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Article ; Online: IgG4-positive Hashimoto thyroiditis and its association with IgG4-related sclerosing disease.

Sharma Khatiwada, Aagat / Choudhury, Natasha

BMJ case reports

2022 Volume 15, Issue 7

Abstract: A woman in her 50s was referred with suspected thyroid malignancy and underwent total thyroidectomy. Immunohistochemical analysis revealed IgG4-positive Hashimoto's thyroiditis. IgG4-related thyroid disease is poorly understood, and thought to encompass ... ...

Abstract	A woman in her 50s was referred with suspected thyroid malignancy and underwent total thyroidectomy. Immunohistochemical analysis revealed IgG4-positive Hashimoto's thyroiditis. IgG4-related thyroid disease is poorly understood, and thought to encompass various entities including IgG4-positive Hashimoto's thyroiditis, Fibrosing Variant of Hashimoto's thyroiditis, Reidel's thyroiditis and Graves' disease with elevated IgG4 levels. Furthermore, it may be associated with a systemic fibrosing condition called 'IgG4-related sclerosing disease'. The clinical significance of IgG4-positive thyroid disease, however, remains unclear.
MeSH term(s)	Female ; Graves Disease/complications ; Graves Disease/diagnosis ; Graves Disease/surgery ; Hashimoto Disease/complications ; Hashimoto Disease/diagnosis ; Humans ; Immunoglobulin G ; Immunoglobulin G4-Related Disease/complications ; Immunoglobulin G4-Related Disease/diagnosis ; Immunologic Tests
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2022-07-06
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-249181
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Article ; Online: Use of pre-operative calcium and vitamin D supplementation to prevent post-operative hypocalcaemia in patients undergoing thyroidectomy: a systematic review.

Khatiwada, A S / Harris, A S

The Journal of laryngology and otology

2021 Volume 135, Issue 7, Page(s) 568–573

Abstract: Objective: This systematic review aimed to establish the evidence behind the use of pre-operative calcium, vitamin D or both calcium and vitamin D to prevent post-operative hypocalcaemia in patients undergoing thyroidectomy.: Method: This review ... ...

Abstract	Objective: This systematic review aimed to establish the evidence behind the use of pre-operative calcium, vitamin D or both calcium and vitamin D to prevent post-operative hypocalcaemia in patients undergoing thyroidectomy. Method: This review included prospective clinical trials on adult human patients that were published in English and which studied the effects of pre-operative supplementation with calcium, vitamin D or both calcium and vitamin D on the rate of post-operative hypocalcaemia following total thyroidectomy. Results: Seven out of the nine trials included reported statistically significantly reduced rates of post-operative laboratory hypocalcaemia (absolute risk reduction, 13-59 per cent) and symptomatic hypocalcaemia (absolute reduction, 11-40 per cent) following pre-operative supplementation. Conclusion: Pre-operative treatment with calcium, vitamin D or both calcium and vitamin D reduces the risk of post-operative hypocalcaemia and should be considered in patients undergoing total thyroidectomy.
MeSH term(s)	Calcitriol/therapeutic use ; Calcium/therapeutic use ; Calcium Carbonate/therapeutic use ; Calcium-Regulating Hormones and Agents/therapeutic use ; Cholecalciferol/therapeutic use ; Humans ; Hydroxycholecalciferols/therapeutic use ; Hypocalcemia/physiopathology ; Hypocalcemia/prevention & control ; Postoperative Complications/prevention & control ; Preoperative Care/methods ; Thyroidectomy/methods ; Vitamin D/therapeutic use ; Vitamins/therapeutic use
Chemical Substances	Calcium-Regulating Hormones and Agents ; Hydroxycholecalciferols ; Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; Calcitriol (FXC9231JVH) ; Calcium Carbonate (H0G9379FGK) ; Calcium (SY7Q814VUP) ; alfacalcidol (URQ2517572)
Language	English
Publishing date	2021-06-14
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215121001523
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Ul II Zs.64: Show issues

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Article ; Online: The impact of insomnia and depression on asthma control.

Rhoads, Sarah L / Edinger, Jack / Khatiwada, Aastha / Zimmer, Joy / Zelarney, Pearlanne / Wechsler, Michael E

The Journal of asthma : official journal of the Association for the Care of Asthma

2024 , Page(s) 1–4

Abstract: Background: Poor sleep quality is often reported by individuals with asthma, particularly by those who have poor asthma control overall. However, there is little understanding of how underlying sleep disorders such as insomnia may impact asthma control. ...

Abstract	Background: Poor sleep quality is often reported by individuals with asthma, particularly by those who have poor asthma control overall. However, there is little understanding of how underlying sleep disorders such as insomnia may impact asthma control. Furthermore, given the frequent overlap of depression and insomnia, the incremental impact of mood disorders and insomnia on asthma control remains unclear. Methods: We conducted a retrospective analysis of patients at a large asthma center to further elucidate connections between these disease processes. Asthma patients with and without a diagnosis of insomnia were matched by age, sex, Charlson comorbidity index, and biologic therapy. We evaluated the presence of concurrent obstructive sleep disorder, mood disorders, exacerbation frequency, and asthma control test (ACT) scores. Results: From a cohort of 659 patients with an asthma diagnosis, 89 subjects with insomnia (13.5%) were matched 1:1 to patients without insomnia. Compared to those without insomnia, patients with insomnia were more likely to have a concurrent diagnosis of obstructive sleep apnea (57.3% vs. 18%, Conclusion: Our data reveal a considerable interaction between insomnia, depression, and obstructive sleep apnea in individuals with asthma. The increased exacerbation rate suggests that underlying sleep and mood disorders negatively affect asthma control.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	603816-5
ISSN	1532-4303 ; 0277-0903
ISSN (online)	1532-4303
ISSN	0277-0903
DOI	10.1080/02770903.2024.2335367
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Article ; Online: Total IgE as a biomarker of omalizumab response in chronic spontaneous urticaria: A meta-analysis.

Keller, Levi / Perera, Ekta K / Bindon, Brittany / Khatiwada, Aastha / Stitt, Jenny M / Dreskin, Stephen C

Allergy and asthma proceedings

2024 Volume 45, Issue 2, Page(s) 97–99

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Omalizumab/therapeutic use ; Chronic Urticaria/drug therapy ; Biomarkers ; Immunologic Tests ; Immunoglobulin E
Chemical Substances	Omalizumab (2P471X1Z11) ; Biomarkers ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	1312445-6
ISSN	1539-6304 ; 1088-5412
ISSN (online)	1539-6304
ISSN	1088-5412
DOI	10.2500/aap.2024.45.230092
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Book ; Online: DIALITE

Khatiwada, Aamod / Shraga, Roee / Miller, Renée J.

Discover, Align and Integrate Open Data Tables

2023

Abstract: We demonstrate a novel table discovery pipeline called DIALITE that allows users to discover, integrate and analyze open data tables. DIALITE has three main stages. First, it allows users to discover tables from open data platforms using state-of-the-art ...

Abstract	We demonstrate a novel table discovery pipeline called DIALITE that allows users to discover, integrate and analyze open data tables. DIALITE has three main stages. First, it allows users to discover tables from open data platforms using state-of-the-art table discovery techniques. Second, DIALITE integrates the discovered tables to produce an integrated table. Finally, it allows users to analyze the integration result by applying different downstreaming tasks over it. Our pipeline is flexible such that the user can easily add and compare additional discovery and integration algorithms. Comment: SIGMOD 2023
Keywords	Computer Science - Databases
Publishing date	2023-04-17
Publishing country	us
Document type	Book ; Online
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Article ; Online: multi-GPA-Tree: Statistical approach for pleiotropy informed and functional annotation tree guided prioritization of GWAS results.

Khatiwada, Aastha / Yilmaz, Ayse Selen / Wolf, Bethany J / Pietrzak, Maciej / Chung, Dongjun

PLoS computational biology

2023 Volume 19, Issue 12, Page(s) e1011686

Abstract: Genome-wide association studies (GWAS) have successfully identified over two hundred thousand genotype-trait associations. Yet some challenges remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), most with ... ...

Abstract	Genome-wide association studies (GWAS) have successfully identified over two hundred thousand genotype-trait associations. Yet some challenges remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), most with small or moderate effect sizes, making them difficult to detect. Second, many complex traits share a common genetic basis due to 'pleiotropy' and and though few methods consider it, leveraging pleiotropy can improve statistical power to detect genotype-trait associations with weaker effect sizes. Third, currently available statistical methods are limited in explaining the functional mechanisms through which genetic variants are associated with specific or multiple traits. We propose multi-GPA-Tree to address these challenges. The multi-GPA-Tree approach can identify risk SNPs associated with single as well as multiple traits while also identifying the combinations of functional annotations that can explain the mechanisms through which risk-associated SNPs are linked with the traits. First, we implemented simulation studies to evaluate the proposed multi-GPA-Tree method and compared its performance with existing statistical approaches. The results indicate that multi-GPA-Tree outperforms existing statistical approaches in detecting risk-associated SNPs for multiple traits. Second, we applied multi-GPA-Tree to a systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), and to a Crohn's disease (CD) and ulcertive colitis (UC) GWAS, and functional annotation data including GenoSkyline and GenoSkylinePlus. Our results demonstrate that multi-GPA-Tree can be a powerful tool that improves association mapping while facilitating understanding of the underlying genetic architecture of complex traits and potential mechanisms linking risk-associated SNPs with complex traits.
MeSH term(s)	Genome-Wide Association Study/methods ; Phenotype ; Computer Simulation ; Genotype ; Polymorphism, Single Nucleotide/genetics ; Genetic Pleiotropy/genetics
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1011686
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Article ; Online: Curcumin does not significantly affect immediate skin tests.

Gross, Lara M / Nelson, Harold S / Khatiwada, Aastha / Hoyte, Flavia C L

Allergy and asthma proceedings

2022 Volume 43, Issue 6, Page(s) 543–545

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Animals ; Humans ; Curcumin/pharmacology ; Cross-Over Studies ; Skin Tests/methods ; Urticaria ; Double-Blind Method ; Histamine ; Skin
Chemical Substances	Curcumin (IT942ZTH98) ; Histamine (820484N8I3)
Language	English
Publishing date	2022-11-05
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1312445-6
ISSN	1539-6304 ; 1088-5412
ISSN (online)	1539-6304
ISSN	1088-5412
DOI	10.2500/aap.2022.43.220067
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Article ; Online: Association of Referral Source and Substance Use with Hepatitis C Virus Outcomes at a Southern Academic Medical Center.

Burton, H Jensie / Khatiwada, Aastha / Chung, Dongjun / Meissner, Eric G

Southern medical journal

2022 Volume 115, Issue 6, Page(s) 352–357

Abstract: Objectives: Therapeutic advances make the cure of chronic hepatitis C virus (HCV) infection achievable for individuals aware of their diagnosis who can access care. Identifying barriers to accessing care is critical to achieve population-level HCV ... ...

Abstract	Objectives: Therapeutic advances make the cure of chronic hepatitis C virus (HCV) infection achievable for individuals aware of their diagnosis who can access care. Identifying barriers to accessing care is critical to achieve population-level HCV elimination and improve the cascade of care from diagnosis to cure. Methods: To identify barriers to HCV care, we performed a retrospective observational analysis of outcomes for patients with chronic HCV referred to an infectious diseases clinic at an academic medical center in Charleston, South Carolina between January 1, 2015 and January 1, 2020. We categorized outcomes in the cascade of care between "never presenting for evaluation" and "completed treatment with documented cure." Patient demographic factors, referral source, ZIP code of residence, insurance status, clinical characteristics, antiviral regimen, psychiatric and substance use history, and route of infection were assessed for associations with care outcomes. Results: Of 407 referrals, 32% of patients never presented for an initial evaluation, an outcome that was associated with active substance use, mental health disease, and referral from an emergency department or obstetrics-gynecology provider. Of the patients who presented for an initial evaluation, 78% of patients initiated treatment. Active substance use was the only variable associated with lack of therapy initiation after presenting for an initial evaluation (odds ratio 2.5, 95% confidence interval 1.07-5.84). Once treatment had been initiated, no clinical or demographic variables were associated with odds of achieving documented or presumed HCV cure. Conclusions: Active substance use, mental health disease, and referral from an emergency department or obstetrics-gynecology provider were associated with a lower odds of presenting for evaluation and initiation of HCV treatment. Innovative models to improve access to care and increase outreach to vulnerable populations will be essential to eliminate HCV.
MeSH term(s)	Academic Medical Centers ; Hepacivirus ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Humans ; Referral and Consultation ; Retrospective Studies ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	185329-6
ISSN	1541-8243 ; 0038-4348
ISSN (online)	1541-8243
ISSN	0038-4348
DOI	10.14423/SMJ.0000000000001402
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Book ; Online: Machine Learning technique for isotopic determination of radioisotopes using HPGe $\mathrm{\gamma}$-ray spectra

Khatiwada, Ajeeta / Klasky, Marc / Lombardi, Marcie / Matheny, Jason / Mohan, Arvind

2023

Abstract: mathrm{\gamma}$-ray spectroscopy is a quantitative, non-destructive technique that may be utilized for the identification and quantitative isotopic estimation of radionuclides. Traditional methods of isotopic determination have various challenges that ... ...

Abstract	$\mathrm{\gamma}$-ray spectroscopy is a quantitative, non-destructive technique that may be utilized for the identification and quantitative isotopic estimation of radionuclides. Traditional methods of isotopic determination have various challenges that contribute to statistical and systematic uncertainties in the estimated isotopics. Furthermore, these methods typically require numerous pre-processing steps, and have only been rigorously tested in laboratory settings with limited shielding. In this work, we examine the application of a number of machine learning based regression algorithms as alternatives to conventional approaches for analyzing $\mathrm{\gamma}$-ray spectroscopy data in the Emergency Response arena. This approach not only eliminates many steps in the analysis procedure, and therefore offers potential to reduce this source of systematic uncertainty, but is also shown to offer comparable performance to conventional approaches in the Emergency Response Application.
Keywords	Physics - Data Analysis ; Statistics and Probability ; Computer Science - Machine Learning
Subject code	006
Publishing date	2023-01-03
Publishing country	us
Document type	Book ; Online
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Article ; Online: Impact of highly effective modulator therapy on chronic rhinosinusitis and health status: 2-year follow-up.

Beswick, Daniel M / Khatiwada, Aastha / Miller, Jessa E / Humphries, Stephen M / Wilson, Alexandra / Vladar, Eszter K / Lynch, David A / Taylor-Cousar, Jennifer L

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

2023

Language	English
Publishing date	2023-10-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2084724-5
ISSN	1873-5010 ; 1569-1993
ISSN (online)	1873-5010
ISSN	1569-1993
DOI	10.1016/j.jcf.2023.09.013
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Zs.MO 459: Show issues

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