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Article: Oxidized cholesterol exacerbates toll-like receptor 4 expression and activity in the hearts of rats with myocardial infarction.

Khorrami, Arash / Ziaee, Mojtaba / Rameshrad, Maryam / Nakhlband, Ailar / Maleki-Dizaji, Nasrin / Garjani, Alireza

Journal of cardiovascular and thoracic research

2020 Volume 12, Issue 1, Page(s) 43–50

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2020-01-30
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2654729-6
ISSN	2008-6830 ; 2008-5117
ISSN (online)	2008-6830
ISSN	2008-5117
DOI	10.34172/jcvtr.2020.07
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Article: Cardiovascular Complications of Chronic Opium Consumption: A Narrative Review Article.

Ziaee, Mojtaba / Hajizadeh, Reza / Khorrami, Arash / Sepehrvand, Nariman / Momtaz, Saeideh / Ghaffari, Samad

Iranian journal of public health

2020 Volume 48, Issue 12, Page(s) 2154–2164

Abstract: Opiates are the second most prevalent abused illicit substance after cannabis in the world. The latest United Nations Office on Drugs and Crime (UNODC) report estimated 30% increment in opium cultivation worldwide. High prevalence of opium consumption in ...

Abstract	Opiates are the second most prevalent abused illicit substance after cannabis in the world. The latest United Nations Office on Drugs and Crime (UNODC) report estimated 30% increment in opium cultivation worldwide. High prevalence of opium consumption in eastern countries may be due to the high availability and traditional misconceptions. Opium consumption has been linked to hypertension, diabetes mellitus, dyslipidemia, and coronary artery diseases (CAD). In this review, we will review the association between opium use, cardiovascular diseases, and clinical outcomes. The present evidence suggests that chronic opiate consumption may increase the risk of cardiovascular diseases and related mortality.
Language	English
Publishing date	2020-01-14
Publishing country	Iran
Document type	Journal Article ; Review
ISSN	2251-6085 ; 0304-4556
ISSN	2251-6085 ; 0304-4556
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Article ; Online: Comparison of the Effects of Clofibrate and Silafibrate on Sperm Parameters Quality and Sex Hormones in Male Rats.

Delashoub, Masoud / Ziaee, Mojtaba / Khorrami, Arash / Banan-Khojasteh, Seyed Mahdi

Urology journal

2018 Volume 15, Issue 2, Page(s) 38–43

Abstract: Purpose: Fibrates are drugs widely used for the treatment of hyperlipidemic disorders. Previous studies on a novel analogue of clofibrate, called silafibrate, have shown good lipid lowering effects. This study was designed to assess the role of ... ...

Abstract	Purpose: Fibrates are drugs widely used for the treatment of hyperlipidemic disorders. Previous studies on a novel analogue of clofibrate, called silafibrate, have shown good lipid lowering effects. This study was designed to assess the role of silafibrate as a peroxisome proliferator-activated receptors (PPARs) agonist on sperm health and spermatogenesis in adult male rats. Material and methods: Seventy male Wistar rats were randomly allocated into 7 groups: Cl-10, Cl-20, and Cl-40 mg/kg/day (clofibrate); Si-10, Si-20, and Si-40 mg/kg/day (silafibrate); and C, control. After a 28-day treatment, all rats were euthanized. Blood samples were taken for determination of testosterone, total antioxidant capacity, levels of malondialdehyde, and oxidized low-density lipoprotein. Reproductive organs were dissected and spermatozoa collected from the epididymis for analysis. Result: Sperm parameters (count, motility, viability, and morphology) and total serum testosterone decreased significantly in clofibrate-treated (20 and 40 mg/kg) rats (P < 0.05) as compared with normal rats. Conclusion: We conclude that PPARs agonists have significant adverse effect on sperm viability, motility, and total serum testosterone, and could be harmful for sperm parameters and male reproductive function in rats.
MeSH term(s)	Animals ; Cell Survival/drug effects ; Clofibrate/analogs & derivatives ; Clofibrate/pharmacology ; Follicle Stimulating Hormone/blood ; Hypolipidemic Agents/pharmacology ; Lipoproteins, LDL/blood ; Luteinizing Hormone/blood ; Male ; Malondialdehyde/blood ; Peroxisome Proliferator-Activated Receptors/agonists ; Random Allocation ; Rats ; Sperm Count ; Sperm Motility/drug effects ; Spermatozoa/drug effects ; Spermatozoa/pathology ; Spermatozoa/physiology ; Testosterone/blood
Chemical Substances	Hypolipidemic Agents ; Lipoproteins, LDL ; Peroxisome Proliferator-Activated Receptors ; silafibrate ; Testosterone (3XMK78S47O) ; Malondialdehyde (4Y8F71G49Q) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0) ; Clofibrate (HPN91K7FU3)
Language	English
Publishing date	2018-03-18
Publishing country	Iran
Document type	Comparative Study ; Journal Article
ZDB-ID	2251940-3
ISSN	1735-546X ; 1735-1308
ISSN (online)	1735-546X
ISSN	1735-1308
DOI	10.22037/uj.v0i0.3954
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Article ; Online: Plasma stable, pH-sensitive non-ionic surfactant vesicles simultaneously enhance antiproliferative effect and selectivity of Sirolimus.

Ghanbarzadeh, Saeed / Khorrami, Arash / Pourmoazzen, Zhaleh / Arami, Sanam

Pharmaceutical development and technology

2015 Volume 20, Issue 3, Page(s) 279–287

Abstract: Objective: The purpose of the present investigation was to prepare a plasma stable, pH-sensitive niosomal formulation to enhance Sirolimus efficacy and selectivity.: Materials and methods: pH-sensitive niosomal formulations bearing PEG-Poly ( ... ...

Abstract	Objective: The purpose of the present investigation was to prepare a plasma stable, pH-sensitive niosomal formulation to enhance Sirolimus efficacy and selectivity. Materials and methods: pH-sensitive niosomal formulations bearing PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymers and cholesteryl hemisuccinate (CHEMS) were prepared by a modified ethanol injection method and characterized with regard to pH-responsiveness and stability in human serum. The ability of pH-sensitive niosomes to enhance the Sirolimus cytotoxicity was evaluated in vitro using human erythromyeloblastoid leukemia cell line (K562) and compared with cytotoxicity effect on human umbilical vein endothelial cells (HUVEC). Results and discussion: This study showed that both formulations can be rendered pH-sensitive property and were found to rapidly release their contents under mildly acidic conditions. However, the CHEMS-based niosomes lost their pH-sensitivity after incubation in plasma, whereas, PEG-PMMI-CholC6 niosomes preserved their ability to respond to pH change. Sirolimus encapsulated in pH-sensitive niosomes exhibited a higher cytotoxicity than the control conventional formulation on K562 cell line. On the other hand, both pH-sensitive niosomes showed lower antiproliferative effect on HUVEC cells. Conclusion: Plasma stable, pH-sensitive PEG-PMMI-CholC6-based niosomes can improve the in vitro efficiency and also reduce the side effects of Sirolimus.
MeSH term(s)	Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/pharmacology ; Cell Proliferation/drug effects ; Chemistry, Pharmaceutical/methods ; Cholesterol Esters/chemistry ; Drug Stability ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydrogen-Ion Concentration ; K562 Cells ; Liposomes ; Polyethylene Glycols/chemistry ; Polymers/chemistry ; Sirolimus/administration & dosage ; Sirolimus/chemistry ; Sirolimus/pharmacology ; Succinates/chemistry ; Surface-Active Agents/chemistry
Chemical Substances	Antibiotics, Antineoplastic ; Cholesterol Esters ; Liposomes ; Polymers ; Succinates ; Surface-Active Agents ; Polyethylene Glycols (30IQX730WE) ; itaconic acid (Q4516562YH) ; cholesteryl succinate (T3J4KS4201) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2015-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1331774-x
ISSN	1097-9867 ; 1083-7450
ISSN (online)	1097-9867
ISSN	1083-7450
DOI	10.3109/10837450.2013.860553
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Article ; Online: Nonionic surfactant-based vesicular system for transdermal drug delivery.

Ghanbarzadeh, Saeed / Khorrami, Arash / Arami, Sanam

Drug delivery

2015 Volume 22, Issue 8, Page(s) 1071–1077

Abstract: Objective: The objective of this study was to formulate and evaluate the Ibuprofen niosomal formulation as a transdermal drug delivery system.: Materials and methods: Niosomes were prepared by a modified ethanol injection method, using Span 60, Tween ...

Abstract	Objective: The objective of this study was to formulate and evaluate the Ibuprofen niosomal formulation as a transdermal drug delivery system. Materials and methods: Niosomes were prepared by a modified ethanol injection method, using Span 60, Tween 60 and Tween 65 as well as cholesterol with various cholesterol:surfactant molar ratios. The prepared vesicles were characterized for entrapment efficiency (EE), particle size, zeta potential and in vitro release study. Skin permeation studies were conducted using modified Franz diffusion cell, and excised rat skin was treated with niosomal, liposomal and conventional Carbopol 914 gel of Ibuprofen. Results and discussion: The results showed that the type of surfactant and molar ratio of cholesterol:surfactant altered the EE, size and in vitro drug release of niosomes. Higher EE was obtained with the niosomes prepared with cholesterol and Span 60 at molar ratio of 0.5:1. It has been observed that both niosomal and liposomal formulations enhanced the drug permeation and the percentage of accumulated dose in the skin compared to control conventional gel formulation. However, niosomes prepared by Span 60 and Tween 65 exhibited higher permeation and retention of Ibuprofen, respectively. Conclusion: Our results suggested that niosomal formulations could be used as a promising carrier for the Ibuprofen transdermal delivery system.
Language	English
Publishing date	2015-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1213261-5
ISSN	1521-0464 ; 1071-7544
ISSN (online)	1521-0464
ISSN	1071-7544
DOI	10.3109/10717544.2013.873837
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Article ; Online: Improvement of the antiproliferative effect of rapamycin on tumor cell lines by poly (monomethylitaconate)-based pH-sensitive, plasma stable liposomes.

Ghanbarzadeh, Saeed / Arami, Sanam / Pourmoazzen, Zhaleh / Khorrami, Arash

Colloids and surfaces. B, Biointerfaces

2014 Volume 115, Page(s) 323–330

Abstract: pH-responsive polymers produce liposomes with pH-sensitive property which can release their encapsulated drug under mild acidic conditions found inside the cellular endosomes, inflammatory tissues and cancerous cells. The aim of this study was preparing ... ...

Abstract	pH-responsive polymers produce liposomes with pH-sensitive property which can release their encapsulated drug under mild acidic conditions found inside the cellular endosomes, inflammatory tissues and cancerous cells. The aim of this study was preparing pH-sensitive and plasma stable liposomes in order to enhance the selectivity and antiproliferative effect of Rapamycin. In the present study we used PEG-poly (monomethylitaconate)-CholC6 (PEG-PMMI-CholC6) copolymer and Oleic acid (OA) to induce pH-sensitive property in Rapamycin liposomes. pH-sensitive liposomal formulations bearing copolymer PEG-PMMI-CholC6 and OA were characterized in regard to physicochemical stability, pH-responsiveness and stability in human plasma. The ability of pH-sensitive liposomes in enhancing the cytotoxicity of Rapamycin was evaluated in vitro by using colon cancer cell line (HT-29) and compared with its cytotoxicity on human umbilical vein endothelial cell (HUVEC) line. Both formulations were found to release their contents under mild acidic conditions rapidly. However, unlike OA-based liposomes, the PEG-PMMI-CholC6 bearing liposomes preserved their pH-sensitivity in plasma. Both types of pH-sensitive Rapamycin-loaded liposomes exhibited high physicochemical stability and could deliver antiproliferative agent into HT-29 cells much more efficiently in comparison with conventional liposomes. Conversely, the antiproliferative effect of pH-sensitive liposomes on HUVEC cell line was less than conventional liposomes. This study showed that both OA and PEG-PMMI-CholC6-based vesicles could submit pH-sensitive property, however, only PEG-PMMI-CholC6-based liposomes could preserve pH-sensitive property after incubation in plasma. As a result pH-sensitive PEG-PMMI-CholC6-based liposomal formulation can improve the selectivity, stability and antiproliferative effect of Rapamycin.
MeSH term(s)	1,2-Dipalmitoylphosphatidylcholine/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cholesterol/analogs & derivatives ; Cholesterol/chemical synthesis ; Cholesterol/chemistry ; Cholesterol/pharmacology ; Drug Stability ; Human Umbilical Vein Endothelial Cells/cytology ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Hydrogen-Ion Concentration ; Liposomes/blood ; Oleic Acid/chemistry ; Polyethylene Glycols/chemical synthesis ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacology ; Polyvinyls/chemical synthesis ; Polyvinyls/chemistry ; Polyvinyls/pharmacology ; Sirolimus/blood ; Sirolimus/pharmacology ; Succinates/chemical synthesis ; Succinates/chemistry ; Succinates/pharmacology
Chemical Substances	Liposomes ; Polyvinyls ; Succinates ; 1,2-Dipalmitoylphosphatidylcholine (2644-64-6) ; Oleic Acid (2UMI9U37CP) ; Polyethylene Glycols (30IQX730WE) ; Cholesterol (97C5T2UQ7J) ; itaconic acid (Q4516562YH) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2014-03-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2013.12.024
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Article ; Online: Fusogenic pH sensitive liposomal formulation for rapamycin: improvement of antiproliferative effect.

Ghanbarzadeh, Saeed / Khorrami, Arash / Mohamed Khosroshahi, Leila / Arami, Sanam

Pharmaceutical biology

2014 Volume 52, Issue 7, Page(s) 848–854

Abstract: Context: Liposomes are increasingly employed to deliver chemotherapeutic agents, antisense oligonucleotides, and genes to various therapeutic targets.: Objective: The present investigation evaluates the ability of fusogenic pH-sensitive liposomes of ... ...

Abstract	Context: Liposomes are increasingly employed to deliver chemotherapeutic agents, antisense oligonucleotides, and genes to various therapeutic targets. Objective: The present investigation evaluates the ability of fusogenic pH-sensitive liposomes of rapamycin in increasing its antiproliferative effect on human breast adenocarcinoma (MCF-7) cell line. Materials and methods: Cholesterol (Chol) and dipalmitoylphosphatidylcholine (DPPC) (DPPC:Chol, 7:3) were used to prepare conventional rapamycin liposomes by a modified ethanol injection method. Dioleoylphosphatidylethanolamine (DOPE) was used to produce fusogenic and pH-sensitive properties in liposomes simultaneously (DPPC:Chol:DOPE, 7:3:4.2). The prepared liposomes were characterized by their size, zeta potential, encapsulation efficiency percent (EE%), and chemical stability during 6 months. The antiproliferative effects of both types of rapamycin liposomes (10, 25, and 50 nmol/L) with optimized formulations were assessed on MCF-7 cells, as cancerous cells, and human umbilical vein endothelial cells (HUVEC), as healthy cells, employing the diphenyltetrazolium bromide (MTT) assay for 72 h. Results and discussion: The particle size, zeta potential, and EE% of the liposomes were 165 ± 12.3 and 178 ± 15.4 nm, -39.6 ± 1.3, and -41.2 ± 2.1 mV as well as 76.9 ± 2.6 and 76.9 ± 2.6% in conventional and fusogenic pH-sensitive liposomes, respectively. Physicochemical stability results indicated that both liposome types were relatively stable at 4 °C than 25 °C. In vitro antiproliferative evaluation showed that fusogenic pH-sensitive liposomes had better antiproliferative effects on MCF-7 cells compared to the conventional liposomes. Conversely, fusogenic pH-sensitive liposomes had less cytotoxicity on HUVEC cell line.
MeSH term(s)	1,2-Dipalmitoylphosphatidylcholine/chemistry ; Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/pharmacology ; Cell Proliferation/drug effects ; Cholesterol/chemistry ; Dose-Response Relationship, Drug ; Drug Stability ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydrogen-Ion Concentration ; Liposomes/chemistry ; MCF-7 Cells ; Particle Size ; Phosphatidylethanolamines/chemistry ; Sirolimus/chemistry ; Sirolimus/pharmacology ; Surface Properties
Chemical Substances	Antibiotics, Antineoplastic ; Liposomes ; Phosphatidylethanolamines ; dioleoyl phosphatidylethanolamine (2462-63-7) ; 1,2-Dipalmitoylphosphatidylcholine (2644-64-6) ; Cholesterol (97C5T2UQ7J) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2014-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.3109/13880209.2013.871640
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Article ; Online: Protective effect of pioglitazone on morphine-induced neuroinflammation in the rat lumbar spinal cord.

Charkhpour, Mohammad / Ghavimi, Hamed / Ghanbarzadeh, Saeed / Yousefi, Bahman / Khorrami, Arash / Mesgari, Mehran / Hassanzadeh, Kambiz

Journal of biomedical science

2015 Volume 22, Page(s) 82

Abstract: Background: Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated receptor gamma (PPAR-γ) agonist, ... ...

Abstract	Background: Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated receptor gamma (PPAR-γ) agonist, on the morphine-induced neuroinflammation in the lumbar region of the male Wistar rat spinal cord. Results: Co-administration of the pioglitazone with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta, and interleukin 6) and nuclear factor-kappa B activity. Administration of the GW-9662 antagonized the above mentioned effects of the pioglitazone. Conclusions: It is concluded that oral administration of the pioglitazone attenuates morphine-induced tolerance and the neuroinflammation in the lumbar region of the rat spinal cord. This action of the pioglitazone may be, at least in part, due to an interaction with the spinal pro-inflammatory cytokine expression and the nuclear factor-kappa B activity.
MeSH term(s)	Animals ; Cytokines/metabolism ; Drug Tolerance ; Inflammation/immunology ; Lumbar Vertebrae ; Male ; Morphine/pharmacology ; PPAR gamma/agonists ; Rats ; Rats, Wistar ; Spinal Cord/drug effects ; Spinal Cord/immunology ; Thiazolidinediones/pharmacology
Chemical Substances	Cytokines ; PPAR gamma ; Thiazolidinediones ; Morphine (76I7G6D29C) ; pioglitazone (X4OV71U42S)
Language	English
Publishing date	2015-09-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1193378-1
ISSN	1423-0127 ; 1021-7770
ISSN (online)	1423-0127
ISSN	1021-7770
DOI	10.1186/s12929-015-0187-2
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Article ; Online: Plasma stable, pH-sensitive fusogenic polymer-modified liposomes: A promising carrier for mitoxantrone.

Ghanbarzadeh, Saeed / Arami, Sanam / Pourmoazzen, Zhaleh / Ghasemian-Yadegari, Javad / Khorrami, Arash

Journal of biomaterials applications

2014 Volume 29, Issue 1, Page(s) 81–92

Abstract: pH-sensitive liposomes are designed to undergo acid-triggered destabilization. In the present study, we prepared polymer-modified, plasma stable, pH-sensitive fusogenic mitoxantrone liposomes to increase efficacy and selectivity on cancer cell lines. ... ...

Abstract	pH-sensitive liposomes are designed to undergo acid-triggered destabilization. In the present study, we prepared polymer-modified, plasma stable, pH-sensitive fusogenic mitoxantrone liposomes to increase efficacy and selectivity on cancer cell lines. Conventional liposomes were prepared using cholesterol and dipalmitoyl-sn-glycero-3-phosphatidylethanolamine. Dioleoylphosphatidylethanolamine and a cholesteryl derivative, poly(monomethylitaconate)-co-poly(N,N-dimethylaminoethyl methacrylate) (PMMI-co-PDMAEMA), were used for the preparation of pH-sensitive fusogenic liposomes. Using polyethylene glycol (PEG)-poly(monomethylitaconate)-CholC6 (PEG-PMMI-CholC6) copolymers instead of cholesterol introduced pH-sensitive and plasma stability properties simultaneously in prepared liposomes. All formulations were prepared by thin film hydration method and subsequently, pH-sensitivity and stability in human serum were evaluated. The ability of pH-sensitive fusogenic liposomes to enhance the mitoxantrone cytotoxicity and selectivity in cancerous cell lines was assessed in vitro compared to normal cell line using human breast cancer cell line (MCF-7), human prostate cancer cell line (PC-3), and human umbilical vein endothelial cells line. Results revealed that both PMMI-co-PDMAEMA and PEG-PMMI-CholC6-based formulations showed pH-sensitive property and were found to rapidly release mitoxantrone under mildly acidic conditions. Nevertheless, only the PEG-PMMI-CholC6-based liposomes preserved pH-sensitivity after incubation in plasma. Mitoxantrone loaded-pH-sensitive fusogenic liposomes exhibited a higher cytotoxicity than the control conventional liposomes on MCF-7 and PC-3 cell lines. On the contrary, both pH-sensitive fusogenic liposomes showed lower cytotoxic effect on human umbilical vein endothelial cell line. Plasma stable, pH-sensitive fusogenic liposomes are promising carriers for enhancing the efficiency and selectivity, besides reduction of the side effects of anticancer agents.
Language	English
Publishing date	2014-07
Publishing country	England
Document type	Journal Article
ZDB-ID	639283-0
ISSN	1530-8022 ; 0885-3282
ISSN (online)	1530-8022
ISSN	0885-3282
DOI	10.1177/0885328213515288
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Article ; Online: Tacrolimus ameliorates functional disturbances and oxidative stress in isoproterenol-induced myocardial infarction.

Khorrami, Arash / Hammami, Mojtaba / Garjani, Mehraveh / Maleki-Dizaji, Nasrin / Garjani, Alireza

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

2014 Volume 22, Page(s) 68

Abstract: Background: The inflammatory responses play a major role in the pathogenesis of acute myocardial infarction (MI). Early inhibition of inflammation may improve post MI cardiac function. The aim of this study was to investigate the effects of tacrolimus ... ...

Abstract	Background: The inflammatory responses play a major role in the pathogenesis of acute myocardial infarction (MI). Early inhibition of inflammation may improve post MI cardiac function. The aim of this study was to investigate the effects of tacrolimus on cardiac function, hemodynamic parameters as well as histopathologic and electrocardiographic changes in isoproterenol-induced myocardial infarction. Methods: Male Wistar rats were randomly divided into six groups of control, isoproterenol alone, tacrolimus alone, and isoproterenol plus tacrolimus (0.5, 1 and 2 mg/kg). Isoproterenol (100 mg/kg) was injected subcutaneously for two consecutive days to induce myocardial infarction, and simultaneously tacrolimus was administered orally twice a day for three days. Results and conclusions: Administration of isoproterenol resulted in myocardial edema and necrosis as well as a marked reduction in the left ventricular systolic pressure (LVSP), left ventricular contractility (LVdP/dtmax) and relaxation (LVdP/dtmin) along with a severe elevation in left ventricular end-diastolic pressure (LVEDP). Isoproterenol also elevated the ST-segment and suppressed the R-amplitude and R-R interval on ECG. It was found that all doses of tacrolimus could amend the ECG pattern and ameliorated the isoproterenol induced disturbances in cardiac function. Acute and short term treatment with tacrolimus at dose of 2 mg/kg significantly (P < 0.001) improved LVdP/dtmax from 2712 ± 82 in myocardial infarcted rats to 4592 ± 149 mmHg/sec. Similarly, tacrolimus lowered LVEDP from 17.6 ± 0.68 in MI group to the value of 5.6 ± 0.22 mmHg (P < 0.001). Furthermore, tacrolimus was found to reduce malondialdehyde concentration in serum and myocardium by 50-70% (P < 0.001).
MeSH term(s)	Administration, Cutaneous ; Animals ; Disease Models, Animal ; Drug Administration Schedule ; Electrocardiography/drug effects ; Isoproterenol ; Male ; Malondialdehyde/blood ; Malondialdehyde/metabolism ; Myocardial Infarction/chemically induced ; Myocardial Infarction/drug therapy ; Myocardial Infarction/physiopathology ; Myocardial Infarction/prevention & control ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Tacrolimus/administration & dosage ; Tacrolimus/pharmacology ; Ventricular Function, Left/drug effects
Chemical Substances	Malondialdehyde (4Y8F71G49Q) ; Isoproterenol (L628TT009W) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2014-10-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2129183-4
ISSN	2008-2231 ; 1560-8115
ISSN (online)	2008-2231
ISSN	1560-8115
DOI	10.1186/s40199-014-0068-3
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