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  1. Article ; Online: Laparoscopic Adjustable Gastric Band Colonization May Indicate Re-classification of Surgical Wounds.

    Ichter, Zach / Khoury, Habib / Voller, Lindsey / Deb, Sayantan / Morton, John

    Obesity surgery

    2023  Volume 34, Issue 1, Page(s) 282–285

    Abstract: Background: Surgical wounds are classified as either clean, clean-contaminated, contaminated, or dirty wounds. Historically laparoscopic adjustable gastric band (LAGB) removals have been classified as clean wounds since there is thought to be no ... ...

    Abstract Background: Surgical wounds are classified as either clean, clean-contaminated, contaminated, or dirty wounds. Historically laparoscopic adjustable gastric band (LAGB) removals have been classified as clean wounds since there is thought to be no existing infection and no transection of the gastrointestinal tract. Surgical site infection (SSI) remains a publicly reported source of morbidity after laparoscopic bariatric surgery and is considered a CMS hospital-acquired condition. We present a retrospective chart review to reveal the rate of bacterial colonization of gastric bands.
    Methods: This retrospective chart review included 15 patients who underwent removal of LAGB. The entire LAGB and port were removed and then sent for aerobic and anaerobic cultures. Patients were followed up to 1 month, and the incidence of surgical site infection development was recorded.
    Results: Of the fifteen LAGBs cultured, eight cases (53%) returned positive for bacterial growth. Five of the cultures (33%) were positive for coagulase-negative Staphylococcus. One culture was positive for micrococcus species (6.7%), one culture was positive for Bacteroides fragilis (6.7%) and another was positive for Propionibacterium (6.7%). None of the 15 patients followed in the study developed an SSI by the end of 1 month.
    Conclusions: Given the consideration of LAGB removals as clean wounds, the incidence of LAGB colonization is high. Classification of the surgical wounds in LAGB removals should be changed from clean to contaminated. Further studies need to be pursued to determine the correlation between colonized LAGBs and the rate of SSIs.
    Key points: • Gastric band removals are a common bariatric procedure. • Surgical site infection remains an outcome of interest to patient, surgeon and payor. • Fifty-three percent of recovered bands were positive for bacterial growth.
    MeSH term(s) Humans ; Gastroplasty/adverse effects ; Gastroplasty/methods ; Obesity, Morbid/surgery ; Retrospective Studies ; Surgical Wound Infection ; Surgical Wound ; Reoperation/methods ; Bariatric Surgery/adverse effects ; Laparoscopy/methods ; Treatment Outcome ; Postoperative Complications/epidemiology
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-023-06790-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Preoperative Predictors and Costs of 30-Day Readmission Following Inpatient Pediatric Tonsillectomy in the United States.

    Khoury, Habib / Azar, Shaghauyegh S / Boutros, Hannah / Shapiro, Nina L

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2021  Volume 165, Issue 3, Page(s) 470–476

    Abstract: Objectives: To understand national trends in 30-day postoperative readmission following inpatient pediatric tonsillectomy and adenoidectomy.: Study design: Retrospective cohort study.: Setting: Nationwide Readmissions Database.: Methods: We ... ...

    Abstract Objectives: To understand national trends in 30-day postoperative readmission following inpatient pediatric tonsillectomy and adenoidectomy.
    Study design: Retrospective cohort study.
    Setting: Nationwide Readmissions Database.
    Methods: We used the Nationwide Readmissions Database to identify and analyze 30-day readmissions following inpatient tonsillectomy from 2010 to 2015. Using the
    Results: Of 66,652 patients who underwent inpatient tonsillectomy, 2660 (4.0%) experienced a readmission. Readmitted patients were more commonly aged <2 years (23.4 vs 10.6%,
    Conclusion: Readmission after inpatient tonsillectomy and adenoidectomy places a substantial financial burden on the health care system. Targeted strategies to improve preoperative assessment and optimize postoperative care may prevent readmission, reduce unnecessary health care expenditures, and improve patient outcomes.
    MeSH term(s) Age Factors ; Child ; Child, Preschool ; Comorbidity ; Databases, Factual ; Female ; Humans ; Infant ; Male ; Patient Readmission/economics ; Patient Readmission/statistics & numerical data ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Factors ; Time Factors ; Tonsillectomy ; United States/epidemiology
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599820980709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A

    Zgheib, Nathalie K / El-Khoury, Habib / Maamari, Dimitri / Basbous, Maya / Saab, Raya / Muwakkit, Samar A

    Personalized medicine

    2021  Volume 18, Issue 5, Page(s) 431–439

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Child ; Genotype ; Glucocorticoids/adverse effects ; Humans ; Osteonecrosis/chemically induced ; Osteonecrosis/genetics ; Polymorphism, Single Nucleotide/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Receptors, N-Methyl-D-Aspartate
    Chemical Substances GRIN3A protein, human ; Glucocorticoids ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2021-08-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2299146-3
    ISSN 1744-828X ; 1741-0541
    ISSN (online) 1744-828X
    ISSN 1741-0541
    DOI 10.2217/pme-2020-0167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Barriers to Receiving Necessary Hearing Care Among US Children.

    Su-Velez, Brooke M / Khoury, Habib / Azar, Shaghauyegh S / Shapiro, Nina L / Bhattacharyya, Neil

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2021  Volume 166, Issue 6, Page(s) 1085–1091

    Abstract: Objective: We aim to clarify the national scope of unmet pediatric hearing care needs and identify specific barriers to hearing care.: Study design: Cross-sectional study of a nationally representative data set.: Setting: This study is based on ... ...

    Abstract Objective: We aim to clarify the national scope of unmet pediatric hearing care needs and identify specific barriers to hearing care.
    Study design: Cross-sectional study of a nationally representative data set.
    Setting: This study is based on the combined 2016 and 2017 National Survey of Children's Health. This survey covers the physical and emotional health, access to care, and social context of US children and adolescents aged 0 to 17 years.
    Methods: Analysis of parent-reported responses of children's hearing status, access to care, and perceived barriers.
    Results: Overall, 0.3% (n = 206,200) of US children surveyed reported needing hearing care, which was not received. A further 1.3% (n = 934,000) reported deafness or problems with hearing, and of these, 6.4% (n = 60,000) reported not receiving necessary hearing care. Rates of insurance coverage between children with deafness/hearing problems and the general population were similar (91.7% vs 93.9%); however, deaf or hard-of-hearing children with unmet hearing care needs were more likely to be from non-White backgrounds (P = .009) and to lack health insurance coverage (P = .001). Rates of unfulfilled hearing care by reason were as follows: 57.5% without eligibility for the service, 45.4% reporting the service was not available in their area, 53.7% with difficulty obtaining an appointment, and 53.5% reporting issues with cost.
    Conclusion: Over 200,000 children annually do not receive necessary hearing-related care despite high rates of insurance coverage, and nearly 60,000 of these children are deaf or hard of hearing. Cost, eligibility for and distribution of services, and timely appointments are the primary barriers to hearing health care.
    MeSH term(s) Adolescent ; Child ; Cross-Sectional Studies ; Deafness/therapy ; Health Services Accessibility ; Hearing ; Humans ; Insurance, Health
    Language English
    Publishing date 2021-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/01945998211032113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Preoperative weight loss: is waiting longer before bariatric surgery more effective?

    Eng, Victor / Garcia, Luis / Khoury, Habib / Morton, John / Azagury, Dan

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2019  Volume 15, Issue 6, Page(s) 951–957

    Abstract: Background: Many insurance companies require patients to undergo supervised weight loss programs lasting several months. However, the association between time to surgery (TTS)-the wait time between the initial consultation visit and the immediate ... ...

    Abstract Background: Many insurance companies require patients to undergo supervised weight loss programs lasting several months. However, the association between time to surgery (TTS)-the wait time between the initial consultation visit and the immediate preoperative visit-and weight loss is not well documented.
    Objectives: To investigate whether TTS affects pre- or postoperative weight loss or complication rates.
    Setting: University hospital, United States.
    Methods: Data from 415 patients undergoing laparoscopic Roux-en-Y gastric bypass (n = 263) or sleeve gastrectomy (n = 152) at a single academic institution between 2014 and 2015 were retrospectively reviewed. TTS was compared with the percentage of total weight lost, change in body mass index, and adverse surgical events.
    Results: Participants had an average body mass index of 47.42 kg/m
    Conclusions: Longer preoperative wait times do not result in improved weight loss or reduced adverse events. Determination of patient eligibility for bariatric surgery should rest with the health team and delay of treatment should be minimized.
    MeSH term(s) Bariatric Surgery/adverse effects ; Bariatric Surgery/methods ; Bariatric Surgery/statistics & numerical data ; Female ; Humans ; Male ; Obesity, Morbid/surgery ; Postoperative Complications/epidemiology ; Preoperative Period ; Retrospective Studies ; Time-to-Treatment/statistics & numerical data ; Weight Loss/physiology
    Language English
    Publishing date 2019-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2019.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mass spectrometry-detected MGUS is associated with obesity and other novel modifiable risk factors in a high-risk population.

    Lee, David J / El-Khoury, Habib / Tramontano, Angela C / Alberge, Jean-Baptiste / Perry, Jacqueline / Davis, Maya I / Horowitz, Erica / Redd, Robert / Sakrikar, Dhananjay / Barnidge, David / Perkins, Mark C / Harding, Stephen / Mucci, Lorelei / Rebbeck, Timothy R / Ghobrial, Irene M / Marinac, Catherine R

    Blood advances

    2024  Volume 8, Issue 7, Page(s) 1737–1746

    Abstract: Abstract: Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition of multiple myeloma with few known risk factors. The emergence of mass spectrometry (MS) for the detection of MGUS has provided new opportunities to evaluate ...

    Abstract Abstract: Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition of multiple myeloma with few known risk factors. The emergence of mass spectrometry (MS) for the detection of MGUS has provided new opportunities to evaluate its risk factors. In total, 2628 individuals at elevated risk for multiple myeloma were enrolled in a screening study and completed an exposure survey (PROMISE trial). Participant samples were screened by MS, and monoclonal proteins (M-proteins) with concentrations of ≥0.2 g/L were categorized as MS-MGUS. Multivariable logistic models evaluated associations between exposures and MS outcomes. Compared with normal weight (body mass index [BMI] of 18.5 to <25 kg/m2), obesity (BMI of ≥30 kg/m2) was associated with MS-MGUS, adjusting for age, sex, Black race, education, and income (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.21-2.47; P = .003). High physical activity (≥73.5 metabolic equivalent of task (MET)-hours per week vs <10.5 MET-hours per week) had a decreased likelihood of MS-MGUS (OR, 0.45, 95% CI, 0.24-0.80; P = .009), whereas heavy smoking and short sleep had increased likelihood of MS-MGUS (>30 pack-years vs never smoker: OR, 2.19; 95% CI, 1.24-3.74; P = .005, and sleep <6 vs ≥6 hours per day: OR, 2.11; 95% CI, 1.26-3.42; P = .003). In the analysis of all MS-detected monoclonal gammopathies, which are inclusive of M-proteins with concentrations of <0.2 g/L, elevated BMI and smoking were associated with all MS-positive cases. Findings suggest MS-detected monoclonal gammopathies are associated with a broader range of modifiable risk factors than what has been previously identified. This trial was registered at www.clinicaltrials.gov as #NCT03689595.
    MeSH term(s) Humans ; Monoclonal Gammopathy of Undetermined Significance/diagnosis ; Monoclonal Gammopathy of Undetermined Significance/epidemiology ; Monoclonal Gammopathy of Undetermined Significance/complications ; Multiple Myeloma/diagnosis ; Multiple Myeloma/epidemiology ; Multiple Myeloma/etiology ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology ; Risk Factors
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010843
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  7. Article: Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia.

    Maamari, Dimitri / El-Khoury, Habib / Saifi, Omran / Muwakkit, Samar A / Zgheib, Nathalie K

    Pharmacogenomics and personalized medicine

    2020  Volume 13, Page(s) 295–317

    Abstract: Despite major advances in the management and high cure rates of childhood acute lymphoblastic leukemia (ALL), patients still suffer from many drug-induced toxicities, sometimes necessitating dose reduction, or halting of cytotoxic drugs with a secondary ... ...

    Abstract Despite major advances in the management and high cure rates of childhood acute lymphoblastic leukemia (ALL), patients still suffer from many drug-induced toxicities, sometimes necessitating dose reduction, or halting of cytotoxic drugs with a secondary risk of disease relapse. In addition, investigators have noted significant inter-individual variability in drug toxicities and disease outcomes, hence the role of pharmacogenetics (PGx) in elucidating genetic polymorphisms in candidate genes for the optimization of disease management. In this review, we present the PGx data in association with main toxicities seen in children treated for ALL in addition to efficacy, with a focus on the most plausible germline PGx variants. We then follow with a summary of the highest evidence drug-gene annotations with suggestions to move forward in implementing preemptive PGx for the individualization of treatment regimens for children with ALL.
    Language English
    Publishing date 2020-08-12
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508173-1
    ISSN 1178-7066
    ISSN 1178-7066
    DOI 10.2147/PGPM.S239602
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  8. Article ; Online: National Analysis of 30-Day Readmission Following Inpatient Sinus Surgery for Chronic Rhinosinusitis.

    Khoury, Habib / Bellamkonda, Nikhil / Benharash, Peyman / Lee, Jivianne T / Wang, Marilene B / Suh, Jeffrey D

    The Laryngoscope

    2020  Volume 131, Issue 5, Page(s) E1422–E1428

    Abstract: Objectives: To characterize the incidence, causes, risk factors, and costs of 30-day readmission after inpatient functional endoscopic sinus surgery (FESS) for patients with chronic rhinosinusitis.: Study design: Retrospective cohort study.: ... ...

    Abstract Objectives: To characterize the incidence, causes, risk factors, and costs of 30-day readmission after inpatient functional endoscopic sinus surgery (FESS) for patients with chronic rhinosinusitis.
    Study design: Retrospective cohort study.
    Methods: The Nationwide Readmissions Database was used to characterize readmission after inpatient sinus surgery for chronic rhinosinusitis from 2015 to 2017. International Classification of Disease codes were used to identify the patient population, which included 5,644 patients. Incidence, causes, costs, and predictors of readmission were analyzed and determined.
    Results: Among 6,386 patients who underwent inpatient FESS, 742 (11.6%) were readmitted within 30 days of discharge. On univariate analysis, patients who were readmitted were more commonly older than 70 years (23.3% vs. 16.2%); had a higher burden of comorbidities including chronic kidney disease (15.0% vs. 7.8%), diabetes (25.6% vs. 20.4%), and hypertension (13.5% vs. 8.5%); had a greater rate of postoperative complications (20.7% vs. 12.2%); and had a longer length of stay (12.4 vs. 6.9 days) compared to patients who were not readmitted. Readmissions cost an additional $27,141 per patient. On multivariable analysis, age greater than 70 years, Medicaid insurance, several comorbidities, prolonged length of stay, postoperative neurologic complications, and lower hospital volume were independent predictors of 30-day readmission. The most common cause for readmission was infection (36.3%).
    Conclusion: Readmission following inpatient FESS is not uncommon. Identification and management of preoperative comorbidities, optimized patient selection for inpatient surgery, and thorough postoperative discharge care may improve patient outcomes and decrease healthcare expenditures.
    Level of evidence: 3 Laryngoscope, 131:E1422-E1428, 2021.
    MeSH term(s) Aged ; Chronic Disease/epidemiology ; Chronic Disease/therapy ; Comorbidity ; Diabetes Mellitus/epidemiology ; Endoscopy/adverse effects ; Female ; Hospital Costs/statistics & numerical data ; Humans ; Hypertension/epidemiology ; Incidence ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Nasal Surgical Procedures/adverse effects ; Patient Discharge ; Patient Readmission/economics ; Patient Readmission/statistics & numerical data ; Postoperative Complications/economics ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Renal Insufficiency, Chronic/epidemiology ; Retrospective Studies ; Rhinitis/epidemiology ; Rhinitis/surgery ; Risk Assessment/statistics & numerical data ; Risk Factors ; Sinusitis/epidemiology ; Sinusitis/surgery ; Time Factors ; United States/epidemiology
    Language English
    Publishing date 2020-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.29117
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  9. Article: Association of preoperative systemic corticosteroid therapy with surgical outcomes in chronic obstructive pulmonary disease patients.

    Arbid, Samer Abou / El-Khoury, Habib / Jamali, Faek / Tamim, Hani / Chami, Hassan

    Annals of thoracic medicine

    2019  Volume 14, Issue 2, Page(s) 141–147

    Abstract: Background: Chronic obstructive pulmonary disease (COPD) patients are at an increased risk of postoperative pulmonary complications (PPCs). The purpose of this study is to evaluate the risks and benefits associated with preoperative steroids in COPD ... ...

    Abstract Background: Chronic obstructive pulmonary disease (COPD) patients are at an increased risk of postoperative pulmonary complications (PPCs). The purpose of this study is to evaluate the risks and benefits associated with preoperative steroids in COPD patients.
    Methods: The National Surgical Quality Improved Program database was used to identify 92 COPD patients who underwent surgery at the American University of Beirut Medical Center between 2009 and 2013. COPD was diagnosed based on postbronchodilator forced expiratory volume in 1 s to forced vital capacity ratio <0.7 and a history of smoking. The exposure of interest was preoperative systemic corticosteroid therapy. The primary outcomes were PPCs and wound complications. Cardiac and urinary complications along with unplanned readmission or reoperation and death were also evaluated.
    Results: Overall 42.4% of patients received preoperative systemic corticosteroids. Postoperative wound complications were significantly more frequent in COPD patients who received preoperative systemic corticosteroids compared to patients who did not (10.3% vs. none, respectively,
    Conclusions: This study suggests that preoperative administration of systemic corticosteroids in stable COPD patients is associated with an increased risk of postoperative wound complications but may not reduce PPCs.
    Language English
    Publishing date 2019-02-18
    Publishing country India
    Document type Journal Article
    ZDB-ID 2241287-6
    ISSN 1998-3557 ; 1817-1737
    ISSN (online) 1998-3557
    ISSN 1817-1737
    DOI 10.4103/atm.ATM_245_18
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  10. Article ; Online: Deep Venous Thrombosis and Pulmonary Embolism in Cardiac Surgical Patients.

    Khoury, Habib / Lyons, Robert / Sanaiha, Yas / Rudasill, Sarah / Shemin, Richard J / Benharash, Peyman

    The Annals of thoracic surgery

    2019  Volume 109, Issue 6, Page(s) 1804–1810

    Abstract: Background: Deep venous thrombosis and pulmonary embolism are life-threatening complications after surgery, warranting prophylaxis. However prophylaxis is not uniformly practiced among cardiac surgical patients. This study aimed to characterize the ... ...

    Abstract Background: Deep venous thrombosis and pulmonary embolism are life-threatening complications after surgery, warranting prophylaxis. However prophylaxis is not uniformly practiced among cardiac surgical patients. This study aimed to characterize the national incidence, mortality, and costs associated with thromboembolism after cardiac surgery.
    Methods: The 2005 to 2015 National Inpatient Sample was used to identify all adult patients undergoing coronary artery bypass grafting or valve surgery. International Classification of Disease codes were used to identify patients with deep venous thrombosis and pulmonary embolism.
    Results: Of approximately 3 million patients undergoing cardiac surgery, 1.62% developed deep venous thrombosis and 0.38% pulmonary embolism. Those with deep venous thrombosis and pulmonary embolism were more commonly women (33.2% and 36.2 vs 31.2%, P < .001), older (68.1 and 66.0% vs 65.7 years, P < .001), and had a higher Elixhauser comorbidity index (4.0 and 4.7 vs 3.7, P < .001). Deep venous thrombosis and pulmonary embolism were associated with increased mortality (4.95% and 14.8% vs 2.67%, P < .001). After adjustment for baseline differences, deep venous thrombosis was associated with an incremental increase in cost of $12,308, whereas pulmonary embolism was associated with $13,879 cost increase after cardiac surgery. Pulmonary embolism was an independent predictor of mortality (adjusted odds ratio, 3.39; 95% confidence interval, 2.74-4.18).
    Conclusions: The mortality and financial burden related to thromboembolism in cardiac surgery are significant. Prophylaxis may be indicated in cardiac surgery patients to improve quality of care and reduce healthcare costs. Future controlled randomized trials investigating the benefit of thromboembolism prophylaxis in cardiac surgery are warranted.
    MeSH term(s) Aged ; Cardiac Surgical Procedures/adverse effects ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Postoperative Complications ; Prognosis ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/etiology ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; Survival Rate/trends ; United States/epidemiology ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology
    Language English
    Publishing date 2019-11-07
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2019.09.055
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