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  1. Book ; Online ; E-Book: Intraocular tumors

    Khetan, Vikas

    2020  

    Author's details Vikas Khetan editor
    Keywords Ophthalmology ; Oncology
    Subject code 617.7
    Language English
    Size 1 Online-Ressource (xiv, 308 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020332700
    ISBN 978-981-15-0395-5 ; 9789811503948 ; 9789811503962 ; 981-15-0395-8 ; 981150394X ; 9811503966
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Masquerade syndrome: A review of uveitic imposters.

    Dutta Majumder, Parthopratim / Khetan, Vikas / Biswas, Jyotirmay

    Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

    2024  Volume 13, Issue 2, Page(s) 100054

    Abstract: Masquerade syndromes in uveitis are complex clinical conditions where non-inflammatory diseases mimic uveitic manifestations, often leading to diagnostic and therapeutic challenges. This review delves into the diverse spectrum of masquerade syndromes, ... ...

    Abstract Masquerade syndromes in uveitis are complex clinical conditions where non-inflammatory diseases mimic uveitic manifestations, often leading to diagnostic and therapeutic challenges. This review delves into the diverse spectrum of masquerade syndromes, categorizing them into neoplastic and non-neoplastic entities. We explore the prevalence of primary intraocular lymphoma, leukaemia, retinoblastoma, and other malignancies, as well as conditions like retinitis pigmentosa and endophthalmitis that can present as uveitis. Through detailed analysis of symptoms, diagnostic methods, and treatment approaches, the review emphasizes the importance of considering masquerade syndromes in differential diagnoses to prevent mismanagement. The synthesis of current knowledge aims to enhance clinicians' ability to discern these complex presentations, advocating for a multidisciplinary approach to diagnosis and care, thereby improving patient outcomes in cases of uveitic masquerade syndromes.
    MeSH term(s) Humans ; Uveitis/diagnosis ; Diagnosis, Differential
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2756329-7
    ISSN 2162-0989 ; 2162-0989
    ISSN (online) 2162-0989
    ISSN 2162-0989
    DOI 10.1016/j.apjo.2024.100054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Circumscribed choroidal hemangioma in a case of neurofibromatosis type 1.

    Vaidya, Harshit / Khetan, Vikas

    Oman journal of ophthalmology

    2022  Volume 15, Issue 2, Page(s) 243–244

    Language English
    Publishing date 2022-06-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2484272-2
    ISSN 0974-7842 ; 0974-620X
    ISSN (online) 0974-7842
    ISSN 0974-620X
    DOI 10.4103/ojo.ojo_369_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: How we manage patients with retinoblastoma.

    Khetan, Vikas

    Community eye health

    2017  Volume 31, Issue 101, Page(s) 30

    Language English
    Publishing date 2017-12-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036859-0
    ISSN 0953-6833
    ISSN 0953-6833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3298: Show issues Location:
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  5. Article ; Online: Retinoblastoma tumour cells in central retinal vessels.

    Mohan, Sashwanthi / Subramanian, Krishnakumar / Khetan, Vikas

    Indian journal of ophthalmology

    2022  Volume 70, Issue 7, Page(s) 2773

    MeSH term(s) Cell Count ; Humans ; Retinal Neoplasms/diagnosis ; Retinal Neoplasms/pathology ; Retinal Vessels/pathology ; Retinoblastoma/diagnosis ; Retinoblastoma/pathology
    Language English
    Publishing date 2022-07-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_1350_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 329: Show issues Location:
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    Zs.MO 598: Show issues

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  6. Article ; Online: Ocular oncology in India.

    Khetan, Vikas

    Indian journal of ophthalmology

    2015  Volume 63, Issue 2, Page(s) 177

    MeSH term(s) Eye Neoplasms/epidemiology ; Humans ; India/epidemiology ; Medical Oncology ; Morbidity/trends ; Ophthalmology
    Language English
    Publishing date 2015-02
    Publishing country India
    Document type Editorial
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/0301-4738.154814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 329: Show issues Location:
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    Zs.MO 598: Show issues

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  7. Article ; Online: Polypoidal choroidal vasculopathy: An update on current management and review of literature.

    Palkar, Amit Harishchandra / Khetan, Vikas

    Taiwan journal of ophthalmology

    2019  Volume 9, Issue 2, Page(s) 72–92

    Abstract: Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration (nAMD), commonly seen in the Asian population. It is dissimilar in epidemiology, genetic heterogeneity, pathogenesis, natural history, and response to ... ...

    Abstract Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration (nAMD), commonly seen in the Asian population. It is dissimilar in epidemiology, genetic heterogeneity, pathogenesis, natural history, and response to treatment in comparison to nAMD. Confocal scanning laser ophthalmoscopy-based simultaneous fluorescein angiography and indocyanine green angiography, spectral-domain optical coherence tomography (OCT) with enhanced depth imaging, swept-source OCT, and OCT angiography have improved the ability to detect PCV, understand its pathology, and monitor treatment response. A plethora of literature has discussed the efficacy of photodynamic therapy, anti-vascular endothelial growth factor (VEGF) monotherapy, and combination of both, but only a few studies with higher level of evidence and limited follow-up duration are available. This review discusses the understanding of PCV with respect to epidemiology, pathogenesis, clinical features, natural history, imaging techniques, and various treatment options. Recent clinical trials (EVEREST-II and PLANET study) have emphasized that either anti-VEGF monotherapy or combination treatment is equally capable to strike a balance between polyp regression and stabilization of visual acuity. The recurrent nature of the disease, the development of macular atrophy, and the long-term poor visual prognosis despite treatment are concerns that open avenues for further research.
    Language English
    Publishing date 2019-06-04
    Publishing country India
    Document type Journal Article ; Review
    ISSN 2211-5072
    ISSN (online) 2211-5072
    DOI 10.4103/tjo.tjo_35_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Commentary: Prognostication of uveal melanoma based on molecular diagnosis - Are we there yet?

    Attiku, Yamini / Khetan, Vikas

    Indian journal of ophthalmology

    2019  Volume 67, Issue 12, Page(s) 1964

    MeSH term(s) Humans ; Melanoma ; Uveal Neoplasms
    Language English
    Publishing date 2019-11-21
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_1899_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 329: Show issues Location:
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    Zs.MO 598: Show issues

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  9. Article ; Online: Retinoblastoma patient-derived stem cells-an in vivo model to study the role of RB1 in adipogenesis.

    Vincent, Ambily / Natarajan, Viswanathan / Khetan, Vikas / Krishnakumar, Subramanian / Parameswaran, Sowmya

    Histochemistry and cell biology

    2022  Volume 158, Issue 2, Page(s) 181–192

    Abstract: Retinoblastoma (RB1) protein is a multifunctional protein that plays an important role in cell cycle regulation and cell differentiation, including adipogenesis. A detailed literature search to understand the role of RB1 in adipogenesis revealed that the ...

    Abstract Retinoblastoma (RB1) protein is a multifunctional protein that plays an important role in cell cycle regulation and cell differentiation, including adipogenesis. A detailed literature search to understand the role of RB1 in adipogenesis revealed that the nature of the RB1 inactivation (in vivo/in vitro) led to differences in adipogenesis. The majority of these studies were animal-based, and the only study in humans employed an in vitro mode of RB1 inactivation. To overcome these differences and lack of human studies, we sought to explore the role of RB1 in adipogenesis using orbital adipose mesenchymal stem cells (OAMSCs) from patients with retinoblastoma that innately carry a heterozygous RB1 mutation. We hypothesized that these patient-derived RB1 mutant OAMSCs can model in vivo RB1 inactivation in humans. Our study revealed increased adipogenesis with a bias toward brown adipogenesis in the RB1 mutant in addition to an increased number of adipocytes in the mitotic phase.
    MeSH term(s) Adipocytes ; Adipogenesis/genetics ; Cell Differentiation ; Humans ; Retinoblastoma/genetics ; Retinoblastoma Binding Proteins/genetics ; Stem Cells/cytology ; Stem Cells/metabolism ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances RB1 protein, human ; Retinoblastoma Binding Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2022-04-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-022-02105-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Knudson to embryo selection: A story of the genetics of retinoblastoma.

    Athavale, Vrushali / Khetan, Vikas

    Taiwan journal of ophthalmology

    2018  Volume 8, Issue 4, Page(s) 196–204

    Abstract: Retinoblastoma, the most common primary intraocular malignancy of the young, is a prototype hereditary cancer. Due to its fairly predictable Mendelian inheritance, easily examinable tumors, and early age of presentation, RB has served as the most ... ...

    Abstract Retinoblastoma, the most common primary intraocular malignancy of the young, is a prototype hereditary cancer. Due to its fairly predictable Mendelian inheritance, easily examinable tumors, and early age of presentation, RB has served as the most extensively studied model for genetics in cancer. The genetic strides in RB have progressed at an exponential rate since the 1970s. The highly morbid, reasonably curable and distinctly predictable inheritance pattern of RB; not to mention its propensity to affect our young, forms the basis of aggressively encouraging genetic diagnosis in all patients of RB. In this article, we present the basic and clinically relevant concepts of the genetics retinoblastoma.
    Language English
    Publishing date 2018-12-31
    Publishing country India
    Document type Journal Article ; Review
    ISSN 2211-5072
    ISSN (online) 2211-5072
    DOI 10.4103/tjo.tjo_37_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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