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  1. Article: Photoluminescent Scaffolds Based on Natural and Synthetic Biodegradable Polymers for Bioimaging and Tissue Engineering.

    Trifanova, Ekaterina M / Babayeva, Gulalek / Khvorostina, Maria A / Atanova, Aleksandra V / Nikolaeva, Maria E / Sochilina, Anastasia V / Khaydukov, Evgeny V / Popov, Vladimir K

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Non-invasive visualization and monitoring of tissue-engineered structures in a living organism is a challenge. One possible solution to this problem is to use upconversion nanoparticles (UCNPs) as photoluminescent nanomarkers in scaffolds. We synthesized ...

    Abstract Non-invasive visualization and monitoring of tissue-engineered structures in a living organism is a challenge. One possible solution to this problem is to use upconversion nanoparticles (UCNPs) as photoluminescent nanomarkers in scaffolds. We synthesized and studied scaffolds based on natural (collagen-COL and hyaluronic acid-HA) and synthetic (polylactic-co-glycolic acids-PLGA) polymers loaded with β-NaYF
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13040870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 3D Printed Gene-Activated Sodium Alginate Hydrogel Scaffolds.

    Khvorostina, Maria A / Mironov, Anton V / Nedorubova, Irina A / Bukharova, Tatiana B / Vasilyev, Andrey V / Goldshtein, Dmitry V / Komlev, Vladimir S / Popov, Vladimir K

    Gels (Basel, Switzerland)

    2022  Volume 8, Issue 7

    Abstract: Gene therapy is one of the most promising approaches in regenerative medicine to restore damaged tissues of various types. However, the ability to control the dose of bioactive molecules in the injection site can be challenging. The combination of ... ...

    Abstract Gene therapy is one of the most promising approaches in regenerative medicine to restore damaged tissues of various types. However, the ability to control the dose of bioactive molecules in the injection site can be challenging. The combination of genetic constructs, bioresorbable material, and the 3D printing technique can help to overcome these difficulties and not only serve as a microenvironment for cell infiltration but also provide localized gene release in a more sustainable way to induce effective cell differentiation. Herein, the cell transfection with plasmid DNA directly incorporated into sodium alginate prior to 3D printing was investigated both in vitro and in vivo. The 3D cryoprinting ensures pDNA structure integrity and safety. 3D printed gene-activated scaffolds (GAS) mediated HEK293 transfection in vitro and effective synthesis of model EGFP protein in vivo, thereby allowing the implementation of the developed GAS in future tissue engineering applications.
    Language English
    Publishing date 2022-07-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels8070421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Natural and Synthetic Polymer Scaffolds Comprising Upconversion Nanoparticles as a Bioimaging Platform for Tissue Engineering.

    Trifanova, Ekaterina M / Khvorostina, Maria A / Mariyanats, Aleksandra O / Sochilina, Anastasia V / Nikolaeva, Maria E / Khaydukov, Evgeny V / Akasov, Roman A / Popov, Vladimir K

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 19

    Abstract: Modern biocompatible materials of both natural and synthetic origin, in combination with advanced techniques for their processing and functionalization, provide the basis for tissue engineering constructs (TECs) for the effective replacement of specific ... ...

    Abstract Modern biocompatible materials of both natural and synthetic origin, in combination with advanced techniques for their processing and functionalization, provide the basis for tissue engineering constructs (TECs) for the effective replacement of specific body defects and guided tissue regeneration. Here we describe TECs fabricated using electrospinning and 3D printing techniques on a base of synthetic (polylactic-co-glycolic acids, PLGA) and natural (collagen, COL, and hyaluronic acid, HA) polymers impregnated with core/shell β-NaYF
    MeSH term(s) Biocompatible Materials/pharmacology ; Collagen/chemistry ; Hyaluronic Acid ; Nanoparticles/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer ; Polymers ; Tissue Engineering ; Tissue Scaffolds/chemistry
    Chemical Substances Biocompatible Materials ; Polymers ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Hyaluronic Acid (9004-61-9) ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27196547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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