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  1. Article ; Online: Anxiety and attention shifting in professional baseball players.

    Han, D H / Kim, B N / Cheong, J H / Kang, K D / Renshaw, P F

    International journal of sports medicine

    2014  Volume 35, Issue 8, Page(s) 708–713

    Abstract: Based on the work of both Eysenck and Nideffer, we hypothesized that higher ranking players (HRP) would have lower competitive anxiety and more flexible attention-shifting, compared to lower ranking players (LRP). In addition, different patterns of ... ...

    Abstract Based on the work of both Eysenck and Nideffer, we hypothesized that higher ranking players (HRP) would have lower competitive anxiety and more flexible attention-shifting, compared to lower ranking players (LRP). In addition, different patterns of attention (low anxiety and flexible attention) would be represented by a different pattern of brain activity within the temporal lobe and dorsolateral prefrontal cortex. In accordance with the rookie draft ranking, the players were classified into 2 groups: HRP (top 30% of those selected in the draft) vs. LRP (bottom 30% of those selected in the draft). For assessment of executive function, a computerized version of the Wisconsin Card-sorting Test (WCST) was used. Brain activity was assessed using 1.5-Tesla functional magnetic resonance imaging. In response to scenes depicting baseball errors, HRP showed increased activation in the left cingulate cortex and decreased activation in right middle temporal gyrus, compared to LRP. In response to the simplified WCST in the scanner, HRP showed increased activation in left superior frontal cortex (DLPFC), compared to LRP. The present results suggest that HRP may demonstrate elevated cingulate activation and lower temporal cortex activation in response to scenes depicting baseball errors.
    MeSH term(s) Adult ; Anxiety ; Attention/physiology ; Baseball/physiology ; Baseball/psychology ; Competitive Behavior/physiology ; Executive Function/physiology ; Humans ; Magnetic Resonance Imaging ; Prefrontal Cortex/physiology ; Temporal Lobe/physiology ; Young Adult
    Language English
    Publishing date 2014-02-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/s-0033-1363235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1561: Show issues Location:
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  2. Article ; Online: Associations between serotonin transporter gene (SLC6A4) methylation and clinical characteristics and cortical thickness in children with ADHD.

    Park, S / Lee, J-M / Kim, J-W / Cho, D-Y / Yun, H J / Han, D H / Cheong, J H / Kim, B-N

    Psychological medicine

    2015  Volume 45, Issue 14, Page(s) 3009–3017

    Abstract: Background: Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Additionally, environmental factors such as perinatal stress and early adversities contribute to the occurrence and severity of ADHD. ... ...

    Abstract Background: Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Additionally, environmental factors such as perinatal stress and early adversities contribute to the occurrence and severity of ADHD. Recently, DNA methylation has emerged as a mechanism that potentially mediates gene-environmental interaction effects in the aetiology and phenomenology of psychiatric disorders. Here, we investigated whether serotonin transporter gene (SLC6A4) methylation patterns were associated with clinical characteristics and regional cortical thickness in children with ADHD.
    Method: In 102 children with ADHD (age 6-15 years), the methylation status of the SLC6A4 promoter was measured. Brain magnetic resonance imaging was obtained and ADHD symptoms were evaluated.
    Results: A higher methylation status of the SLC6A4 promoter was significantly associated with worse clinical presentations (more hyperactive-impulsive symptoms and more commission errors). Additionally, a negative correlation was observed between SLC6A4 methylation levels and cortical thickness values in the right occipito-temporal regions.
    Conclusions: Our results suggest that the SLC6A4 methylation status may be associated with certain symptoms of ADHD, such as behavioural disinhibition, and related brain changes. Future studies that use a larger sample size and a control group are required to corroborate these results.
    MeSH term(s) Adolescent ; Attention Deficit Disorder with Hyperactivity/genetics ; Brain/pathology ; Child ; DNA Methylation ; Female ; Gene-Environment Interaction ; Genotype ; Humans ; Hyperkinesis/genetics ; Magnetic Resonance Imaging ; Male ; Promoter Regions, Genetic ; Psychiatric Status Rating Scales ; Republic of Korea ; Serotonin Plasma Membrane Transport Proteins/genetics
    Chemical Substances SLC6A4 protein, human ; Serotonin Plasma Membrane Transport Proteins
    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S003329171500094X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transcriptional profiling of SHR/NCrl prefrontal cortex shows hyperactivity-associated genes responsive to amphetamine challenge.

    Dela Peña, I J I / Dela Peña, I / de la Peña, J B / Kim, H J / Sohn, A / Shin, C Y / Han, D H / Kim, B-N / Ryu, J H / Cheong, J H

    Genes, brain, and behavior

    2017  Volume 16, Issue 7, Page(s) 664–674

    Abstract: Several studies suggest a strong genetic component of attention-deficit/hyperactivity disorder (ADHD), a complex neurodevelopmental disorder characterized by inappropriate levels of hyperactivity, impulsivity and inattention. Determining specific genetic ...

    Abstract Several studies suggest a strong genetic component of attention-deficit/hyperactivity disorder (ADHD), a complex neurodevelopmental disorder characterized by inappropriate levels of hyperactivity, impulsivity and inattention. Determining specific genetic risk variants for each symptom dimension of ADHD may aid in the identification of the biological risk factors of the disorder. In this study, we explored the potential genetic underpinnings of the hyperactive phenotype of ADHD. To this end, we examined differentially expressed genes (DEGs) in the prefrontal cortex (PFC) of SHR/NCrl, an animal model of ADHD, compared with its genetic control, the Wistar Kyoto (WKY/NCrl) rat and the Wistar rat, strain used to represent the 'normal' heterogeneous population. Relative to WKY/NCrl and Wistar controls, SHR/NCrl showed hyperactivity in the open-field test. Treatment with the ADHD drug, amphetamine (AMPH) reduced hyperactivity in SHR/NCrl. Meanwhile, AMPH increased locomotor activity in WKY/NCrl and Wistar rats. Gene expression analysis found 21 common upregulated and 36 downregulated genes in the PFC of drug-naive SHR/NCrl when compared with WKY/NCrl and Wistar rats. Of these DEGs, expression levels of two genes, Atxn7 and Per2, which are involved in transcription and circadian rhythm, respectively, were downregulated following AMPH treatment in SHR/NCrl. Quantitative real-time-polymerase chain reaction analyses verified expression patterns of these genes in the PFC of drug-naïve and AMPH-treated SHR/NCrl. The present findings indicate genetic risk variants that may be associated with the hyperactive phenotype in ADHD. Further studies are warranted to establish the roles of Atxn7 and Per2 in mediating hyperactivity.
    Language English
    Publishing date 2017-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2075819-4
    ISSN 1601-183X ; 1601-1848
    ISSN (online) 1601-183X
    ISSN 1601-1848
    DOI 10.1111/gbb.12388
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    Zs.A 5642: Show issues Location:
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  4. Article: Anxiety and Attention Shifting in Professional Baseball Players

    Han, D. H. / Kim, B. N. / Cheong, J. H. / Kang, K. D. / Renshaw, P. F.

    International Journal of Sports Medicine

    2014  Volume 35, Issue 08, Page(s) 708–713

    Abstract: Based on the work of both Eysenck and Nideffer, we hypothesized that higher ranking players (HRP) would have lower competitive anxiety and more flexible attention-shifting, compared to lower ranking players (LRP). In addition, different patterns of ... ...

    Abstract Based on the work of both Eysenck and Nideffer, we hypothesized that higher ranking players (HRP) would have lower competitive anxiety and more flexible attention-shifting, compared to lower ranking players (LRP). In addition, different patterns of attention (low anxiety and flexible attention) would be represented by a different pattern of brain activity within the temporal lobe and dorsolateral prefrontal cortex. In accordance with the rookie draft ranking, the players were classified into 2 groups: HRP (top 30% of those selected in the draft) vs. LRP (bottom 30% of those selected in the draft). For assessment of executive function, a computerized version of the Wisconsin Card-sorting Test (WCST) was used. Brain activity was assessed using 1.5-Tesla functional magnetic resonance imaging. In response to scenes depicting baseball errors, HRP showed increased activation in the left cingulate cortex and decreased activation in right middle temporal gyrus, compared to LRP. In response to the simplified WCST in the scanner, HRP showed increased activation in left superior frontal cortex (DLPFC), compared to LRP. The present results suggest that HRP may demonstrate elevated cingulate activation and lower temporal cortex activation in response to scenes depicting baseball errors.
    Keywords professional baseball players ; attention shifting ; anxiety ; temporal cortex ; cingulate ; dorsolateral prefrontal cortex ; perseverative error
    Language English
    Publishing date 2014-02-19
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/s-0033-1363235
    Database Thieme publisher's database

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  5. Article ; Online: No significant association between the alpha-2A-adrenergic receptor gene and treatment response in combined or inattentive subtypes of attention-deficit hyperactivity disorder.

    Park, S / Kim, J-W / Kim, B-N / Hong, S-B / Shin, M-S / Yoo, H-J / Cho, S-C

    Pharmacopsychiatry

    2013  Volume 46, Issue 5, Page(s) 169–174

    Abstract: Introduction: Given the shortage of pharmacogenetic studies on treatment response according to subtype of attention-deficit hyperactivity disorder (ADHD), we investigated the associations between the MspI and DraI polymorphisms of the alpha-2 A- ... ...

    Abstract Introduction: Given the shortage of pharmacogenetic studies on treatment response according to subtype of attention-deficit hyperactivity disorder (ADHD), we investigated the associations between the MspI and DraI polymorphisms of the alpha-2 A-adrenergic receptor gene (ADRA2A) and treatment response to methylphenidate according to subtype of ADHD.
    Methods: We enrolled 115 medication-naïve children with ADHD into an open label 8-week trial of methylphenidate. The participants were genotyped and evaluated using the Clinical -Global Impression (CGI), ADHD rating scale, and Continuous Performance Test (CPT) pre- and post-treatment.
    Results: There was no statistically significant association between the MspI or DraI genotypes and the relative frequency of CGI-improvement (CGI-I) 1 or 2 status among any of the groups (all types of ADHD, ADHD-C, or ADHD-I). However, among the children with ADHD-C, those subjects with the C/C genotype at the ADRA2A DraI polymorphism tended to have a CGI-I 1 or 2 status post-treatment (OR=4.45, p=0.045).
    Discussion: The results of this study do not support the association between the the MspI or DraI genotypes and treatment response to methylphenidate in ADHD. However, our results -suggest that subtypes might influence pharmacogenetic results in ADHD.·available online at http://www.thieme-connect.de/ejournals/toc/pharmaco.
    MeSH term(s) Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit Disorder with Hyperactivity/genetics ; Child ; Female ; Genotype ; Humans ; Male ; Methylphenidate/therapeutic use ; Neuropsychological Tests ; Polymorphism, Single Nucleotide/genetics ; Receptors, Adrenergic, alpha-2/genetics ; Treatment Outcome
    Chemical Substances Receptors, Adrenergic, alpha-2 ; Methylphenidate (207ZZ9QZ49)
    Language English
    Publishing date 2013-07
    Publishing country Germany
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605670-2
    ISSN 1439-0795 ; 0720-4280 ; 0176-3679
    ISSN (online) 1439-0795
    ISSN 0720-4280 ; 0176-3679
    DOI 10.1055/s-0033-1343485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 481: Show issues Location:
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  6. Article ; Online: A study on knowledge and attitude toward brain death and organ retrieval among health care professionals in Korea.

    Jeon, K O / Kim, B N / Kim, H S / Byeon, N-I / Hong, J J / Bae, S H / Son, S Y

    Transplantation proceedings

    2012  Volume 44, Issue 4, Page(s) 859–861

    Abstract: Purpose: The practice of retrieving vital organs from brain-dead donors is legally and medically accepted in Korea, but health care professionals' beliefs and opinions regarding these matters have not been sufficiently explored. The purpose of this ... ...

    Abstract Purpose: The practice of retrieving vital organs from brain-dead donors is legally and medically accepted in Korea, but health care professionals' beliefs and opinions regarding these matters have not been sufficiently explored. The purpose of this study was to evaluate the knowledge and attitudes of health care professionals to the concepts of brain death and organ retrieval.
    Methods: Data were collected using a 41-item questionnaire during a week in June 2011. Sixty-one doctors and 109 nurses from five hospitals with more than 2000 beds in Seoul, Korea, participated in the survey. The data was analyzed using SPSS version 17.0 (SPSS Inc. Chicago, Illinois, USA).
    Results: There were statistically significant differences in the scores on knowledge according to marital status (P = .001) education level (P = .019), whether the participants were informed about organ donation from a brain-dead donor (P = .002), and the participant's experience managing potential brain-dead patients (P = .037). There were statistically significant differences in the scores on the attitude according to gender (P < .001), age (P < .001), marital status (P < .001), education level (P = .003), job position (P < .001), and the participant's experience referring brain-dead patients to the hospital-based organ procurement organization (P = .001). Significantly, attitude's positively correlated with knowledge about brain-dead organ donation (P < .001).
    Conclusion: Compared with previous studies, the knowledge and attitudes of health care professionals' regarding brain death and organ retrieval were not improved. There are passive attitudes to brain death and organ retrieval. More research must be performed to promote knowledge and understanding toward brain death and organ retrieval among health care professionals.
    MeSH term(s) Adult ; Asian Continental Ancestry Group/psychology ; Attitude of Health Personnel/ethnology ; Attitude to Death/ethnology ; Brain Death ; Comprehension ; Cross-Sectional Studies ; Cultural Characteristics ; Educational Status ; Employment/psychology ; Female ; Health Knowledge, Attitudes, Practice/ethnology ; Humans ; Male ; Marital Status/ethnology ; Middle Aged ; Republic of Korea/epidemiology ; Surveys and Questionnaires ; Tissue and Organ Harvesting/psychology ; Tissue and Organ Procurement ; Young Adult
    Language English
    Publishing date 2012-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2012.02.019
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  7. Article: A case of spontaneous bacterial empyema and bacteremia caused by Aeromonas hydrophila.

    Kim, B N / Chung, H / Shim, T S

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2001  Volume 20, Issue 3, Page(s) 214–215

    MeSH term(s) Aeromonas hydrophila/isolation & purification ; Bacteremia/etiology ; Empyema/etiology ; Humans ; Male ; Middle Aged ; Peritonitis/etiology
    Language English
    Publishing date 2001-05-01
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/pl00011255
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    Zs.A 1732: Show issues Location:
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  8. Article ; Online: Association between phthalates and externalizing behaviors and cortical thickness in children with attention deficit hyperactivity disorder.

    Park, S / Lee, J-M / Kim, J-W / Cheong, J H / Yun, H J / Hong, Y-C / Kim, Y / Han, D H / Yoo, H J / Shin, M-S / Cho, S-C / Kim, B-N

    Psychological medicine

    2015  Volume 45, Issue 8, Page(s) 1601–1612

    Abstract: Background: Previous studies have implicated the relationship between environmental phthalate exposure and attention deficit hyperactivity disorder (ADHD) symptoms of childhood, but no studies have been conducted in children who have a confirmed ... ...

    Abstract Background: Previous studies have implicated the relationship between environmental phthalate exposure and attention deficit hyperactivity disorder (ADHD) symptoms of childhood, but no studies have been conducted in children who have a confirmed diagnosis of ADHD obtained through meticulous diagnostic testing. We aimed to determine whether phthalate metabolites in urine would be higher in children with ADHD than in those without ADHD and would correlate with symptom severity and cortical thickness in ADHD children.
    Method: A cross-sectional examination of urine phthalate metabolite concentrations was performed; scores for ADHD symptoms, externalizing problems, and continuous performance tests were obtained from 180 children with ADHD, and brain-imaging data were obtained from 115 participants. For the control group, children without ADHD (N = 438) were recruited. Correlations between phthalate metabolite concentrations and clinical measures and brain cortical thickness were investigated.
    Results: Concentrations of phthalate metabolites, particularly the di(2-ethylhexyl) phthalate (DEHP) metabolite, were significantly higher in boys with ADHD than in boys without ADHD. Concentrations of the di-n-butyl phthalate (DBP) metabolite were significantly higher in the combined or hyperactive-impulsive subtypes compared to the inattentive subtype, and the metabolite was positively correlated with the severity of externalizing symptoms. Concentrations of the DEHP metabolite were negatively correlated with cortical thickness in the right middle and superior temporal gyri.
    Conclusions: The results of this study suggest an association between phthalate concentrations and both the diagnosis and symptom severity of ADHD. Imaging findings suggest a negative impact of phthalates on regional cortical maturation in children with ADHD.
    MeSH term(s) Adolescent ; Analysis of Variance ; Attention Deficit Disorder with Hyperactivity/pathology ; Attention Deficit Disorder with Hyperactivity/urine ; Cerebral Cortex/pathology ; Child ; Cross-Sectional Studies ; Environmental Exposure ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Phthalic Acids/urine ; Republic of Korea ; Severity of Illness Index
    Chemical Substances Phthalic Acids
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291714002694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Kidneys from deceased donors with oliguria are feasible for kidney transplantation.

    Kim, J M / Kim, S J / Joh, J-W / Kwon, C H D / Song, S / Shin, M / Kim, B N / Lee, S-K

    Transplantation proceedings

    2011  Volume 43, Issue 6, Page(s) 2355–2358

    Abstract: Background: Since kidneys from deceased donors with oliguria have not been widely used, compared their outcomes with those in recipients of kidneys without oliguria at the time of organ procurement.: Methods: We reviewed the deceased donors and ... ...

    Abstract Background: Since kidneys from deceased donors with oliguria have not been widely used, compared their outcomes with those in recipients of kidneys without oliguria at the time of organ procurement.
    Methods: We reviewed the deceased donors and kidney recipients between January 1999 and December 2009, all of whom were defined as standard criteria donors (SCD).
    Results: The group included 26 recipients whose terminal serum creatinine level (P < .001), estimated glomerular filtration rates (P < .001), and deceased donor scores (P < .001) were higher than those of the control group. Delayed graft function (P = .044) occurred more often among recipients with donor kidneys with oliguria than those without oliguria, and their hospitalization period was longer (P = .012). The serum creatinine levels in both groups were comparable posttransplantation; there was no significant difference in graft survivals.
    Conclusion: Deceased donors with oliguria at organ procurement appeared to be poor predictors of outcomes in the early posttransplantation period. Kidneys from deceased donors with oliguria should not be discarded for transplantation. The present study suggested that it is acceptable to use kidneys from selected deceased donors with oliguria.
    MeSH term(s) Adolescent ; Adult ; Biomarkers/blood ; Child ; Creatinine/blood ; Donor Selection ; Female ; Glomerular Filtration Rate ; Graft Rejection/etiology ; Graft Survival ; Humans ; Kaplan-Meier Estimate ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Oliguria/blood ; Oliguria/complications ; Oliguria/physiopathology ; Primary Graft Dysfunction/etiology ; Republic of Korea ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Tissue Donors/supply & distribution ; Treatment Outcome ; Young Adult
    Chemical Substances Biomarkers ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2011-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2011.06.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Kidney donation after cardiac death in Korea.

    Kim, J M / Kim, S-J / Joh, J-W / Kwon, C H D / Song, S / Shin, M / Kim, B N / Lee, S-K

    Transplantation proceedings

    2011  Volume 43, Issue 5, Page(s) 1434–1437

    Abstract: Organ donation after cardiac death (DCD) has been suggested due to the shortage of allografts in Korea. We investigated the outcomes of 446 deceased donor kidney transplant recipients in our center between September 1, 1995, and December 31, 2009. Twenty- ...

    Abstract Organ donation after cardiac death (DCD) has been suggested due to the shortage of allografts in Korea. We investigated the outcomes of 446 deceased donor kidney transplant recipients in our center between September 1, 1995, and December 31, 2009. Twenty-four (5.4%) of those patients received DCD kidney grafts. The DCD group had a long intensive care unit stay, frequent inotropics use (such as norepinephrine and dopamine), low mean blood pressure and estimated glomerular filtration rate, and high serum creatinine and deceased donor scores compared to the standard criteria donor (SCD) group and the expanded criteria donor (ECD) group. Mean true warm ischemic time of the DCD group was 59.7 minutes based on asystole time. The DCD group had a long hospital stay after transplantation, but there was no statistically significant difference in delayed graft function and primary nonfunction. Serum creatinine levels at 3 months after transplantation in the ECD and DCD group were significantly higher than the SCD group (P < .001) but lower in the DCD group than in the ECD group at 6 months and 9 months (P < .001 and P = .004) posttransplantation. There were no statistically significant differences in serum creatinine levels or in the graft survival rates between groups at 12 months (P = .160 and P = .737). The use of DCD attracted Korean surgeons because DCD allografts are equivalent to a heart-beating donor. Donors who die during the evaluation of brain death should not be abandoned for procurement, and we need to try to harvest allografts after cardiac death (type 4 DCD) to expand donor pools.
    MeSH term(s) Adolescent ; Adult ; Creatinine/blood ; Death ; Female ; Graft Survival ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Republic of Korea ; Tissue Donors
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2011-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2011.01.185
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