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  1. Article: Choledochal cyst and benign stenosis of the main pancreatic duct.

    Hiramatsu, K / Paye, F / Kianmanesh, A R / Sauvanet, A / Terris, B / Belghiti, J

    Journal of hepato-biliary-pancreatic surgery

    2001  Volume 8, Issue 1, Page(s) 92–94

    Abstract: We report here the first case of choledochal cyst associated with a benign stenosis of the cephalic part of the main pancreatic duct. The pancreatic ductal stenosis was associated with a protein plug located upstream of the stenosis. Preoperatively, it ... ...

    Abstract We report here the first case of choledochal cyst associated with a benign stenosis of the cephalic part of the main pancreatic duct. The pancreatic ductal stenosis was associated with a protein plug located upstream of the stenosis. Preoperatively, it was not possible to rule out a localized intraductal pancreatic tumor, and a pylorus-preserving pancreaticoduodenectomy was performed. This association has not been described previously, and gives new insights into the pathogenesis of acute pancreatitis associated with choledochal cyst.
    MeSH term(s) Adult ; Choledochal Cyst/surgery ; Constriction, Pathologic ; Female ; Humans ; Pancreatic Ducts/pathology ; Pancreaticoduodenectomy
    Language English
    Publishing date 2001-03-21
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 1181222-9
    ISSN 1436-0691 ; 0944-1166
    ISSN (online) 1436-0691
    ISSN 0944-1166
    DOI 10.1007/s005340170056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4024: Show issues Location:
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  2. Article: Resection of hepatocellular carcinoma: a European experience on 328 cases.

    Belghiti, J / Regimbeau, J M / Durand, F / Kianmanesh, A R / Dondero, F / Terris, B / Sauvanet, A / Farges, O / Degos, F

    Hepato-gastroenterology

    2002  Volume 49, Issue 43, Page(s) 41–46

    Abstract: Background/aims: Surgical liver resection has been demonstrated in Asian countries to be the best therapeutic option in patients with hepatocellular carcinoma. Because the value of this treatment is still debated in Western countries, the aim of this ... ...

    Abstract Background/aims: Surgical liver resection has been demonstrated in Asian countries to be the best therapeutic option in patients with hepatocellular carcinoma. Because the value of this treatment is still debated in Western countries, the aim of this paper was to report a European experience of resection for hepatocellular carcinoma.
    Methodology: From 1990 to 1999, 239 men and 61 women aged from 15 to 77 years old underwent 328 resections including major resection in 138 (42%) cases. Normal liver was present in 53 patients (17%) and chronic liver disease was present in 247 including 152 (50%) with cirrhosis.
    Results: In-hospital mortality was 6.4% and was significantly influenced by the presence of chronic liver disease (1.7% vs. 7.4%). Mortality after resection in alcoholic patients (14%), in patients with hepatitis C (9%) was significantly higher than in patients chronic hepatitis B (1%) (P < 0.05). The overall survival rates were 81%, 57%, 37%, and 13% at 1, 3, 5 and 10 years. Five-year survival rate was significantly higher (P < 0.05) in patients with normal liver as compared to chronic liver disease (50% vs. 34%). In patients with chronic liver disease parameters, which significantly influenced survival rate, were vascular invasion, tumor differentiation and the extent of resection.
    Conclusions: In this European study with varied profile of etiologies associated with hepatocellular carcinoma we showed that a five-year survival rate of 40% can be expected after resection and that chronic liver disease is a major factor influencing short and long-term prognosis.
    MeSH term(s) Adolescent ; Adult ; Aged ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/surgery ; Chronic Disease ; Europe ; Female ; Hepatectomy/mortality ; Hospital Mortality ; Humans ; Liver Diseases/complications ; Liver Neoplasms/complications ; Liver Neoplasms/mortality ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Survival Analysis ; Survivors ; Treatment Outcome
    Language English
    Publishing date 2002-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 801013-4
    ISSN 0172-6390
    ISSN 0172-6390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Impact de la coelioscopie opératoire en chirurgie générale et digestive.

    Johanet, H / Cossa, J P / Opsahl, S / Kianmanesh, A R / Marmuse, J P / Benhamou, G

    Journal de chirurgie

    1995  Volume 132, Issue 11, Page(s) 434–437

    Abstract: A retrospective study was conducted to evaluate the impact of laparoscopic surgery on activity in general and digestive surgery. From May 1990 to December 1994, 2256 laparoscopic procedures were performed for cholecystectomy (36%), appendicectomy (20.4%) ...

    Title translation Impact of celioscopic surgery in general and digestive system surgery.
    Abstract A retrospective study was conducted to evaluate the impact of laparoscopic surgery on activity in general and digestive surgery. From May 1990 to December 1994, 2256 laparoscopic procedures were performed for cholecystectomy (36%), appendicectomy (20.4%) or inguinal hernia (19.8%). 23.2% of all procedures performed in 1994 were done laparoscopically. The use of laparoscopy did not, in our experience, added any new indications from 1988 to 1994. The conversion rate was 8.15%. 24% of the conversion cases could not be predicted. Mortality was 0.18% and 1.19% of the patients had to undergo a second operation due to complications of laparsocopic surgery. The impact of laparoscopic procedures, 7 years after the first laparoscopic cholecystectomy has been great. The results of this surgical technique must be evaluated to determine its medical and economic impact.
    MeSH term(s) Appendectomy/methods ; Cholecystectomy, Laparoscopic/methods ; Hernia, Inguinal/surgery ; Humans ; Laparoscopy/methods ; Laparotomy ; Postoperative Complications ; Retrospective Studies
    Language French
    Publishing date 1995-11
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 218138-1
    ISSN 1773-0422 ; 0021-7697
    ISSN (online) 1773-0422
    ISSN 0021-7697
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  4. Article ; Online: Impact of cirrhosis in patients undergoing laparoscopic liver resection in a nationwide multicentre survey.

    Hobeika, C / Fuks, D / Cauchy, F / Goumard, C / Soubrane, O / Gayet, B / Salamé, E / Cherqui, D / Vibert, E / Scatton, O / Nomi, T / Oudafal, N / Kawai, T / Komatsu, S / Okumura, S / Petrucciani, N / Laurent, A / Bucur, P / Barbier, L /
    Trechot, B / Nunèz, J / Tedeschi, M / Allard, M-A / Golse, N / Ciacio, O / Pittau, G / Cunha, A Sa / Adam, R / Laurent, C / Chiche, L / Leourier, P / Rebibo, L / Regimbeau, J-M / Ferre, L / Souche, F R / Chauvat, J / Fabre, J-M / Jehaes, F / Mohkam, K / Lesurtel, M / Ducerf, C / Mabrut, J-Y / Hor, T / Paye, F / Balladur, P / Suc, B / Muscari, F / Millet, G / El Amrani, M / Ratajczak, C / Lecolle, K / Boleslawski, E / Truant, S / Pruvot, F-R / Kianmanesh, A-R / Codjia, T / Schwarz, L / Girard, E / Abba, J / Letoublon, C / Chirica, M / Carmelo, A / VanBrugghe, C / Cherkaoui, Z / Unterteiner, X / Memeo, R / Pessaux, P / Buc, E / Lermite, E / Barbieux, J / Bougard, M / Marchese, U / Ewald, J / Turini, O / Thobie, A / Menahem, B / Mulliri, A / Lubrano, J / Zemour, J / Fagot, H / Passot, G / Gregoire, E / Hardwigsen, J / le Treut, Y-P / Patrice, D

    The British journal of surgery

    2020  Volume 107, Issue 3, Page(s) 268–277

    Abstract: Background: The aim was to analyse the impact of cirrhosis on short-term outcomes after laparoscopic liver resection (LLR) in a multicentre national cohort study.: Methods: This retrospective study included all patients undergoing LLR in 27 centres ... ...

    Abstract Background: The aim was to analyse the impact of cirrhosis on short-term outcomes after laparoscopic liver resection (LLR) in a multicentre national cohort study.
    Methods: This retrospective study included all patients undergoing LLR in 27 centres between 2000 and 2017. Cirrhosis was defined as F4 fibrosis on pathological examination. Short-term outcomes of patients with and without liver cirrhosis were compared after propensity score matching by centre volume, demographic and tumour characteristics, and extent of resection.
    Results: Among 3150 patients included, LLR was performed in 774 patients with (24·6 per cent) and 2376 (75·4 per cent) without cirrhosis. Severe complication and mortality rates in patients with cirrhosis were 10·6 and 2·6 per cent respectively. Posthepatectomy liver failure (PHLF) developed in 3·6 per cent of patients with cirrhosis and was the major cause of death (11 of 20 patients). After matching, patients with cirrhosis tended to have higher rates of severe complications (odds ratio (OR) 1·74, 95 per cent c.i. 0·92 to 3·41; P = 0·096) and PHLF (OR 7·13, 0·91 to 323·10; P = 0·068) than those without cirrhosis. They also had a higher risk of death (OR 5·13, 1·08 to 48·61; P = 0·039). Rates of cardiorespiratory complications (P = 0·338), bile leakage (P = 0·286) and reoperation (P = 0·352) were similar in the two groups. Patients with cirrhosis had a longer hospital stay than those without (11 versus 8 days; P = 0·018). Centre expertise was an independent protective factor against PHLF in patients with cirrhosis (OR 0·33, 0·14 to 0·76; P = 0·010).
    Conclusion: Underlying cirrhosis remains an independent risk factor for impaired outcomes in patients undergoing LLR, even in expert centres.
    MeSH term(s) Aged ; Carcinoma, Hepatocellular/surgery ; Disease-Free Survival ; Female ; Hepatectomy/adverse effects ; Humans ; Laparoscopy/adverse effects ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Population Surveillance ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Propensity Score ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2020-01-09
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A "distant" bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distant transduced tumor.

    Kianmanesh, A R / Perrin, H / Panis, Y / Fabre, M / Nagy, H J / Houssin, D / Klatzmann, D

    Human gene therapy

    1997  Volume 8, Issue 15, Page(s) 1807–1814

    Abstract: Antitumor gene therapy using herpes simplex type 1 thymidine kinase (TKh) and ganciclovir (GCV) treatment has revealed an important intratumoral bystander effect. A whole tumor can be eliminated when only a fraction of its tumor cells express TKh. We now ...

    Abstract Antitumor gene therapy using herpes simplex type 1 thymidine kinase (TKh) and ganciclovir (GCV) treatment has revealed an important intratumoral bystander effect. A whole tumor can be eliminated when only a fraction of its tumor cells express TKh. We now report that the bystander effect not only acts within a tumor, but also between distant tumors. One TKh+ tumor was generated simultaneously with one or multiple TKh- tumors in different rat liver lobes such that there was no contact between the resulting tumors. Both the TKh+ and the TKh- tumors regressed after GCV treatment and showed infiltration with macrophages and T lymphocytes. This distant bystander effect, which is likely immune mediated, should be of major importance for gene therapy of disseminated tumors.
    MeSH term(s) 3T3 Cells ; Animals ; Carcinoma, Hepatocellular/therapy ; Cell Transformation, Viral ; Colonic Neoplasms/secondary ; Colonic Neoplasms/therapy ; Ganciclovir/therapeutic use ; Genetic Therapy ; Genetic Vectors ; Herpesvirus 1, Human/enzymology ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Male ; Mice ; Rats ; Remission Induction ; Thymidine Kinase/genetics ; Thymidine Kinase/therapeutic use ; Tumor Cells, Cultured
    Chemical Substances Thymidine Kinase (EC 2.7.1.21) ; Ganciclovir (P9G3CKZ4P5)
    Language English
    Publishing date 1997-10-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1028152-6
    ISSN 1557-7422 ; 1043-0342
    ISSN (online) 1557-7422
    ISSN 1043-0342
    DOI 10.1089/hum.1997.8.15-1807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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