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  1. Article: Evacuation of Non-ST Elevation Myocardial Infarction in West Africa: 19 Hours of Lessons Learned in Prolonged Casualty Care and En Route Care.

    Speicher, Matthew V / McGowan, Joel / Pruett, Sean / Shurden, Jaimie / Bianchi, William D / Kibler, Aaron

    Journal of special operations medicine : a peer reviewed journal for SOF medical professionals

    2023  Volume 23, Issue 1, Page(s) 114–116

    Abstract: Trauma casualty care has historically been the cornerstone of special operations military medical training. A recent case of myocardial infarction at a remote base of operations in Africa highlights the importance of foundational medical knowledge and ... ...

    Abstract Trauma casualty care has historically been the cornerstone of special operations military medical training. A recent case of myocardial infarction at a remote base of operations in Africa highlights the importance of foundational medical knowledge and training. A 54-year-old government contractor supporting operations in the AFRICOM area of responsibility (AOR) presented to the Role 1 medic with substernal chest pain with onset during exercise. Abnormal rhythm strips concerning for ischemia were obtained from his monitors. A MEDEVAC to a Role 2 facility was arranged and executed. At the Role 2 a non-ST-elevation myocardial infarction (NSTEMI) was diagnosed. The patient was emergently evacuated on a lengthy flight to a civilian Role 4 treatment facility for definitive care. He was found to have a 99% occlusion of the left anterior descending (LAD) coronary artery, as well as a 75% occlusion of the posterior coronary artery and a chronic 100% occlusion of the circumflex artery. The LAD and posterior arteries were stented, and the patient made a favorable recovery. This case highlights the importance of preparedness for medical emergencies and care of medically critical patients in remote and austere locations.
    MeSH term(s) Male ; Humans ; Middle Aged ; Non-ST Elevated Myocardial Infarction/surgery ; Electrocardiography ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy ; Coronary Vessels ; Africa, Western ; Coronary Angiography
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3006517-3
    ISSN 1553-9768
    ISSN 1553-9768
    DOI 10.55460/JIDF-CWE7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7196: Show issues Location:
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  2. Article: Vitamin D receptor as a therapeutic target for benign prostatic hyperplasia.

    Manchanda, Parmeet Kaur / Kibler, Aaron J / Zhang, Mei / Ravi, Janani / Bid, Hemant K

    Indian journal of urology : IJU : journal of the Urological Society of India

    2013  Volume 28, Issue 4, Page(s) 377–381

    Abstract: The bioactive form of vitamin D, 1α, 25-dihydroxyvitamin D3 (1α, 25(OH)2D3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor super-family expressed in many cell types, and modulates a variety of ... ...

    Abstract The bioactive form of vitamin D, 1α, 25-dihydroxyvitamin D3 (1α, 25(OH)2D3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor super-family expressed in many cell types, and modulates a variety of biological functions. 1α, 25(OH)2D3 is essential for bone and mineral homeostasis, but also regulates growth and differentiation of multiple cell types, and displays immunoregulatory and anti-inflammatory activities. The antiproliferative, prodifferentiative, antibacterial, immunomodulatory and anti-inflammatory properties of synthetic VDR agonists could be exploited to treat a variety of chronic inflammatory and autoimmune diseases, including benign prostatic hyperplasia (BPH). It has been hypothesized that VDR may influence both the risk of a variety of diseases and their occurrence and prognosis. However, earlier studies investigating the associations between specific VDR polymorphisms and various diseases often show controversial results. We performed a systematic review of the current literature on vitamin D and BPH using the PubMed and Web of Knowledge databases. The aim of this review is to summarize the current knowledge on the utility of the VDR gene regarding prostate growth as well as the pathogenesis and treatment of BPH, a complex syndrome characterized by a static component related to prostate overgrowth, a dynamic component responsible for urinary storage symptoms, and an inflammatory component. Despite the massive advances in recent decades, further research is needed to fully characterize the exact underlying mechanisms of VDR action on BPH and to comprehend how these cellular changes translate into clinical development in physical concert.
    Language English
    Publishing date 2013-02-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 639268-4
    ISSN 1998-3824 ; 0970-1591
    ISSN (online) 1998-3824
    ISSN 0970-1591
    DOI 10.4103/0970-1591.105745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3165: Show issues Location:
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  3. Article ; Online: Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.

    Bid, Hemant K / Kibler, Aaron / Phelps, Doris A / Manap, Sagymbek / Xiao, Linlin / Lin, Jiayuh / Capper, David / Oswald, Duane / Geier, Brian / DeWire, Mariko / Smith, Paul D / Kurmasheva, Raushan T / Mo, Xiaokui / Fernandez, Soledad / Houghton, Peter J

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2013  Volume 19, Issue 24, Page(s) 6716–6729

    Abstract: Purpose: The BT-40 low-grade childhood astrocytoma xenograft model expresses mutated BRAF(V600E) and is highly sensitive to the MEK inhibitor selumetinib (AZD6244). In this study, we developed and characterized selumetinib resistance and explored ... ...

    Abstract Purpose: The BT-40 low-grade childhood astrocytoma xenograft model expresses mutated BRAF(V600E) and is highly sensitive to the MEK inhibitor selumetinib (AZD6244). In this study, we developed and characterized selumetinib resistance and explored approaches to circumventing the mechanisms of acquired resistance.
    Experimental design: BT-40 xenografts were selected in vivo for selumetinib resistance. Resistant tumors were obtained and characterized, as were tumors that reverted to sensitivity. Characterization included expression profiling, assessment of MEK signature and compensatory pathways, MEK inhibition, BRAF expression, and cytokine levels. Combination treatment of BT-40/AZD-resistant tumors with the MEK inhibitor and a STAT3 inhibitor (LLL12) was assessed.
    Results: Resistance was unstable, tumors reverting to selumetinib sensitivity when passaged in untreated mice, and MEK was equally inhibited in sensitive and resistant tumors by selumetinib. Drug resistance was associated with an enhanced MEK signature and increased interleukin (IL)-6 and IL-8 expression. Selumetinib treatment induced phosphorylation of STAT3 (Y705) only in resistant xenografts, and similar results were observed in BRAF(V600E) astrocytic cell lines intrinsically resistant to selumetinib. Treatment of BT-40-resistant tumors with selumetinib or LLL12 had no significant effect, whereas combined treatment induced complete regressions of BT-40/AZD-resistant xenografts.
    Conclusions: Resistance to selumetinib selected in vivo in BT-40 tumor xenografts was unstable. In resistant tumors, selumetinib activated STAT3, and combined treatment with selumetinib and LLL12 induced complete responses in resistant BT-40 tumors. These results suggest dual targeting BRAF (V600E) signaling and STAT3 signaling may be effective in selumetinib-resistant tumors or may retard or prevent onset of resistance.
    MeSH term(s) Animals ; Anthraquinones/pharmacology ; Astrocytoma/drug therapy ; Astrocytoma/genetics ; Astrocytoma/pathology ; Benzimidazoles/administration & dosage ; Cell Line, Tumor ; Child ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Heterografts ; Humans ; Interleukin-6/biosynthesis ; Interleukin-8/biosynthesis ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 1/genetics ; Mice ; Proto-Oncogene Proteins B-raf/genetics ; STAT3 Transcription Factor/genetics ; Sulfonamides/pharmacology
    Chemical Substances AZD 6244 ; Anthraquinones ; Benzimidazoles ; IL6 protein, human ; Interleukin-6 ; Interleukin-8 ; LLL12 compound ; STAT3 Transcription Factor ; STAT3 protein, human ; Sulfonamides ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; MAP Kinase Kinase 1 (EC 2.7.12.2)
    Language English
    Publishing date 2013-10-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-13-0842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
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