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Article ; Online: Near-Infrared Fluorescent Silica Nanoparticles Based on Gold-Silver Alloy Nanoclusters for Clinical Diagnosis.

Ichimaru, Hiroaki / Kikuchi, Shigetoshi

2024 Volume 72, Issue 1, Page(s) 121–126

Abstract: In clinical diagnosis, fluorescent particles are applied to detect analytes in biofluids, such as blood and saliva. However, current fluorescence detection methods have not been optimized to account for the overlapping autofluorescence peaks of ... ...

Abstract	In clinical diagnosis, fluorescent particles are applied to detect analytes in biofluids, such as blood and saliva. However, current fluorescence detection methods have not been optimized to account for the overlapping autofluorescence peaks of biological substances. Gold and silver nanoclusters are known to the novel fluorescent materials and their emission wavelengths depend on cluster size. In this study, we developed fluorescent silica nanoparticles using gold-silver alloy nanoclusters and chitosan (CS) (NH
MeSH term(s)	Animals ; Horses ; Gold Alloys ; Silver ; Silicon Dioxide ; Gold ; Metal Nanoparticles
Chemical Substances	Gold Alloys ; Silver (3M4G523W1G) ; Silicon Dioxide (7631-86-9) ; Gold (7440-57-5)
Language	English
Publishing date	2024-01-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	213307-6
ISSN	1347-5223 ; 0009-2363
ISSN (online)	1347-5223
ISSN	0009-2363
DOI	10.1248/cpb.c23-00688
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Article ; Online: Admission screening form and osteoporosis educational appointment: a novel fracture liaison service system for identifying osteoporosis patients and facilitating medication initiation.

Kikuchi, Shunsuke / Suda, Yasunori

Archives of osteoporosis

2023 Volume 18, Issue 1, Page(s) 117

Abstract: Our FLS team aimed to ensure that patients admitted to the orthopedic department were promptly initiated for medication and identify and initiate medication for patients admitted to other departments. Our innovative FLS system along with admission ... ...

Abstract	Our FLS team aimed to ensure that patients admitted to the orthopedic department were promptly initiated for medication and identify and initiate medication for patients admitted to other departments. Our innovative FLS system along with admission screening and osteoporosis education have proven effective in identifying patients with osteoporosis and initiating medication. Purpose: The fracture liaison service (FLS) plays a crucial role in the secondary prevention of fragility fractures by involving various medical professionals. Our FLS team had two goals for preventing primary and secondary fractures: ensuring that patients admitted to the orthopedic department were promptly initiated on medication and identifying and initiating medication for patients admitted to other departments. Methods: From April 2020 to March 2023, we analyzed the number of dual-energy X-ray absorptiometry (DEXA) scans performed, the DEXA rate among patients with proximal femoral fractures, and the rate of medication initiation each year. Our hospital implemented the FLS system in April 2022. It is a unique system utilizing admission screening form and osteoporosis educational appointments conducted by rehabilitation staff to initiate medication for orthopedic and non-orthopedic patients. Results: The average monthly number of DEXA scans increased significantly, with 47.7 in 2020, 57.0 in 2021, and 90.8 in 2022. The DEXA rate among proximal femoral fracture patients increased from 23.3% in 2020 to 88.1% in 2021 and 100% in 2022. The rate of treatment initiation also increased remarkably, from 21.7% in 2020, to 68.7% in 2021, reaching 97.8% in 2022. We performed 504 interventions, resulting in 251 patients diagnosed with osteoporosis, of whom 134 (56 from non-orthopedic departments) successfully started medication. Conclusions: Our innovative FLS system, incorporating an admission screening form and osteoporosis educational appointments, proved effective in identifying patients with osteoporosis and facilitating medication initiation, which will prevent both primary and secondary fractures.
MeSH term(s)	Humans ; Fractures, Bone ; Osteoporosis/diagnosis ; Osteoporosis/drug therapy ; Hospitalization ; Hospitals ; Proximal Femoral Fractures
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2253231-6
ISSN	1862-3514 ; 1862-3522
ISSN (online)	1862-3514
ISSN	1862-3522
DOI	10.1007/s11657-023-01326-7
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Article ; Online: Intrarenal Venous Flow as a Mirror of the Impact of Secondary Mitral Regurgitation on Systemic Circulation in Patients Undergoing Mitral Transcatheter Edge-to-Edge Repair.

Kikuchi, Shohei / Seo, Yoshihiro

Circulation journal : official journal of the Japanese Circulation Society

2023 Volume 88, Issue 4, Page(s) 517–518

MeSH term(s)	Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Mitral Valve/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Treatment Outcome ; Cardiac Catheterization
Language	English
Publishing date	2023-08-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-23-0521
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Article ; Online: 2019 ISSLS Wiltse Lifetime Achievement Award.

Kikuchi, Shinichi

Spine

2019 Volume 44, Issue 11, Page(s) 753–754

Language	English
Publishing date	2019-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000003038
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Zs.A 1305: Show issues

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Article ; Online: Magnetic Polystyrene Nanoparticles Prepared by Emulsion Solvent-Evaporation for the Chemiluminescent Immunoassay.

Ichimaru, Hiroaki / Kurimoto, Masashi / Kikuchi, Shigetoshi

Chemical & pharmaceutical bulletin

2024 Volume 72, Issue 3, Page(s) 340–344

Abstract: In clinical diagnosis, magnetic polystyrene nanoparticles (MPS NPs) are commonly applied to, e.g., the chemiluminescent immunoassay (CLEIA). However, the conventional preparation method of MPS NPs requires a long duration of heating to form polymer ... ...

Abstract	In clinical diagnosis, magnetic polystyrene nanoparticles (MPS NPs) are commonly applied to, e.g., the chemiluminescent immunoassay (CLEIA). However, the conventional preparation method of MPS NPs requires a long duration of heating to form polymer particles, which is inefficient. In this study, we prepared MPS NPs by emulsion solvent-evaporation without heating. We evaluated the effect of the solvent in the water and organic phases on the magnetic particle content. MPS NPs prepared by 4% (v/v) MeOH aqueous solution and adding stearic acid (SA) (4MeSA-MPS NPs) exhibited the highest magnetic particle content. Furthermore, CLEIA analysis indicates that the C-reactive protein detection limit is 80 pg/mL. Thus, 4MeSA-MPS NPs are promising for clinical diagnoses.
MeSH term(s)	Emulsions ; Immunoassay/methods ; Magnetic Phenomena ; Nanoparticles ; Particle Size ; Polystyrenes ; Solvents ; Water ; Luminescence
Chemical Substances	Emulsions ; Polystyrenes ; Solvents ; Water (059QF0KO0R)
Language	English
Publishing date	2024-03-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	213307-6
ISSN	1347-5223 ; 0009-2363
ISSN (online)	1347-5223
ISSN	0009-2363
DOI	10.1248/cpb.c23-00864
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Article ; Online: Higher proportions of a healthy gastric mucosa in healthy Japanese adults with later birth year: analysis of 41 957 participants.

Saito, Yoko / Kikuchi, Shogo

Japanese journal of clinical oncology

2022 Volume 52, Issue 10, Page(s) 1143–1149

Abstract: Background: In Japan, most gastric cancers are associated with gastric mucosal atrophy caused by chronic infection with Helicobacter pylori (H. pylori). Recognizing the condition of the gastric mucosa and determining the infection status of H. pylori ... ...

Abstract	Background: In Japan, most gastric cancers are associated with gastric mucosal atrophy caused by chronic infection with Helicobacter pylori (H. pylori). Recognizing the condition of the gastric mucosa and determining the infection status of H. pylori are important for predicting the individual risk of gastric cancer. This study aimed to determine the proportion of Japanese adults with a healthy gastric mucosa (without H. pylori infection) among 12 birth-year groups encompassing 1935-1990 by morphological images. Methods: The gastric mucosa was classified as healthy or having gastritis based on routine double-contrast upper gastrointestinal barium X-ray radiography. The participants included 41 957 healthy Japanese adults. Serum or urine H. pylori antibody levels were also assessed. Results: In total, 25 424 participants had healthy mucosa without a history of H. pylori eradication. The proportions of participants with a healthy mucosa by birth year were 19.8% (57/288), 27.1% (306/1128), 32.4% (569/1756), 37.6% (1808/4811), 49.2% (3207/6522), 60.1% (3966/6550), 71.2% (5224/7342), 77.2% (5114/6624), 80.6% (3342/4149), 85.0% (1404/1652), 85.3% (302/354) and 94.7% (125/132) in 1935, 1940, 1945, 1950, 1955, 1960, 1965, 1970, 1975, 1980, 1985 and after 1990, respectively (P for trend <0.01). All the participants with a healthy mucosa showed negative results in the H. pylori antibody tests. Conclusions: The proportion of participants with normal gastric mucosa linearly increased with the birth years. The prevalence of morphologically healthy gastric mucosa could have consistently increased with decreasing prevalence of H. pylori infection.
MeSH term(s)	Adult ; Barium ; Gastric Mucosa ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Japan/epidemiology ; Stomach Neoplasms/complications
Chemical Substances	Barium (24GP945V5T)
Language	English
Publishing date	2022-06-17
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyac097
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Zs.A 1298: Show issues

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Article ; Online: Effect of surfactants on the elasticity of the liquid-liquid interface.

Kikuchi, Shunta / Watanabe, Hiroshi

The Journal of chemical physics

2022 Volume 158, Issue 12, Page(s) 124901

Abstract: We investigated the effect of surfactants on an interface between two kinds of liquids by molecular dynamics (MD) simulation. We adopted the simple bead-spring model with two atoms as the surfactants. We controlled the interfacial tension of the ... ...

Abstract	We investigated the effect of surfactants on an interface between two kinds of liquids by molecular dynamics (MD) simulation. We adopted the simple bead-spring model with two atoms as the surfactants. We controlled the interfacial tension of the surfactant adsorbed on the interface by changing the bond length. Although the interface's structure changed depending on the magnitude of the interfacial tension, the interface was stable even under conditions where the interfacial tension was virtually zero. The Fourier spectrum of the fluctuations of the surface structure showed a crossover from q
Language	English
Publishing date	2022-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0138733
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Article ; Online: Evaluation of renal circulation in heart failure using superb microvascular imaging, a microvascular flow imaging system.

Kikuchi, Shohei / Kayama, Kiyomi / Kawada, Yu / Kitada, Shuichi / Seo, Yoshihiro

Journal of medical ultrasonics (2001)

2024

Abstract: Purpose: Renal circulation evaluation is essential in understanding the cardiorenal relationship in heart failure (HF), and there is a growing interest in imaging techniques that visualize renal circulation. This study aimed to assess the effectiveness ... ...

Abstract	Purpose: Renal circulation evaluation is essential in understanding the cardiorenal relationship in heart failure (HF), and there is a growing interest in imaging techniques that visualize renal circulation. This study aimed to assess the effectiveness of superb microvascular imaging (SMI) in evaluating renal circulation in HF patients. Method: The study included 71 HF patients undergoing cardiac catheterization. Prior to catheterization, renal ultrasound examinations were performed. A control group of 18 subjects without HF was also included. SMI was used to measure the vascular index (VI), which was calculated as the percentage of blood flow signal area in the region of interest. The intrarenal perfusion index (IRPI) was determined as a fluctuation index of VI, reflecting variations in the number of blood cells moving through renal tissue during the cardiac cycle. Results: Using the upper 95% confidence interval of IRPI (0.6) from the control group, HF patients were classified into two groups. Patients with IRPI > 0.6 showed a more congestive profile. Right atrial pressure and biphasic or monophasic Doppler intrarenal flow pattern were independent determinants of IRPI > 0.6. In addition, IRPI remained a significant predictor of estimated glomerular filtration rate (eGFR). Conclusion: The parameter IRPI as variations in SMI signal during the cardiac cycle may be a useful evaluation method for renal perfusion impairment in HF.
Language	English
Publishing date	2024-01-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-023-01397-6
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Zs.B 2695: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.B 2695 -Engl.Ausg.-: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Athlete Sleep Behavior Questionnaire in Japanese (ASBQ-J): An Adaptation and Validation Study.

Tsukahara, Yuka / Kodama, Satoshi / Kikuchi, Saaya / Day, Carly

Open access journal of sports medicine

2023 Volume 14, Page(s) 89–97

Abstract: Purpose: The Athlete Sleep Behavior Questionnaire (ASBQ) is an 18-item self-reported questionnaire that can be used to screen for sleep disorders in athletes and assess environmental, behavioral, and sports-related factors along with sleep disorders. ... ...

Abstract	Purpose: The Athlete Sleep Behavior Questionnaire (ASBQ) is an 18-item self-reported questionnaire that can be used to screen for sleep disorders in athletes and assess environmental, behavioral, and sports-related factors along with sleep disorders. This study aimed to analyze the reliability and validity of the ASBQ translated into Japanese (ASBQ-J). Patients and methods: 111 female collegiate athletes completed both the initial test and retest. Independent variables were what kind of sports they perform, level as an athlete, grade (freshman, sophomore, junior, senior), and age. The reliability of the survey was assessed using Cronbach's alpha and intraclass correlation, and Pearson's correlation coefficient was calculated to determine the correlation between the total ASBQ scores and three components which were routine/environmental, behavioral, and sports factors. Results: A total of 37.8% of athletes had ASBQ scores equal or less than 36 indicating good sleep. However, 19.8% of athletes scored more than 42, indicating poor sleep. Cronbach alpha was 0.62 and 0.65 for test and retest, respectively. Intraclass correlation was 0.78 ( Conclusion: ASBQ-J is a reliable questionnaire for assessing sleep disorders in athletes whose primary language is Japanese.
Language	English
Publishing date	2023-11-16
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2586658-8
ISSN	1179-1543 ; 1179-1543
ISSN (online)	1179-1543
ISSN	1179-1543
DOI	10.2147/OAJSM.S431820
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Article ; Online: The Recent Trend in Diagnosis and Treatment of Chronic Low Back Pain.

Kikuchi, Shinichi

Spine surgery and related research

2017 Volume 1, Issue 1, Page(s) 1–6

Abstract: Introduction: Development of evidence-based medicine has made a big change in diagnosis and treatment of chronic low back pain. The recent trend is assessed through a review of literature.: Methods: The articles published in these 10 years are ... ...

Abstract	Introduction: Development of evidence-based medicine has made a big change in diagnosis and treatment of chronic low back pain. The recent trend is assessed through a review of literature. Methods: The articles published in these 10 years are reviewed, and important points are examined. Results: In diagnosis, challenges for history taking and limit of imaging or clinical guidelines are revealed. In treatment, cognitive behavioral treatment and exercises are proved effective. Sleep disturbance has recently attracted attention as a factor associated with low back pain. Cost-effectiveness of diagnosis and treatment modalities has come to be emphasized. Conclusions: Diagnosis and treatment of chronic low back pain have been significantly changing. Multidisciplinary and multidimensional approach is essential. Chronic low back pain should be treated as a total pain, not a local pain.
Language	English
Publishing date	2017-12-20
Publishing country	Japan
Document type	Journal Article ; Review
ISSN	2432-261X
ISSN (online)	2432-261X
DOI	10.22603/ssrr.1.2016-0022
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