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  1. Article ; Online: Host variations in SARS-CoV-2 infection.

    Altiok, Doruk / Savci, Elif Zeynep / Özkara, Büşra / Alkan, Kamil / Namdar, Dilara Sultan / Tunçer, Gizem / Kilinç, Buğrahan Regaip / Suiçmez, Evren / Çetin, Güneysu / Ünal, Sinan / Dönmüş, Beyza / Karagülleoğlu, Zeynep Yağmur / Uncuoğlu, Dilruba Beyza / Tekeli, Cansu / Mendi, Hanife Ayşegül / Bengi, Vahdi Umut / Cengiz Seval, Güldane / Kiliç, Pelin / Güneş Altuntaş, Evrim /
    Demir-Dora, Devrim

    Turkish journal of biology = Turk biyoloji dergisi

    2021  Volume 45, Issue 4, Page(s) 404–424

    Abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the "Coronavirus Disease of 2019 (COVID-19)", and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by ... ...

    Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the "Coronavirus Disease of 2019 (COVID-19)", and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by which the host interacts with the SARS-CoV-2 have not been fully enlightened. The epidemiological factors -e.g. age, sex, race-, the polymorphisms of the host proteins, the blood types and individual differences have all been in discussions about affecting the progression and the course of COVID-19 both individually and collectively, as their effects are mostly interwoven. We focused mainly on the effect of polymorphic variants of the host proteins that have been shown to take part in and/or affect the pathogenesis of COVID-19. Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.
    Language English
    Publishing date 2021-08-30
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2046470-8
    ISSN 1303-6092 ; 1303-6092
    ISSN (online) 1303-6092
    ISSN 1303-6092
    DOI 10.3906/biy-2104-67
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SARS-CoV-2 Mutations and their Viral Variants.

    Cosar, Begum / Karagulleoglu, Zeynep Yagmur / Unal, Sinan / Ince, Ahmet Turan / Uncuoglu, Dilruba Beyza / Tuncer, Gizem / Kilinc, Bugrahan Regaip / Ozkan, Yunus Emre / Ozkoc, Hikmet Ceyda / Demir, Ibrahim Naki / Eker, Ali / Karagoz, Feyzanur / Simsek, Said Yasin / Yasar, Bunyamin / Pala, Mehmetcan / Demir, Aysegul / Atak, Irem Naz / Mendi, Aysegul Hanife / Bengi, Vahdi Umut /
    Cengiz Seval, Guldane / Gunes Altuntas, Evrim / Kilic, Pelin / Demir-Dora, Devrim

    Cytokine & growth factor reviews

    2021  Volume 63, Page(s) 10–22

    Abstract: Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occur spontaneously during replication. Thousands of mutations have accumulated and continue to since the emergence of the virus. As novel mutations continue appearing at the ... ...

    Abstract Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occur spontaneously during replication. Thousands of mutations have accumulated and continue to since the emergence of the virus. As novel mutations continue appearing at the scene, naturally, new variants are increasingly observed. Since the first occurrence of the SARS-CoV-2 infection, a wide variety of drug compounds affecting the binding sites of the virus have begun to be studied. As the drug and vaccine trials are continuing, it is of utmost importance to take into consideration the SARS-CoV-2 mutations and their respective frequencies since these data could lead the way to multi-drug combinations. The lack of effective therapeutic and preventive strategies against human coronaviruses (hCoVs) necessitates research that is of interest to the clinical applications. The reason why the mutations in glycoprotein S lead to vaccine escape is related to the location of the mutation and the affinity of the protein. At the same time, it can be said that variations should occur in areas such as the receptor-binding domain (RBD), and vaccines and antiviral drugs should be formulated by targeting more than one viral protein. In this review, a literature survey in the scope of the increasing SARS-CoV-2 mutations and the viral variations is conducted. In the light of current knowledge, the various disguises of the mutant SARS-CoV-2 forms and their apparent differences from the original strain are examined as they could possibly aid in finding the most appropriate therapeutic approaches.
    MeSH term(s) COVID-19/virology ; Humans ; Mutation ; Protein Binding ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-07-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1330534-7
    ISSN 1879-0305 ; 1359-6101
    ISSN (online) 1879-0305
    ISSN 1359-6101
    DOI 10.1016/j.cytogfr.2021.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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