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  1. Article ; Online: A rare case of all-trans retinoic acid induced myocarditis.

    Ul Hassan, Imtiaz / Chowdhary, Amrit / Kidambi, Ananth

    European heart journal. Cardiovascular Imaging

    2021  Volume 22, Issue 8, Page(s) e131

    MeSH term(s) Humans ; Myocarditis/chemically induced ; Myocarditis/diagnostic imaging ; Tretinoin/adverse effects
    Chemical Substances Tretinoin (5688UTC01R)
    Language English
    Publishing date 2021-05-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeab082
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  2. Article ; Online: An unusual case of apical myocarditis: a case report.

    Das, Arka / Kidambi, Ananth / Plein, Sven / Dall'Armellina, Erica

    European heart journal. Case reports

    2020  Volume 4, Issue 6, Page(s) 1–5

    Abstract: Background: Myocardial infarction with non-obstructed coronary arteries (MINOCA) syndrome accounts for ∼6-8% of acute coronary syndrome presentations. Historically, MINOCA has been thought of as a benign condition, however, recent evidence suggests that ...

    Abstract Background: Myocardial infarction with non-obstructed coronary arteries (MINOCA) syndrome accounts for ∼6-8% of acute coronary syndrome presentations. Historically, MINOCA has been thought of as a benign condition, however, recent evidence suggests that some aetiologies of MINOCA such as cardiomyopathies are associated with significantly higher mortality than other causes such as myocarditis. Therefore, identifying the underlying cause of MINOCA is important in determining patient management and prognosis.
    Case summary: We describe the case of a 58-year-old lady with an acute admission with MINOCA syndrome. Cardiac magnetic resonance (CMR) examination on Day 9 demonstrated hypertrophy of the apical segments of the left ventricle (LV), with diffuse mid-wall hyper-enhancement on late gadolinium enhancement (LGE) images. T2-weighted imaging was suggestive of active inflammation in the hypertrophied segments. A repeat CMR scan was performed 3 months later showed normalization of LV wall thickness, LGE and T2 values in the apical segments.
    Discussion: This case report highlights the benefits of CMR with oedema-weighted imaging in the acute stages of MINOCA syndrome, as well as the importance of serial imaging in this patient cohort. While baseline imaging raised the possibility of apical hypertrophic cardiomyopathy, resolution of apical hypertrophy on follow-up CMR showed that the patient had acute myocarditis, specifically involving the apical segments.
    Language English
    Publishing date 2020-11-07
    Publishing country England
    Document type Journal Article
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytaa347
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  3. Article ; Online: Risk stratification in acute myocardial infarction with multiparametric cardiac magnetic resonance imaging: getting to the core of the matter.

    Kidambi, Ananth / Plein, Sven

    European heart journal

    2016  Volume 37, Issue 13, Page(s) 1060–1062

    MeSH term(s) Heart ; Humans ; Magnetic Resonance Imaging ; Myocardial Infarction ; Risk
    Language English
    Publishing date 2016-04-01
    Publishing country England
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehv517
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  4. Article: A shot to the heart: a rare case of cardiac embolization.

    Elsisi, Islam Fathi Hussein Ali / Kidambi, Ananth

    Echo research and practice

    2018  Volume 5, Issue 1, Page(s) K19–K21

    Abstract: SummaryThis is a case report of intracardiac foreign bodies that gained access to the heart by migration from a peripheral vein. The case report describes the diagnostic findings on cardiac imaging and summarizes different approaches to management.: ... ...

    Abstract SummaryThis is a case report of intracardiac foreign bodies that gained access to the heart by migration from a peripheral vein. The case report describes the diagnostic findings on cardiac imaging and summarizes different approaches to management.
    Learning points: Appearance of embolized cardiac missiles with reverberation and acoustic shadowing.Role of different imaging modalities in the diagnosis of intracardiac foreign bodies.Indications for surgical or transcatheter retrieval.
    Language English
    Publishing date 2018-02-12
    Publishing country England
    Document type Case Reports
    ZDB-ID 2777997-X
    ISSN 2055-0464
    ISSN 2055-0464
    DOI 10.1530/ERP-17-0073
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  5. Article ; Online: Detection of intramyocardial haemorrhage by MRI--no single rule.

    Kidambi, Ananth / Plein, Sven

    Nature reviews. Cardiology

    2015  Volume 12, Issue 4, Page(s) 198

    MeSH term(s) Animals ; Hemorrhage/etiology ; Humans ; Myocardial Infarction/complications
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/nrcardio.2014.188-c1
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  6. Article ; Online: Transcoronary electrophysiological parameters in patients undergoing elective and acute coronary intervention.

    Javid, Rabeia / Slater, Thomas A / Bowes, Robert / Veerasamy, Murugapathy / Wassef, Nancy / Rossington, Jennifer A / Mozid, Abdul M / Kidambi, Ananth / Wheatcroft, Stephen B / Tayebjee, Muzahir H

    PloS one

    2023  Volume 18, Issue 2, Page(s) e0281374

    Abstract: Introduction: Percutaneous coronary intervention is performed routinely in the management of myocardial infarction with obstructive coronary disease, but intervention to arteries supplying nonviable myocardium may be harmful. It is important therefore ... ...

    Abstract Introduction: Percutaneous coronary intervention is performed routinely in the management of myocardial infarction with obstructive coronary disease, but intervention to arteries supplying nonviable myocardium may be harmful. It is important therefore to establish myocardial viability, and there is an unmet need in current clinical practice for real time viability assessment to aid in decision making. Transcoronary pacing to assess myocardial electrophysiological parameters may be a novel viability assessment technique which could be used in this regard.
    Methods: Coronary intervention was carried out according to standard departmental procedure with standard equipment. An exchange length coronary guidewire was passed into both target and reference coronary vessels and an over-the-wire balloon or microcatheter was used to insulate the guidewire and allow electrophysiological parameters to be assessed. Readings were obtained from all major epicardial vessels and substantial branches. At each position, an intracoronary electrocardiogram was recorded, and R wave amplitude was measured. Transcoronary pacing was then performed to establish threshold and impedance for each myocardial segment. A viability cardiac MRI scan was performed for each patient. A standard segmental model was used to determine viability in each segment using an 'infarct score' based on degree of late gadolinium enhancement. Studies were reported blinded to the electrical parameters obtained from the coronary guidewire. The primary outcome was the relationship between pacing threshold and myocardial segment infarct score. Secondary outcomes included the relationship between segmental infarct score and R wave height, and between segmental infarct score and pacing impedance. Data were collected on the feasibility of studying the coronary segments as well as safety.
    Results: Sixty-five patients presenting with stable coronary artery disease or acute coronary syndromes to Leeds General Infirmary between September 2019 and August 2021 were included in the study. Electrophysiological parameters from segments with an infarct score of zero were obtained, with wide variances seen, with no significant difference in impedance or threshold in any territory. There was a significant difference in sensitivity for segments in the right coronary artery territory for both elective and acute patients. This likely relates to reduced myocardial mass in these territories. No significant association between infarct score and sensitivity, impedance or threshold were seen.
    Conclusion: This study has established intracoronary electrophysiological parameters in both normal myocardium and areas of myocardial scar. No reliable association was seen between impedance, threshold or R wave amplitude and degree of myocardial viability, contrasting with prior findings from our group and others. More work is therefore required to fully understand the role of transcoronary pacing in this setting.
    MeSH term(s) Humans ; Contrast Media ; Gadolinium ; Myocardium ; Myocardial Infarction/therapy ; Coronary Artery Disease/therapy ; Percutaneous Coronary Intervention ; Treatment Outcome
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0281374
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  7. Article ; Online: Subclinical Systemic Sclerosis Primary Heart Involvement by Cardiovascular Magnetic Resonance Shows No Significant Interval Change.

    Dumitru, Raluca B / Bissell, Lesley-Anne / Erhayiem, Bara / Fent, Graham / Kidambi, Ananth / Abignano, Giuseppina / Greenwood, John P / Biglands, John / Del Galdo, Francesco / Plein, Sven / Buch, Maya H

    ACR open rheumatology

    2023  Volume 5, Issue 2, Page(s) 71–80

    Abstract: Objective: Subclinical systemic sclerosis (SSc) primary heart involvement is commonly described. Whether these findings progress over time is not clear. The study aimed to investigate cardiovascular magnetic resonance (CMR) interval change of ... ...

    Abstract Objective: Subclinical systemic sclerosis (SSc) primary heart involvement is commonly described. Whether these findings progress over time is not clear. The study aimed to investigate cardiovascular magnetic resonance (CMR) interval change of subclinical SSc primary heart involvement.
    Methods: Patients with SSc with no cardiovascular disease underwent two CMR scans that included T1 mapping and quantitative stress perfusion. The CMR change (mean difference) and association between CMR measures and clinical phenotype were assessed. The study had a prospective design.
    Results: Thirty-one patients with SSc participated, with a median (interquartile range) follow-up of 33 (17-37) months (10 [32%] in the diffuse subset, 16 [52%] with interstitial lung disease [ILD], and 11 [29%] who were Scl-70+). Four of thirty-one patients had focal late gadolinium enhancement (LGE) at visit 1; one of four had an increase in LGE scar mass between visits. Two patients showed new focal LGE at visit 2. No change in other CMR indices was noted. The three patients with SSc with increased or new LGE at visit 2 had diffuse cutaneous SSc with ILD, and two were Scl-70+. A reduction in forced vital capacity and total lung capacity was associated with a reduction in left ventricular ejection fraction (ρ = 0.413, P = 0.021; ρ = 0.335, P = 0.07) and myocardial perfusion reserve (MPR) (ρ = 0.543, P = 0.007; ρ = 0.627, P = 0.002). An increase in the N-terminal pro-brain natriuretic peptide level was associated with a reduction in MPR (ρ = -0.448, P = 0.042). Patients on disease-modifying antirheumatic drugs (DMARDs) had an increase in native T1 (mean [SD] 1208 [65] vs. 1265 [56] milliseconds, P = 0.008). No other clinically meaningful CMR change in patients receiving DMARDs or vasodilators was noted.
    Conclusion: Serial CMR detects interval subclinical SSc primary heart involvement progression; however, this study suggests abnormalities remain largely stable with follow-up.
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5745
    ISSN (online) 2578-5745
    DOI 10.1002/acr2.11515
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  8. Article ; Online: 4D Flow Cardiac MR in Primary Mitral Regurgitation.

    Gorecka, Miroslawa / Cole, Charlotte / Bissell, Malenka M / Craven, Thomas P / Chew, Pei G / Dobson, Laura E / Brown, Louise A E / Paton, Maria F / Higgins, David M / Thirunavukarasu, Sharmaine / Sharrack, Noor / Javed, Wasim / Kotha, Sindhoora / Giannoudi, Marilena / Procter, Henry / Parent, Martine / Kidambi, Ananth / Swoboda, Peter P / Plein, Sven /
    Levelt, Eylem / Garg, Pankaj / Greenwood, John P

    Journal of magnetic resonance imaging : JMRI

    2024  

    Abstract: Background: Four-dimensional-flow cardiac MR (4DF-MR) offers advantages in primary mitral regurgitation. The relationship between 4DF-MR-derived mitral regurgitant volume (MR-Rvol) and the post-operative left ventricular (LV) reverse remodeling has not ... ...

    Abstract Background: Four-dimensional-flow cardiac MR (4DF-MR) offers advantages in primary mitral regurgitation. The relationship between 4DF-MR-derived mitral regurgitant volume (MR-Rvol) and the post-operative left ventricular (LV) reverse remodeling has not yet been established.
    Purpose: To ascertain if the 4DF-MR-derived MR-Rvol correlates with the LV reverse remodeling in primary mitral regurgitation.
    Study type: Prospective, single-center, two arm, interventional vs. nonintervention observational study.
    Population: Forty-four patients (male N = 30; median age 68 [59-75]) with at least moderate primary mitral regurgitation; either awaiting mitral valve surgery (repair [MVr], replacement [MVR]) or undergoing "watchful waiting" (WW).
    Field strength/sequence: 5 T/Balanced steady-state free precession (bSSFP) sequence/Phase contrast imaging/Multishot echo-planar imaging pulse sequence (five shots).
    Assessment: Patients underwent transthoracic echocardiography (TTE), phase-contrast MR (PMRI), 4DF-MR and 6-minute walk test (6MWT) at baseline, and a follow-up PMRI and 6MWT at 6 months. MR-Rvol was quantified by PMRI, 4DF-MR, and TTE by one observer. The pre-operative MR-Rvol was correlated with the post-operative decrease in the LV end-diastolic volume index (LVEDVi).
    Statistical tests: Included Student t-test/Mann-Whitney test/Fisher's exact test, Bland-Altman plots, linear regression analysis and receiver operating characteristic curves. Statistical significance was defined as P < 0.05.
    Results: While Bland-Altman plots demonstrated similar bias between all the modalities, the limits of agreement were narrower between 4DF-MR and PMRI (bias 15; limits of agreement -36 mL to 65 mL), than between 4DF-MR and TTE (bias -8; limits of agreement -106 mL to 90 mL) and PMRI and TTE (bias -23; limits of agreement -105 mL to 59 mL). Linear regression analysis demonstrated a significant association between the MR-Rvol and the post-operative decrease in the LVEDVi, when the MR-Rvol was quantified by PMRI and 4DF-MR, but not by TTE (P = 0.73). 4DF-MR demonstrated the best diagnostic performance for reduction in the post-operative LVEDVi with the largest area under the curve (4DF-MR 0.83; vs. PMRI 0.78; and TTE 0.51; P = 0.89).
    Data conclusion: This study demonstrates the potential clinical utility of 4DF-MR in the assessment of primary mitral regurgitation.
    Evidence level: 2 TECHNICAL EFFICACY: Stage 5.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.29284
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  9. Article ; Online: Understanding LV remodeling following myocardial infarction: are T1 maps by CMR the new guide?

    Plein, Sven / Kidambi, Ananth

    JACC. Cardiovascular imaging

    2012  Volume 5, Issue 9, Page(s) 894–896

    MeSH term(s) Extracellular Matrix/pathology ; Heart Ventricles/pathology ; Humans ; Myocardial Infarction/complications ; Myocardium/pathology ; Ventricular Dysfunction, Left/pathology ; Ventricular Remodeling
    Language English
    Publishing date 2012-09
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2012.07.006
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  10. Article ; Online: Relation of circumferential and longitudinal strain to other independent prognostic imaging markers in first time ST-elevation myocardial infarction.

    Garg, Pankaj / Kidambi, Ananth / Plein, Sven

    International journal of cardiology

    2015  Volume 186, Page(s) 202–203

    MeSH term(s) Female ; Humans ; Image Enhancement/methods ; Magnetic Resonance Imaging, Cine/methods ; Male ; Myocardial Infarction/physiopathology
    Language English
    Publishing date 2015-03-18
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2015.03.214
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