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  1. Article: Evaluation of Botulinum Toxin A as an Optional Treatment for Atopic Dermatitis.

    Khattab, Fathia M

    The Journal of clinical and aesthetic dermatology

    2020  Volume 13, Issue 7, Page(s) 32–35

    Abstract: OBJECTIVE: ...

    Abstract OBJECTIVE:
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 1941-2789
    ISSN 1941-2789
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  2. Article ; Online: Incretin serum level as a biomarker of insulin resistance in acne vulgaris patients.

    Khattab, Fathia M / Fawzy, Manal

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 10, Page(s) 5181–5186

    Abstract: Objective: To investigate the relationship between serum Incretin and acne vulgaris (AV) and insulin resistance (IR), and to find the biological indicators of acne vulgaris with insulin resistance.: Methods: 60 patients diagnosed with acne vulgaris ... ...

    Abstract Objective: To investigate the relationship between serum Incretin and acne vulgaris (AV) and insulin resistance (IR), and to find the biological indicators of acne vulgaris with insulin resistance.
    Methods: 60 patients diagnosed with acne vulgaris in the dermatology department of Zagazig University and 56 healthy people in the health examination center of this hospital were collected, respectively, as the control group; all the included people were drawn fasting blood to test serum Incretin, blood lipids, sex hormones and INS release test to explore the role of serum Incretin in acne vulgaris and insulin resistance.
    Results: The average level of Incretin in the acne group was lower than that in the control group, and the difference was statistically significant (t = 7.189, p < 0.001). The average level of Incretin in the acne group with insulin resistance was lower than that in the acne without insulin resistance group, the difference was statistically significant (t = 22.328, p < 0.001). In the acne group, the insulin resistance index decreased with the increase of Incretin level, and the two showed a negative correlation. (R = -0.711, p < 0.001).
    Conclusions: Patients with acne vulgaris are prone to have insulin resistance. Insulin resistance in patients with acne vulgaris is negatively correlated with Incretin. Serum Incretin may be expected to be a biomarker for diagnosing acne vulgaris patients with insulin resistance. The severity of acne vulgaris may have no obvious correlation with insulin resistance and serum incretin.
    MeSH term(s) Humans ; Insulin Resistance ; Incretins ; Case-Control Studies ; Acne Vulgaris/diagnosis ; Biomarkers
    Chemical Substances Incretins ; Biomarkers
    Language English
    Publishing date 2022-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15025
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  3. Article ; Online: Botulinum toxin type-A versus 5-fluorouracil in the treatment of plaque psoriasis: Comparative study.

    Khattab, Fathia M / Samir, Mai A

    Journal of cosmetic dermatology

    2021  Volume 20, Issue 10, Page(s) 3128–3132

    Abstract: Background: Long-term remission and total clearance in Psoriasis can only be achieved in a few patients.: Aim: To compare the efficacy and safety of intradermal Botulinum toxin (BTX) in the treatment of plaque psoriasis.: Subjects and methods: A ... ...

    Abstract Background: Long-term remission and total clearance in Psoriasis can only be achieved in a few patients.
    Aim: To compare the efficacy and safety of intradermal Botulinum toxin (BTX) in the treatment of plaque psoriasis.
    Subjects and methods: A comparative study conducted in thirty-five patients with chronic plaque psoriasis was treated by split-body therapy. The patients were either treated with intradermal BTX or with intralesional 5-fluorouracil (5-FU) to each of 2 bilaterally symmetrical psoriatic plaque lesions. The outcomes were assessed using the following criteria: the sum of erythema, scaling, and induration scores and the clearing percentage of the target plaque lesion assessed by 2 blinded observers.
    Results: At the end of the study, the response rate was 85% on the BTX treatment side and 90% on the 5-FU side. There was no significant difference between both sides regarding a clinical response or side effects. The recurrence rate was 15% on both sides.
    Conclusions: Botulinum toxin was a novel, safe, single injection, and effective therapy for plaque-type psoriasis. More studies are required to further prove the efficacy of BTX in the treatment of plaque psoriasis.
    MeSH term(s) Botulinum Toxins, Type A/adverse effects ; Fluorouracil ; Humans ; Psoriasis/drug therapy ; Recurrence ; Treatment Outcome
    Chemical Substances Botulinum Toxins, Type A (EC 3.4.24.69) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2021-07-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14306
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  4. Article ; Online: Keloid therapy: A neoteric comparative study.

    Khattab, Fathia M / Bessar, Hagar / Khater, Elsayed M

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 9, Page(s) 3962–3969

    Abstract: Background: Keloids are considered disorders of fibroproliferation characterized by accumulation of collagen fibers in hypodermis and dermis, caused by inflammation, surgery, and trauma.: Objectives: The main goal of the study was to approach a ... ...

    Abstract Background: Keloids are considered disorders of fibroproliferation characterized by accumulation of collagen fibers in hypodermis and dermis, caused by inflammation, surgery, and trauma.
    Objectives: The main goal of the study was to approach a better modality for the treatment of keloids by comparing the effects and the side effects of intralesional cryotherapy and intralesional injection of bleomycin.
    Methods: This interventional, comparative clinical trial was conducted on 60 cases and was divided equally into the group (A), combined group who were subjected to intralesional bleomycin followed by cryotherapy in the same session, group (B) who were subjected to intralesional injection of bleomycin, and group (C) intralesional cryotherapy. All cases were subjected to clinical examination, complete history taking, dermatological examination, examination, and evaluation of scar lesion using the Vancouver scar scale.
    Results: There was a statistically significant decrease in pliability among the combined group. Also, pliability decreased in the bleomycin group and cryotherapy, but this decrease wasn't statistically significant. Our results revealed that there was a statistically significant decrease in lesion height among all the studied groups, but the decrease was more among the combined group.
    Conclusion: Intralesional cryotherapy was effective as intralesional bleomycin. Combined therapy was a valid and more effective technique with few adverse effects than either alone for keloids as it achieved a decrease in volumes of scars or accompanied symptoms.
    MeSH term(s) Bleomycin/adverse effects ; Cicatrix, Hypertrophic/drug therapy ; Collagen/therapeutic use ; Humans ; Injections, Intralesional ; Keloid/drug therapy ; Keloid/therapy ; Treatment Outcome
    Chemical Substances Bleomycin (11056-06-7) ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15247
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  5. Article ; Online: Recent modalities in treatment of telogen effluvium: Comparative study.

    Khattab, Fathia M / Rady, Areeg / Khashaba, Shrook A

    Dermatologic therapy

    2022  Volume 35, Issue 10, Page(s) e15720

    Abstract: Telogen effluvium is one of the most common forms of diffuse, non-scarring hair loss for which patients present for clinical evaluation. It is usually a reactive and reversible disorder. Identifying and correcting the underlying cause is the most ... ...

    Abstract Telogen effluvium is one of the most common forms of diffuse, non-scarring hair loss for which patients present for clinical evaluation. It is usually a reactive and reversible disorder. Identifying and correcting the underlying cause is the most important component in management, yet there is always a need for therapeutic options. This study aims to evaluate the efficacy of single session botulinum toxin A injection versus multiple sessions of multivitamins mesotherapy in the treatment of telogen effluvium. A randomized clinical trial was conducted in the Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Zagazig University Hospitals. Twenty-four patients with telogen effluvium were randomly divided into two groups each group included 12 patients. Group I received a single session of Botulinum toxin A injection and group II received multiple sessions of multivitamins mesotherapy injection. Both botulinum toxin A and multivitamins mesotherapy are effective in the treatment of telogen effluvium, which was reflected on the improvement of hair parameters as terminal hair and multiple follicular units. Both treatment modalities had minimal and well-tolerated side effects. Although both therapies have equivalent success rates, single session of botulinum toxin A is a better choice than multiple mesotherapy sessions.
    MeSH term(s) Alopecia/diagnosis ; Alopecia/etiology ; Alopecia/therapy ; Alopecia Areata ; Botulinum Toxins, Type A/adverse effects ; Hair ; Humans
    Chemical Substances Botulinum Toxins, Type A (EC 3.4.24.69)
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15720
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  6. Article ; Online: 308-nm excimer laser: a hopeful and optional therapy for pityriasis versicolor.

    Khattab, Fathia M / Omran, Farida H

    The Journal of dermatological treatment

    2020  Volume 32, Issue 7, Page(s) 795–799

    Abstract: Background: Pityriasis Versicolor (PV) is known as a superficial fungal infection. It is suggested that resistant strains to azoles may be developed and hence, the treatment would be difficult. This study aimed to evaluate the efficacy of excimer laser ( ...

    Abstract Background: Pityriasis Versicolor (PV) is known as a superficial fungal infection. It is suggested that resistant strains to azoles may be developed and hence, the treatment would be difficult. This study aimed to evaluate the efficacy of excimer laser (308 nm) as an alternative therapy for PV.
    Materials and methods: This is a prospective intra-patient left-to-right, randomized, placebo-controlled study conducted on 26 patients with bilateral lesions which are not responding to the PV standard treatment. Patients were randomly assigned to right or left-side therapy for a duration of 8 weeks with either excimer laser (308 nm three times weekly) or topical placebo. Clinical assessment and mycological evaluation were performed before the initiation of treatment and at the fourth and eighth week of therapy.
    Results: A decrease in the mean clinical score of cases was recorded from 7.1 at the baseline evaluation to 1.56 after 4 weeks and to 1.96 after 8 weeks of treatment. At week 4, there was a statistically significant reduction in the clinical scores compared with pretreatment scores and with the placebo group (p < .001).
    Conclusion: 308-nm excimer laser can be considered as a hopeful and optional therapy for PV.
    MeSH term(s) Humans ; Lasers, Excimer/therapeutic use ; Prospective Studies ; Tinea Versicolor/therapy ; Treatment Outcome
    Language English
    Publishing date 2020-03-06
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2020.1713972
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  7. Article ; Online: Assessment of neopterin level and severity in lichen planus patients treated with narrow-band ultraviolet B.

    Khattab, Fathia M / Samir, Mai A

    Journal of cosmetic dermatology

    2020  Volume 19, Issue 12, Page(s) 3389–3392

    Abstract: Background: Neopterin is a cellular immunity biochemical marker. Serum and saliva neopterin levels have been reported to increase in lichen Planus. Nonetheless, analysis has not yet been made for the direct link between narrow band ultraviolet B and ... ...

    Abstract Background: Neopterin is a cellular immunity biochemical marker. Serum and saliva neopterin levels have been reported to increase in lichen Planus. Nonetheless, analysis has not yet been made for the direct link between narrow band ultraviolet B and severity of Lichen planus.
    Aim: We aimed to assess serum neopterin levels in patients who receive narrow band ultraviolet B therapy treatment with lichen planus, paired with the severity of the disease.
    Patients and methods: The study consisted of 35 lichen planus patients and 30 healthy individuals. A 35 patient group received narrow band ultraviolet B therapy. An enzyme-related immunosorbent assay procedure was used in serum neopterin analysis before and post-therapy.
    Results: The correlation between the level and severity of the patient group was statistically significant (P = .001). In patients with severe disease, serum neopterin levels were significantly increased. Also, in the severe lichen planus group, the serum neopterin level was statistically higher than that of the mild or moderate groups (P = .001).Also, a significant decrease was seen following therapy according to serum neopterin level.
    Conclusion: Serum neopterin levels are a useful marker for the assessment of the severity and effectiveness of narrow band ultraviolet therapy. Thus, our findings may provide a new approach with the management of disease and follow-up strategies in patients with lichen planus.
    MeSH term(s) Biomarkers ; Humans ; Lichen Planus ; Neopterin ; Ultraviolet Therapy
    Chemical Substances Biomarkers ; Neopterin (670-65-5)
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.13417
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  8. Article ; Online: Correlation between serum IL 37 levels with keloid severity.

    Khattab, Fathia M / Samir, Mai A

    Journal of cosmetic dermatology

    2020  Volume 19, Issue 9, Page(s) 2428–2431

    Abstract: Background: Keloids are dermal fibroproliferative disorders that characterized by over deposition of components of the extracellular matrix. Interleukin 37 (IL-37) is known by its ability to inhibit the proliferation of keloid fibroblasts by inhibiting ... ...

    Abstract Background: Keloids are dermal fibroproliferative disorders that characterized by over deposition of components of the extracellular matrix. Interleukin 37 (IL-37) is known by its ability to inhibit the proliferation of keloid fibroblasts by inhibiting extracellular matrix production induced by transforming growth factor β (TGF-β). Thus, Il-37 is suggested to be used as an early preventive treatment for keloids.
    Aims: This study aimed to evaluate the correlation between serum levels of IL37 level and the keloid severity.
    Patients/methods: This is a cross-sectional analytic study involving thirty-two patients diagnosed clinically as having Keloid. An assessment of keloid severity was conducted by using Vancouver Scar Scale (VSS). Blood samples were collected from every patient to measure and assess the serum levels of IL37.
    Results: A negative correlation was found between IL37 level and the keloid severity (P = .0001; r = -.737). Also, there was a nonsignificant correlation between IL37 levels in patient with keloid and age, gender, duration of lesions, and family history.
    Conclusion: Lower level of plasma IL 37 could be an indicator of the severity of Keloids.
    MeSH term(s) Cell Proliferation ; Cells, Cultured ; Cross-Sectional Studies ; Extracellular Matrix ; Fibroblasts/pathology ; Humans ; Interleukin-1/blood ; Keloid/pathology ; Transforming Growth Factor beta
    Chemical Substances IL37 protein, human ; Interleukin-1 ; Transforming Growth Factor beta
    Language English
    Publishing date 2020-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.13290
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  9. Article: Efficacy of Polycaprolactone Threads in Treating Atrophic Acne Scars: A Split-face Comparative Study.

    Khattab, Fathia M / Samir, Mai A / El Khouly, Shaimaa S / Atwa, Enayat M

    The Journal of clinical and aesthetic dermatology

    2023  Volume 16, Issue 9, Page(s) 33–37

    Abstract: Background: Polycaprolactone (PCL) threads are a novel treatment option for promoting collagen production and smoothing the skin.: Objective: This study aimed to compare the efficacy and safety of threads versus microneedling with autologous platelet- ...

    Abstract Background: Polycaprolactone (PCL) threads are a novel treatment option for promoting collagen production and smoothing the skin.
    Objective: This study aimed to compare the efficacy and safety of threads versus microneedling with autologous platelet-rich plasma (PRP) in the treatment of atrophic acne scars.
    Methods: The study included 24 patients (12 females, 12 males) aged 20 to 37 years with atrophic acne scars. Each patient was treated in a split-face manner; a microneedling pen device was used to treat the right side with microneedling and PRP, whereas the left side was treated with threads. Four microneedling plus PRP sessions were used to treat the right side and a single session of threads was used on the left side. For scoring, a global scarring grading system was utilized. Patients were evaluated every three months following the conclusion of treatment. A six-month follow-up was conducted.
    Results: Significant clinical improvement was observed in 95.8 percent of the patients on the threads-treated side of the face and in 83.3 percent of the patients on the microneedling plus PRP side. Patient satisfaction was significantly greater in the threads group than in the microneedling+PRP group (
    Conclusion: Based on our results, we conclude that both threads insertion and microneedling with autologous PRP can yield satisfactory results with minor side effects (fine edema and erythema) that resolve rapidly.
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2571623-2
    ISSN 1941-2789
    ISSN 1941-2789
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  10. Article ; Online: A comparative study of topical cantharidin and intralesional PPD to treat molluscum contagiosum.

    Khattab, Fathia M / Nasr, Mohamed M

    The Journal of dermatological treatment

    2019  Volume 31, Issue 8, Page(s) 850–854

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Administration, Topical ; Adolescent ; Adult ; Bacterial Proteins/administration & dosage ; Cantharidin/administration & dosage ; Cantharidin/adverse effects ; Child ; Child, Preschool ; Female ; Humans ; Immunocompetence ; Immunotherapy/methods ; Injections, Intralesional/adverse effects ; Male ; Molluscum Contagiosum/drug therapy ; Molluscum Contagiosum/therapy ; Remission Induction ; Tuberculin/administration & dosage ; Tuberculin/adverse effects
    Chemical Substances Bacterial Proteins ; Tuberculin ; Cantharidin (IGL471WQ8P)
    Language English
    Publishing date 2019-08-29
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2019.1657226
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