 mL/min/1.73 m Conclusion: Among non-critically-ill patients hospitalized in internal medicine departments, reduced eGFR is associated with increased risk of hypoglycaemia. Glucose monitoring for all inpatients with CKD is suggested, regardless of DM status.
MeSH term(s)	Aged ; Aged, 80 and over ; Cohort Studies ; Female ; Glomerular Filtration Rate ; Hospitalization ; Humans ; Hypoglycemia/epidemiology ; Hypoglycemia/physiopathology ; Incidence ; Male ; Middle Aged ; Retrospective Studies
Language	English
Publishing date	2021-11-27
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1303661-0
ISSN	1440-1797 ; 1320-5358
ISSN (online)	1440-1797
ISSN	1320-5358
DOI	10.1111/nep.13984
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Article ; Online: Documented hypoglycemia is associated with poor short and long term prognosis among patients admitted to general internal medicine departments.

Leibovitz, Eyal / Khanimov, Israel / Wainstein, Julio / Boaz, Mona

Diabetes & metabolic syndrome

2018 Volume 13, Issue 1, Page(s) 222–226

Abstract: Aim: To study the association of documented hypoglycemia with length of stay, 30-day mortality, and 1-year mortality, among patients with and without diabetes admitted to internal medicine units.: Methods: The electronic medical records of all ... ...

Abstract	Aim: To study the association of documented hypoglycemia with length of stay, 30-day mortality, and 1-year mortality, among patients with and without diabetes admitted to internal medicine units. Methods: The electronic medical records of all patients hospitalized in internal medicine departments at E. Wolfson Medical Center, Holon, Israel, between 1/1/2010 and 31/12/2013, were reviewed. Data extracted included all glucose measurements (performed using an institutional blood glucose monitoring system). Patients were considered hypoglycemic if at least one hypoglycemic event was recorded. Regression analysis was used to assess the association between documented hypoglycemia and length of stay, 30-day and one-year mortality. Age, sex, reason for admission, and the Charlson comorbidity index were entered as covariates, and the most conservative model was developed. Results: The study population included 45,272 patients (mean age 68.9 ± 17.8 years, 49.4% males, 21.0% had diabetes mellitus). The rate of hypoglycemia in the total study population was 7.5% (16.8% among DM patients, 6.0% among patients without diabetes, p < 0.001). Patients with documented hypoglycemia had a longer length of hospital stay (9.3 ± 18.7 vs. 3.1 ± 6.4 days, p < 0.001), as well as higher risk for both 30-day (23.7% vs. 7.0%, p < 0.001) and 1-year mortality (41.6% vs. 15.3%, p < 0.001). Cox regression analysis showed that hypoglycemia significantly increased risk death at one year (HR 2.436, 95% CI 2.298-2.582, p < 0.001) independent of age, sex, the Charlson comorbidity index, DM status and reason for admission. Conclusion: Documented hypoglycemia is associated with prolonged length of hospital stay and increased risk for both 30-day and 1-year mortality, regardless of diabetes mellitus status.
MeSH term(s)	Aged ; Biomarkers/analysis ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 2/drug therapy ; Documentation ; Female ; Follow-Up Studies ; Glycated Hemoglobin A/analysis ; Hospitalization/statistics & numerical data ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemia/diagnosis ; Hypoglycemic Agents/adverse effects ; Internal Medicine ; Male ; Prognosis ; Risk Factors
Chemical Substances	Biomarkers ; Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; hemoglobin A1c protein, human
Language	English
Publishing date	2018-07-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2018.07.004
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Article ; Online: Tinea capitis caused by Trichophyton tonsurans among adults: Clinical characteristics and treatment response.

Galili, Eran / Goldsmith, Tomer / Khanimov, Israel / Arbel, Chen / Sharvit, Sharon / Lyakhovitsky, Anna / Shemer, Avner / Barzilai, Aviv / Astman, Nadav

Mycoses

2022

Abstract: Background: Trichophyton tonsurans tinea capitis has become a growing epidemiological concern. Yet, its clinical manifestations and treatment response, specifically among adults, have only been described among small sample size studies.: Objective: ... ...

Abstract	Background: Trichophyton tonsurans tinea capitis has become a growing epidemiological concern. Yet, its clinical manifestations and treatment response, specifically among adults, have only been described among small sample size studies. Objective: To assess clinical manifestations and treatment outcome of T. tonsurans tinea capitis among adults. Patients and methods: A retrospective cohort study was carried out among 111 adults with T. tonsurans tinea capitis. Diagnosis was confirmed by fungal culture or polymerase chain reaction. Examinees' demographics, disease characteristics and treatment response were measured. The risk factors for the treatment failure were evaluated. Results: The mean age was 20.1 years (±3.1), with men (98.2%) outnumbering women. The follow-up lasted 12.2 months (±5.6). The majority of T. tonsurans tinea capitis was seen in the occipital area (87.6%). In 78.9% of the cases, the scalp manifestation was non-inflammatory (scaly plaques and papules:76.1% and seborrhoea-like: 2.8%). 21.1% of cases presented with inflammatory tinea capitis (21.1%; Kerion: 10.1% and pustular: 11%). Concomitant involvement of other than scalp areas was common: tinea corporis was seen in 38.7% of the cases; tinea faciei and barbae in 24.3%; nape and anterior neck in 76.6% and 2.7% of the cases, respectively. An adequate treatment course with oral terbinafine resulted in 83.2% clinical cure rate. Treatment failure was significantly associated with concomitant tinea corporis (odds ratio 3.9; 95% confidence interval 1.3-12.1, p-Value< .02). Conclusion: The most common clinical presentation of T. tonsurans tinea capitis included occipital scaly plaques and papules with concomitant non-scalp lesions. Oral terbinafine was found to be highly effective. Concomitant tinea corporis increased the risk for treatment failure.
Language	English
Publishing date	2022-10-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392487-7
ISSN	1439-0507 ; 0933-7407
ISSN (online)	1439-0507
ISSN	0933-7407
DOI	10.1111/myc.13536
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