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Article: PRE-SURGICAL DIAGNOSTIC PARALLELS IN BASAL CELL CARCINOMA OF THE SKIN.

Zaychenko, Y / Kucher, A / Mota, I / Kiladze, N

2022 , Issue 322, Page(s) 90–94

Abstract: The aim of the study was to determine the basic dermatoscopic principles for diagnosis of nonpigmented basal cell carcinoma in young patients, to analyze the volume of preoperative high-resolution ultrasound, to compare indicators and to justify the ... ...

Abstract	The aim of the study was to determine the basic dermatoscopic principles for diagnosis of nonpigmented basal cell carcinoma in young patients, to analyze the volume of preoperative high-resolution ultrasound, to compare indicators and to justify the expediency of using a double diagnostic test "Dermatoscopy + ultrasound" to determine the indications for surgery. The paper presents 15 cases of basal cell carcinoma in young patients, all cases studied by dermatoscopy (Kittler's algorithm) and high-frequency ultrasonography. In cases of the superficial type of BCC, hypoechoic formations with uneven growth in the dermis to a depth of 0.5-0.8 mm with a uniform structure and enhanced vascularization were observed. Dermatoscopically, this variety is characterized by a varied pattern of vessels - serpentine, branched, monomorphic. Erosive surfaces are represented by structureless areas. Irregular white lines, perpendicular in places, are also characteristic. In the nodular form, the lesions were hypoechoic, with clear, even symmetrical contours, regular oval or round shape, with a germination depth of 1.3-1.5 mm. When measuring blood flow, increased vascularization was observed. Dermatoscopically was fixed monomorphic branched vascular pattern, structureless areas and serpentine white lines Both ultrasound and dermatoscopic indices fully confirm the diagnosis of basal cell carcinomas, establish penetration depth, the documented dimensions make possible to resolve the issue of optimal surgical intervention.
MeSH term(s)	Carcinoma, Basal Cell/diagnostic imaging ; Carcinoma, Basal Cell/surgery ; Dermoscopy ; Humans ; Neovascularization, Pathologic ; Skin Neoplasms/diagnostic imaging ; Ultrasonography
Language	English
Publishing date	2022-02-05
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clear Cell Acanthoma/Pseudolymphoma

Shulaia T. / Kiladze N. / Miriamidze A.

Львівський клінічний вісник, Vol 1, Iss 25, Pp 21-

Clinical Dermatoscopic and Histological Correlation

2019 Volume 26

Abstract: Introduction. Skin tumors make up the largest group due to the complex structure of this organ. Benign skin tumors are one of the most common pathologies that occupy an intermediate position at the interface of dermatol ogy, oncology and surgery, and ... ...

Abstract	Introduction. Skin tumors make up the largest group due to the complex structure of this organ. Benign skin tumors are one of the most common pathologies that occupy an intermediate position at the interface of dermatol ogy, oncology and surgery, and their timely diagnosis and removal are important not only for these three specialties, but also for the general medical network. Differential diagnosis of such tumors is still an urgent problem, and a variety of diagnostic methods does not solve the problem. Today, the most affordable method of optical diagnostics of the skin is dermatoscopy, the noninvasiveness and simplicity of which made it indispensable in modern practice. The article describes dermatoscopic characteristics and their correlation with the data of pathomorphological stud ies in two cases from our own practice clear cell acanthoma and pseudolymphoma. Both of these tumors are rare, benign, and present certain difficulties for diagnosis. The aim of the study. Analysis of available literature and the description of clinical cases from own practice. Мaterials and methods. Content analysis, method of system and comparative analysis, bibliosemantic method of studying of relevant scientific research were used. The search for sources was carried out in scientometric med ical information bases: PubMedNCBI, Medline, CochraneLibrary, EMBASE, ResearchGate in accordance with the keywords: clear cell acanthoma, pseudolymphoma, dermatoscopy. Digital dermatoscopy images were obtained using a dermatoscope (DermLite DL3 dermatoscope) attached to a digital camera (Galaxy S4 Samsung Corpora tion). For the immersion dermatoscopy ultrasound gel was used. All obtained images were estimated in accordance with the algorithm of G. Kittler. Results. Clear cell acanthoma is a rare benign epithelial tumor with unclear etiology. It is believed that the basis of its development is an impaired keratinocyte maturation. Some authors do not refer it to tumors, but consider that this is a local hyperplastic process. Clear ...
Keywords	clear cell acanthoma ; dermatoscopy ; pseudolymphoma ; Medicine ; R
Subject code	610
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	Publishing House "Kyrylytsya"
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research Capacity Training on Environmental Health and Noncommunicable Diseases in the Country of Georgia: Challenges and Lessons Learned during the COVID-19 Pandemic.

Berg, Carla J / Sturua, Lela / Marsit, Carmen J / Baramidze, Levan / Kiladze, Nino / Caudle, William Michael

International journal of environmental research and public health

2022 Volume 19, Issue 13

Abstract: COVID-19 presented challenges for global health research training programs. The Clean Air Research and Education (CARE) program, which aims to enhance research capacity related to noncommunicable diseases and environmental health in the country of ... ...

Abstract	COVID-19 presented challenges for global health research training programs. The Clean Air Research and Education (CARE) program, which aims to enhance research capacity related to noncommunicable diseases and environmental health in the country of Georgia, was launched in 2020-as the COVID-19 pandemic began. At its foundation is mentorship and mentored research, alongside formal didactic training, informal training/meetings, and other supports. Current analyses examined CARE's initial 1.5 years (e.g., program benefits, mentorship relationships) using data from an evaluation survey among trainees and faculty in January 2022. Trainees (100% response rate:
MeSH term(s)	COVID-19/epidemiology ; Environmental Health ; Georgia (Republic)/epidemiology ; Humans ; Noncommunicable Diseases ; Pandemics ; Program Evaluation ; United States
Language	English
Publishing date	2022-07-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19138154
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Article: IMPACT OF SULPHUR DIOXIDE ON THE RESPIRATORY SYSTEM OF TBILISI POPULATION.

Vepkhvadze, N / Kiladze, N / Khorbaladze, M / Kochoradze, T / Kugoti, I

Georgian medical news

2017 , Issue 265, Page(s) 1114–1119

Abstract: The possible relationship between levels of sulphur dioxide (SO2) in the air and the rate of respiratory diseases has been studied. Results of monitoring of main contaminants of outdoor air were analyzed and they are reflected in Environmental Report ... ...

Abstract	The possible relationship between levels of sulphur dioxide (SO2) in the air and the rate of respiratory diseases has been studied. Results of monitoring of main contaminants of outdoor air were analyzed and they are reflected in Environmental Report 2015. Information on morbidity by respiratory system diseases of Tbilisi population is has been taken from 2011-2015 reports of the National Center of Disease Control. Identified that there is no consistent correlation between sulphur dioxide concentration in the air and respiratory system disease rates in the population, including children. Obtained data demonstrated that during the study period maximum SO2 concentration was registered in 2015 - 0,14 mg/m3 (exceeding almost 3 times maximum permissible concentration - 0,5 mg/m3) and in the same year high morbidity rates are registered (incidence -18106,08), though the lowest rates are registered in 2011 (0,09 mg/m3), when incidence of respiratory system diseases in this period (13103.2) exceeds the rates registered in 2012, 2013 and 2014 (12736.4, 11336.3, 13009.0 accordingly). There is no direct correlation between the morbidity rates of 0-15 year old children and SO2 concentration. Maximum incidence rate is registered in 2015 (48487.0) and in the same year is also registered maximum concentration of SO2 (0,14 mg/m3), whereas the lowest rate is registered in 2013 (35538,70), when SO2 concentration in 2013 is lower only by 0.02 mg/m3 compared to the concentration in 2015. Direct correlation between morbidity with asthma in children and concentration of SO2 was not identified. Prevalence of asthma is minimal in 2014 (65,4), maximal in 2012 (207,1), whereas SO2 concentration in 2014 (0,13 mg/m3) exceeds the concentration in 2012 (0,12 mg/m3). It has to be considered, that besides SO2 there are many small intensity adverse factors, which are also risk factors for development of respiratory diseases. Isolated action of these factors with certain concentrations may not demonstrate any adverse effects on human health, but the combined effect of their action is stronger and obviously will affect general health and specifically - respiratory system. Implementation of urgent measures for further improvement of their ambient air quality has been recommended, which will be the basis for minimizing of many chronic diseases.
MeSH term(s)	Adolescent ; Air Pollutants/toxicity ; Child ; Child, Preschool ; Georgia (Republic)/epidemiology ; Humans ; Infant ; Infant, Newborn ; Respiratory System/drug effects ; Respiratory Tract Diseases/chemically induced ; Respiratory Tract Diseases/epidemiology ; Sulfur Dioxide/toxicity
Chemical Substances	Air Pollutants ; Sulfur Dioxide (0UZA3422Q4)
Language	English
Publishing date	2017-04
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dermatoscopic features of pigmented and non-pigmented basal cell carcinoma.

Kiladze, N / Shulaia, T / Bulinska, A / Abrahamovych, L

Georgian medical news

2015 , Issue 238, Page(s) 50–53

Abstract: Basal cell carcinoma (BCC) is one of the most common malignant tumors, which accounts for about 75% of all skin cancers, its early diagnosis is crucial for proper treatment. In recent years, an increasingly important role in the early and differential ... ...

Abstract	Basal cell carcinoma (BCC) is one of the most common malignant tumors, which accounts for about 75% of all skin cancers, its early diagnosis is crucial for proper treatment. In recent years, an increasingly important role in the early and differential diagnosis of skin tumors plays dermatoscopy, making possible to improve the diagnosis of pigmented and nonpigmented skin lesions, especially in the early stages of development. The aim of this work is to study the dermatoscopic criteria for pigmented and nonpigmented BCC using the algorithm of H. Kittler. Were studied 78 cases of different clinical types of BCC, diagnosis was based on clinical and dermatoscopic picture with further confirmation by cytology. The obtained data show that for pigmented BCC are characteristic five major signs of dermatoscopy - lines, dots, clods, circles and pseudopodia, whereas for non-pigmented form - pattern of blood vessels and, as an additional feature, structureless areas. Further studies are needed to evaluate specific dermoscopic hallmarks regarding different categories of BCC and sensitivity of these dermatoscopic features.
MeSH term(s)	Carcinoma, Basal Cell/diagnosis ; Carcinoma, Basal Cell/pathology ; Dermoscopy ; Diagnosis, Differential ; Humans ; Pigments, Biological ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology
Chemical Substances	Pigments, Biological
Language	English
Publishing date	2015-01
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Non-melanoma Skin Cancers in Uranium Miners – Clinical Cases

Rosendahl C. / Kiladze N. / Shulaia T.

Львівський клінічний вісник, Vol 3, Iss 23, Pp 52-

2018 Volume 57

Abstract: Introduction. Using sources of ionizing radiation in various spheres of human life became an integral part of the existence of modern society and the necessary condition for further scientific and technological progress. However, along with the obvious ... ...

Abstract	Introduction. Using sources of ionizing radiation in various spheres of human life became an integral part of the existence of modern society and the necessary condition for further scientific and technological progress. However, along with the obvious benefits, this increases the radiation burden and number of malignant neoplasms and the related reduction in life expectancy. The various health risks associated with uranium exposure are well known, mainly it concerns the lung cancer, but recently there has been a hypothesis that if uranium is photoactivated by ultraviolet radiation, it may be more dangerous for the skin. This idea is confirmed by statistics on countries with high levels of solar radiation and uranium deposits, which are being actively developed, such as Australia, Kazakhstan, Canada, Russia, etc. The following article provides a brief overview of the literature and presents 2 cases of basal cell carcinoma in the miners of the uranium mine. The aim of the study. To analyze the overview of the accessible literature and the description of two clinical cases of non-melanoma skin cancers in uranium miners from the own practice. Materials and methods. The content analysis, method of systemic comparative analysis, bibliosemantic method of studying of actual scientific researches concerning the practice of non-invasive methods of evaluation were used. The search for sources was carried out in the scientific meteorological databases: PubMed-NCBI, Medline, CochraneLibrary, EMBASE, ResearchGate by keywords: “uranium miners”, “non-melanoma skin cancer”, “UV”, “dermatoscopy”. Digital dermoscopic images were captured using dermatoscope (DermLite DL3 dermatoscope) mounted on a digital camera (Galaxy S-4 Samsung Corporation). Ultrasound gel was also used for immersion dermatoscopy. All images were evaluated using the algorithm of H. Kittler. Conclusions. The overview of the modern literature and clinical cases from our own practice suggest that uranium mining and processing are associated with a wide range of ...
Keywords	dermatoscopy ; non-melanoma skin cancer ; uranium miners ; Medicine ; R
Subject code	616
Language	English
Publishing date	2018-09-01T00:00:00Z
Publisher	Publishing House "Kyrylytsya"
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phages in Treatment of Some Deep Purulent Skin Infections

Kiladze N. / Chanishvili N. / Shulaia T. / Bendeliani Z. / Zaichenko Y.

Львівський клінічний вісник, Vol 2-3, Iss 18-19, Pp 39-

2017 Volume 43

Abstract: Introduction. The questions of treatment of chronic skin purulent infections are extremely important due to their wide spread, severe clinical course of some nosological forms, development of resistance to the traditional means, and growth of undesirable ...

Abstract	Introduction. The questions of treatment of chronic skin purulent infections are extremely important due to their wide spread, severe clinical course of some nosological forms, development of resistance to the traditional means, and growth of undesirable side effects of antibiotic therapy. Chronic suppurative skin diseases connected with skin appendages are disorders of common occurrence and a major constituent of pyodermas. They still remain a problem due to their chronic character and difficulty of treatment, as well as its large impact on patients’ quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective because of resistance to antibiotics therefore it is desirable to provide the treatment with effective alternatives to commonly used antibiotics to reduce the resistance and obtain a highly specific agent which is able to destroy bacteria effectively. In the same time across the world a growing number of scientists are noting the promising positive results of phage therapy and its advantages, especially in the treatment of chronic cases. The aim of this communication, which is a continuation of previously presented research, is to report the data and results of treatment of some common chronic suppurative skin disease with phages. Materials and methods. In the present investigation were included 87 males aged 18 to 56 with chronic folliculites (n=52), syccosis (n=30) and folliculitis et perifolliculitis capitis abscendens et suffodiens, Hoffmann (n=5), in all cases was approved prevalence of staphylococcal flora and all of them were treated before with antibiotics, but unsuccessfully. The treatment was provided with pyophages produced by Giorgi Eliava Institute (Tbilisi, Georgia) which include Staphylococcus aureus, Streptococcus (different cultures), Escherichia coli (different serotypes), Psedomonas aeruginosa, Proteus vulgaris, mirabilis. Taking into consideration deep locations for treatment was chosen mesotherapy technique – phage solution was injected ...
Keywords	folliculitis ; mesotherapy ; pyobacteriophages ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	Publishing House "Kyrylytsya"
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Histological Changes of Linear Scleroderma “en Coup de Sabre”

Matoshvili M. / Katsitadze A. / Kiladze N. / Tophuria D.

Львівський клінічний вісник, Vol 4, Iss 8, Pp 34-

2014 Volume 35

Abstract: Introduction. Scleroderma is a chronic disease of unknown aetiology characterized by skin fibrosis and is divided into two clinical entities: localized scleroderma and systemic sclerosis. But the localized scleroderma is not accompanied by Raynaud’s ... ...

Abstract	Introduction. Scleroderma is a chronic disease of unknown aetiology characterized by skin fibrosis and is divided into two clinical entities: localized scleroderma and systemic sclerosis. But the localized scleroderma is not accompanied by Raynaud’s phenomenon, acrosclerosis and internal organ involvement and the life prognosis of patients with localized scleroderma is good. Scleroderma “en coup de sabre” (ECDS) is considered a linear localized form of scleroderma or morphoea. It usually involves, unilaterally, the frontoparietal area, but may extend downwards to the face. Most cases begin before 10 years of age. The aim of our study was to investigate the histological characteristics and their clinical association in ECDS. Materials and methods. The present study was carried out at the Department of Dermatology and Venereology in Tbilisi State Medical University. 11 patients (2 men and 9 women) with lesions clinically and histologically diagnosed as ECDS were retrospectively included. Patients who were treated with immunomodulating agents, including systemic corticosteroids and immunosuppressants before presentation, or patients complicated with Parry – Romberg syndrome were excluded from the study. All patients were subjected to: history taking including: age, sex, duration of the disease, family history; clinical examination; skin biopsy – evaluated for epidermal atrophy, spongiosis, vacuolar degeneration of basal cell layer, satellite cell necrosis, basal pigmentation, melanin incontinence, perivascular infiltrate, perineural infiltrate, periappendageal infiltrate, vacuolar changes of follicular epithelium and dermal fibrosis. Results. All ECDS patients demonstrated epidermal lymphocytic infiltrate, tagging of lymphocytes along the dermo-epidermal junction and vacuolar changes, regardless of disease duration, clinical presentation and the intensity of perivascular lymphocytic infiltrate. Furthermore, when we defined patients with disease duration of < 3 years and of ≥ 6 years, respectively, the degrees of ...
Keywords	“en coup de sabre” ; histological changes ; localized scleroderma ; Medicine ; R
Subject code	610
Language	English
Publishing date	2014-12-01T00:00:00Z
Publisher	Publishing House "Kyrylytsya"
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dermatoscopic Criteria of Non-pigmented Basal Cell Carcinoma

Kiladze N. / Shulaia T. / Bulinska A. / Abrahamovych L.

Львівський клінічний вісник, Vol 3, Iss 7, Pp 32-

2014 Volume 34

Abstract: Introduction. Basal cell carcinoma is one of the most common malignant tumors, which accounts for about 75.0 % of all skin cancers. Despite the fact that the characteristic manifestations of BCC are fairly typical, different clinical sub-varieties can ... ...

Abstract	Introduction. Basal cell carcinoma is one of the most common malignant tumors, which accounts for about 75.0 % of all skin cancers. Despite the fact that the characteristic manifestations of BCC are fairly typical, different clinical sub-varieties can vary greatly and require extended differential diagnosis. The aim of the present study – definition and detalization of dermatoscopic criteria for non-pigmented basal cell carcinoma of the skin. Materials and methods. During the three years study were revealed 75 cases of non-pigmented basal cell carcinoma in 58 men and 17 women aged from 47 to 80 years (mean age – 62 years). All patients were with I–II type of skin photosensitivity in accordance to Fitzpatrick. The diagnosis was exhibited on the basis of clinical, dermatoscopic picture and further cytological or histological studies. Dermatoscopic images were received due to DermLite 3 GEN DL3 connected to Samsung Galaxy (Android) smartphone. The evaluation of dermatoscopic picture of different types of BCC was done in accordance with H. Kittler pattern analysis algorithm. Results. In patients with light skin types the non- pigmented forms of basal cell carcinoma are dominant; such forms are often described as pink pearl nodes or sites of erythema with desquamation and ulceration located mainly on the open photo exposed areas. In such cases the clinical diagnosis is often uncertain or implicates a variety of differential diagnoses. In this context, dermoscopic features may be of primary importance. The main dermatoscopic criteria for the diagnosis of non-pigmented BCC is the pattern of blood vessels according to the existing literature. A further important hint in the diagnosis might be found in the presence of small ulcerations, which appear on dermoscopy as red to yellow or skin colored structureless area. The most consistent global pattern of vessels in all categories of non-pigmented BCCs was mono- or polymorphic pattern of vessels, which in the majority of cases was represented by serpentine and coiled ...
Keywords	basal cell carcinoma ; dermatoscopic criteria ; dermatoscopy ; Medicine ; R
Subject code	610
Language	English
Publishing date	2014-09-01T00:00:00Z
Publisher	Publishing House "Kyrylytsya"
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Irradiation doses of population in mountainous Adjara region of Georgia].

Kugoti, I E / Vepkhvadze, N R / Kiladze, N A

Georgian medical news

2012 , Issue 202, Page(s) 64–68

Abstract: Radionuclide content of food and water in high mountainous regions of Georgia - Adjara (Keda, Shuakhevi, Khulo) has been studied, internal and total irradiation doses for the population have been defined and preventive measures for its reduction have ... ...

Abstract	Radionuclide content of food and water in high mountainous regions of Georgia - Adjara (Keda, Shuakhevi, Khulo) has been studied, internal and total irradiation doses for the population have been defined and preventive measures for its reduction have been proposed. Internal irradiation dose for the population caused by K-40 was identified as 0,63 mSv/y, total irradiation dose - 1,73 mSv/y, that slightly exceeds acceptable levels, due to this it seems desirable to provide some measures with aim to reduce the radiation dose of the population and conduct further observation of the radiation situation. Measures intended to reduce irradiation doses includes: provision of population with less radioactive water sources, the regulation of medical radiation procedures (mostly - X-ray diagnostic procedures), the rational use of fertilizers with 40K content, construction of buildings on the territories with the lowest values of gamma radiation and radon release from soil, use of materials with low content of natural radionuclides for building construction, provision of premises with effective ventilation and radiation monitoring of buildings at any stages of construction, reconstruction or repair.
MeSH term(s)	Background Radiation ; Food Contamination, Radioactive ; Georgia (Republic)/epidemiology ; Humans ; Population ; Potassium/adverse effects ; Radiation Monitoring/methods ; Radioisotopes/adverse effects ; Radon/adverse effects
Chemical Substances	Radioisotopes ; Radon (Q74S4N8N1G) ; Potassium (RWP5GA015D)
Language	Russian
Publishing date	2012-01
Publishing country	Georgia (Republic)
Document type	English Abstract ; Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
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