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  1. Article ; Online: Longitudinal imaging of murine atherosclerosis with 2-deoxy-2-[

    Khare, Harshvardhan A / Binderup, Tina / Hag, Anne Mette Fisker / Kjaer, Andreas

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 22983

    Abstract: In a longitudinal design, four arterial segments in mice were followed by positron emission tomography/computed tomography (PET/CT) imaging. We aimed to determine how the tracers reflected the development of atherosclerosis via the uptake of 2-deoxy-2-[ ...

    Abstract In a longitudinal design, four arterial segments in mice were followed by positron emission tomography/computed tomography (PET/CT) imaging. We aimed to determine how the tracers reflected the development of atherosclerosis via the uptake of 2-deoxy-2-[
    MeSH term(s) Mice ; Animals ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography/methods ; Sodium Fluoride ; Glucose ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/genetics ; Aorta, Abdominal ; Apolipoproteins E/genetics ; Apolipoproteins ; Positron-Emission Tomography ; Radiopharmaceuticals
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Sodium Fluoride (8ZYQ1474W7) ; Glucose (IY9XDZ35W2) ; Apolipoproteins E ; Apolipoproteins ; Radiopharmaceuticals
    Language English
    Publishing date 2023-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-49585-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Combination of [

    Simón, Marina / Jørgensen, Jesper Tranekjær / Khare, Harshvardhan A / Christensen, Camilla / Nielsen, Carsten Haagen / Kjaer, Andreas

    Pharmaceutics

    2022  Volume 14, Issue 6

    Abstract: Peptide receptor radionuclide therapy (PRRT) relies on α- and β-emitting radionuclides bound to a peptide that commonly targets somatostatin receptors (SSTRs) for the localized killing of tumors through ionizing radiation. A Lutetium-177 ( ...

    Abstract Peptide receptor radionuclide therapy (PRRT) relies on α- and β-emitting radionuclides bound to a peptide that commonly targets somatostatin receptors (SSTRs) for the localized killing of tumors through ionizing radiation. A Lutetium-177 (
    Language English
    Publishing date 2022-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14061284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In vivo detection of urokinase-type plasminogen activator receptor (uPAR) expression in arterial atherogenesis using [

    Khare, Harshvardhan A / Døssing, Kristina B V / Ringgaard, Lars / Christensen, Esben / Urbak, Laerke / Sillesen, Henrik / Ripa, Rasmus S / Binderup, Tina / Pedersen, Sune F / Kjaer, Andreas

    Atherosclerosis

    2022  Volume 352, Page(s) 103–111

    Abstract: Background and aims: Urokinase-type plasminogen activator receptor (uPAR) is associated with extracellular matrix (ECM) degradation and cancer aggressiveness. Its role in arterial atherogenesis as a molecular imaging target is not well-established. The ... ...

    Abstract Background and aims: Urokinase-type plasminogen activator receptor (uPAR) is associated with extracellular matrix (ECM) degradation and cancer aggressiveness. Its role in arterial atherogenesis as a molecular imaging target is not well-established. The aim of this study was to non-invasively visualize uPAR expression in atherosclerosis by a novel uPAR-targeting positron emission tomography (PET) tracer [
    Methods: We used molecular biology to investigate uPAR expression by analyzing human atherosclerotic plaques and cultured cells. A retrospective analysis was performed on patients, who underwent combined PET/CT (n = 10) to measure [
    Results: The in vitro assay for THP-1 monocytes displayed a significantly upregulated uPAR expression upon stimulation (5.2-fold upregulation, p < 0.0001 by a one-way ANOVA followed by Tukey's test) by single-cell flowcytometric analysis. Freshly excised human atherosclerotic plaques underwent flow cytometric and microarray analyses manifesting 73.9 ± 2.9% of mononuclear phagocyte system (MPS) cells expressing uPAR and had a greater than 7-fold higher gene expression of plasminogen activator urokinase receptor (PLAUR, p = 0.002), integrin subunit alpha X (ITGAX, p = 0.0008), and cluster of differentiation 163 (CD163, p < 0.0001). The tissue-to-background ratios (TBR
    Conclusions: uPAR is abundantly expressed by MPS cells in atherosclerotic plaques and can be visualized by the novel PET tracer [
    MeSH term(s) Arteries/metabolism ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/genetics ; Copper Radioisotopes ; Heterocyclic Compounds, 1-Ring ; Humans ; Oligopeptides ; Plaque, Atherosclerotic ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography/methods ; Receptors, Urokinase Plasminogen Activator/genetics ; Receptors, Urokinase Plasminogen Activator/metabolism ; Retrospective Studies ; Urokinase-Type Plasminogen Activator
    Chemical Substances Copper Radioisotopes ; Heterocyclic Compounds, 1-Ring ; Oligopeptides ; Receptors, Urokinase Plasminogen Activator ; beta-cyclohexylalanyl-phenylalanyl-seryl-arginyl-tyrosyl-leucyl-tryptophyl-serine ; 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid (1HTE449DGZ) ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
    Language English
    Publishing date 2022-03-30
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2022.03.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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