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  1. Article ; Online: Health Problems Related to Presenteeism Among Japanese Employees.

    Ozawa, Sakiko / Monma, Takafumi / Tsuchida, Momoko / Kikuchi, Ayako / Takeda, Fumi

    Journal of occupational and environmental medicine

    2023  Volume 66, Issue 1, Page(s) e1–e7

    Abstract: Objective: This study identified primary health problems related to presenteeism stratified by sex.: Methods: A cross-sectional study was conducted to analyze the relationship between 26 health problems and presenteeism using data from health-related ...

    Abstract Objective: This study identified primary health problems related to presenteeism stratified by sex.
    Methods: A cross-sectional study was conducted to analyze the relationship between 26 health problems and presenteeism using data from health-related data and World Health Organization Health and Work Performance Questionnaire among 12,526 employees in Japan.
    Results: Sex-stratified multiple regression analyses showed that presenteeism was associated with nine health problems in both sexes, depressive symptoms, followed by lack of appetite, insufficient sleep, heart palpitations, or shortness of breath demonstrated the strongest relationship. Men had five additional health problems associated with presenteeism; furthermore, the relationships of those were stronger than women.
    Conclusions: The primary health problems related to presenteeism were depressive symptoms and indefinite complaints in both sexes. Men had more and stronger relationship between health problems and presenteeism than women.
    MeSH term(s) Male ; Humans ; Female ; Japan/epidemiology ; Presenteeism ; Cross-Sectional Studies ; Surveys and Questionnaires ; Work Performance ; Workplace
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002985
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  2. Article ; Online: Corrigendum to "Risk factors for multiple metabolic syndrome components in obese and non-obese Japanese individuals" [Preventive Medicine 153 (2021) 106855].

    Kikuchi, Ayako / Monma, Takafumi / Ozawa, Sakiko / Tsuchida, Momoko / Tsuda, Michiko / Takeda, Fumi

    Preventive medicine

    2022  Volume 161, Page(s) 107109

    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 184600-0
    ISSN 1096-0260 ; 0091-7435
    ISSN (online) 1096-0260
    ISSN 0091-7435
    DOI 10.1016/j.ypmed.2022.107109
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    Zs.A 878: Show issues Location:
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  3. Article ; Online: Symptoms, performance status and phase of illness in advanced cancer: multicentre cross-sectional study of palliative care unit admissions.

    Ohinata, Hironori / Aoyama, Maho / Hiratsuka, Yusuke / Mori, Masanori / Kikuchi, Ayako / Tsukuura, Hiroaki / Matsuda, Yosuke / Suzuki, Kozue / Kohara, Hiroyuki / Maeda, Isseki / Morita, Tatsuya / Miyashita, Mitsunori

    BMJ supportive & palliative care

    2024  Volume 13, Issue e3, Page(s) e1174–e1180

    Abstract: Objectives: To clarify the relationship between Phase of Illness at the time of admission to palliative care units and symptoms of patients with advanced cancer.: Methods: This study was a secondary analysis of the East Asian collaborative cross- ... ...

    Abstract Objectives: To clarify the relationship between Phase of Illness at the time of admission to palliative care units and symptoms of patients with advanced cancer.
    Methods: This study was a secondary analysis of the East Asian collaborative cross-cultural Study to Elucidate the Dying process. Palliative physicians recorded data, including Phase of Illness, physical function and the Integrated Palliative care Outcome Scale. We used multinomial logistic regression to analyse ORs for factors associated with Phase of Illness. Twenty-three palliative care units in Japan participated from January 2017 to September 2018.
    Results: In total, 1894 patients were analysed-50.9% were male, mean age was 72.4 (SD±12.3) years, and Phase of Illness at the time of admission to the palliative care unit comprised 177 (8.9%) stable, 579 (29.2%) unstable, 921 (46.4%) deteriorating and 217 (10.9%) terminal phases. Symptoms were most distressing in the terminal phase for all items, followed by deteriorating, unstable and stable (p<0.001). The stable phase had lower association with shortness of breath (OR 0.73, 95% CI 0.57 to 0.94) and felt at peace (OR 0.73, 95% CI 0.56 to 0.90) than the unstable phase. In the deteriorating phase, weakness or lack of energy (OR 1.20, 95% CI 1.02 to 1.40) were higher, while drowsiness (OR 0.82, 95% CI 0.71 to 0.97) and felt at peace (OR 0.81, 95% CI 0.71 to 0.94) were significantly lower.
    Conclusion: Our study is reflective of the situation in palliative care units in Japan. Future studies should consider the differences in patients' medical conditions and routinely investigate patients' Phase of Illness and symptoms.
    Trial registrarion number: UMIN000025457.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Cross-Sectional Studies ; Hospitalization ; Logistic Models ; Neoplasms/complications ; Neoplasms/therapy ; Palliative Care ; Middle Aged ; Aged, 80 and over
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Multicenter Study
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/spcare-2022-003806
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  4. Article ; Online: Effects of molecular targeting agents and immune-checkpoint inhibitors in patients with advanced cancer who are near the end of life.

    Hiramoto, Shuji / Taniyama, Tomohiko / Kikuchi, Ayako / Hori, Tetsuo / Yoshioka, Akira / Inoue, Akira

    Palliative & supportive care

    2021  Volume 19, Issue 6, Page(s) 709–714

    Abstract: Background: In recent years, the use of both molecular targeting agents (MTAs) and immune-checkpoint inhibitors (ICIs) tend to occupy important positions in systemic anticancer therapy (SACT). The objective of this study is to describe the predictors of ...

    Abstract Background: In recent years, the use of both molecular targeting agents (MTAs) and immune-checkpoint inhibitors (ICIs) tend to occupy important positions in systemic anticancer therapy (SACT). The objective of this study is to describe the predictors of SACT include both MTAs and ICIs near the end of life (EOL) and the effect on EOL care in patients with advanced cancer.
    Methods: We analyzed all patients who died of advanced cancer from August 2016 to August 2019, and we analyzed the survival time of patients who underwent anticancer agents excluded due to the loss of information about the last administration of SACT. The primary endpoint of this study was to identify predictors during the last administration of SACT near EOL.
    Results: In a multivariate analysis, the Eastern Cooperative Oncology Group performance status (ECOG-PS) (ORs 33.781) was significantly related factors within 14 days of death from the last administration of SACT. Age (ORs 0.412), ECOG-PS (ORs 11.533), primary cancer site of upper GI cancers (ORs 2.205), the number of comorbidities (ORs 0.207), MTAs (ORs 3.139), and ICIs (ORs 3.592) were significantly related factors within 30 days of death. The median survival time (MST) of patients with PS 3-4 was 29 days, while that of patients with both PS 0-2 was 76 days. The prevalence rate of delirium with MTAs was 17.5%, which was significantly lower than that of patients without it (31.8%). The prevalence rate of the mean dose of opioids in patients with ICIs was 97.9 mg/day, which was significantly higher than that of patients without it (44.9 mg/day).
    Conclusions: Age, ECOG-PS, primary cancer site, the number of comorbidities, MTAs, and ICIs use were significant associated with SACT near EOL. Information on these factors may aid clinical decision making in referral to palliative care institutes.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Molecular Targeted Therapy ; Retrospective Studies ; Neoplasms/complications ; Neoplasms/drug therapy ; Death ; Lung Neoplasms
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2454009-2
    ISSN 1478-9523 ; 1478-9515
    ISSN (online) 1478-9523
    ISSN 1478-9515
    DOI 10.1017/S147895152100002X
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    Zs.A 6697: Show issues Location:
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  5. Article ; Online: Risk factors for multiple metabolic syndrome components in obese and non-obese Japanese individuals.

    Kikuchi, Ayako / Monma, Takafumi / Ozawa, Sakiko / Tsuchida, Momoko / Tsuda, Michiko / Takeda, Fumi

    Preventive medicine

    2021  Volume 153, Page(s) 106855

    Abstract: Many studies have reported that even non-obese individuals have multiple metabolic syndrome (MetS) components, such as hypertension, hyperglycemia, and lipid abnormalities have a higher cardiovascular disease mortality rate and incidence. However, the ... ...

    Abstract Many studies have reported that even non-obese individuals have multiple metabolic syndrome (MetS) components, such as hypertension, hyperglycemia, and lipid abnormalities have a higher cardiovascular disease mortality rate and incidence. However, the risk factors for multiple MetS components in non-obese individuals have not been sufficiently clarified. This study compared risk factors, including overall lifestyle habits, for multiple MetS components possession between obese and non-obese individuals. A cross-sectional study was conducted using data from specific health checkups of 47,172 individuals (age, 40-64 years) who belonged to the health insurance societies of five manufacturing companies in Japan in 2015. Multiple logistic regression analysis was conducted in the non-obese and obese groups with multiple MetS components as the objective variable, and attributes, body weight change, and 11 lifestyle habits (smoking, exercise, diet, drinking, and sleep) as explanatory variables. For both groups, men, older age, current smoking, weight gain of ≥10 kg since age of 20, slow walking speed, fast eating speed, and greater amounts of alcohol consumption were risk factors for having multiple MetS components. The odds ratio of each risk factor, with the exception of walking speed and eating speed, tended to be higher in non-obese individuals than in obese individuals. The only risk factor specific to obese individuals was lack of regular exercise. These results suggest that almost all risk factors for possession of multiple MetS components were common to both obese and non-obese individuals, and the risk level of each risk factor tended to be higher in non-obese individuals.
    MeSH term(s) Adult ; Cross-Sectional Studies ; Humans ; Japan/epidemiology ; Male ; Metabolic Syndrome/epidemiology ; Middle Aged ; Obesity/complications ; Risk Factors
    Language English
    Publishing date 2021-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184600-0
    ISSN 1096-0260 ; 0091-7435
    ISSN (online) 1096-0260
    ISSN 0091-7435
    DOI 10.1016/j.ypmed.2021.106855
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 878: Show issues Location:
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  6. Article ; Online: Prognostic factors in patients who received end-of-life chemotherapy for advanced cancer.

    Hiramoto, Shuji / Tamaki, Tomoko / Nagashima, Kengo / Hori, Tetsuo / Kikuchi, Ayako / Yoshioka, Akira / Inoue, Akira

    International journal of clinical oncology

    2018  Volume 24, Issue 4, Page(s) 454–459

    Abstract: Background: Clinical efficacy of aggressive end-of-life (EOL) chemotherapy remains unclear.: Method: Medical records of patients with advanced cancer between August 2011 and August 2016 were retrospectively analyzed. The primary endpoint was to ... ...

    Abstract Background: Clinical efficacy of aggressive end-of-life (EOL) chemotherapy remains unclear.
    Method: Medical records of patients with advanced cancer between August 2011 and August 2016 were retrospectively analyzed. The primary endpoint was to identify prognostic factors at the last administration of chemotherapy. The secondary endpoint was to analyze the relationship between EOL symptoms and EOL treatment details.
    Results: Among 300 evaluated patients, the number of patients who died within 14 and 30 days from the last administration of chemotherapy were 16 (5.3%) and 50 (16.7%), respectively. Multivariate analysis revealed that ECOG-PS (OR 3.698, p < 0.001) and GPS2 (OR 3.791, p = 0.028) were significant prognostic factors. The MST of patients with both PS 2-4 and GPS2 (+) was 38 days, while that in patients with both PS 0-1 and GPS2 (-) was 134.5 days. The prevalence rate of nausea and vomiting (25.0%) and the mean hydration volume (0.50 L/day) in patients who died within 30 days from the chemotherapy was significantly higher than others (7.4%) (0.20 L/day).
    Conclusion: ECOG-PS and GPS were significant prognostic factors for aggressive EOL chemotherapy. Information on these factors may aid clinical decision-making in terms of risk-benefit balance, particularly in patients with poor prognosis.
    MeSH term(s) Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Nausea/chemically induced ; Neoplasms/drug therapy ; Neoplasms/mortality ; Neoplasms/therapy ; Prognosis ; Retrospective Studies ; Terminal Care/methods ; Treatment Outcome ; Vomiting/chemically induced
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2018-10-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1400227-9
    ISSN 1437-7772 ; 1341-9625
    ISSN (online) 1437-7772
    ISSN 1341-9625
    DOI 10.1007/s10147-018-1363-7
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    Zs.A 4828: Show issues Location:
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  7. Article ; Online: Efficacy of palliative radiotherapy and chemo-radiotherapy for unresectable gastric cancer demonstrating bleeding and obstruction.

    Hiramoto, Shuji / Kikuchi, Ayako / Tetsuso, Hori / Yoshioka, Akira / Kohigashi, Yasushi / Maeda, Isseki

    International journal of clinical oncology

    2018  Volume 23, Issue 6, Page(s) 1090–1094

    Abstract: Background: Bleeding and obstruction are common localized symptoms in patients with unresectable gastric cancer. Although there are several reports about surgical and endoscopic therapies for gastric cancer, there are few regarding palliative radiation ... ...

    Abstract Background: Bleeding and obstruction are common localized symptoms in patients with unresectable gastric cancer. Although there are several reports about surgical and endoscopic therapies for gastric cancer, there are few regarding palliative radiation therapy.
    Methods: We retrospectively analyzed data for 23 gastric cancer patients who underwent palliative radiation between April 2006 and March 2014, with either localized bleeding (n = 18) or upper gastric obstruction (n = 10).
    Results: The median (range) total dose and fraction (Fr) of radiotherapy (RT) were 42 (18-60) Gy and 20 (9-30) Fr, respectively. The response rates were 88.8% (bleeding) and 80% (obstruction). The median event-free survival times of the bleeding and obstruction groups from the start of radiation were 103 and 104 days, respectively. Adverse events with RT and chemo-radiotherapy (CRT) were grade 2 nausea (n = 4) and grade 2 esophagitis (n = 3) and grade 2 neutropenia (n = 3). In univariate analysis, the antrum as the gastric primary site (p = 0.063) and peritoneal metastasis (p = 0.054) occurred more frequently in the non-responders (n = 4) than the responders (n = 19).
    MeSH term(s) Adenocarcinoma/complications ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemoradiotherapy ; Female ; Gastrointestinal Hemorrhage/complications ; Gastrointestinal Hemorrhage/pathology ; Gastrointestinal Hemorrhage/therapy ; Humans ; Intestinal Obstruction/complications ; Intestinal Obstruction/pathology ; Intestinal Obstruction/therapy ; Male ; Middle Aged ; Palliative Care ; Prognosis ; Radiotherapy Dosage ; Retrospective Studies ; Stomach Neoplasms/complications ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy ; Survival Rate
    Language English
    Publishing date 2018-07-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1400227-9
    ISSN 1437-7772 ; 1341-9625
    ISSN (online) 1437-7772
    ISSN 1341-9625
    DOI 10.1007/s10147-018-1317-0
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    Zs.A 4828: Show issues Location:
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  8. Article ; Online: Diagnostic models for impending death in terminally ill cancer patients: A multicenter cohort study.

    Mori, Masanori / Yamaguchi, Takuhiro / Maeda, Isseki / Hatano, Yutaka / Yamaguchi, Takashi / Imai, Kengo / Kikuchi, Ayako / Matsuda, Yosuke / Suzuki, Kozue / Tsuneto, Satoru / Hui, David / Morita, Tatsuya

    Cancer medicine

    2021  Volume 10, Issue 22, Page(s) 7988–7995

    Abstract: Background: Accurately predicting impending death is essential for clinicians to clarify goals of care. We aimed to develop diagnostic models to predict death ≤3 days in cancer patients.: Methods: In this multicenter cohort study, we consecutively ... ...

    Abstract Background: Accurately predicting impending death is essential for clinicians to clarify goals of care. We aimed to develop diagnostic models to predict death ≤3 days in cancer patients.
    Methods: In this multicenter cohort study, we consecutively enrolled advanced cancer patients admitted to 23 inpatient hospices in 2017. Fifteen clinical signs related to impending death were documented daily from the day when the Palliative Performance Scale (PPS) declined to ≤20-14 days later. We conducted recursive partitioning analysis using the entire data set and performed cross-validation to develop the model (prediction of 3-day impending death-decision tree [P3did-DT]). Then, we summed the number of systems (nervous/cardiovascular/respiratory/musculoskeletal), where any sign was present to underpin P3did score (range = 0-4).
    Results: Data following PPS ≤20 were obtained from 1396 of 1896 inpatients (74%). The mean age was 73 ± 12 years, and 399 (29%) had gastrointestinal tract cancer. The P3did-DT was based on three variables and had four terminal leaves: urine output (u/o) ≤200 ml/day and decreased response to verbal stimuli, u/o ≤200 ml/day and no decreased response to verbal stimuli, u/o >200 ml/day and Richmond Agitation-Sedation Scale (RASS) ≤-2, and u/o >200 ml/day and RASS ≥-1. The 3-day mortality rates were 80.3%, 53.3%, 39.9%, and 20.6%, respectively (accuracy = 68.3%). In addition, 79.6%, 62.9%, 47.2%, 32.8%, and 17.4% of patients with P3did scores of 4, 3, 2, 1, and 0, respectively, died ≤3 days.
    Conclusion: We successfully developed diagnostic models for death ≤3 days. These may further help clinicians predict impending death and help patients/families prepare for their final days.
    MeSH term(s) Aged ; Cohort Studies ; Female ; Humans ; Male ; Neoplasms/mortality ; Neoplasms/rehabilitation ; Palliative Care/methods ; Prospective Studies ; Terminally Ill
    Language English
    Publishing date 2021-09-29
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.4314
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  9. Article ; Online: Efficacy of Proportional Sedation and Deep Sedation Defined by Sedation Protocols: A Multicenter, Prospective, Observational Comparative Study.

    Imai, Kengo / Morita, Tatsuya / Yokomichi, Naosuke / Kawaguchi, Takashi / Kohara, Hiroyuki / Yamaguchi, Takashi / Kikuchi, Ayako / Odagiri, Takuya / Watanabe, Yuki Sumazaki / Kamura, Rena / Maeda, Isseki / Kawashima, Natsuki / Ito, Satoko / Baba, Mika / Matsuda, Yosuke / Oya, Kiyofumi / Kaneishi, Keisuke / Hiratsuka, Yusuke / Naito, Akemi Shirado /
    Mori, Masanori

    Journal of pain and symptom management

    2021  Volume 62, Issue 6, Page(s) 1165–1174

    Abstract: Purpose: To investigate the efficacy of two types of palliative sedation: proportional and deep sedation, defined by sedation protocols.: Methods: From a multicenter prospective observational study, we analyzed the data of those patients who received ...

    Abstract Purpose: To investigate the efficacy of two types of palliative sedation: proportional and deep sedation, defined by sedation protocols.
    Methods: From a multicenter prospective observational study, we analyzed the data of those patients who received the continuous infusion of midazolam according to the sedation protocol. The primary endpoint was goal achievement at 4 hours: in proportional sedation, symptom relief (Integrated Palliative care Outcome Scale: IPOS ≤ 1) and absence of agitation (modified Richmond Agitation-Sedation Scale: RASS ≤ 0); in deep sedation, the achievement of deep sedation (RASS ≤ -4). Secondary endpoints included deep sedation as a result of proportional sedation, communication capacity (Communication Capacity Scale item 4 ≤ 2), IPOS and RASS scores, and adverse events.
    Results: A total of 81 patients from 14 palliative care units were analyzed: proportional sedation (n = 64) and deep sedation (n = 17). At 4 hours, the goal was achieved in 77% (n = 49; 95% confidence interval: 66-87) with proportional sedation; and 88% (n = 15; 71-100) with deep sedation. Deep sedation was necessary in 45% of those who received proportional sedation. Communication capacity was maintained in 34% with proportional sedation and 10% with deep sedation. IPOS decreased from 3.5 to 0.9 with proportional sedation, and 3.5 to 0.4 with deep sedation; RASS decreased from +0.3 to -2.6, and +0.4 to -4.2, respectively. Fatal events related to the treatment occurred in 2% (n = 1) with proportional and none with deep sedation.
    Conclusion: Proportional sedation achieved satisfactory symptom relief while maintaining some patients' consciousness, and deep sedation achieved good symptom relief while the majority of patients lost consciousness.
    MeSH term(s) Deep Sedation ; Humans ; Hypnotics and Sedatives/therapeutic use ; Intensive Care Units ; Midazolam/therapeutic use ; Multicenter Studies as Topic ; Observational Studies as Topic ; Palliative Care/methods ; Prospective Studies ; Respiration, Artificial
    Chemical Substances Hypnotics and Sedatives ; Midazolam (R60L0SM5BC)
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639142-4
    ISSN 1873-6513 ; 0885-3924
    ISSN (online) 1873-6513
    ISSN 0885-3924
    DOI 10.1016/j.jpainsymman.2021.06.005
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    Zs.A 2252: Show issues Location:
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  10. Article: Black Tea High-Molecular-Weight Polyphenol Increases the Motility of Sea Urchin Sperm by Activating Mitochondrial Respiration

    KIKUCHI, Ayako / SHIBA, Kogiku / OZAWA, Tetsuo / NAKANO, Kentaro / INABA, Kazuo / NUMATA, Osamu

    Bioscience, biotechnology, and biochemistry. 2012 Dec. 23, v. 76, no. 12

    2012  

    Abstract: Mitochondria activation factor (MAF) is a high-molecular-weight polyphenol purified from black tea that activates mitochondrial respiration. It increased the mitochondrial membrane potential and motility of sea urchin sperm, by up to 8%, to the same ... ...

    Abstract Mitochondria activation factor (MAF) is a high-molecular-weight polyphenol purified from black tea that activates mitochondrial respiration. It increased the mitochondrial membrane potential and motility of sea urchin sperm, by up to 8%, to the same extent as sperm-activating peptides (SAPs) secreted by the egg. Unlike SAPs, MAF had no effect on sperm swimming behavior, suggesting that the mechanism of sperm activation by MAF is different from that of SAPs.
    Keywords Echinoidea ; biotechnology ; black tea ; eggs ; membrane potential ; mitochondria ; mitochondrial membrane ; peptides ; polyphenols ; sperm capacitation ; spermatozoa
    Language English
    Dates of publication 2012-1223
    Size p. 2321-2324.
    Publishing place Japan Society for Bioscience, Biotechnology, and Agrochemistry
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1271/bbb.120493
    Database NAL-Catalogue (AGRICOLA)

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