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  1. Article ; Online: Disparities in US Lung Cancer Clinical Trial Enrollment.

    Kilic, Seyda / Zhao, Jenny / Okut, Hayrettin / Jani, Chinmay T / Radwan, Amr / Dudipala, Harshitha / Burns, Laura / Tapan, Umit

    Journal of racial and ethnic health disparities

    2023  

    Abstract: Background: Disparities within clinical trial enrollment are well-documented, reducing the generalizability of results. Although nearly 30 years have passed since Congress passed the NIH Revitalization Act to encourage the participation of minoritized ... ...

    Abstract Background: Disparities within clinical trial enrollment are well-documented, reducing the generalizability of results. Although nearly 30 years have passed since Congress passed the NIH Revitalization Act to encourage the participation of minoritized populations in clinical trials, these patients continue to be underrepresented. This study aimed to investigate lung cancer clinical trial enrollment disparities for race/ethnicity, sex, and age.
    Methods: We queried the National Institutes of Health: US National Library of Medicine database of clinical trials for all US-based lung cancer clinical trials completed between 2004 and 2021 and collected data on race and ethnicity, gender, and age breakdown. This data was compared to Surveillance, Epidemiology, and End Results (SEER) database data. Independent sample t-tests and Kruskal-Wallis's approach were used to analyze the data.
    Results: Of 311 eligible trials with exclusive US enrollment, 136 (44%) reported race and ethnicity breakdown for the patient cohort representing 9869 patients. Hispanic, Non-Hispanic American Indian/Alaska Native, Non-Hispanic Black, and Non-Hispanic Unreported participants were underrepresented (p = 0.001, p = 0.005, p = 0.014, p = 0.002, respectively). Non-Hispanic White participants were overrepresented (p = 0.018). Disparities worsened from 2017 to 2021 for Hispanic patients (p = 0.03). No significant differences were found for sex or age.
    Conclusions: Disparities for clinical lung cancer trial enrollment have not shown statistically significant improvement since 2004, and representation remains unequal, especially for racial and ethnic minorities.
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2760524-3
    ISSN 2196-8837 ; 2197-3792
    ISSN (online) 2196-8837
    ISSN 2197-3792
    DOI 10.1007/s40615-023-01776-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fate and Efficacy of Engineered Allogeneic Stem Cells Targeting Cell Death and Proliferation Pathways in Primary and Brain Metastatic Lung Cancer.

    Moleirinho, Susana / Kitamura, Yohei / Borges, Paulo S G N / Auduong, Sophia / Kilic, Seyda / Deng, David / Kanaya, Nobuhiko / Kozono, David / Zhou, Jing / Gray, Jeffrey J / Revai-Lechtich, Esther / Zhu, Yanni / Shah, Khalid

    Stem cells translational medicine

    2023  Volume 12, Issue 7, Page(s) 444–458

    Abstract: Primary and metastatic lung cancer is a leading cause of cancer-related death and novel therapies are urgently needed. Epidermal growth factor receptor (EGFR) and death receptor (DR) 4/5 are both highly expressed in primary and metastatic non-small cell ... ...

    Abstract Primary and metastatic lung cancer is a leading cause of cancer-related death and novel therapies are urgently needed. Epidermal growth factor receptor (EGFR) and death receptor (DR) 4/5 are both highly expressed in primary and metastatic non-small cell lung cancer (NSCLC); however, targeting these receptors individually has demonstrated limited therapeutic benefit in patients. In this study, we created and characterized diagnostic and therapeutic stem cells (SC), expressing EGFR-targeted nanobody (EV) fused to the extracellular domain of death DR4/5 ligand (DRL) (EVDRL) that simultaneously targets EGFR and DR4/5, in primary and metastatic NSCLC tumor models. We show that EVDRL targets both cell surface receptors, and induces caspase-mediated apoptosis in a broad spectrum of NSCLC cell lines. Utilizing real-time dual imaging and correlative immunohistochemistry, we show that allogeneic SCs home to tumors and when engineered to express EVDRL, alleviate tumor burden and significantly increase survival in primary and brain metastatic NSCLC. This study reports mechanistic insights into simultaneous targeting of EGFR- and DR4/5 in lung tumors and presents a promising approach for translation into the clinical setting.
    MeSH term(s) Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; ErbB Receptors/therapeutic use ; Cell Death ; Brain Neoplasms/therapy ; Cell Proliferation ; Brain/pathology ; Hematopoietic Stem Cell Transplantation
    Chemical Substances ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2642270-0
    ISSN 2157-6580 ; 2157-6580
    ISSN (online) 2157-6580
    ISSN 2157-6580
    DOI 10.1093/stcltm/szad033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Disparities in Lung Cancer Clinical Trial Discussion and Enrollment at a Safety Net Hospital.

    Dudipala, Harshitha / Burns, Laura / Jani, Chinmay T / Radwan, Amr / Al Omari, Omar / Patel, Mohini / Kilic, Seyda / Zhao, Jenny / Mak, Kimberley / Suzuki, Kei / Tapan, Umit

    Community health equity research & policy

    2023  , Page(s) 2752535X231221394

    Abstract: Background: In the United States, less than 5% of all adult cancer patients enroll in clinical trials. Few studies explore participation in cancer clinical trials at safety net hospitals, which disproportionately care for minoritized, low-income, ... ...

    Abstract Background: In the United States, less than 5% of all adult cancer patients enroll in clinical trials. Few studies explore participation in cancer clinical trials at safety net hospitals, which disproportionately care for minoritized, low-income, uninsured, and underinsured populations. Our study aims to investigate disparities in clinical trial discussions and enrollment among lung cancer patients at Boston Medical Center, the largest safety net hospital in New England.
    Methods: We included 1121 patients diagnosed with lung cancer between January 2015 and December 2020. Electronic Medical Records (EMR) were queried, and patients were categorized into three groups: (1) clinical trial discussed and the patient enrolled, (2) clinical trial discussed but the patient not enrolled, and (3) clinical trial not discussed. Sociodemographic variables such as age, gender, race, ethnicity, city, primary language, median household income, medical insurance type, and education level were also collected. Chi-squared,
    Results: Of the 1121 patients, clinical trials were discussed in 141 patients (12.6%), of which 22 (15.6%) were enrolled. Clinical trial discussions were conducted more with younger patients (68.19 vs 71.37,
    Conclusion: Additional study of barriers to cancer clinical trial discussion and enrollment at safety net institutions can serve as a prerequisite to ameliorating racial disparities observed on a national scale.
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ISSN 2752-5368
    ISSN (online) 2752-5368
    DOI 10.1177/2752535X231221394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Imaging findings of Nasu-Hakola disease: a case report.

    Kilic, Seyda Andac / Oner, A Yusuf / Yuce, Cemal / Ozlu, Ilksen Canpolat

    Clinical imaging

    2012  Volume 36, Issue 6, Page(s) 877–880

    Abstract: Nasu-Hakola disease (NHD), also known as polycystic lipomembranous osteodysplasia and sclerosing leukoencephalopathy, is a rare and fatal hereditary disease with less than 200 cases reported in the literature [Madry H, Prudlo J, Grgic A, Freyschmidt J. ... ...

    Abstract Nasu-Hakola disease (NHD), also known as polycystic lipomembranous osteodysplasia and sclerosing leukoencephalopathy, is a rare and fatal hereditary disease with less than 200 cases reported in the literature [Madry H, Prudlo J, Grgic A, Freyschmidt J. Nasu-Hakola disease (PLOSL): report of five cases and review of the literature. Clin Orthop Relat Res 2007;454:262-269]. This progressive disease is characterized by multiple cystic bone lesions, complicated with pathologic fractures and progressive dementia. Here in this article we report the imaging findings including magnetic resonance imaging of a newly diagnosed NHD case, with emphasis on the awareness of the radiologist for prompt recognition of this rare entity.
    MeSH term(s) Brain/pathology ; Diagnosis, Differential ; Humans ; Lipodystrophy/diagnosis ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Osteochondrodysplasias/diagnosis ; Subacute Sclerosing Panencephalitis/diagnosis ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2012-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1028123-x
    ISSN 1873-4499 ; 0899-7071
    ISSN (online) 1873-4499
    ISSN 0899-7071
    DOI 10.1016/j.clinimag.2012.01.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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