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Article ; Online: Pancreatic mesenchymal stem cells might protect β-cells.

Khatri, Rahul / Linn, Thomas

2022 Volume 18, Issue 12, Page(s) 725–726

MeSH term(s)	Humans ; Mesenchymal Stem Cells ; Insulin-Secreting Cells ; Pancreas ; Pancreatic Neoplasms ; Cell Differentiation
Language	English
Publishing date	2022-11-21
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2489381-X
ISSN	1759-5037 ; 1759-5029
ISSN (online)	1759-5037
ISSN	1759-5029
DOI	10.1038/s41574-022-00763-7
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Article ; Online: Analysis of energy storage materials for developments in solar cookers.

Khatri, Rahul / Goyal, Rahul / Sharma, Ravi Kumar

F1000Research

2023 Volume 11, Page(s) 1292

Abstract: Solar energy is accessible freely and can be utilized for many household and industrial applications. The consumption of solar energy for cooking applications has found significant success. Various innovations have been employed in facilitating cooking ... ...

Abstract	Solar energy is accessible freely and can be utilized for many household and industrial applications. The consumption of solar energy for cooking applications has found significant success. Various innovations have been employed in facilitating cooking during off-sunshine hours. Thermal energy storage helps in overcoming the fluctuations in the supply of energy required for cooking during different time periods of the day. This study focuses on the different types of thermal energy storage mediums that are currently utilized in solar cooking. Primarily, oils and pebbles are most commonly used as sensible heat storage (SHS) while organic phase change materials (PCMs) are used as latent heat thermal energy storage materials (LHTES). The properties and performances of various SHS and latent heat storage (LHS) mediums have been compared for their suitable utilization. SHS materials are cost-effective but have lower thermal gradient compared to LHTES materials. The energy storage capability of LHTES is high while degradation with the increasing number of charging and discharging cycles is also considerable. The melting point should be close to the utilization temperature for being used as LHTES as thermal diffusivity of the materials greatly influences the performance of solar cookers. The cooking time is lower for solar cooking systems equipped with energy storage compared to non-equipped cooking systems. It is recognized that the use of energy storage has been proved as a huge advantage to solar cooking systems, however, the design, and heat transfer characteristics of the cooking vessel along with the storage material type and volume must be optimized in order to make this technology more influential.
MeSH term(s)	Humans ; Body Fluids ; Cooking ; Food ; Hot Temperature ; Patient Discharge
Language	English
Publishing date	2023-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.126864.2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Antidiabetic effect of the intrapancreatic application of mesenchymal stem cells through beta-cell regeneration

Khatri, Rahul [Verfasser]

2020

Author's details	Rahul Khatri
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Universitätsbibliothek
Publishing place	Gießen
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Current Strategies to Modulate Regulatory T Cell Activity in Allergic Inflammation.

Bellinghausen, Iris / Khatri, Rahul / Saloga, Joachim

Frontiers in immunology

2022 Volume 13, Page(s) 912529

Abstract: Over the past decades, atopic diseases, including allergic rhinitis, asthma, atopic dermatitis, and food allergy, increased strongly worldwide, reaching up to 50% in industrialized countries. These diseases are characterized by a dominating type 2 immune ...

Abstract	Over the past decades, atopic diseases, including allergic rhinitis, asthma, atopic dermatitis, and food allergy, increased strongly worldwide, reaching up to 50% in industrialized countries. These diseases are characterized by a dominating type 2 immune response and reduced numbers of allergen-specific regulatory T (Treg) cells. Conventional allergen-specific immunotherapy is able to tip the balance towards immunoregulation. However, in mouse models of allergy adaptive transfer of Treg cells did not always lead to convincing beneficial results, partially because of limited stability of their regulatory phenotype activity. Besides genetic predisposition, it has become evident that environmental factors like a westernized lifestyle linked to modern sanitized living, the early use of antibiotics, and the consumption of unhealthy foods leads to epithelial barrier defects and dysbiotic microbiota, thereby preventing immune tolerance and favoring the development of allergic diseases. Epigenetic modification of Treg cells has been described as one important mechanism in this context. In this review, we summarize how environmental factors affect the number and function of Treg cells in allergic inflammation and how this knowledge can be exploited in future allergy prevention strategies as well as novel therapeutic approaches.
MeSH term(s)	Allergens ; Animals ; Desensitization, Immunologic/methods ; Inflammation/metabolism ; Mice ; Rhinitis, Allergic ; T-Lymphocytes, Regulatory
Chemical Substances	Allergens
Language	English
Publishing date	2022-05-26
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.912529
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Article ; Online: Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration.

Khatri, Rahul / Petry, Sebastian Friedrich / Linn, Thomas

Stem cell research & therapy

2021 Volume 12, Issue 1, Page(s) 121

Abstract: Background: Type 1 diabetes mellitus (T1D) is characterized by the autoimmune destruction of the pancreatic β cells. The transplantation of mesenchymal stromal/stem cells (MSC) was reported to rescue the damaged pancreatic niche. However, there is an ... ...

Abstract	Background: Type 1 diabetes mellitus (T1D) is characterized by the autoimmune destruction of the pancreatic β cells. The transplantation of mesenchymal stromal/stem cells (MSC) was reported to rescue the damaged pancreatic niche. However, there is an ongoing discussion on whether direct physical contact between MSC and pancreatic islets results in a superior outcome as opposed to indirect effects of soluble factors released from the MSC entrapped in the lung microvasculature after systemic administration. Hence, MSC were studied in direct contact (DC) and indirect contact (IDC) with murine pancreatic β cell line MIN6-cells damaged by nitrosourea derivative streptozotocin (STZ) in vitro. Further, the protective and antidiabetic outcome of MSC transplantation was evaluated through the intrapancreatic route (IPR) and intravenous route (IVR) in STZ-induced diabetic NMRI nude mice. Methods: MSC were investigated in culture with STZ-damaged MIN6-cells, either under direct contact (DC) or separated through a semi-permeable membrane (IDC). Moreover, multiple low doses of STZ were administered to NMRI nude mice for the induction of hyperglycemia. 0.5 × 10 Results: The administration of MSC through IPR ameliorated hyperglycemia in contrast to IVR, STZ, and non-diabetic control in a 30-day window. IPR resulted in a higher number of replicating islet cells, number of islets, islet area, growth factor (EGF), and balancing of the Th1/Th2 response in vivo. Physical contact also provided a superior protection to MIN6-cells from STZ through the AKT and ERK pathway in vitro in comparison with IDC. Conclusion: Our study suggests that the physical contact between MSC and pancreatic islet cells is required to fully unfold their protective potential.
MeSH term(s)	Animals ; Diabetes Mellitus, Experimental/therapy ; Insulin ; Islets of Langerhans ; Mesenchymal Stem Cell Transplantation ; Mice ; Mice, Nude ; Streptozocin
Chemical Substances	Insulin ; Streptozocin (5W494URQ81)
Language	English
Publishing date	2021-02-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-021-02173-4
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Article ; Online: Design and assessment of solar PV plant for girls hostel (GARGI) of MNIT University, Jaipur city

Khatri, Rahul

A case study

2016

Abstract: In this paper designing and assessment of a solar PV plant for meeting the energy demand of girl's hostel at MNIT University Jaipur city was analyzed. A solar PV plant was designed with its financial and environmental assessment considering recent market ...

Abstract	In this paper designing and assessment of a solar PV plant for meeting the energy demand of girl's hostel at MNIT University Jaipur city was analyzed. A solar PV plant was designed with its financial and environmental assessment considering recent market prices. All the aspects related to a solar PV plant were considered for financial feasibility of PV plant near this location. The different financial parameters which affect the financial feasibility of PV plant were considered i.e. discount rate, effective discount rate, rate of escalation of electricity cost, salvage value of the plant etc. The environmental aspect related with the energy generated with PV plant i.e. reduction in carbon emission and carbon credits earned was also considered. Result obtained with the assessment of the proposed plant with different discount rate and current rate of inflation shows that the max IRR 6.85% and NPV of $ 1,430,834 was obtained with a discount rate of 8% and an inflation rate of 7.23% when no land cost considered and if land cost was considered the maximum IRR was 1.96% and NPV of $ 630,833. Minimum discounted payback of the plant will be 13.4 years if inflation was considered.
Keywords	ddc:330 ; Financial assessment ; Payback period & carbon credits ; PV plant
Subject code	580
Language	English
Publisher	Amsterdam: Elsevier
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Class I and II Histone Deacetylase Inhibitor LBH589 Promotes Endocrine Differentiation in Bone Marrow Derived Human Mesenchymal Stem Cells and Suppresses Uncontrolled Proliferation.

Schröder, Christoph / Khatri, Rahul / Petry, Sebastian Friedrich / Linn, Thomas

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

2020 Volume 129, Issue 5, Page(s) 357–364

Abstract: Mesenchymal stem cells are useful tools employed in clinical and preclinical medicine. Their beneficial potential in especially degenerative as well as autoimmune diseases is a constant focus of research. Regarding diabetes mellitus, transplantation of ... ...

Abstract	Mesenchymal stem cells are useful tools employed in clinical and preclinical medicine. Their beneficial potential in especially degenerative as well as autoimmune diseases is a constant focus of research. Regarding diabetes mellitus, transplantation of stem cells is seen as a possible therapeutic approach to overcome the loss of endocrine pancreatic cells. It was reported that co-transplantation of mesenchymal stem cells with pancreatic islet cells improves function and survival of the graft. However, these multipotent progenitors may be able to form tumors, especially under immunosuppressed conditions. Histone deacetylase inhibitors might offer the potential to overcome this issue. These small molecules can induce cell differentiation and control proliferation. Their potential to control lineage development of stem cells has been distinctly demonstrated in the treatment of cancer, mainly in hematopoietic neoplasias.In this study, we demonstrate that human bone marrow-derived mesenchymal stem cells exhibit low carcinogenic potential in an immunosuppressed condition
MeSH term(s)	Bone Marrow Cells/drug effects ; Carcinogenesis/drug effects ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Islets of Langerhans/drug effects ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/drug effects ; Panobinostat/pharmacology
Chemical Substances	Histone Deacetylase Inhibitors ; Panobinostat (9647FM7Y3Z)
Language	English
Publishing date	2020-02-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/a-1103-1900
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Article ; Online: Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway.

Khatri, Rahul / Mazurek, Sybille / Petry, Sebastian Friedrich / Linn, Thomas

Stem cell research & therapy

2020 Volume 11, Issue 1, Page(s) 497

Abstract: Background: Mesenchymal stem cells (MSC) are non-haematopoietic, fibroblast-like multipotent stromal cells. In the injured pancreas, these cells are assumed to secrete growth factors and immunomodulatory molecules, which facilitate the regeneration of ... ...

Abstract	Background: Mesenchymal stem cells (MSC) are non-haematopoietic, fibroblast-like multipotent stromal cells. In the injured pancreas, these cells are assumed to secrete growth factors and immunomodulatory molecules, which facilitate the regeneration of pre-existing β-cells. However, when MSC are delivered intravenously, their majority is entrapped in the lungs and does not reach the pancreas. Therefore, the aim of this investigation was to compare the regenerative support of hTERT-MSC (human telomerase reverse transcriptase mesenchymal stem cells) via intrapancreatic (IPR) and intravenous route (IVR). Methods: hTERT-MSC were administered by IPR and IVR to 50% pancreatectomized NMRI nude mice. After eight days, blood glucose level, body weight, and residual pancreatic weight were measured. Proliferating pancreatic β-cells were labelled and identified with bromodeoxyuridine (BrdU) in vivo. The number of residual islets and the frequency of proliferating β-cells were compared in different groups with sequential pancreatic sections. The pancreatic insulin content was evaluated by enzyme-linked immunosorbent assay (ELISA) and the presence of hTERT-MSC with human Alu sequence. Murine gene expression of growth factors, β-cell specific molecules and proinflammatory cytokines were inspected by real-time polymerase chain reaction (RT-PCR) and Western blot. Results: This study evaluated the regenerative potential of the murine pancreas post-hTERT-MSC administration through the intrapancreatic (IPR) and intravenous route (IVR). Both routes of hTERT-MSC transplantation (IVR and IPR) increased the incorporation of BrdU by pancreatic β-cells compared to control. MSC induced epidermal growth factor (EGF) expression and inhibited proinflammatory cytokines (IFN-γ and TNF-α). FOXA2 and PDX-1 characteristics for pancreatic progenitor cells were activated via AKT/ PDX-1/ FoxO1 signalling pathway. Conclusion: The infusion of hTERT-MSC after partial pancreatectomy (Px) through the IVR and IPR facilitated the proliferation of autochthonous pancreatic β-cells and provided evidence for a regenerative influence of MSC on the endocrine pancreas. Moderate benefit of IPR over IVR was observed which could be a new treatment option for preventing diabetes mellitus after pancreas surgery.
MeSH term(s)	Animals ; Diabetes Mellitus, Experimental ; Down-Regulation ; Forkhead Box Protein O1/genetics ; Insulin-Secreting Cells ; Mesenchymal Stem Cells ; Mice ; Mice, Nude
Chemical Substances	Forkhead Box Protein O1 ; Foxo1 protein, mouse
Language	English
Publishing date	2020-11-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-020-02007-9
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Article ; Online: A Novel Amperometric Genosensor for Rapid Detection of Canine Parvovirus in Feces.

Khatri, Rahul / Mohan, Hari / Brar, Basanti / Prasad, Minakshi / Pundir, C S

Journal of nanoscience and nanotechnology

2021 Volume 21, Issue 6, Page(s) 3524–3530

Abstract: A highly sensitive novel amperometric genosensor has been developed for rapid detection of canine parvovirus (CPV) DNA in fecal swabs of naturally infected dogs. The genosensor is based on a single stranded 5°-thiolated (SH) DNA probe complementary to ... ...

Abstract	A highly sensitive novel amperometric genosensor has been developed for rapid detection of canine parvovirus (CPV) DNA in fecal swabs of naturally infected dogs. The genosensor is based on a single stranded 5°-thiolated (SH) DNA probe complementary to VP1/VP2 gene of canine parvo vaccine strain, immobilized covalently on a polycrystalline gold (Au) electrode. The genosensor has been characterized by scanning electron microscopy (SEM), Fourier Transform Infra-Red Spectroscopy (FTIR), cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectra (EIS). The ssDNA-SH/Au electrode was hybridized with single stranded target DNA (ss T-DNA) in the sample. This hybridization was detected by reduction in current, generated by interaction of methylene blue (MB) with free guanine of ssDNA. The current response of genosensor was determined by CV, DPV and EIS. The sensor detected single stranded genomic DNA (ss g-DNA) isolated from vaccine strain of CPV in the range, 1.0-12.0 ng/
MeSH term(s)	Animals ; Biosensing Techniques ; DNA, Viral ; Dogs ; Electrochemical Techniques ; Feces ; Gold ; Nucleic Acid Hybridization ; Parvovirus, Canine/genetics
Chemical Substances	DNA, Viral ; Gold (7440-57-5)
Language	English
Publishing date	2021-11-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1533-4899
ISSN (online)	1533-4899
DOI	10.1166/jnn.2021.18998
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cell wall fraction of Mycobacterium indicus pranii shows potential Th1 adjuvant activity.

Saqib, Mohd / Khatri, Rahul / Singh, Bindu / Gupta, Ananya / Bhaskar, Sangeeta

International immunopharmacology

2019 Volume 70, Page(s) 408–416

Abstract: Very few adjuvants inducing Th1 immune response have been developed and are under clinical investigation. Hence, there is the need to find an adjuvant that elicits strong Th1 immune response which should be safe when injected in the host along with ... ...

Abstract	Very few adjuvants inducing Th1 immune response have been developed and are under clinical investigation. Hence, there is the need to find an adjuvant that elicits strong Th1 immune response which should be safe when injected in the host along with vaccines. Mycobacterium indicus pranii (MIP), a non-pathogenic vaccine candidate, has shown strong immunomodulatory activity in leprosy/tuberculosis/cancer and in genital warts patients where its administration shifted the host immune response towards Th1 type. These findings prompted us to study the components of MIP in detail for their Th1 inducing property. Since mycobacterial cell wall is very rich in immunostimulatory components and is known to play important role in immune modulation, we investigated the activity of MIP cell wall using Ovalbumin antigen (OVA) as model antigen. 'Whole cell wall' (CW) and 'aqueous soluble cell wall fractions' (ACW) induced significant Th1 immune response while 'cell wall skeleton' (CWS) induced strong Th2 type of immune response. Finally, functional activity of fractions having Th1 inducing activity was evaluated in mouse model of melanoma. CW demonstrated significant anti-tumor activity similar to whole MIP. Anti-tumor activity of CW could be correlated with enhanced tumor antigen specific Th1 immune response observed in tumor draining lymph nodes.
MeSH term(s)	Animals ; Antigens, Neoplasm/immunology ; Cell Wall/immunology ; Cell Wall/metabolism ; Humans ; Immunomodulation ; Lymphocyte Activation ; Melanoma/immunology ; Melanoma/therapy ; Melanoma, Experimental ; Mice ; Mice, Inbred C57BL ; Mycobacterium/metabolism ; Neoplasms, Experimental ; Th1 Cells/immunology ; Th1-Th2 Balance ; Th2 Cells/immunology
Chemical Substances	Antigens, Neoplasm
Language	English
Publishing date	2019-03-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2019.02.049
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