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Article ; Online: In2Q2: A New Entry of 16-Membered Tetraazamacrocycle Concatenating Indole and Quinoline Units.

Kihara, Kazuki / Kobayashi, Toi / Xu, Wei / Kumagai, Naoya

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e202304176

Abstract: A new family of 16-membered macrocycles comprising two indole (In) and two quinoline (Q) units, coined In2Q2, was synthesized. Each unit is diagonally located and concatenated in a head-to-tail fashion, furnishing a non-flat saddle-shaped architecture ... ...

Abstract	A new family of 16-membered macrocycles comprising two indole (In) and two quinoline (Q) units, coined In2Q2, was synthesized. Each unit is diagonally located and concatenated in a head-to-tail fashion, furnishing a non-flat saddle-shaped architecture with C
Language	English
Publishing date	2024-02-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202304176
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Article ; Online: Cell-Based Biohybrid Sensor Device for Chemical Source Direction Estimation.

Oda, H / Kihara, K / Morimoto, Y / Takeuchi, S

Cyborg and bionic systems (Washington, D.C.)

2021 Volume 2021, Page(s) 8907148

Abstract: This paper describes a method to estimate the direction from which the signal molecule reaches the sensor by using living cells. In this context, biohybrid sensors that utilize a sophisticated sensing system of cells can potentially offer high levels of ... ...

Abstract	This paper describes a method to estimate the direction from which the signal molecule reaches the sensor by using living cells. In this context, biohybrid sensors that utilize a sophisticated sensing system of cells can potentially offer high levels of chemical-detection sensitivity and selectivity. However, biohybrid-sensor-based chemical-source-direction estimation has not received research attention because the cellular response to chemicals has not been examined in the context of directional information. In our approach, we fabricated a device that can limit the interface between the cell-laden hydrogel and the chemical solution of interest to enhance the time difference over which the chemical solution reaches the cells. Chemical detection by cells that express specific receptors is reflected as the fluorescence of the calcium indicator within the cells. Our device has eight chambers that each house 3D cell-laden collagen hydrogels facing circularly outward. The device also works as a cover to prevent chemicals from permeating the hydrogel from above. In our study, by observing the time course of the fluorescence emission of each chamber, we were able to successfully estimate the chemical-source direction within an error range of 7-13°. Our results suggest that a combination of microstructure devices embedded with living cells can be used to exploit cell functionalities to yield chemical-source directional information.
Language	English
Publishing date	2021-01-23
Publishing country	United States
Document type	Journal Article
ISSN	2692-7632
ISSN (online)	2692-7632
DOI	10.34133/2021/8907148
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Article ; Online: Following car reduces motorcycles' size-arrival effect: A study using online experiments.

Wu, Yanbin / Kihara, Ken / Takeda, Yuji

Applied ergonomics

2023 Volume 114, Page(s) 104153

Abstract: Many fatal motorcycle accidents occur because car drivers infringe on motorcycle riders' right-of-way. The size-arrival effect refers to observers' tendency to judge larger objects as arriving sooner than smaller objects when estimating an approaching ... ...

Abstract	Many fatal motorcycle accidents occur because car drivers infringe on motorcycle riders' right-of-way. The size-arrival effect refers to observers' tendency to judge larger objects as arriving sooner than smaller objects when estimating an approaching object's arrival time, which is one cause of right-of-way motorcycle accidents. Previous research has focused on a single vehicle that approaches the driver. However, it is also possible that a motorcycle approaches a driver along with other vehicles driving on multiple-lane roads. This paper presents the results of two online experiments; Experiment 1 validated the size-arrival effect when either a car or a motorcycle approached a driver waiting to turn across an intersection; and Experiment 2 investigated the size-arrival effect when a motorcycle and a parallelly driven car simultaneously approached the driver. Participants (n = 1723) in Experiment 1 and (n = 986) in Experiment 2 took part in the study. The results (1) validated the size-arrival effect; drivers accepted a smaller gap for approaching motorcycles than cars; (2) in the present settings drivers made turn decisions based on the distance gap rather than the time-to-arrival gap; (3) driver's acceptance of the gap when facing a motorcycle and a car was comparable to when facing only the car and significantly larger than facing only a motorcycle. These findings indicate that a car driving parallelly or behind a motorcycle reduces the size-arrival effect. These findings provide implications to suggest a safe riding strategy for motorcycle riders. We also suggest that such online experiments would facilitate studying large samples with less effort.
MeSH term(s)	Humans ; Accidents, Traffic/prevention & control ; Automobile Driving ; Motorcycles ; Automobiles
Language	English
Publishing date	2023-10-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2003513-5
ISSN	1872-9126 ; 0003-6870
ISSN (online)	1872-9126
ISSN	0003-6870
DOI	10.1016/j.apergo.2023.104153
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Article ; Online: The function of REM and NREM sleep on memory distortion and consolidation.

Kaida, Kosuke / Mori, Ikue / Kihara, Ken / Kaida, Naoko

Neurobiology of learning and memory

2023 Volume 204, Page(s) 107811

Abstract: During rapid eye movement (REM) sleep, newly consolidated memories can be distorted to adjust the existing memory base in memory integration. However, only a few studies have demonstrated the role of REM sleep in memory distortion. The present study aims ...

Abstract	During rapid eye movement (REM) sleep, newly consolidated memories can be distorted to adjust the existing memory base in memory integration. However, only a few studies have demonstrated the role of REM sleep in memory distortion. The present study aims to clarify the role of REM sleep in the facilitation of memory distortion, that is, hindsight bias, compared to non-rapid eye movement (NREM) sleep and wake states. The split-night paradigm was used to segregate REM and NREM sleep. The hypotheses are (1) hindsight bias-memory distortion-is more substantial during REM-rich sleep (late-night sleep) than during NREM-rich sleep (early-night sleep); (2) memory stabilization is more substantial during NREM-rich sleep (early-night sleep) than during REM-rich sleep (late-night sleep); and (3) memory distortion takes longer time than memory stabilization. The results of the hindsight bias test show that more memory distortions were observed after the REM condition in comparison to the NREM condition. Contrary to the hindsight bias, the correct response in the word-pair association test was observed more in the NREM than in the REM condition. The difference in the hindsight bias index between the REM and NREM conditions was identified only one week later. Comparatively, the difference in correct responses in the word-pair association task between the conditions appeared three hours later and one week later. The present study found that (1) memory distortion occurs more during REM-rich sleep than during NREM-rich sleep, while memory stabilization occurs more during NREM-rich sleep than during REM-rich sleep. Moreover, (2) the newly encoded memory could be stabilized immediately after encoding, but memory distortion occurs over several days. These results suggest that the roles of NREM and REM sleep in memory processes could be different.
MeSH term(s)	Humans ; Sleep, REM/physiology ; Memory/physiology ; Sleep/physiology ; Sleep, Slow-Wave ; Memory Disorders ; Sleep Stages/physiology ; Memory Consolidation/physiology
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1223366-3
ISSN	1095-9564 ; 1074-7427
ISSN (online)	1095-9564
ISSN	1074-7427
DOI	10.1016/j.nlm.2023.107811
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Article ; Online: Surgical resection of a retinal pigment epithelium adenoma with exudative retinal detachment.

Harada, Yosuke / Hiyama, Tomona / Kihara, Keita

American journal of ophthalmology

2023 Volume 256, Page(s) e1–e3

MeSH term(s)	Humans ; Retinal Detachment/diagnosis ; Retinal Detachment/surgery ; Retinal Pigment Epithelium ; Retinal Perforations ; Adenoma/complications ; Adenoma/diagnosis ; Adenoma/surgery ; Fluorescein Angiography
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2023.09.006
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Article ; Online: Investigation of air bubble properties: Relevance to prevention of coronary air embolism during cardiac surgery.

Kihara, Kazuki / Orihashi, Kazumasa

Artificial organs

2021 Volume 45, Issue 9, Page(s) E349–E358

Abstract: Although de-airing procedures are commonly performed during cardiac surgery, use of these procedures is not necessarily based on evidence. Uncertainly remains around the size of bubbles that can be detected by echocardiography, whether embolized air or ... ...

Abstract	Although de-airing procedures are commonly performed during cardiac surgery, use of these procedures is not necessarily based on evidence. Uncertainly remains around the size of bubbles that can be detected by echocardiography, whether embolized air or carbon dioxide can be absorbed, and the reasons for embolic events occurring despite extensive de-airing. Since air bubbles are invisible in the blood, we used simple experimental models employing water and 10% dextran solution to determine the correlation between actual bubble size and the depicted size on echocardiography, bubble size, and floatation velocity and the absorption of carbon dioxide under embolization and irrigation conditions. Bubbles depicted as larger than 1 mm were overestimated by echocardiography: the actual size was larger than 0.4 mm in diameter. While bubbles of 0.5 mm had a floatation velocity of 2 to 3 cm/s, the buoyancy of bubbles smaller than 0.3 mm was negligible. Thus, bubbles that are depicted as larger than 1 mm on echocardiography or that present with apparent buoyancy should be visible and need to be meticulously removed. However, echocardiography cannot distinguish bubbles of around 0.1 mm in diameter from those of capillary size (<10 μm). Thus, we advise continuous venting of dense bubbles until they become sparse. While carbon dioxide was rapidly absorbed when circulating, the absorption of embolized carbon dioxide was negligible. These results suggest that detected intracardiac air represents residual "air," with carbon dioxide already absorbed. Therefore, the use of conventional de-airing procedures needs reconsideration: air and buoyant bubbles should be removed from the heart before they are expelled into the aorta; this requires timely and precise assessment with transesophageal echocardiography and effective collaboration between surgeons, anesthesiologists, and perfusionists.
MeSH term(s)	Carbon Dioxide/analysis ; Cardiac Surgical Procedures ; Echocardiography, Transesophageal ; Embolism, Air/diagnostic imaging ; Embolism, Air/prevention & control ; Humans ; In Vitro Techniques ; Models, Cardiovascular
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2021-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.13975
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Article: The Role of Low-Spatial Frequency Components in the Processing of Deceptive Faces: A Study Using Artificial Face Models.

Kihara, Ken / Takeda, Yuji

Frontiers in psychology

2019 Volume 10, Page(s) 1468

Abstract: Interpreting another's true emotion is important for social communication, even in the face of deceptive facial cues. Because spatial frequency components provide important clues for recognizing facial expressions, we investigated how we use spatial ... ...

Abstract	Interpreting another's true emotion is important for social communication, even in the face of deceptive facial cues. Because spatial frequency components provide important clues for recognizing facial expressions, we investigated how we use spatial frequency information from deceptive faces to interpret true emotion. We conducted two different tasks: a face-generating experiment in which participants were asked to generate deceptive and genuine faces by tuning the intensity of happy and angry expressions (Experiment 1) and a face-classification task in which participants had to classify presented faces as either deceptive or genuine (Experiment 2). Low- and high-spatial frequency (LSF and HSF) components were varied independently. The results showed that deceptive happiness (i.e., anger is the hidden expression) involved different intensities for LSF and HSF. These results suggest that we can identify hidden anger by perceiving unbalanced intensities of emotional expression between LSF and HSF information contained in deceptive faces.
Language	English
Publishing date	2019-06-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2019.01468
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Article ; Online: A frame at a different depth than a photograph enhances the apparent depth in the photograph.

Shimono, Koichi / Higashiyama, Atsuki / Kihara, Ken / Matsuda, Yusuke

Attention, perception & psychophysics

2021 Volume 83, Issue 8, Page(s) 3216–3226

Abstract: Two experiments showed that a photo frame placed at a distance from the photo itself enhances the apparent depth of contents within the photo. In Experiment 1, 32 observers rated the apparent depth of 60 successively presented photos of scenes with ... ...

Abstract	Two experiments showed that a photo frame placed at a distance from the photo itself enhances the apparent depth of contents within the photo. In Experiment 1, 32 observers rated the apparent depth of 60 successively presented photos of scenes with pictorial depth cues. In a separate block of trials, the photos were presented either with a frame in front of each photo or without a frame. Observers also assessed apparent depth of the same 60 photos by choosing the photo that had greater apparent depth when a framed and a frameless photo of the same scene were presented side by side. We found that mean depth ratings were higher for framed than for frameless photos, and framed photos were chosen more often than frameless photos. In Experiment 2, 12 observers rated the apparent depth of 20 different photos that were successively presented with or without a frame. The frame was placed in front of, at the same distance as, or behind each photo. Mean ratings for front-framed and behind-framed photos were higher than those for equidistant-framed or frameless photos, and mean ratings increased with the distance between the photo and the frame. We hypothesize that having to process the relative depth between a photo and a frame reduces the effectiveness of flatness information provided by the photo.
MeSH term(s)	Cues ; Humans
Language	English
Publishing date	2021-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2464550-3
ISSN	1943-393X ; 1943-3921
ISSN (online)	1943-393X
ISSN	1943-3921
DOI	10.3758/s13414-021-02345-7
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Article ; Online: Prefrontal GABA and glutamate-glutamine levels affect sustained attention.

Kondo, Hirohito M / Terashima, Hiroki / Kihara, Ken / Kochiyama, Takanori / Shimada, Yasuhiro / Kawahara, Jun I

Cerebral cortex (New York, N.Y. : 1991)

2023 Volume 33, Issue 19, Page(s) 10441–10452

Abstract: Attention levels fluctuate during the course of daily activities. However, factors underlying sustained attention are still unknown. We investigated mechanisms of sustained attention using psychological, neuroimaging, and neurochemical approaches. ... ...

Abstract	Attention levels fluctuate during the course of daily activities. However, factors underlying sustained attention are still unknown. We investigated mechanisms of sustained attention using psychological, neuroimaging, and neurochemical approaches. Participants were scanned with functional magnetic resonance imaging (fMRI) while performing gradual-onset, continuous performance tasks (gradCPTs). In gradCPTs, narrations or visual scenes gradually changed from one to the next. Participants pressed a button for frequent Go trials as quickly as possible and withheld responses to infrequent No-go trials. Performance was better for the visual gradCPT than for the auditory gradCPT, but the 2 were correlated. The dorsal attention network was activated during intermittent responses, regardless of sensory modality. Reaction-time variability of gradCPTs was correlated with signal changes (SCs) in the left fronto-parietal regions. We also used magnetic resonance spectroscopy (MRS) to measure levels of glutamate-glutamine (Glx) and γ-aminobutyric acid (GABA) in the left prefrontal cortex (PFC). Glx levels were associated with performance under undemanding situations, whereas GABA levels were related to performance under demanding situations. Combined fMRI-MRS results demonstrated that SCs of the left PFC were positively correlated with neurometabolite levels. These findings suggest that a neural balance between excitation and inhibition is involved in attentional fluctuations and brain dynamics.
MeSH term(s)	Humans ; Glutamine ; Glutamic Acid/analysis ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy ; Prefrontal Cortex ; gamma-Aminobutyric Acid/analysis
Chemical Substances	Glutamine (0RH81L854J) ; Glutamic Acid (3KX376GY7L) ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad294
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Article ; Online: Application of gasless laparoendoscopic single port surgery, GasLESS, to partial nephrectomy for renal cell carcinoma: GasLESS-clampless partial nephrectomy as a multiply satisfactory method.

Kihara, Kazunori

International journal of urology : official journal of the Japanese Urological Association

2012 Volume 19, Issue 1, Page(s) 3–4

MeSH term(s)	Carcinoma, Renal Cell/surgery ; Endoscopy/instrumentation ; Endoscopy/methods ; Humans ; Kidney Neoplasms/surgery ; Minimally Invasive Surgical Procedures/instrumentation ; Minimally Invasive Surgical Procedures/methods ; Nephrectomy/instrumentation ; Nephrectomy/methods ; Surgical Instruments
Language	English
Publishing date	2012-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/j.1442-2042.2011.02881.x
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Zs.MO 278: Show issues

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