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  1. AU="Khedis, Mehdi"
  2. AU="Radford, R L"
  3. AU="Kulkarni, Anand V"

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  1. Article: Vasectomie et chirurgies contraceptives déférentielles: aspects légaux et techniques.

    Huyghe, Eric / Blanc, Anthony / Nohra, Joe / Khedis, Mehdi / Labarthe, Pierre / Rouge, Daniel / Plante, Pierre

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

    2007  Volume 17, Issue 4, Page(s) 789–793

    Abstract: Objectives: To analyse technical innovations, their results and the changing legislation in France concerning sterilizing or contraceptive vas deferens surgery.: Material and methods: A review of the literature was performed using the key words: male/ ...

    Title translation Vasectomy and vas deferens contraceptive surgery: legal and technical aspects.
    Abstract Objectives: To analyse technical innovations, their results and the changing legislation in France concerning sterilizing or contraceptive vas deferens surgery.
    Material and methods: A review of the literature was performed using the key words: male/contraception/vas deferens. From the 332 research articles obtained from PUBMED, we selected 54 articles for their methodological quality and the importance of their results.
    Results: Vasectomy remains the only validated vas deferens surgical technique. Although microsurgical reconstructive techniques have improved the vas deferens restoration rate, vasectomy must be considered to be a definitive method of sterilization. The other contraceptive (reversible) vas deferens surgical techniques have not demonstrated sufficient efficacy to be used outside of the context of clinical trials. However the encouraging results ofsome ofthese studies could allow their development in the intermediate term. From a legal point of view, since the reform of sterilizing surgery in Article L2123-1 of the French Public Health Act, vasectomy is now authorized in a regulatory framework.
    Conclusion: The urology community must take into account progress in the field of contraceptive vas deferens surgical techniques.
    MeSH term(s) Contraception/methods ; France ; Humans ; Male ; Vas Deferens/surgery ; Vasectomy/legislation & jurisprudence ; Vasectomy/methods
    Language French
    Publishing date 2007-07-03
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1186190-3
    ISSN 1166-7087
    ISSN 1166-7087
    DOI 10.1016/s1166-7087(07)92293-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Abcès epidural après biopsies prostatiques.

    Labarthe, Pierre / Laroche, Michel / Massip, Patrice / Khedis, Mehdi / Huyghe, Eric / Plante, Pierre / Soulié, Michel

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

    2005  Volume 15, Issue 4, Page(s) 733–735

    Abstract: Prostatic biopsy is a routine clinical procedure often wrongly considered to be perfectly harmless. The authors report the first case of epidural abscess after prostatic biopsy, despite properly conducted antibiotic prophylaxis. Although the epidural ... ...

    Title translation Epidural abscess after prostatic biopsies.
    Abstract Prostatic biopsy is a routine clinical procedure often wrongly considered to be perfectly harmless. The authors report the first case of epidural abscess after prostatic biopsy, despite properly conducted antibiotic prophylaxis. Although the epidural space is a known site of infection, the relationship with prostatic biopsies has never been previously reported. This clinical case emphasizes the need for complete patient information and the importance of anti-infective prophylaxis guidelines.
    MeSH term(s) Biopsy/adverse effects ; Epidural Abscess/etiology ; Humans ; Male ; Middle Aged ; Prostate/pathology
    Language French
    Publishing date 2005-09
    Publishing country France
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 1186190-3
    ISSN 1166-7087
    ISSN 1166-7087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Successful retransplantation of a kidney allograft affected by thrombotic microangiopathy into a second transplant recipient.

    Kamar, Nassim / Rischmann, Pascal / Guilbeau-Frugier, Céline / Sallusto, Federico / Khedis, Mehdi / Delisle, Marie-Bernadette / Noury, Didier / Fort, Marylise / Rostaing, Lionel

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2008  Volume 52, Issue 3, Page(s) 591–594

    Abstract: The donor organ shortage has compelled transplant centers to use organs from nontraditional sources. One example is the reuse of a previously transplanted organ, such as a kidney or liver retrieved from a brain-dead allograft recipient. For the first ... ...

    Abstract The donor organ shortage has compelled transplant centers to use organs from nontraditional sources. One example is the reuse of a previously transplanted organ, such as a kidney or liver retrieved from a brain-dead allograft recipient. For the first time, we reused a previously transplanted kidney that experienced intractable recurrent thrombotic microangiopathy (TMA) from a living allograft recipient. Within a few weeks posttransplantation, a deceased kidney allograft recipient developed intractable severe recurrent idiopathic TMA in the allograft despite intensive plasma exchanges and steroid and rituximab therapy. This required nephrectomy to cure TMA. The index recipient was believed to have a well-functioning allograft despite TMA (serum creatinine, 1.36 mg/dL [120 micromol/L]) and microalbuminuria with albumin of 1.2 g/dL [12 g/L]), and it appeared mildly damaged on biopsy examination. After donor and recipient informed consents were obtained and after approval of the French Agency of Biomedicine, the TMA allograft was reused and transplanted into a recipient whose original kidney disease was polycystic kidney disease. The retransplantation was uneventful, and at 6 months posttransplantation, the ultimate recipient's serum creatinine level was 1.06 mg/L (97 micromol/L) and albuminuria was 0.5 g/dL (5 g/L). A routine kidney biopsy showed mild glomerular lesions. After allograft nephrectomy, the donor's hematologic TMA symptoms dissipated within 10 days. We conclude that a kidney allograft with TMA recurrence can be successfully retransplanted into another recipient with excellent kidney function while still curing the first recipient of recurrent TMA. This might increase the number of kidney allografts from extended criteria donors.
    MeSH term(s) Adult ; Biopsy ; Female ; Humans ; Kidney/pathology ; Kidney Transplantation/adverse effects ; Middle Aged ; Nephrectomy ; Recurrence ; Thrombosis/etiology ; Thrombosis/surgery ; Tissue Donors ; Tissue and Organ Procurement/methods ; Transplantation, Homologous
    Language English
    Publishing date 2008-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2008.03.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Polyorchidism: presentation of 2 cases, review of the literature and a new management strategy.

    Khedis, Mehdi / Nohra, Joe / Dierickx, Laurence / Walschaerts, Marie / Soulié, Michel / Thonneau, Patrick F / Plante, Pierre / Huyghe, Eric

    Urologia internationalis

    2008  Volume 80, Issue 1, Page(s) 98–101

    Abstract: Objectives: To present 2 cases with polyorchidism, to review the literature about polyorchidism, and to propose a rational therapeutic algorithm.: Methods: In our institution, we encountered 2 patients with polyorchidism: The 1st patient had ... ...

    Abstract Objectives: To present 2 cases with polyorchidism, to review the literature about polyorchidism, and to propose a rational therapeutic algorithm.
    Methods: In our institution, we encountered 2 patients with polyorchidism: The 1st patient had bilateral double testis with testicular torsion, and the 2nd patient presented with an indolent scrotal mass. We also performed a literature search (PubMed) for other reports of polyorchidism.
    Results: Polyorchidism is a rare congenital anomaly that is not well known by most urologists. So far, as illustrated by our 2 cases, the management of polyorchidism is rarely conservative, and usually the supernumerary testis is removed without any evidence supporting this attitude. Rare cases are complicated by torsion (case 1), cryptorchidism, or testicular neoplasm. In case of torsion, the conservative approach depends on the viability of the twisted testis. In case of cryptorchidism, notably in children or young adults, conservative management should be proposed, if technically feasible. In case of signs of malignancy, orchiectomy must be performed.
    Conclusions: Conservative treatment is advised in all uncomplicated cases. Complicated cases need a careful management, but several situations can be managed conservatively. Based on the literature, we propose a simple, rational therapeutic algorithm.
    MeSH term(s) Adult ; Algorithms ; Cryptorchidism/diagnosis ; Cryptorchidism/therapy ; Humans ; Male ; Middle Aged ; Spermatic Cord Torsion/diagnosis ; Testicular Diseases/diagnosis ; Testicular Neoplasms/diagnosis ; Testis/abnormalities ; Testis/pathology ; Urology/methods
    Language English
    Publishing date 2008
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 204045-1
    ISSN 1423-0399 ; 0042-1138
    ISSN (online) 1423-0399
    ISSN 0042-1138
    DOI 10.1159/000111738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Néphrectomie partielle par clampage parenchymateux sélectif utilisant un nouveau clamp.

    Khedis, Mehdi / Bellec, Laurent / Leobon, Bertrand / Thoulouzan, Matthieu / Labarthe, Pierre / Nohra, Joe / Soulie, Michel / Huyghe, Eric / Plante, Pierre

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

    2007  Volume 17, Issue 1, Page(s) 41–44

    Abstract: Objective: To study the results of open partial nephrectomy by selective renal parenchymal clamping using a new renal parenchyma clamp, the Réniclamp.: Material and methods: Partial nephrectomy was performed in 37 patients using the Réniclamp for an ... ...

    Title translation Partial nephrectomy by selective renal parenchymal clamping using a new clamp.
    Abstract Objective: To study the results of open partial nephrectomy by selective renal parenchymal clamping using a new renal parenchyma clamp, the Réniclamp.
    Material and methods: Partial nephrectomy was performed in 37 patients using the Réniclamp for an imperative indication in 7 patients (solitary kidneys) and an elective indication in 30 patients. The tumour was situated in a pole in 22 cases and on the lateral border of the kidney in 15 cases. The mean tumour diameter was 29 mm (range: 10 - 60 mm).
    Results: The mean operating time was 147 minutes and the mean clamping time was 25 minutes. Mean blood loss was 191 cc (range : 50-450 cc) and no patient required blood transfusion. No cases of slipping of the clamp or renal parenchymal lesion due to the clamp were observed.
    Complications: A urinary fistula treated by endoscopy and obstructive clot of the upper urinary tract, which required endoscopic treatment and selective embolisation. The surgical margins were negative in every case.
    Conclusion: Partial nephrectomy by selective renal parenchymal clamping is an alternative to the pedicle clamping technique in almost every case of renal tumour except for central renal lesions. Réniclamp distributes the pressure homogeneously, avoiding damage to the parenchyma due to excess pressure on the proximal part of the clamp and bleeding due to insufficient pressure on the distal part of the clamp.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Constriction ; Equipment Design ; Humans ; Kidney Neoplasms/surgery ; Middle Aged ; Nephrectomy/instrumentation ; Nephrectomy/methods
    Language French
    Publishing date 2007-03-06
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 1186190-3
    ISSN 1166-7087
    ISSN 1166-7087
    DOI 10.1016/s1166-7087(07)92223-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Lethal posttraumatic rupture of a pheochromocytoma: lesson from a postmortem diagnosis.

    Huyghe, Eric / Nohra, Joe / Caron, Philippe / Bennet, Antoine / Khedis, Mehdi / Otal, Philippe / Soulie, Michel / Yeung, Sai-Ching Jim / Plante, Pierre

    Urologia internationalis

    2007  Volume 79, Issue 1, Page(s) 83–85

    Abstract: Pheochromocytoma is challenging to diagnose, and a life-threatening situation may occur if pheochromocytoma is incorrectly diagnosed and treated. We report the first case of a lethal posttraumatic rupture of an undiagnosed pheochromocytoma in a 46-year- ... ...

    Abstract Pheochromocytoma is challenging to diagnose, and a life-threatening situation may occur if pheochromocytoma is incorrectly diagnosed and treated. We report the first case of a lethal posttraumatic rupture of an undiagnosed pheochromocytoma in a 46-year-old man who presented with peripheral vasoconstriction and signs of peritoneal irritation after being kicked by a horse. Computed tomography, arteriography, and two exploratory laparotomies were performed. The patient died of multiorgan failure 8 h after the trauma. The diagnosis of ruptured pheochromocytoma of the left adrenal gland was made during the postmortem examination. Pheochromocytoma should be considered in cases of blunt abdominal trauma associated with unstable blood pressure, peripheral vasoconstriction and adrenal hematoma.
    MeSH term(s) Abdominal Injuries/complications ; Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/diagnosis ; Fatal Outcome ; Humans ; Male ; Middle Aged ; Pheochromocytoma/complications ; Pheochromocytoma/diagnosis ; Rupture ; Wounds, Nonpenetrating/complications
    Language English
    Publishing date 2007
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 204045-1
    ISSN 1423-0399 ; 0042-1138
    ISSN (online) 1423-0399
    ISSN 0042-1138
    DOI 10.1159/000102920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Synchronous epidermoid cyst and mature teratoma of the testis: an unusual association.

    Huyghe, Eric / Mazerolles, Catherine / Moran, Cesar / Khedis, Mehdi / Khoury, Elias / Nohra, Joe / Soulié, Michel / Plante, Pierre

    Urologia internationalis

    2007  Volume 78, Issue 4, Page(s) 364–366

    Abstract: We describe here the first case of a synchronous epidermoid cyst and mature teratoma of the testis occurring in a young man presenting a with bilateral testicular tumor. After a clinical, biological and ultrasound evaluation, testis-sparing surgery was ... ...

    Abstract We describe here the first case of a synchronous epidermoid cyst and mature teratoma of the testis occurring in a young man presenting a with bilateral testicular tumor. After a clinical, biological and ultrasound evaluation, testis-sparing surgery was performed on the left testis and a total orchiectomy on the right side in accordance with oncological principles. Histopathological examination revealed a simple epidermoid cyst on the left side and a mature teratoma on the right side, following Price's criteria. No metastasis was detected, and the patient was closely followed. The patient remains disease-free and has normal postoperative testosterone levels 3 years after the surgery.
    MeSH term(s) Adult ; Epidermal Cyst/complications ; Epidermal Cyst/pathology ; Humans ; Male ; Teratoma/pathology ; Teratoma/surgery ; Testicular Neoplasms/complications ; Testicular Neoplasms/pathology ; Testicular Neoplasms/surgery ; Testis/pathology ; Testosterone/blood ; Treatment Outcome
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2007
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 204045-1
    ISSN 1423-0399 ; 0042-1138
    ISSN (online) 1423-0399
    ISSN 0042-1138
    DOI 10.1159/000100844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Efficacité et tolérance du Pelvicol dans le traitement des prolapsus par voie vaginale.

    Doumerc, Nicolas / Mouly, Patrick / Thanwerdas, Jacky / Vazzoler, Nicolas / Khedis, Mehdi / Huyghe, Eric / Soulié, Michel / Plante, Pierre

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

    2006  Volume 16, Issue 1, Page(s) 58–61

    Abstract: Objectives: To evaluate the efficacy and safety of a porcine biomaterial (Pelvicol) in the transvaginal surgical treatment of urogenital prolapse.: Material and method: Prospective study from June 2001 to February 2004 based on 132 patients with a ... ...

    Title translation Efficacy and safety of Pelvicol in the vaginal treatment of prolapse.
    Abstract Objectives: To evaluate the efficacy and safety of a porcine biomaterial (Pelvicol) in the transvaginal surgical treatment of urogenital prolapse.
    Material and method: Prospective study from June 2001 to February 2004 based on 132 patients with a mean age of 67.6 +/- 9.89 years presenting major urogenital prolapse: 132 cystoceles and 84 rectoceles with 100% and 63.4% of grade 2 or 3, respectively. Patients were evaluated by questionnaire and clinical examination at 1 month, 6 months, 12 months and 24 months after the operation. Two hundred and sixteen Pelvicol implants were inserted via a vaginal approach: 132 anterior implants and 84 posterior implants.
    Results: The mean follow-up was 21 months [range: 6-24]. No intraoperative complication was observed. The postoperative complication rate was 11.3% (15/132) including 1 prosthetic exposure with a favourable outcome. After 6 months, 1 recurrence of cystoceles and 1 recurrence of rectoceles were found in 132 patients. Out of the 117 patients followed up for 12 months, 6 presented with grade 2 cystoceles and 1 grade 2 rectoceles. After 24 months, out of the 107 patients evaluated, 18 cystoceles and 9 rectoceles of grade 2 or 3 were found. Globally, 83.1% of patients did not present with grade 2 or 3 recurrences after 24 months. Safety was considered to be good with 10% of moderate pelvic pain and 6% of de novo dyspareunia at 12 months. The overall satisfaction rate was 94%.
    Conclusion: These preliminary results demonstrate an efficacy of 83.1% at 24 months and the good safety of Pelvicol in the transvaginal surgical treatment of urogenital prolapse.
    MeSH term(s) Aged ; Animals ; Biocompatible Materials ; Bioprosthesis ; Collagen ; Female ; Humans ; Prospective Studies ; Rectal Prolapse/therapy ; Swine ; Uterine Prolapse/therapy
    Chemical Substances Biocompatible Materials ; Collagen (9007-34-5)
    Language French
    Publishing date 2006-02
    Publishing country France
    Document type Clinical Trial ; English Abstract ; Journal Article
    ZDB-ID 1186190-3
    ISSN 1166-7087
    ISSN 1166-7087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Open partial nephrectomy with selective renal parenchymal control: a new reliable clamp.

    Huyghe, Eric / Nohra, Joe / Leobon, Bertrand / El Khoury, Elias / Khedis, Mehdi / Soulié, Michel / Plante, Pierre

    Urology

    2006  Volume 68, Issue 3, Page(s) 658–660

    Abstract: We describe our experience of open partial nephrectomy with a parenchymal clamp, the Reni-Clamp, in 30 patients from January 2002 to May 2005. The mean operative and clamping time was 150 and 27 minutes, respectively, and the blood loss was 150 mL. The ... ...

    Abstract We describe our experience of open partial nephrectomy with a parenchymal clamp, the Reni-Clamp, in 30 patients from January 2002 to May 2005. The mean operative and clamping time was 150 and 27 minutes, respectively, and the blood loss was 150 mL. The Reni-Clamp enabled us to perform partial nephrectomy safely in all cases of polar or external edge renal tumor.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Equipment Design ; Humans ; Middle Aged ; Nephrectomy/instrumentation ; Nephrectomy/methods
    Language English
    Publishing date 2006-09
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2006.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Polyorchidism: Presentation of 2 Cases, Review of the Literature and a New Management Strategy

    Khedis, Mehdi / Nohra, Joe / Dierickx, Laurence / Walschaerts, Marie / Soulié, Michel / Thonneau, Patrick F. / Plante, Pierre / Huyghe, Eric

    Urologia Internationalis

    2008  Volume 80, Issue 1, Page(s) 98–101

    Abstract: Objectives: To present 2 cases with polyorchidism, to review the literature about polyorchidism, and to propose a rational therapeutic algorithm. Methods: In our institution, we encountered 2 patients with polyorchidism: The 1st patient had bilateral ... ...

    Institution Department of Urology and Andrology, Rangueil Hospital Department of Nuclear Medicine and Radiology, Institute Claudius Regaud, and Human Fertility Research Group, EA 3694, Department of Urology and Andrology, Paule de Viguier Hospital, Toulouse, France
    Abstract Objectives: To present 2 cases with polyorchidism, to review the literature about polyorchidism, and to propose a rational therapeutic algorithm. Methods: In our institution, we encountered 2 patients with polyorchidism: The 1st patient had bilateral double testis with testicular torsion, and the 2nd patient presented with an indolent scrotal mass. We also performed a literature search (PubMed) for other reports of polyorchidism. Results: Polyorchidism is a rare congenital anomaly that is not well known by most urologists. So far, as illustrated by our 2 cases, the management of polyorchidism is rarely conservative, and usually the supernumerary testis is removed without any evidence supporting this attitude. Rare cases are complicated by torsion (case 1), cryptorchidism, or testicular neoplasm. In case of torsion, the conservative approach depends on the viability of the twisted testis. In case of cryptorchidism, notably in children or young adults, conservative management should be proposed, if technically feasible. In case of signs of malignancy, orchiectomy must be performed. Conclusions: Conservative treatment is advised in all uncomplicated cases. Complicated cases need a careful management, but several situations can be managed conservatively. Based on the literature, we propose a simple, rational therapeutic algorithm.
    Keywords Testicular neoplasms ; Polyorchidism ; Spermatic torsion ; Cryptorchidism
    Language English
    Publishing date 2008-01-18
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Paper
    ZDB-ID 204045-1
    ISSN 1423-0399 ; 0042-1138
    ISSN (online) 1423-0399
    ISSN 0042-1138
    DOI 10.1159/000111738
    Database Karger publisher's database

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