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  1. Book ; Online: Measurements on the 3He+\eta System at ANKE

    Khoukaz, A.

    2010  

    Abstract: The differential and total cross-sections for the dp \to 3He \eta reaction have been measured in a high precision high statistics COSY-ANKE experiment near threshold using a continuous beam energy ramp up to an excess energy Q of 11.3 MeV with ... ...

    Abstract The differential and total cross-sections for the dp \to 3He \eta reaction have been measured in a high precision high statistics COSY-ANKE experiment near threshold using a continuous beam energy ramp up to an excess energy Q of 11.3 MeV with essentially 100% acceptance. The kinematics allowed the mean value of Q to be determined to about 9 keV. Evidence is found for the effects of higher partial waves for Q > 4 MeV. The very rapid rise of the total cross-section to its maximum value within 0.5 MeV of threshold implies a very large \eta 3He scattering length and hence the presence of a quasi-bound state extremely close to threshold. In addition, differential and total cross-sections have been measured at excess energies of 19.5, 39.4, and 59.4 MeV over the full angular range. While at 19.5 MeV the results can be described in terms of s- and p-wave production, by 59.4 MeV higher partial waves are required. Including the 19.5 MeV point together with the near-threshold data in a global s- and p-wave fit gives a poorer overall description of the data though the position of the pole in the \eta 3He scattering amplitude, corresponding to the quasi-bound or virtual state, is hardly changed.

    Comment: Invited talk at the International Symposium on Mesic Nuclei, Krakow, 16 June 2010
    Keywords Nuclear Experiment
    Subject code 551
    Publishing date 2010-11-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  2. Book ; Online: GSI-FAIR: PANDA: Aufbau eines Cluster-Jet-Targets hoher Dichte für das PANDA-Experiment

    Khoukaz, A

    Abschlussbericht zur Förderperiode 01.07.2009 bis 30.06.2012

    2012  

    Institution Institut für Kernphysik
    Author's details Institut für Kernphysik, Universität Münster. Antragsteller: A. Khoukaz
    Language German
    Size Online-Ressource (18 S., 589 KB), Ill., graph. Darst.
    Publisher Technische Informationsbibliothek u. Universitätsbibliothek
    Publishing place Hannover ; Münster
    Document type Book ; Online
    Note Förderkennzeichen BMBF 05P09PMFP8 [neu] - 06MS9149I [alt] ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Book: GSI-FAIR: PANDA: Aufbau eines Cluster-Jet-Targets hoher Dichte für das PANDA-Experiment

    Khoukaz, A

    Abschlussbericht zur Förderperiode 01.07.2009 bis 30.06.2012

    2012  

    Institution Institut für Kernphysik
    Author's details Institut für Kernphysik, Universität Münster. Antragsteller: A. Khoukaz
    Language German
    Size 18 Bl., Ill., graph. Darst.
    Publishing place Münster
    Document type Book
    Note Förderkennzeichen BMBF 05P09PMFP8 [neu] - 06MS9149I [alt] ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article ; Online: Determination of hydrogen cluster velocities and comparison with numerical calculations.

    Täschner, A / Köhler, E / Ortjohann, H-W / Khoukaz, A

    The Journal of chemical physics

    2013  Volume 139, Issue 23, Page(s) 234312

    Abstract: The use of powerful hydrogen cluster jet targets in storage ring experiments led to the need of precise data on the mean cluster velocity as function of the stagnation temperature and pressure for the determination of the volume density of the target ... ...

    Abstract The use of powerful hydrogen cluster jet targets in storage ring experiments led to the need of precise data on the mean cluster velocity as function of the stagnation temperature and pressure for the determination of the volume density of the target beams. For this purpose a large data set of hydrogen cluster velocity distributions and mean velocities was measured at a high density hydrogen cluster jet target using a trumpet shaped nozzle. The measurements have been performed at pressures above and below the critical pressure and for a broad range of temperatures relevant for target operation, e.g., at storage ring experiments. The used experimental method is described which allows for the velocity measurement of single clusters using a time-of-flight technique. Since this method is rather time-consuming and these measurements are typically interfering negatively with storage ring experiments, a method for a precise calculation of these mean velocities was needed. For this, the determined mean cluster velocities are compared with model calculations based on an isentropic one-dimensional van der Waals gas. Based on the obtained data and the presented numerical calculations, a new method has been developed which allows to predict the mean cluster velocities with an accuracy of about 5%. For this two cut-off parameters defining positions inside the nozzle are introduced, which can be determined for a given nozzle by only two velocity measurements.
    Language English
    Publishing date 2013-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/1.4848720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nm-sized cryogenic hydrogen clusters for a laser-driven proton source.

    Grieser, S / Aurand, B / Aktan, E / Bonaventura, D / Büscher, M / Cerchez, M / Engin, I / Leßmann, L / Mannweiler, C / Prasad, R / Willi, O / Khoukaz, A

    The Review of scientific instruments

    2019  Volume 90, Issue 4, Page(s) 43301

    Abstract: A cryogenic hydrogen cluster-jet target is described which has been used for laser-plasma interaction studies. Major advantages of the cluster-jet are, on the one hand, the compatibility to pulsed high repetition lasers as the target is operated ... ...

    Abstract A cryogenic hydrogen cluster-jet target is described which has been used for laser-plasma interaction studies. Major advantages of the cluster-jet are, on the one hand, the compatibility to pulsed high repetition lasers as the target is operated continuously and, on the other hand, the absence of target debris. The cluster-jet target was characterized using the Mie-scattering technique allowing to determine the cluster size and to compare the measurements with an empirical formula. In addition, an estimation of the cluster beam density was performed. The system was implemented at the high power laser system ARCTURUS, and the measurements show the acceleration of protons after irradiation of the cluster target by high intensity laser pulses with a repetition rate of 5 Hz.
    Language English
    Publishing date 2019-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/1.5080011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A phase I study of the combination of atezolizumab, tiragolumab, and stereotactic body radiation therapy in patients with metastatic multiorgan cancer.

    Roussot, Nicolas / Fumet, Jean-David / Limagne, Emeric / Thibaudin, Marion / Hervieu, Alice / Hennequin, Audrey / Zanetta, Sylvie / Dalens, Lorraine / Fourrier, Théo / Galland, Loick / Jacob, Pierre / Bertaut, Aurélie / Rederstorff, Emilie / Chevalier, Cédric / Ghirardi, Sarah / Gilbert, Elodie / Khoukaz, Azzat / Martin, Etienne / Nicolet, Constance /
    Quivrin, Magali / Thibouw, David / Vulquin, Noémie / Truc, Gilles / Rouffiac, Magali / Ghiringhelli, Francois / Mirjolet, Céline

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 1080

    Abstract: Background: Immunotherapy targeting the PD-1/PD-L1 pathway is a standard of care in a number of metastatic malignancies, but less than a fifth of patients are expected to respond to ICIs (Immune Checkpoint Inhibitors). In a clinical trial, combining the ...

    Abstract Background: Immunotherapy targeting the PD-1/PD-L1 pathway is a standard of care in a number of metastatic malignancies, but less than a fifth of patients are expected to respond to ICIs (Immune Checkpoint Inhibitors). In a clinical trial, combining the anti-TIGIT (T cell immunoreceptor with Ig and ITIM domains) Mab (monoclonal antibody) tiragolumab with atezolizumab improved outcomes in non-small cell lung cancer. In preclinical models, SBRT (Stereotactic Body Radiation Therapy) could increase expression levels of the inhibitory co-receptors TIGIT and PD-L1. We aim to assess the combination of tiragolumab with atezolizumab and SBRT in metastatic, previously treated by ICIs, non-small cell lung cancer, head and neck cancer, bladder cancer, and renal cell cancer.
    Methods: This phase I study (ClinicalTrials.gov NCT05259319) will assess the efficacy and safety of the combination of atezolizumab with tiragolumab and stereotactic body radiation therapy in patients with histologically proven metastatic non-small cell lung cancer, renal cell cancer, bladder cancer, and head and neck cancer previously treated. First part: 2 different schedules of SBRT in association with a fixed dose of atezolizumab and tiragolumab will be investigated only with metastatic non-small cell lung cancer patients (cohort 1). The expansion cohorts phase will be a multicentric, open-label study at the recommended scheme of administration and enroll additional patients with metastatic bladder cancer, renal cell cancer, and head and neck cancer (cohort 2, 3 and 4). Patients will be treated until disease progression, unacceptable toxicity, intercurrent conditions that preclude continuation of treatment, or patient refusal in the absence of progression or intolerance. The primary endpoint of the first phase is the safety of the combination in a sequential or concomitant scheme and to determine the expansion cohorts phase recommended scheme of administration. The primary endpoint of phase II is to evaluate the efficacy of tiragolumab + atezolizumab + SBRT in terms of 6-month PFS (Progression-Free Survival). Ancillary analyses will be performed with peripheral and intratumoral immune biomarker assessments.
    Trial registration: This study is registered on ClinicalTrials.gov: NCT05259319, since February 28th, 2022.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Carcinoma, Non-Small-Cell Lung/drug therapy ; B7-H1 Antigen ; Carcinoma, Renal Cell/drug therapy ; Radiosurgery/adverse effects ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/drug therapy ; Antineoplastic Agents/therapeutic use ; Antibodies, Monoclonal/adverse effects ; Kidney Neoplasms/drug therapy ; Head and Neck Neoplasms/drug therapy ; Urinary Bladder Neoplasms/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances atezolizumab (52CMI0WC3Y) ; B7-H1 Antigen ; Antineoplastic Agents ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Clinical Trial, Phase I ; Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11534-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Thesis: Messungen zur schwellennahen Produktion geladener Pionenpaare in der Proton-Proton-Streuung

    Khoukaz, Alfons

    1996  

    Author's details von Alfons Khoukaz
    Language German
    Size III, 91, VI S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Münster, 1996
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Thesis: Messungen zur schwellennahen Produktion geladener Pionenpaare in der Proton-Proton-Streuung

    Khoukaz, Alfons

    1996  

    Author's details von Alfons Khoukaz
    Language German
    Size III, 91, VI S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Münster, 1996
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Determination of the η(')-proton scattering length in free space.

    Czerwiński, E / Moskal, P / Silarski, M / Bass, S D / Grzonka, D / Kamys, B / Khoukaz, A / Klaja, J / Krzemień, W / Oelert, W / Ritman, J / Sefzick, T / Smyrski, J / Täschner, A / Wolke, M / Zieliński, M

    Physical review letters

    2014  Volume 113, Issue 6, Page(s) 62004

    Abstract: Taking advantage of both the high mass resolution of the COSY-11 detector and the high energy resolution of the low-emittance proton beam of the cooler synchrotron COSY, we determine the excitation function for the pp→ppη(') reaction close to threshold. ... ...

    Abstract Taking advantage of both the high mass resolution of the COSY-11 detector and the high energy resolution of the low-emittance proton beam of the cooler synchrotron COSY, we determine the excitation function for the pp→ppη(') reaction close to threshold. Combining these data with previous results, we extract the scattering length for the η(')-proton potential in free space to be Re(a(pη(')))=0±0.43  fm and Im(a(pη(')))=0.37(-0.16)(+0.40)  fm.
    Language English
    Publishing date 2014-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.113.062004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Determination of the total width of the η' meson.

    Czerwiński, E / Moskal, P / Grzonka, D / Czyzykiewicz, R / Gil, D / Kamys, B / Khoukaz, A / Klaja, J / Klaja, P / Krzemień, W / Oelert, W / Ritman, J / Sefzick, T / Siemaszko, M / Silarski, M / Smyrski, J / Täschner, A / Wolke, M / Wüstner, P /
    Zdebik, J / Zieliński, M / Zipper, W

    Physical review letters

    2010  Volume 105, Issue 12, Page(s) 122001

    Abstract: Taking advantage of both the low-emittance proton beam of the cooler synchrotron COSY and the high momentum precision of the COSY-11 detector system, the mass distribution of the η' meson was measured with a resolution of 0.33  MeV/c2 (FWHM), improving ... ...

    Abstract Taking advantage of both the low-emittance proton beam of the cooler synchrotron COSY and the high momentum precision of the COSY-11 detector system, the mass distribution of the η' meson was measured with a resolution of 0.33  MeV/c2 (FWHM), improving the experimental mass resolution by almost an order of magnitude with respect to previous results. Based on the sample of more than 2300 reconstructed pp → ppη' events, the total width of the η' meson was determined to be Γ(η') = 0.226 ± 0.017(stat) ± 0.014(syst)  MeV/c2.
    Language English
    Publishing date 2010-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.105.122001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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